The Dopamine D2, but not D3or D4, Receptor Subtype is Essential for the Disruption of Prepulse Inhibition Produced by Amphetamine in Mice
Open accessAbstract
Brain dopamine (DA) systems are involved in the modulation of the sensorimotor gating phenomenon known as prepulse inhibition (PPI). The class of D2-like receptors, including the D2, D3, and D4 receptor subtypes, have all been implicated in the control of PPI via studies of DA agonists and antagonists in rats. Nevertheless, the functional relevance of each receptor subtype remains unclear because these ligands are not specific. To determine the relevance of each receptor subtype, we used genetically altered strains of “knock-out” mice lacking the DA D2, D3, or D4 receptors. We tested the effects of each knock-out on both the phenotypic expression of PPI and the disruption of PPI produced by the indirect DA agonist d-amphetamine (AMPH). No phenotypic differences in PPI were observed at baseline. AMPH significantly disrupted PPI in the D2 (+/+) mice but had no effect in the D2 (−/−) mice. After AMPH treatment, both DA D3 and D4 receptor (+/+) and (−/−) mice had significant disruptions in PPI. These findings indicate that the AMPH-induced disruption of PPI is mediated via the DA D2 receptor and not the D3 or D4 receptor subtypes. Uncovering the neural mechanisms involved in PPI will further our understanding of the substrates of sensorimotor gating and could lead to better therapeutics to treat gating disorders, such as schizophrenia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Studies in mice indicate that administration of direct-acting DA agonists such as apomorphine and indirect DA agonists such as cocaine disrupt PPI primarily via D1 receptors, whereas D2 receptors seem to modulate amphetamine-induced PPI deficits.
“Studies in mice have indicated that administration of direct-acting DA agonists (such as apomorphine) and indirect DA agonists (such as cocaine) to mice disrupt PPI primarily via D1 receptors [369], whereas D2 receptors seem to modulate amphetamine-induced PPI deficits [370].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [370]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Sokoloff, P., Bruno Giros, A., Martres, M., Bouthenet, M.-L., & Schwartz, J. (1990) · Nature · doi:10.1038/347146a0 · Cited by 2,608 · see citing works
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1976) · Science · doi:10.1126/science.3854 · Cited by 2,220 · see citing works
Crawley, J. N., Belknap, J. K., Collins, A. C., Crabbe, J. C., Frankel, W. N., Henderson, N. D., HITZEMANN, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., et al. (1997) · Psychopharmacology · doi:10.1007/s002130050327 · Cited by 1,372 · see citing works
Gating and Habituation of the Startle Reflex in Schizophrenic Patients
Braff, D. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820030038005 · Cited by 1,027 · see citing works
Dopamine receptor pharmacology
Seeman, P. M., & Tol, H. H. M. V. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90323-9 · Cited by 969 · see citing works
Assessing the Validity of an Animal Model of Deficient Sensorimotor Gating in Schizophrenic Patients
Swerdlow, N. R. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020063007 · Cited by 708 · see citing works
Dopaminergic stimulation disrupts sensorimotor gating in the rat
Mansbach, R. S., Geyer, M. A., & BRAFF, D. L. (1988) · Psychopharmacology · doi:10.1007/bf00212846 · Cited by 608 · see citing works
Self-citationMice Lacking Dopamine D4 Receptors Are Supersensitive to Ethanol, Cocaine, and Methamphetamine
Rubinstein, M., Phillips, T. J., Bunzow, J. R., Falzone, T. L., Dziewczapolski, G., Zhang, G., Fang, Y., Larson, J. L., McDougall, J. A., Chester, J. A., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80365-7 · Cited by 473 · see citing works
Self-citationA targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice.
