Spontaneous Network Activity in the Embryonic Spinal Cord Regulates AMPAergic and GABAergic Synaptic Strength
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Spontaneous network activity (SNA) has been described in most developing circuits, including the spinal cord, retina, and hippocampus. Despite the widespread nature of this developmental phenomenon, its role in network maturation is poorly understood. We reduced SNA in the intact embryo and found compensatory increases in synaptic strength of spinal motoneuron inputs. AMPAergic miniature postsynaptic current (mPSC) amplitude and frequency increased following the reduction of activity. Interestingly, excitatory GABAergic mPSCs also increase in amplitude through a process of synaptic scaling. Finally, the normal modulation of GABAergic mPSC amplitude was accelerated. Together, these compensatory responses appear to increase the excitability of the cord and could act to maintain appropriate SNA levels, thus demonstrating a distinct functional role for synaptic homeostasis. Because spontaneous network activity can regulate AMPAergic and GABAergic synaptic strength during development, SNA is likely to play an important role in a coordinated maturation of excitatory and inhibitory synaptic strength.
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During embryonic and early postnatal development, homeostatic mechanisms can ensure that spontaneous activity is present in developing spinal circuits.
“For example, during embryonic and early postnatal development, homeostatic mechanisms can ensure that spontaneous activity is present in developing spinal circuits (Gonzalez-Islas and Wenner 2006;Knogler et al. 2010), where such activity is vital for driving proper circuit connectivity (Hanson and Landmesser 2004).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Gonzalez-Islas and Wenner 2006
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Self-citation
- Authors
- Gonzalez-Islas, C., & Wenner, P.
- Affiliations
- Emory University (US)
- Corresponding author
- Wenner, Peter
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 49
- Issue
- 4
- Pages
- 563-575
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2067168460
- Cited by
- 191
- References
- 5
- Citations by year
- 2025: 6 · 2024: 6 · 2023: 1 · 2022: 4 · 2021: 7 · 2020: 36 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 9 · 2013: 17 · 2012: 14
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2723 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-046510)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- spontaneous network activity, embryonic spinal cord, synaptic scaling, synaptic homeostasis, GABAergic synapses, miniature postsynaptic currents, spinal motoneurons, network maturation, excitation-inhibition balance
- MeSH terms
- Anesthetics, Local, Animals, Bicuculline, Chick Embryo, Dose-Response Relationship, Radiation, Drug Interactions, Electric Stimulation, gamma-Aminobutyric Acid, Lidocaine, Membrane Potentials, Nerve Net, Neural Inhibition, Synaptic Transmission, Neurons, Reaction Time, Spinal Cord, Synapses, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, 6-Cyano-7-nitroquinoxaline-2,3-dione, GABA Antagonists
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