Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice
Billings, Lauren M., Oddo, Salvatore, Green, Kim N., McGaugh, James L., LaFerla, Frank M.·2005·Neuron
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- Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's diseaseScott J. Webster, Adam D. Bachstetter, Linda J. Van Eldik · 2013 · Alzheimer s Research & Therapy
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- Brain cholinergic vulnerability: Relevance to behavior and diseaseMichael McKinney · 2005 · Biochemical Pharmacology
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- Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanismsJonathan T. Ting, Brooke G. Kelley, Talley J. Lambert, David G. Cook, Jane Sullivan · 2006 · Proceedings of the National Academy of Sciences