Accili, D., Fishburn, C. S., Drago, J., Steiner, H., Lachowicz, J. E., Park, B.-H., Gauda, E. B., Lee, E.-C., Cool, M. H., Sibley, D. R., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.1945 · Cited by 466 · see citing works
Startle response models of sensorimotor gating and habituation deficits in schizophrenia
Geyer, M. A., Swerdlow, N. R., Mansbach, R. S., & Braff, D. L. (1990) · Brain Research Bulletin · doi:10.1016/0361-9230(90)90241-q · Cited by 456 · see citing works
Self-citationKelly, M. A., Rubinstein, M., Phillips, T. J., Lessov, C. N., Burkhart‐Kasch, S., Zhang, G., Bunzow, J. R., Fang, Y., Gerhardt, G. A., Grandy, D. K., et al. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03470.1998 · Cited by 447 · see citing works
Self-citationKelly, M. A., Rubinstein, M., Asa, S. L., Zhang, G., Sáez, C., Bunzow, J. R., Allen, R. G., Hnasko, R. M., Ben‐Jonathan, N., Grandy, D. K., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80351-7 · Cited by 425 · see citing works
Self-citationInbred strain differences in prepulse inhibition of the mouse startle response
Paylor, R. E., & Crawley, J. N. (1997) · Psychopharmacology · doi:10.1007/s002130050333 · Cited by 382 · see citing works
Xu, M., Koeltzow, T. E., Santiago, G. T., Moratalla, R., Cooper, D., Hu, X., White, N. M., Graybiel, A. M., White, F. J., & Tonegawa, S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80965-4 · Cited by 315 · see citing works
Cadenhead, K. S., Geyer, M. A., & BRAFF, D. L. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.12.1862 · Cited by 307 · see citing works
Self-citationSwerdlow, N. R., Keith, V. A., BRAFF, D. L., & Geyer, M. A. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23018-x · Cited by 247 · see citing works
Self-citationAtypical Neuroleptics Have Low Affinity for Dopamine D2 Receptors or Are Selective for D4 Receptors
Seeman, P. M. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00187-x · Cited by 236 · see citing works
Swerdlow, N. R., Mansbach, R. S., Geyer, M. A., Pulvirenti, L., Koob, G. F., & BRAFF, D. L. (1990) · Psychopharmacology · doi:10.1007/bf02244616 · Cited by 235 · see citing works
Self-citationMeasurement of Startle Response, Prepulse Inhibition, and Habituation
Geyer, M. A., & Swerdlow, N. R. (1998) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0807s03 · Cited by 219 · see citing works
Self-citationClozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia
Swerdlow, N. R., & Geyer, M. A. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90193-w · Cited by 191 · see citing works
Self-citationJohansson, C., Jackson, D. M., Zhang, J., & Svensson, L. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00160-x · Cited by 148 · see citing works
Apomorphine disrupts the inhibition of acoustic startle induced by weak prepulses in rats
Davis, M., Mansbach, R. S., Swerdlow, N. R., Campeau, S., Braff, D. L., & Geyer, M. A. (1990) · Psychopharmacology · doi:10.1007/bf02245735 · Cited by 139 · see citing works
Self-citationPeng, R. Y., Mansbach, R. S., BRAFF, D. L., & Geyer, M. A. (1990) · PubMed · Cited by 137 · see citing works
Self-citationSchizophrenia and L-745, 870, a novel dopamine D4 receptor antagonist
Bristow, L. J., Kramer, M. S., Kulagowski, J. J., Patel, S. S., RAGAN, C. I., & Seabrook, G. R. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01066-3 · Cited by 132 · see citing works
Dulawa, S. C., Hen, R., Scearce-Levie, K. A., & Geyer, M. A. (1997) · Psychopharmacology · doi:10.1007/s002130050328 · Cited by 122 · see citing works
Self-citationBullock, A. E., Slobe, B. S., Vázquez, V., & Collins, A. C. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.6.1353 · Cited by 119 · see citing works
Bristow, L. J., Collinson, N., Cook, G. P., Curtis, N. R., Freedman, S. B., Kulagowski, J. J., Leeson, P. D., Patel, S., RAGAN, C. I., Ridgill, M. P., et al. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37123-x · Cited by 103 · see citing works
Bullock, A. E., Slobe, B. S., Vázquez, V., et al. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.6.1353 · Cited by 103 · see citing works
Psychopharmacology of prepulse inhibition in mice.
