The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
The Endocannabinoid Anandamide Protects Neurons during CNS Inflammation by Induction of MKP-1 in Microglial Cells
Open accessAbstract
Endocannabinoids are released after brain injury and believed to attenuate neuronal damage by binding to CB(1) receptors and protecting against excitotoxicity. Such excitotoxic brain lesions initially result in primary destruction of brain parenchyma, which attracts macrophages and microglia. These inflammatory cells release toxic cytokines and free radicals, resulting in secondary neuronal damage. In this study, we show that the endocannabinoid system is highly activated during CNS inflammation and that the endocannabinoid anandamide (AEA) protects neurons from inflammatory damage by CB(1/2) receptor-mediated rapid induction of mitogen-activated protein kinase phosphatase-1 (MKP-1) in microglial cells associated with histone H3 phoshorylation of the mkp-1 gene sequence. As a result, AEA-induced rapid MKP-1 expression switches off MAPK signal transduction in microglial cells activated by stimulation of pattern recognition receptors. The release of AEA in injured CNS tissue might therefore represent a new mechanism of neuro-immune communication during CNS injury, which controls and limits immune response after primary CNS damage.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“AEA inhibits microglial nitric oxide (NO) synthesis through the mitogen-activated protein kinase pathway (Eljaschewitsch et al, 2006) and inhibits tumor necrosis factor α (TNF-α) activation of the transcription nuclear factor kappa B (Sancho et al, 2003).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Eljaschewitsch et al, 2006
Citations
Cites
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Molecular characterization of a peripheral receptor for cannabinoids
Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913
Determination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321
2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., & Waku, K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2437 · Cited by 2,196
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957
Galiègue, S., Mary, S., Marchand, J., Dussossoy, D., Carrière, D., Carayon, P., Bouaboula, M., Shire, D. J., Fur, G. L., & Casellas, P. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20780.x · Cited by 1,776
Formation and inactivation of endogenous cannabinoid anandamide in central neurons
Marzo, V. D., Fontana, A., Cadas, H., Schinelli, S., Cimino, G., Schwartz, J.-C., & Piomelli, D. (1994) · Nature · doi:10.1038/372686a0 · Cited by 1,585
Flagged first, then by citations
Research works printed but not linked: 1
- Matsuda, 1988, Structure of a cannabinoid receptor in rat brain, Mol. Pharmacol., 34, 605
Cited by
Sorted by citations
Items 401–446 of 446
The endocannabinoid system : a translational study from Achilles tendinosis to cyclooxygenase
Björklund, E. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Angefertigt mit Genehmigung der Mathematisch-Naturwissenschaftlichen Fakultät der
Bonn, R. F.-W.-U. (2012)
Endocannabinoid system modulation of the ocular immune response
Toguri, J. T. (2015) · DalSpace (Dalhousie University)
Mechanisms underlying the neuroprotective effects of histone deacetylase inhibitors
Durham, B. S. (2015) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Anandamide Modulation of Endotoxin-Induced Inflammation
Henry, D. M. K. R. (2013) · Anatomy & Physiology · doi:10.4172/2161-0940.1000e130
Emerging Oral Medications for Multiple Sclerosis
Fredrikson, S., & Hillert, J. A. (2012) · doi:10.2217/9781780840482
SFB TRR43: Das Gehirn als Ziel von entzündlichen Prozessen
Heppner, F. L., & Zipp, F. (2008) · e-Neuroforum · doi:10.1515/nf-2008-0308
Therapeutic Mechanisms for Cannabinoid-Promoted Survival of Oligodendrocytes
Ribeiro, R. B. (2013)
O potencial terapêutico de compostos canabinoides em um modelo in vitro de morte neuronal.
