An Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity?

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Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo

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NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

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Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease

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AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss

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Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦

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Intraneuronal Aβ42 Accumulation in Human Brain

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Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

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Amyloid β-Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

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Aducanumab—Hope or Disappointment for Alzheimer’s Disease

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Myelin in Alzheimer’s disease: culprit or bystander?

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Cytosolic calcium: Judge, jury and executioner of neurodegeneration in Alzheimer's disease and beyond

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Multi-target approach to Alzheimer’s disease prevention and treatment: antioxidant, anti-inflammatory, and amyloid- modulating mechanisms

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Psychedelics for alzheimer's disease-related dementia: Unveiling therapeutic possibilities and pathways

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The pathomimetic oAβ25–35 model of Alzheimer's disease: Potential for screening of new therapeutic agents

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c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases

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The Roles of the Amyloid Beta Monomers in Physiological and Pathological Conditions

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The probable role of tissue plasminogen activator/neuroserpin axis in Alzheimer’s disease: a new perspective

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Unveiling the Potential of Polyphenols as Anti-Amyloid Molecules in Alzheimer’s Disease

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The role of parvalbumin interneuron dysfunction across neurodegenerative dementias

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Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid β metabolism

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Antiseizure Medications in Alzheimer’s Disease from Preclinical to Clinical Evidence

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Qifu-yin activates the Keap1/Nrf2/ARE signaling and ameliorates synaptic injury and oxidative stress in APP/PS1 mice

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Genetic and environmental risk factors for dementia in African adults: A systematic review

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Cognitive Decline Risk Stratification in People with Late-Onset Epilepsy of Unknown Etiology: An Electroencephalographic Connectivity and Graph Theory Pilot Study

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The association between gamma-aminobutyric acid levels and suicidal behavior in depression

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Effects of Dietary Fiber, Phenolic Compounds, and Fatty Acids on Mental Health: Possible Interactions with Genetic and Epigenetic Aspects

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Plant-derived compounds and neurodegenerative diseases: Different mechanisms of action with therapeutic potential

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Epilepsy and Alzheimer’s Disease: Current Concepts and Treatment Perspective on Two Closely Related Pathologies

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Potential therapeutic targets for Alzheimer’s disease: Fibroblast growth factors and their regulation of ferroptosis, pyroptosis and autophagy

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Epm2aR240X knock-in mice present earlier cognitive decline and more epileptic activity than Epm2a mice

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Integration of Microfluidic Devices with Microelectrode Arrays to Functionally Assay Amyloid-β-Induced Synaptotoxicity

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Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the App NL - F Mouse Model of Alzheimer’s Disease

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Oral Administration of Ethanolic Extract of Shrimp Shells-Loaded Liposome Protects against Aβ-Induced Memory Impairment in Rats

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Locally Synthetized 17-β-Estradiol Reverses Amyloid-β-42-Induced Hippocampal Long-Term Potentiation Deficits

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Progress in the development of naturally derived active metabolites‐based drugs: Potential therapeutics for Alzheimer's disease

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Understanding the mechanisms of green tea EGCG against amyloid β oligomer neurotoxicity through computational studies

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E2F4DN Transgenic Mice: A Tool for the Evaluation of E2F4 as a Therapeutic Target in Neuropathology and Brain Aging

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Traditional and Innovative Anti-seizure Medications Targeting Key Physiopathological Mechanisms: Focus on Neurodevelopment and Neurodegeneration

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Magnetic stirring with iron oxide nanospinners accretes neurotoxic Aβ42 oligomers into phagocytic clearable plaques for Alzheimer's disease treatment

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Amyloidogenic proteolysis of APP regulates glutamatergic presynaptic functionPreprint

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Cognitive dysfunction in type 1 diabetes: role of TREM2 in microglial activation and Aβ pathology

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Elevated concentrations of amyloid‐β oligomers and their proapoptotic effects on age‐related cataract

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Amyloid beta biosensors in neurodegenerative disease