Dulawa, S. C., & Geyer, M. A. (1996) · PubMed · Cited by 91 · see citing works
Self-citationDavis, M., Svensson, T. H., & Aghajanian, G. K. (1975) · Psychopharmacology · doi:10.1007/bf00437607 · Cited by 85 · see citing works
Mansbach, R. S., Brooks, E., Zorn, S. H., & Sanner, M. A. (1998) · Psychopharmacology · doi:10.1007/s002130050501 · Cited by 82 · see citing works
Varty, G. B., & Higgins, G. A. (1994) · Journal of Psychopharmacology · doi:10.1177/026988119400800302 · Cited by 78 · see citing works
Self-citationCaine, S. B., Geyer, M. A., & Swerdlow, N. R. (1995) · Neuropsychopharmacology · doi:10.1016/0893-133x(94)00071-7 · Cited by 71 · see citing works
Self-citationBakshi, V. P., Geyer, M. A., Taaid, N., & Swerdlow, N. R. (1995) · Behavioural Pharmacology · doi:10.1097/00008877-199512000-00005 · Cited by 59 · see citing works
Self-citationBowery, B. J., Razzaque, Z., Emms, F., Patel, S., Freedman, S. B., Bristow, L. J., Kulagowski, J. J., & Seabrook, G. R. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb16063.x · Cited by 58 · see citing works
Bristow, L. J., Cook, G. P., Gay, J. C., Kulagowski, J. J., Landon, L. A., Murray, F., Saywell, K. L., Young, L., & Hutson, P. H. (1996) · Neuropharmacology · doi:10.1016/0028-3908(96)00179-7 · Cited by 55 · see citing works
Varty, G. B., & Higgins, G. A. (1998) · Behavioural Pharmacology · doi:10.1097/00008877-199809000-00008 · Cited by 50 · see citing works
Self-citationSchizophrenia and L-745, 870, a novel dopamine D4 receptor antagonist
Bristow, L. J., Kramer, M. S., Kulagowski, J. J., et al. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)90618-0 · Cited by 48 · see citing works
Rigdon, G. (2005) · Psychopharmacology · doi:10.1007/bf02244115 · Cited by 41 · see citing works
Influence of Some Organic Salts on the Absorption of Potassium by Vermiculite
MORTLAND, M. M. (1961) · Nature · doi:10.1038/192481a0 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Geyer, M. A., Krebs-Thomson, K., Braff, D. L., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100811 · Cited by 1,484 · see citing works
Self-citationRealistic expectations of prepulse inhibition in translational models for schizophrenia research
Swerdlow, N. R., Weber, M., Qu, Y., Light, G. A., & Braff, D. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1072-4 · Cited by 529 · see citing works
The dopamine D4 receptor: one decade of research
Oak, J. N., Oldenhof, J., & Tol, H. H. M. V. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00562-8 · Cited by 421 · see citing works
Swerdlow, N. R., BRAFF, D. L., & Geyer, M. A. (2000) · Behavioural Pharmacology · doi:10.1097/00008877-200006000-00002 · Cited by 392 · see citing works
Self-citationvan den Buuse, M. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp132 · Cited by 340 · see citing works
Psychosis pathways converge via D2High dopamine receptors
Seeman, P. M., Schwarz, J., Chen, J., Szechtman, H., Perreault, M. L., McKnight, G. S., Roder, J., Quirion, R., Boksa, P., Srivastava, L. K., et al. (2006) · Synapse · doi:10.1002/syn.20303 · Cited by 328 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Behavioral characterization of neuropeptide Y knockout mice
Bannon, A. W., Seda, J., Carmouché, M., Francis, J. M., Norman, M. H., Karbon, B., & McCaleb, M. L. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02285-x · Cited by 288 · see citing works