Vrechi, T. A. D. M. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2016.tde-11082016-090204
Potential drug targets for oral medications
Luessi, F., & Zipp, F. (2012) · doi:10.2217/ebo.12.32
Cellina, M. I., & Orsi, M. (2018) · Neuroimmunology and Neuroinflammation · doi:10.20517/2347-8659.2018.15
Crunfli, F. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2018.tde-14032018-110624
Khorasani, N. M. (2015) · Spiral (Imperial College London) · doi:10.25560/52433
Park, H., Kim, M., Park, T. H., Jeon, T. J., Chun, H., & Ryu, S. E. (2019) · Bulletin of the Korean Chemical Society · doi:10.1002/bkcs.11670
Natural molecules as epigenetic modifiers in reproduction
Natarajan, L., & Saldanha, S. N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819753-0.00018-0
Cannabinoid Receptor and InflammationPreprint
Osafo, N., Yeboah, K. O., Antwi, A. O., & Ainooson, G. K. (2020) · doi:10.22541/au.159986420.00633539 · Cited by 1
Papel de Endocanabinoides na modulação de células-tronco de Papila Apical in vitro
Meneses, C. C. B. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.23.2020.tde-24022021-154422
Investigation of the endocannabinoid system using in vivo and in vitro models
Ternes, S. (2013) · bonndoc (University of Bonn)
Luessi, F. (2021) · Neuromethods · doi:10.1007/978-1-0716-1213-2_18
Pertwee, R. G. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717967813.793467396
He, X., Zhao, Y., Li, G., Luo, J., Xu, J., Zheng, H., Zhang, L., & Hu, X. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4072048
Endogenous Mediators of Neuroinflammation: The Endocannabinoid System at the Retina
Duraikkannu, D., & Chatterjee, N. (2022) · Springer eBooks · doi:10.1007/978-981-16-8313-8_25
Therapeutic implications of the endocannabinoid system in neurodegenerative diseases
Goren, A., & University of Rome "G.Marconi" (2015) · Clinical Case Reports and Reviews · doi:10.15761/ccrr.1000126
Exercise Improved P2Y12-Regulated Microglial Dynamics During Stroke Via Endocannabinoid SignalingPreprint
He, X., Zhao, Y., Li, G., Luo, J., Xu, J., Zheng, H., Zhang, L., & Hu, X. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.24.538065
ТЕРАПЕВТИЧЕСКИЕ ЭФФЕКТЫ КАННАБИНОИДОВ ПРИ ПАТОЛОГИИ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ (ОБЗОР ЛИТЕРАТУРЫ)
Колесников, А. Н., Гридасова, Е. И., & Абрамова, Е. А. (2023) · Military and tactical medicine Emergency medicine · doi:10.55359/2782-3296.2023.90.22.013
Leweke, F. M., & Rohleder, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19081-0.00020-2
Anandamide: From modulation of neuronal excitation to antimicrobial activities—What is in common?
Sionov, R. V., & Steinberg, D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19081-0.00017-2
Epigenetic modulation by the endocannabinoid system in the central nervous system
Pereira-Teixeira, C., Pereira, F. C., Carvalho, F., & Silva, J. P. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-13908-6.00015-3
Cannabinoids for the Control of multiple Sclerosis
Pryce, G., Jackson, S., & Baker, D. (2007) · Springer eBooks · doi:10.1007/978-0-387-74349-3_18
Boury‐Esnault, N., Marschal, C., Probst, J.-M. K., & Barnathan, G. (2002) · INFM-OAR (INFN Catania) · doi:10.5281/zenodo.155630
Endocannabinoid system, inflammation, and mental well-being
Iqbal, A. Z., Wu, S., Yaseen, M., Suwindi, P. M., Chang, J. P., & Su, K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-28842-5.00023-5
Anti-inflammatory effects of single cannabinoids and in combinationsPreprint
Mikkelsen, J. D., Prösser, L. A., Sørensen, H. K., Nabizada, E., Ortega, R. N. G., Ujhelyi, A., Okeyo, P. O., Breum, J., Rose, M., & Allesø, M. (2026) · Research Square · doi:10.21203/rs.3.rs-9759455/v1
