Cited by 1,294Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

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Billings, Lauren M., Oddo, Salvatore, Green, Kim N., McGaugh, James L., LaFerla, Frank M.·2005·Neuron

DOI 10.1016/j.neuron.2005.01.040

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Abstract

Progressive memory loss and cognitive dysfunction are the hallmark clinical features of Alzheimer's disease (AD). Identifying the molecular triggers for the onset of AD-related cognitive decline presently requires the use of suitable animal models, such as the 3xTg-AD mice, which develop both amyloid and tangle pathology. Here, we characterize the onset of learning and memory deficits in this model. We report that 2-month-old, prepathologic mice are cognitively unimpaired. The earliest cognitive impairment manifests at 4 months as a deficit in long-term retention and correlates with the accumulation of intraneuronal Abeta in the hippocampus and amygdala. Plaque or tangle pathology is not apparent at this age, suggesting that they contribute to cognitive dysfunction at later time points. Clearance of the intraneuronal Abeta pathology by immunotherapy rescues the early cognitive deficits on a hippocampal-dependent task. Reemergence of the Abeta pathology again leads to cognitive deficits. This study strongly implicates intraneuronal Abeta in the onset of cognitive dysfunction.

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
Self-citation
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,506
Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431
Attention and executive deficits in Alzheimer's disease: A critical review
Perry, R. J. (1999) · Brain · doi:10.1093/brain/122.3.383 · Cited by 1,252

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Ciavardelli, D., Silvestri, E., Viscovo, A. D., Bomba, M., Gregorio, D. D., Moreno, M., Ilio, C. D., Goglia, F., Canzoniero, L. M. T., & Sensi, S. L. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.68 · Cited by 58
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Zhang, W., Wang, G. M., Wang, P. J., Zhang, Q., & Sha, S. H. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23299 · Cited by 54
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MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer’s brain, and prevent the progression of Alzheimer’s pathogenesis
Oka, S., Leon, J., Sakumi, K., Abolhassani, N., Sheng, Z., Tsuchimoto, D., LaFerla, F. M., & Nakabeppu, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-84640-9 · Cited by 51
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Authors: Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., & LaFerla, F. M.
Affiliations: University of California, Irvine (US)
Corresponding author: LaFerla, Frank M.
ORCID: Billings, Lauren M.
Oddo, Salvatore
Green, Kim N.
LaFerla, Frank M.
Venue: Neuron
Publisher: Elsevier BV
Published: 2005-03
Volume: 45
Issue: 5
Pages: 675-688
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2005.01.040
OpenAlex: W1973276273
Cited by: 1,294
References: 47
Citations by year: 2026: 29 · 2025: 47 · 2024: 55 · 2023: 55 · 2022: 46 · 2021: 61 · 2020: 75 · 2019: 62 · 2018: 55 · 2017: 56 · 2016: 64 · 2015: 59 · 2014: 72 · 2013: 68 · 2012: 65
FWCI: 40.55
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3060 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
Funders: National Institute on Aging (AG0212982, F32AG024035, F32 AG24035-01)
National Institute of Mental Health (MH12526)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: intraneuronal amyloid-beta, Alzheimer's disease, 3xTg-AD mice, learning and memory impairment, long-term memory retention, hippocampus, amygdala, amyloid plaques, neurofibrillary tangles, immunotherapy, animal models of Alzheimer's disease
MeSH terms: Alzheimer Disease, Animals, Cognition Disorders, Female, Hippocampus, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Amyloid beta-Peptides, Mice

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Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

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