The Dopamine D2 Receptor: New Surprises from an Old Friend

Dopamine receptors: from structure to function

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Neurobiology of Depression

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The cellular neurobiology of depression

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Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs

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An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior

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Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia

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DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS

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Dopamine Receptor Signaling

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Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade

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Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission

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Dopamine supersensitivity correlates with D2 High states, implying many paths to psychosis

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Dopamine, depression and antidepressants

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RGS9 Modulates Dopamine Signaling in the Basal Ganglia

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Synaptic plasticity and drug addiction

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The Ventral Tegmental Area Is Required for the Behavioral and Nucleus Accumbens Neuronal Firing Responses to Incentive Cues

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Interaction with Neuronal Calcium Sensor NCS-1 Mediates Desensitization of the D2 Dopamine Receptor

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Dopamine D2 and D3 receptors are linked to the actin cytoskeleton via interaction with filamin A

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The Dopamine D₂, but not D₃or D₄, Receptor Subtype is Essential for the Disruption of Prepulse Inhibition Produced by Amphetamine in Mice

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Cooperative Activation of Dopamine D1and D2Receptors Increases Spike Firing of Nucleus Accumbens Neurons via G-Protein βγ Subunits

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Par-4 Links Dopamine Signaling and Depression

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Inhibition of glycogen synthase kinase 3β in sensory neurons in culture alters filopodia dynamics and microtubule distribution in growth cones

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Homo- and hetero-oligomerization of G protein-coupled receptors

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GIPC Recruits GAIP (RGS19) To Attenuate Dopamine D2Receptor Signaling

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Atypical Protein Kinase C Is a Novel Mediator of Dopamine-Enhanced Firing in Nucleus Accumbens Neurons

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

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The Role of Dopamine in Schizophrenia from a Neurobiological and Evolutionary Perspective: Old Fashioned, but Still in Vogue

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Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors

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Synaptic Activity Unmasks Dopamine D2 Receptor Modulation of a Specific Class of Layer V Pyramidal Neurons in Prefrontal Cortex

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Impact of GPCRs in clinical medicine: Monogenic diseases, genetic variants and drug targets

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Frequency-specific and D 2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling

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Genetic Polymorphisms in Monoamine Neurotransmitter Systems Show Only Weak Association with Acute Post-Surgical Pain in Humans

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Presynaptic D2 Dopamine Receptors Control Long-Term Depression Expression and Memory Processes in the Temporal Hippocampus

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Imaging analysis of clock neurons reveals light buffers the wake-promoting effect of dopamine

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Variants of Dopamine and Serotonin Candidate Genes as Predictors of Response to Risperidone Treatment in First-Episode Schizophrenia

Ikeda, M., Yamanouchi, Y., Kinoshita, Y., Kitajima, T., Yoshimura, R., Hashimoto, S., O’Donovan, M. C., Nakamura, J., Ozaki, N., & Iwata, N. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.10.1437 · Cited by 110 · see citing works

Nitrated α-Synuclein Induces the Loss of Dopaminergic Neurons in the Substantia Nigra of Rats

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The orphan GPCR, GPR88, modulates function of the striatal dopamine system: A possible therapeutic target for psychiatric disorders?

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Genetic association studies of methamphetamine use disorders: A systematic review and synthesis

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Age-dependent regulation of synaptic connections by dopamine D2 receptors

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Dopamine abnormalities in the neocortex of patients with temporal lobe epilepsy

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Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder

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Molecular and cellular mechanisms of dopamine-mediated behavioral plasticity in the striatum

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Secretion of brain‐derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling

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Basal ganglia for beginners: the basic concepts you need to know and their role in movement control

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D2/D3 receptor agonist ropinirole protects dopaminergic cell line against rotenone‐induced apoptosis through inhibition of caspase‐ and JNK‐dependent pathways

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Human olfactory epithelial cells generated in vitro express diverse neuronal characteristics

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Circuit Analysis of a Drosophila Dopamine Type 2 Receptor That Supports Anesthesia-Resistant Memory

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Dopamine Genes and Nicotine Dependence in Treatment-Seeking and Community Smokers

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Pro-apoptotic Par-4 and dopamine D2 receptor in temporal cortex in schizophrenia, bipolar disorder and major depression

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RGS9‐2 mediates specific inhibition of agonist‐induced internalization of D2‐dopamine receptors

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Age-related changes in binding of the D2/3 receptor radioligand [11C](+)PHNO in healthy volunteers

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Protein Kinase A Activity Controls the Regulation of T-type CaV3.2 Channels by Gβγ Dimers

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Dopaminergic Regulation of Nucleus Accumbens Cholinergic Interneurons Demarcates Susceptibility to Cocaine Addiction

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Cocaine Dependence and Stroke: Pathogenesis and Management

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Brain Control of Sexually Dimorphic Liver Function and Disease: The Endocrine Connection

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Dopamine-Induced Apoptosis of Lactotropes Is Mediated by the Short Isoform of D2 Receptor

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Distinct roles of presynaptic dopamine receptors in the differential modulation of the intrinsic synapses of medium-spiny neurons in the nucleus accumbens

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Dopamine signaling regulates hematopoietic stem and progenitor cell function