Permann, S., Brunner, E., Alsabil, K., Werner, M., Waltl, L., Viault, G., D’Avino, D., Perkowski, B. J., Siller, A., Fritsch, L., et al. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.06.056
Klekowski, J., Fortuna, P., Chabowski, M., Lewandowski, Ł., Szewczak, W., Mosna, K., Maciejewska, G., Zawadzki, M., Krzystek‐Korpacka, M., & Fleszar, M. G. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1900337
Li, X., Wen, L., Du, Y., Zhou, J., Xue, N., Fan, X., Zhao, H., & Qu, M. (2026) · European journal of medical research · doi:10.1186/s40001-026-04990-w
Bietar, B., Tanner, S., Abdolmohammadi, P., Kasheke, G. D. S., Zhou, J., & Lehmann, C. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117539
Endocannabinoid regulation of microglia–astrocyte crosstalk in Alzheimer’s disease
Rao, J. S., Tangarife, M. A., Rodríguez‐Soacha, D. A., & Mukunda, R. (2026) · Academia Drug Development and Pharmacotherapy · doi:10.20935/acaddrug8564
Cannabinoids in the Brain: Their Metabolism, Roles, and Involvement in Neurological Disorders
Farooqui, A. A. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9940-5_5
Cannabinoids for the control of experimental multiple sclerosis
Pryce, G. (2010) · OpenGrey (Institut de l'Information Scientifique et Technique)
THE ROLE OF CANNABINOIDS AND CANNABINOID RECEPTORS IN ENTERIC NEURONAL SURVIVAL
Li, Y. (2009) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/rszw-w547
Investigating the role of mitogen activated protein kinase phosphatase-2 on CNS function
Rahman, N. Z. A. (2015) · STAX · doi:10.48730/t2m5-nd82
Liput, D. J. (2013) · UKnowledge (University of Kentucky)
Metadata
- Authors
- Eljaschewitsch, E., Witting, A., Mawrin, C., Lee, T., Schmidt, P. M., Wolf, S., Hoertnagl, H., Raine, C. S., Schneider-Stock, R., Nitsch, R., & Ullrich, O.
- Affiliations
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Washington (US)
- Charité – Universitätsmedizin Berlin (DE)
- Max Delbrück Center (DE)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Ullrich, Oliver
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 49
- Issue
- 1
- Pages
- 67-79
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1968740815
- Cited by
- 445
- References
- 76
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 12 · 2023: 14 · 2022: 26 · 2021: 17 · 2020: 10 · 2019: 16 · 2018: 13 · 2017: 18 · 2016: 25 · 2015: 29 · 2014: 23 · 2013: 20 · 2012: 31
- FWCI
- 23.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- University of Miami
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- National Heart, Lung, and Blood Institute (N01-HO-3284)
- National Institute of Mental Health (R24-MH-59724, R24MH059724)
- National Institute of Neurological Disorders and Stroke (NS-08952, NS-11920, R01NS008952)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- anandamide, endocannabinoid system, MKP-1, microglia, neuroinflammation, neuroprotection, CB1 receptor, CB2 receptor, MAPK signaling, histone H3 phosphorylation, neuroimmune interactions, pattern recognition receptors, excitotoxicity, secondary neuronal damage
- MeSH terms
- Adult, Animals, Arachidonic Acids, Cell Survival, Cells, Cultured, Encephalitis, Humans, Middle Aged, Multiple Sclerosis, Neurons, Nitric Oxide, Phosphoprotein Phosphatases, Phosphorylation, Tissue Distribution, Protein Tyrosine Phosphatases, Rats, Wistar, Microglia, Immediate-Early Proteins, Neuroprotective Agents, Cell Cycle Proteins, Nitric Oxide Synthase, MAP Kinase Signaling System, Receptors, Cannabinoid, Extracellular Signal-Regulated MAP Kinases, Mice, Rats, Polyunsaturated Alkamides, Dual Specificity Phosphatase 1, Protein Phosphatase 1, Cannabinoid Receptor Modulators, Endocannabinoids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review