Mouse genetic models for prepulse inhibition: an early review
Geyer, M. A., McIlwain, K. L., & Paylor, R. E. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001159 · Cited by 289 · see citing works
Self-citationReavill, C., Taylor, S. G., Wood, M. D., Ashmeade, T., Austin, N. E., Avenell, K. Y., Boyfield, I., Branch, C. L., Cilia, J., Coldwell, M. C., et al. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39184-0 · Cited by 287 · see citing works
Ralph, R. J., Paulus, M. P., Fumagalli, F., Caron, M. G., & Geyer, M. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00305.2001 · Cited by 271 · see citing works
Self-citationRegulation of Akt Signaling by D2and D3Dopamine ReceptorsIn Vivo
Beaulieu, J., Tirotta, E., Sotnikova, T. D., Masri, B., Salahpour, A., Gainetdinov, R. R., Borrelli, E., & Caron, M. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5074-06.2007 · Cited by 269 · see citing works
Self-citationZweifel, L. S., Fadok, J. P., Argilli, E., Garelick, M. G., Jones, G. L., Dickerson, T. M. K., Allen, J. M., Mizumori, S. J. Y., Bonci, A., & Palmiter, R. D. (2011) · Nature Neuroscience · doi:10.1038/nn.2808 · Cited by 256 · see citing works
Dopamine D3 receptor antagonists as therapeutic agents
Joyce, J. N., & Millan, M. J. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03491-4 · Cited by 237 · see citing works
Caine, S. B., Negus, S. S., Mello, N. K., Patel, S., Bristow, L., Kulagowski, J., Vallone, D., Saiardi, A., & Borrelli, E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02977.2002 · Cited by 234 · see citing works
Prepulse inhibition and genetic mouse models of schizophrenia
Powell, S. B., Zhou, X., & Geyer, M. A. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.021 · Cited by 218 · see citing works
Self-citationDopamine is necessary for cue-dependent fear conditioning
Fadok, J. P., Dickerson, T. M. K., & Palmiter, R. D. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1616-09.2009 · Cited by 213 · see citing works
Optogenetic dissection of medial prefrontal cortex circuitry
Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00230 · Cited by 208 · see citing works
Facilitated Glutamatergic Transmission in the Striatum of D2Dopamine Receptor-Deficient Mice
Cepeda, C., Hurst, R. S., Altemus, K. L., Flores‐Hernández, J., Calvert, C. R., Jokel, E. S., Grandy, D. K., Low, M. J., Rubinstein, M., Ariano, M. A., et al. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.2.659 · Cited by 203 · see citing works
Self-citationGenetic animal models: focus on schizophrenia
Gainetdinov, R. R., Mohn, A. R., & Caron, M. G. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01886-5 · Cited by 201 · see citing works
Self-citationEhrlichman, R. S., Gandal, M. J., Maxwell, C. R., Lazarewicz, M. T., Finkel, L. H., Contreras, D., Turetsky, B. I., & Siegel, S. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.031 · Cited by 171 · see citing works
The mouse: genetics meets behaviour
Bućan, M., & Abel, T. G. (2002) · Nature Reviews Genetics · doi:10.1038/nrg728 · Cited by 170 · see citing works
Behavioral characterization of dopamine D-sub-5 receptor null mutant mice.
Holmes, A., Hollon, T. R., Gleason, T., Liu, Z., Dreiling, J. L., Sibley, D. R., & Crawley, J. N. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.5.1129 · Cited by 166 · see citing works
The family of sensorimotor gating disorders: Comorbidities or diagnostic overlaps?