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Ginkgo biloba extract (EGb 761) modulates the expression of dopamine-related genes in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice

Rojas, P., Ruiz-Sánchez, E., Rojas, C., & Ögren, S. O. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.004 · Cited by 41 · see citing works

Polymorphisms of dopamine receptor/transporter genes and risk of non-small cell lung cancer

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Repeated cocaine exposure decreases dopamine D₂‐like receptor modulation of Ca²⁺homeostasis in rat nucleus accumbens neurons

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Involvement of PKA/DARPP-32/PP1α and β- arrestin/Akt/GSK-3β Signaling in Cadmium-Induced DA-D2 Receptor-Mediated Motor Dysfunctions: Protective Role of Quercetin

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Dopamine D2 Receptors Modulate Pyramidal Neurons in Mouse Medial Prefrontal Cortex through a Stimulatory G-Protein Pathway

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Intramolecular allosteric communication in dopamine D2 receptor revealed by evolutionary amino acid covariation

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Atlas of type 2 dopamine receptors in the human brain: Age and sex dependent variability in a large PET cohort

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In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias

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Dopamine Receptor Interacting Proteins: Targeting Neuronal Calcium Sensor-1/D2 Dopamine Receptor Interaction for Antipsychotic Drug Development

Kabbani, N., Woll, M. P., Nordman, J. C., & Levenson, R. G. (2011) · Current Drug Targets · doi:10.2174/138945012798868515 · Cited by 31 · see citing works

Three Mechanisms by which Striatal Denervation Causes Breakdown of Dopamine Signaling

Dreyer, J. K. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1458-14.2014 · Cited by 31 · see citing works

Dopamine as a Potential Target for Learning and Memory: Contributing to Related Neurological Disorders

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DARPP-32 and NCS-1 Expression is not Altered in Brains of Rats Treated with Typical or Atypical Antipsychotics

Souza, B. R., Motta, B. S., Rosa, D. V., Torres, K., de Castro, A. A., Comim, C. M., Sampaio, A. M., Lima, F. F., Jeromin, A., Quevedo, J., et al. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9470-2 · Cited by 31 · see citing works

Possible association of β‐arrestin 2 gene with methamphetamine use disorder, but not schizophrenia

Ikeda, M., Ozaki, N., Suzuki, T., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., Kishi, T., Sekine, Y., Iyo, M., Harano, M., et al. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00237.x · Cited by 31 · see citing works

D2-Dopaminergic Receptor-Linked Pathways: Critical Regulators of CYP3A, CYP2C, and CYP2D

Daskalopoulos, E. P., Lang, M. A., Μαρσέλος, Μ., Malliou, F., & Konstandi, M. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.078709 · Cited by 30 · see citing works

Pre‐ and postsynaptic contributions to age‐related alterations in corticostriatal synaptic plasticity

Akopian, G. K., & Walsh, J. P. (2006) · Synapse · doi:10.1002/syn.20289 · Cited by 29 · see citing works

Regulation of dopaminergic neuron firing by heterogeneous dopamine autoreceptors in the substantia nigra pars compacta

Jang, J. Y., Jang, M., Kim, S. H., Um, K. B., Kang, Y. K., Kim, H. J., Chung, S., & Park, M. K. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07107.x · Cited by 27 · see citing works

D2‐Dopamine receptors target regulator of G protein signaling 9‐2 to detergent‐resistant membrane fractions

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Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra

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Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver

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Efficacy, Safety, and Tolerability of Ansofaxine (LY03005) Extended-Release Tablet for Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding, Phase 2 Clinical Trial

Mi, W., Yang, F., Li, H., Xu, X., Li, L., Tan, Q., Wang, G., Zhang, K., Tian, F., Luo, J., et al. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab074 · Cited by 24 · see citing works

Canonical and Non-Canonical Antipsychotics’ Dopamine-Related Mechanisms of Present and Next Generation Molecules: A Systematic Review on Translational Highlights for Treatment Response and Treatment-Resistant Schizophrenia

de Bartolomeis, A., Ciccarelli, M., Simone, G. D., Mazza, B., Barone, A., & Vellucci, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065945 · Cited by 25 · see citing works

Evaluation of the effects of vitamin A supplementation on adult rat substantia nigra and striatum redox and bioenergetic states: Mitochondrial impairment, increased 3-nitrotyrosine and α-synuclein, but decreased D2 receptor contents

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Lack of effects of typical and atypical antipsychotics in DARPP-32 and NCS-1 levels in PC12 cells overexpressing NCS-1

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Unraveling Activation-Related Rearrangements and Intrinsic Divergence from Ligand-Specific Conformational Changes of the Dopamine D3 and D2 Receptors

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Cdc42 signaling regulated by dopamine D2 receptor correlatively links specific brain regions of hippocampus to cocaine addiction

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Dopamine D1 receptor agonist alleviates post-weaning isolation-induced neuroinflammation and depression-like behaviors in female mice

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Big data-driven target identification by machine learning: DRD2 as a therapeutic target for psoriasis

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Kinetic studies of dopamine D2 receptor molecular pharmacology

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Developing New Dopamine D2 Receptor Agonists and Partial Agonists for Parkinson’s Disease and Schizophrenia

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