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Cited by 124Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

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Synapse-Specific Adaptations to Inactivity in Hippocampal Circuits Achieve Homeostatic Gain Control while Dampening Network Reverberation

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Kim, Jimok, Tsien, Richard W.·2008·Neuron
DOI 10.1016/j.neuron.2008.05.009PMC PMC2561251
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Abstract

Synaptic homeostasis, induced by chronic changes in neuronal activity, is well studied in cultured neurons, but not in more physiological networks where distinct synaptic circuits are preserved. We characterized inactivity-induced adaptations at three sets of excitatory synapses in tetrodotoxin-treated organotypic hippocampal cultures. The adaptation to inactivity was strikingly synapse specific. Hippocampal throughput synapses (dentate-to-CA3 and CA3-to-CA1) were upregulated, conforming to homeostatic gain control in order to avoid extreme limits of neuronal firing. However, chronic inactivity decreased mEPSC frequency at CA3-to-CA3 synapses, which were isolated pharmacologically or surgically. This downregulation of recurrent synapses was opposite to that expected for conventional homeostasis, in apparent conflict with typical gain control. However, such changes contributed to an inactivity-induced shortening of reverberatory bursts generated by feedback excitation among CA3 pyramids, safeguarding the network from possible runaway excitation. Thus, synapse-specific adaptations of synaptic weight not only contributed to homeostatic gain control, but also dampened epileptogenic network activity.

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Metadata

Authors
Kim, J., & Tsien, R. W.
Affiliations
Stanford Medicine (US)
Corresponding author
Tsien, Richard W.
ORCID
Tsien, Richard W.
Venue
Neuron
Publisher
Elsevier BV
Published
2008-06
Volume
58
Issue
6
Pages
925-937
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2008.05.009
PMC
PMC2561251
OpenAlex
W2001651016
Cited by
124
References
0
Citations by year
2026: 4 · 2025: 6 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 9 · 2013: 20 · 2012: 8
FWCI
3.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R37MH071739)
  • National Institute of General Medical Sciences (R01GM058234)
  • National Institute of Neurological Disorders and Stroke (R01NS024067)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
synaptic homeostasis, hippocampus, excitatory synapses, CA3 pyramidal cells, epileptogenesis, organotypic hippocampal slice cultures, tetrodotoxin
MeSH terms
Adaptation, Physiological, Animals, Hippocampus, Homeostasis, Nerve Net, Neural Inhibition, Neuronal Plasticity, Synapses, Rats, Sprague-Dawley, Excitatory Postsynaptic Potentials, Rats

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