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Alzheimer’s Disease, Epilepsy, and Vascular Dementia: Convergent Mechanisms and Shared Therapeutic Pathways

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Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease

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Natural Chiral Scaffolds in Alzheimer′s Disease: Therapeutic Potential, Mechanism, and Clinical Aspects

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Development of an electrochemical aptasensor based on self-assembled 6-(ferrocenyl)hexanethiol for detecting the Alzheimer's disease biomarker Aβ1–42

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Mitochondrial ecosystem restoration in Alzheimer’s disease: from mechanisms to multi-target therapeutic strategies

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Presynaptic accumulation of APP-CTFβ may contribute to synaptic dysfunction in Alzheimer’s disease

Kapadia, A., Schuhmann, F., Daşkın, E., Walter, J., Lindahl, I., Rahmani, N., Morrema, T. H. J., Rozemüller, A. J. M., Boon, B. D. C., Pezeshkian, W., et al. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00899-6 · Cited by 1 · see citing works

Subregional Functional Connectivity of the Precuneus as a Preclinical Biomarker in Alzheimer’s Disease

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Correlation of brain tissue volume loss with inflammatory biomarkers IL1β, P-tau, T-tau, and NLPR3 in the aging cognitively impaired population

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Physiological roles of amyloid precursor protein in vivo - zebrafish as a model

Chebli, J. (2021) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Editorial: Epilepsy in older adults: From physiopathology to improvements in diagnosis and management

Romigi, A., Costa, C., Sen, A., & Giorgi, F. S. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.1063299

Antidepressant Role in Modulating Neurotransmitter Imbalance to Improve Cognitive Impairment in Patient with Alzheimer’s Disease

Nasrallah, J. (2024) · Journal of Neuro Psychiatry Reports · doi:10.47363/jnpr/2024(2)102

Different drugs used as therapeutic targets against AD till date

Nahar, M., Khan, A. G., Rai, R., & Jat, D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15540-6.00009-4

Amyloid beta aggregation promoted by iron leads to neuronal loss in an ex vivo model of Alzheimer’s diseasePreprint

Sunkara, S., Krishnamoorthy, R., Radulović, S., Leoni, M., Patz, S., Goessler, W., Kaufmann, W. A., Birkl-Toeglhofer, A. M., Haybaeck, J., & Leitinger, G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.11.664035

Additional file 5 of Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures

Aloi, M. S., Prater, K. E., Sánchez, R. E. A., Beck, A., Pathan, J. L., Davidson, S., Wilson, A. M., Keene, C. D., de la Iglesia, H. O., Jayadev, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26573215

Additional file 3 of Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures

Aloi, M. S., Prater, K. E., Sánchez, R. E. A., Beck, A., Pathan, J. L., Davidson, S., Wilson, A. M., Keene, C. D., de la Iglesia, H. O., Jayadev, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26573209

Additional file 1 of Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures

Aloi, M. S., Prater, K. E., Sánchez, R. E. A., Beck, A., Pathan, J. L., Davidson, S., Wilson, A. M., Keene, C. D., de la Iglesia, H. O., Jayadev, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26573197

Additional file 4 of Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures

Aloi, M. S., Prater, K. E., Sánchez, R. E. A., Beck, A., Pathan, J. L., Davidson, S., Wilson, A. M., Keene, C. D., de la Iglesia, H. O., Jayadev, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26573212

Additional file 2 of Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures

Aloi, M. S., Prater, K. E., Sánchez, R. E. A., Beck, A., Pathan, J. L., Davidson, S., Wilson, A. M., Keene, C. D., de la Iglesia, H. O., Jayadev, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26573203

Additional file 6 of Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures

Aloi, M. S., Prater, K. E., Sánchez, R. E. A., Beck, A., Pathan, J. L., Davidson, S., Wilson, A. M., Keene, C. D., de la Iglesia, H. O., Jayadev, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26573218