Geyer, M. A. (2006) · Neurotoxicity Research · doi:10.1007/bf03033358 · Cited by 159 · see citing works
Self-citationRolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity
Kanes, S., Tokarczyk, J., Siegel, S. J., Bilker, W. B., Abel, T. G., & Kelly, M. P. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.026 · Cited by 158 · see citing works
Self-citationHolmes, A., Lachowicz, J. E., & Sibley, D. R. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.034 · Cited by 133 · see citing works
Current and Novel Approaches to the Drug Treatment of Schizophrenia
Rowley, M., Bristow, L. J., & Hutson, P. H. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm0002432 · Cited by 129 · see citing works
Genetic Models of Sensorimotor Gating: Relevance to Neuropsychiatric Disorders
Powell, S. B., Weber, M., & Geyer, M. A. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_195 · Cited by 120 · see citing works
Self-citationErrico, F., Rossi, S., Napolitano, F., Catuogno, V., Topo, E., Fisone, G., D’Aniello, A., Centonze, D., & Usiello, A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1618-08.2008 · Cited by 120 · see citing works
Millan, M. J., Dekeyne, A., Rivet, J., Dubuffet, T., Lavielle, G., & Brocco, M. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39333-4 · Cited by 119 · see citing works
Ralph, R. J., Paulus, M. P., Zhuang, X., Hen, R., & Geyer, M. A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01489-0 · Cited by 119 · see citing works
Self-citationThe changing roles and targets for animal models of schizophrenia
Kilts, C. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01286-0 · Cited by 116 · see citing works
The Dopamine D2 Receptor: New Surprises from an Old Friend
Bonci, A., & Hopf, F. W. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.015 · Cited by 115 · see citing works
Activation of dopamine D 4 receptors by ABT-724 induces penile erection in rats
Brioni, J. D., Moreland, R. B., Cowart, M., Hsieh, G. C., Stewart, A. O., Hedlund, P., Donnelly‐Roberts, D. L., Nakane, M., Lynch, J. J., Kolasa, T., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308292101 · Cited by 114 · see citing works
Perception Measurement in Clinical Trials of Schizophrenia: Promising Paradigms From CNTRICS
Green, M. F., Butler, P. D., Chen, Y., Geyer, M. A., Silverstein, S., Wynn, J. K., Yoon, J. H., & Zemon, V. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn156 · Cited by 113 · see citing works
Self-citationChandran, J. S., Lin, X. Z., Zapata, A. G., Höke, A., Shimoji, M., Moore, S. O., Galloway, M. P., Laird, F. M., Wong, P. C., Price, D. L., et al. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.11.011 · Cited by 112 · see citing works
Ralph, R. J., Masten, V. L., Otero-Corchón, V., Low, M. J., & Geyer, M. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09604.2002 · Cited by 110 · see citing works
Self-citationHuman and animal studies of schizophrenia-related gating deficits
Light, G. A., & BRAFF, D. L. (1999) · Current Psychiatry Reports · doi:10.1007/s11920-999-0008-y · Cited by 108 · see citing works
Ralph, R. J., Paulus, M. P., & Geyer, M. A. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29362-9 · Cited by 109 · see citing works
Self-citationOxytocin as a natural antipsychotic: a study using oxytocin knockout mice
Caldwell, H. K., Stephens, S. L., & Young, W. S. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002150 · Cited by 108 · see citing works
Dopamine D1 Rather than D2 Receptor Agonists Disrupt Prepulse Inhibition of Startle in Mice
Ralph-Williams, R. J., Lehmann-Masten, V., & Geyer, M. A. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300017 · Cited by 105 · see citing works
Self-citationOuagazzal, A. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00282-2 · Cited by 103 · see citing works
Barr, A. M., Lehmann-Masten, V., Paulus, M., Gainetdinov, R. R., Caron, M. G., & Geyer, M. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300343 · Cited by 103 · see citing works
Self-citationRalph, R. J., & Caine, S. B. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.074468 · Cited by 103 · see citing works
Self-citationPhosphodiesterase inhibitors: A novel mechanism for receptor-independent antipsychotic medications
Maxwell, C. R., Kanes, S., Abel, T. G., & Siegel, S. J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.038 · Cited by 103 · see citing works
Effects of strain and serotonergic agents on prepulse inhibition and habituation in mice
Dulawa, S. C., & Geyer, M. A. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00030-7 · Cited by 99 · see citing works
Self-citationHow antipsychotics work—From receptors to reality
Kapur, S., Agid, O., Mizrahi, R., & Li, M. (2006) · NeuroRx · doi:10.1016/j.nurx.2005.12.003 · Cited by 100 · see citing works
Logue, S. F., Grauer, S. M., Paulsen, J. E., Graf, R., Taylor, N., Sung, M.-L. A., Zhang, L., Hughes, Z. A., Pulito, V. L., Liu, F., et al. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.09.007 · Cited by 93 · see citing works
Drolet, G. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00303-2 · Cited by 93 · see citing works
Siuta, M., Robertson, S. D., Kocalis, H. E., Saunders, C., Gresch, P. J., Khatri, V., Shiota, C., Kennedy, J. P., Lindsley, C. W., Daws, L. C., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000393 · Cited by 92 · see citing works
Urs, N. M., Snyder, J. C., Jacobsen, J. P. R., Peterson, S. M., & Caron, M. G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215489109 · Cited by 91 · see citing works
Self-citationEnhanced dopamine function in DISC1‐L100P mutant mice: implications for schizophrenia
Lipina, T. V., Niwa, M., Jaaro-Peled, H., Fletcher, P. J., Seeman, P. M., Sawa, A., & Roder, J. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00615.x · Cited by 90 · see citing works
Hazlett, E. A., Buchsbaum, M. S., Tang, C. Y., Fleischman, M. B., Wei, T.-C., Byne, W. M., & Haznedar, M. M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01094-0 · Cited by 87 · see citing works
LI, Q., Lü, G., Antonio, G. E., Mak, Y. F., Rudd, J. A., Fan, M., & Yew, D. T. W. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.02.005 · Cited by 86 · see citing works
Connolly, P. M., Maxwell, C. R., Liang, Y., Kahn, J. B., Kanes, S., Abel, T. G., Gur, R. E., Turetsky, B. I., & Siegel, S. J. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000023605.68408.fb · Cited by 84 · see citing works
Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment?
Yang, P., Perlmutter, J. S., Benzinger, T. L. S., Morris, J. C., & Xu, J. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100994 · Cited by 81 · see citing works
Young, J. W., Powell, S. B., Scott, C. N., Zhou, X., & Geyer, M. A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.054 · Cited by 80 · see citing works
Self-citationMillan, M. J., Loiseau, F., Dekeyne, A., Gobert, A., Flik, G., Cremers, T. I. F. H., Rivet, J., Sicard, D., Billiras, R., & Brocco, M. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.134536 · Cited by 79 · see citing works
Papp, M. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00349-4 · Cited by 78 · see citing works
Xu, T., Sotnikova, T. D., Liang, C., Zhang, J., Jung, J. U., Spealman, R. D., Gainetdinov, R. R., & Yao, W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0974-09.2009 · Cited by 76 · see citing works
The Role of Extrastriatal Dopamine D2 Receptors in Schizophrenia
Takahashi, H., Higuchi, M., & Suhara, T. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.01.022 · Cited by 75 · see citing works
Xu, R., Hranilović, D., Fetsko, L. A., Bućan, M., & Wang, Y. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001145 · Cited by 75 · see citing works
Self-citationLaHoste, G. J., Henry, B. L., & Marshall, J. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06666.2000 · Cited by 73 · see citing works
Dopamine receptor functions: lessions from knockout mice
Glickstein, S. B., & Schmauss, C. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00145-0 · Cited by 71 · see citing works
The potential role of lamotrigine in schizophrenia
Large, C. H., Webster, E. L., & Goff, D. C. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0020-9 · Cited by 69 · see citing works
Lamotrigine prevents ketamine but not amphetamine-induced deficits in prepulse inhibition in mice