Electroacupuncture reduces amyloid beta accumulation and improves cerebral ischemia-induced cognitive impairment in a N6-methyladenosine-dependent manner

Yang, J., Xu, J., Wang, X., Ma, Z., Dai, Y., & Lin, X. (2026) · Journal of Molecular Histology · doi:10.1007/s10735-025-10700-3

Patient-Derived PSEN1 Cerebral Organoids Revealed Parallel Development of Amyloid-β Accumulation and Network DysfunctionPreprint

Angelovski, A., Hříbková, H., Sedmík, J., Liscakova, B., Švecová, O., Cesnarikova, S., Černá, K. A., Pospíšilová, V., Král, M., Kolajová, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.02.707990

Myelin alterations in early stages of Alzheimer's disease and preclinical assessment of the protective and therapeutic potential of neurosteroid 3α-O-allyl-allopregnanolone

Okechukwu, N. G. (2023) · theses.fr (ABES) · doi:10.70675/ec1ca2c3zfad7z48b7zba08z6bb3bb44334f

Soticlestat for drug-resistant epilepsy: Current evidence and clinical perspectives

Dell’Isola, G. B., Costa, C., Tozzi, A., Roberti, R., Russo, E., Ferrara, P., Salpietro, V., & Verrotti, A. (2026) · Seizure · doi:10.1016/j.seizure.2026.04.003

Unknotting the Role of circRNAs and IGF2BP3 in Alzheimer’s Disease

Firdous, S. M., Jayathilaka, S. N. S., Marick, S., & Porel, P. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01724-8

Early postnatal exposure to permethrin and deltamethrin mixtures induces sex-specific hippocampal neurobehavioral and neurochemical alterations in adulthood

Slimen, S. B., Boukholda, K., Ammar, R., Aman, C., Allain, A., Deurwaerdère, P. D., Boudawara, O., Chagraoui, A., Bouchard, M., & Fetoui, H. (2026) · NeuroToxicology · doi:10.1016/j.neuro.2026.103468

APP-CTFβ/C99 Oligomers Drive Synaptic Vesicle Tethering through C-Terminal InteractionsPreprint

Kapadia, A., Cijffers, E., Van, S., & Hafner, A. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7162192 · Cited by 1 · see citing works

Patient-Derived PSEN1 Cerebral Organoids Revealed Parallel Development of Amyloid-β Accumulation and Network Dysfunction

Angelovski, A., Hříbková, H., Sedmík, J., Liscakova, B., Švecová, O., Cesnarikova, S., Černá, K. A., Pospíšilová, V., Král, M., Kolajová, M., et al. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01779-7

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651 · see citing works

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

Tu, S., Okamoto, S., Lipton, S. A., & Xu, H. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-48 · Cited by 582 · see citing works

Effect of Aβ Oligomers on Neuronal APP Triggers a Vicious Cycle Leading to the Propagation of Synaptic Plasticity Alterations to Healthy Neurons

Rolland, M., Powell, R., Jacquier‐Sarlin, M. R., Boisseau, S., Reynaud-Dulaurier, R., Hernández, J. M., André, L., Borel, E., Buisson, A., & Lanté, F. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2501-19.2020 · Cited by 38 · see citing works

Pore-Forming Neurotoxin-Like Mechanism for Aβ Oligomer-Induced Synaptic Failure

Aguayo, L. G., Parodí, J., Sepúlveda, F. J., & Opazo, C. (2009) · Springer eBooks · doi:10.1007/978-0-387-87995-6_2 · Cited by 5 · see citing works

Synaptic dysregulation and hyperexcitability induced by intracellular amyloid beta oligomers

Fernández-Pérez, E. J., Muñoz, B., Bascuñán, D., Peters, C., Riffo-Lepe, N., Flores-Espinoza, M. P., Morgan, P. J., Filippi, C., Bourboulou, R., Sengupta, U., et al. (2021) · Aging Cell · doi:10.1111/acel.13455 · Cited by 36 · see citing works