Brody, S. A., Geyer, M. A., & Large, C. H. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1421-2 · Cited by 67 · see citing works
Self-citationThe dopamine D4 receptors and mechanisms of antipsychotic atypicality
Wong, A. H. C., & Tol, H. H. M. V. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.005 · Cited by 65 · see citing works
Bannon, A. W., Seda, J., Carmouché, M., Francis, J. M., Jarosinski, M. A., & DOUGLASS, J. O. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29225-9 · Cited by 65 · see citing works
Varty, G. B., Walters, N., Cohen-Williams, M. E., & Carey, G. J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01115-3 · Cited by 65 · see citing works
Self-citationWaddington, J. L., Clifford, J. J., McNamara, F. N., Tomiyama, K., Koshikawa, N., & Croke, D. T. (2001) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00152-x · Cited by 60 · see citing works
Dopamine D4 Receptors in Psychostimulant Addiction
Ciano, P. D., Grandy, D. K., & Foll, B. L. (2014) · Advances in pharmacology · doi:10.1016/b978-0-12-420118-7.00008-1 · Cited by 58 · see citing works
Self-citationDoherty, J. M., Masten, V. L., Powell, S. B., Ralph, R. J., Klamer, D., Low, M. J., & Geyer, M. A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301657 · Cited by 58 · see citing works
Self-citationConnolly, P. M., Maxwell, C. R., Kanes, S., Abel, T. G., Liang, Y., Tokarczyk, J., Bilker, W. B., Turetsky, B. I., Gur, R. E., & Siegel, S. J. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.035 · Cited by 52 · see citing works
Fetsko, L. A., Xu, R., & Wang, Y. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04277-4 · Cited by 51 · see citing works
Self-citationBehavioral genetic contributions to the study of addiction-related amphetamine effects
Phillips, T. J., Kamens, H. M., & Wheeler, J. M. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.10.008 · Cited by 50 · see citing works
Roussos, P., Giakoumaki, S. G., & Bitsios, P. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.020 · Cited by 50 · see citing works
Assessments of Cognitive Deficits in Mutant Mice
Levin, E. D., & Buccafusco, J. J. (2006) · CRC Press eBooks · doi:10.1201/9781420004335-17 · Cited by 48 · see citing works
An Investigation of the Efficacy of Mood Stabilizers in Rodent Models of Prepulse Inhibition
Ong, J. C., Brody, S. A., Large, C. H., & Geyer, M. A. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.090845 · Cited by 48 · see citing works
Self-citationde Bruin, N. M. W. J., Ellenbroek, B. A., van Luijtelaar, E. L. J. M., Cools, A. R., & Stevens, K. E. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00183-x · Cited by 43 · see citing works
miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation
Kozuka, T., Omori, Y., Watanabe, S., Tarusawa, E., Yamamoto, H., Chaya, T., Furuhashi, M., Morita, M., Sato, T., Hirose, S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-38910-2 · Cited by 42 · see citing works
Grottick, A. J., Bagnol, D., Phillips, S., McDonald, J., Behan, D. P., Chalmers, D. T., & Hakak, Y. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.05.020 · Cited by 42 · see citing works
O'Sullivan, G. J., Kinsella, A., Sibley, D. R., Tighe, O., Croke, D. T., & Waddington, J. L. (2005) · Synapse · doi:10.1002/syn.20107 · Cited by 42 · see citing works
Effects of age and dopamine D2L receptor-deficiency on motor and learning functions
Fetsko, L. A., Xu, R., & Wang, Y. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.04.005 · Cited by 41 · see citing works
Self-citationAssociation analysis of dopamine D2-like receptor genes and methamphetamine abuse
Chen, C., Hu, X., Lin, S., Sham, P. C., Loh, E., Li, T., Murray, R. M., & Ball, D. M. (2004) · Psychiatric Genetics · doi:10.1097/00041444-200412000-00011 · Cited by 39 · see citing works
Assessing prepulse inhibition of startle in wild-type and knockout mice
Geyer, M. A. (1999) · Psychopharmacology · doi:10.1007/s002130051130 · Cited by 39 · see citing works
Self-citationClifford, J. J. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00141-4 · Cited by 39 · see citing works
Transgenic mice in the study of drug addiction and the effects of psychostimulant drugs
Sora, I., Li, B., Igari, M., Hall, F. S., & Ikeda, K. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05276.x · Cited by 38 · see citing works
van den Buuse, M., Morris, M. J., Chavez, C. A., Martin, S., & Wang, J. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705511 · Cited by 39 · see citing works
Alsene, K. M., Fallace, K., & Bakshi, V. P. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.106 · Cited by 34 · see citing works
Sensorimotor Gating Deficits in Transgenic Mice Expressing a Constitutively Active Form of Gsα
Gould, T. J., Bizily, S. P., Tokarczyk, J., Kelly, M. P., Siegel, S. J., Kanes, S., & Abel, T. G. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300309 · Cited by 35 · see citing works
Self-citationTan, S., Hermann, B., & Borrelli, E. (2003) · International review of neurobiology · doi:10.1016/s0074-7742(03)54005-3 · Cited by 32 · see citing works
Working memory span capacity improved by a D2 but not D1 receptor family agonist
Tarantino, I. S., Sharp, R. F., Geyer, M. A., Meves, J. M., & Young, J. W. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.12.037 · Cited by 32 · see citing works
Self-citationChavez, C. A., Gogos, A., Jones, M. E. E., & van den Buuse, M. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1604-6 · Cited by 32 · see citing works
Prepulse inhibition in HIV-1 gp120 transgenic mice after withdrawal from chronic methamphetamine
Henry, B. L., Geyer, M. A., Buell, M. R., Perry, W., Young, J. W., & Minassian, A. (2013) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000012 · Cited by 32 · see citing works
Self-citationBay-Richter, C., O’Tuathaigh, C. M. P., O'Sullivan, G., Heery, D. M., Waddington, J. L., & Moran, P. M. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009656 · Cited by 29 · see citing works
Auditory information processing in rat genotypes with different dopaminergic properties
de Bruin, N. M. W. J., van Luijtelaar, E., Cools, A. R., & Ellenbroek, B. A. (2001) · Psychopharmacology · doi:10.1007/s002130100785 · Cited by 29 · see citing works
Developing New Drugs for Schizophrenia: From Animals to the Clinic
Jones, D. N. C., Gartlon, J. E., Minassian, A., Perry, W., & Geyer, M. A. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373861-5.00008-4 · Cited by 28 · see citing works
Self-citationvan den Buuse, M., Martin, S., Brosda, J., Leck, K. J., MATTHAEI, K. I., & Hendry, I. A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0181-6 · Cited by 28 · see citing works
Assessments of Cognitive Deficits in Mutant Mice
Rodriguiz, R. M., & Wetsel, W. C. (2006) · Frontiers in neuroscience · doi:10.1201/9781420004335.ch12 · Cited by 27 · see citing works
Plappert, C. F., & Pilz, P. K. D. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00299-6 · Cited by 26 · see citing works
- Authors
- Ralph, R. J., Varty, G. B., Kelly, M. A., Wang, Y.-M., Caron, M. G., Rubinstein, M., Grandy, D. K., Low, M. J., & Geyer, M. A.
- Affiliations
- University of California San Diego (US)
- Vollum Institute (US)
- Howard Hughes Medical Institute (US)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Oregon Health & Science University (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-06-01
- Volume
- 19
- Issue
- 11
- Pages
- 4627-4633
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6782596
- OpenAlex
- W2100216270
- Cited by
- 174
- References
- 38
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 6
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Alliance for Research on Schizophrenia and Depression
- National Institute of Mental Health (K05-MH01228, F31MH012086)
- National Institute on Drug Abuse
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- prepulse inhibition, sensorimotor gating, dopamine D2 receptor, dopamine D3 receptor, dopamine D4 receptor, amphetamine, receptor knockout mice, schizophrenia
- MeSH terms
- Acoustic Stimulation, Amphetamine, Animals, Mice, Mutant Strains, Neural Inhibition, Receptors, Dopamine, Reflex, Startle, Dopamine Agents, Receptors, Dopamine D2, Mice, Knockout, Receptors, Dopamine D3, Receptors, Dopamine D4, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review