Rapid Translation of Arc/Arg3.1 Selectively Mediates mGluR-Dependent LTD through Persistent Increases in AMPAR Endocytosis Rate

Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors

Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D. (2002) · Science · doi:10.1126/science.1067081 · Cited by 1,992

Protein synthesis and memory: A review.

Davis, H. P., & Squire, L. R. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.96.3.518 · Cited by 1,505

Altered synaptic plasticity in a mouse model of fragile X mental retardation

Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349

Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites

Lyford, G. L., Yamagata, K., Kaufmann, W. E., Barnes, C. A., Sanders, L. K., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Lanahan, A. A., & Worley, P. F. (1995) · Neuron · doi:10.1016/0896-6273(95)90299-6 · Cited by 1,212

Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting

Ehlers, M. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00129-x · Cited by 1,096

Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles

Guzowski, J. F., McNaughton, B. L., Barnes, C. A., & Worley, P. F. (1999) · Nature Neuroscience · doi:10.1038/16046 · Cited by 1,032

Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.

Huber, K., Kayser, M., & Bear, M. (2000) · Science · doi:10.1126/science.288.5469.1254 · Cited by 1,015

Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory

Guzowski, J. F., Lyford, G. L., Stevenson, G. D., Houston, F. P., McGaugh, J. L., Worley, P. F., & Barnes, C. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-03993.2000 · Cited by 992

Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites.

Steward, O., Wallace, C. S., Lyford, G., & Worley, P. (1998) · Neuron · doi:10.1016/s0896-6273(00)80591-7 · Cited by 845

Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories

Plath, N., Ohana, O., Dammermann, B., Errington, M. L., Schmitz, D., Gross, C., Mao, X., Engelsberg, A., Mahlke, C., Welzl, H., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.024 · Cited by 827

Electrical nerve stimulation and the relief of chronic pain through regulation of the accumulation of synaptic Arc protein

Liu, Y.-P., & Liu, S. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.05.006 · Cited by 3

ARC de LTD

Wiedemann, C. G. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2482 · Cited by 3

A High-content Assay for Monitoring AMPA Receptor Trafficking

Ghane, M. A., Yakout, D. W., & Mabb, A. M. (2019) · Journal of Visualized Experiments · doi:10.3791/59048 · Cited by 3

Familiarity with a vocal category biases the compartmental expression ofArc/Arg3.1in core auditory cortexPreprint

Ivanova, T. N., Groß, C., Mappus, R. C., Kwon, Y. J., Bassell, G. J., & Liu, R. C. (2017) · Learning & Memory · doi:10.1101/lm.046086.117 · Cited by 4

GPCR Signaling from Intracellular Membranes

Jong, Y.-J. I., Harmon, S. K., & O’Malley, K. L. (2022) · Wiley eBooks · doi:10.1002/9781119564782.ch8 · Cited by 3

Framework for internal sensation of pleasure using constraints from disparate findings in nucleus accumbens

Vadakkan, K. I. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i10.681 · Cited by 2

ArcKR expression modifies synaptic plasticity following epileptic activity: Differential effects with in vitro and in vivo seizure‐induction protocols

Bhandare, A., Haley, M., Anderson, V. T., Domingos, L. B., Lopes, M., Corrêa, S. A. L., & Wall, M. J. (2024) · Epilepsia · doi:10.1111/epi.17981 · Cited by 2

A Nanobody-Based Proximity Ligation Assay Detects Constitutive and Stimulus-Regulated Native Arc/Arg3.1 Oligomers in Hippocampal Neuronal Dendrites

Baldinotti, R., Pauzin, F. P., Fevang, H., Ishizuka, Y., & Bramham, C. R. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04508-7 · Cited by 2

NeuropsychopharmARCology: Shaping Neuroplasticity through Arc/ Arg3.1 Modulation

Mottarlini, F., Caffino, L., Fumagalli, F., Calabrese, F., & Brivio, P. (2024) · Current Neuropharmacology · doi:10.2174/011570159x338335240903075655 · Cited by 2

Group 1 mGluR stimulation rescues APOE4-mediated translation defects in neurons

Radhakrishna, B. K., Kaladiyil, A. P., Chakraborty, A., Gautam, V., & Muddashetty, R. S. (2025) · Life Science Alliance · doi:10.26508/lsa.202503287 · Cited by 3

mRNA Trafficking to Synapses and Memory Formation ☆

Farris, S., Dynes, J. L., & Steward, O. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21108-5 · Cited by 2

Temporal quantitative proteomics of protein translation and phosphorylation in synaptic plasticityPreprint

van Gelder, C. A. G. H., Penning, R., Catsburg, L. A. E., Hoogenraad, C. C., MacGillavry, H. D., & Altelaar, M. A. F. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/668434 · Cited by 2

Exploration of new space elicits phosphorylation of GluA1(Ser831) and S6K and expression of Arc in the hippocampus in vivo as in long-term potentiation

Cagnetta, R., Lacaille, J., & Sonenberg, N. (2024) · Molecular Brain · doi:10.1186/s13041-024-01100-x · Cited by 1

Incubation with tau aggregates increases hippocampal circuit excitability and enhances long-term depression in acute mouse hippocampal slices

Wang, A., Hill, E., Wang, A., Richardson, A., Emmett, I., Friedmann, D., Saskia, B., & Magnus, R. (2025) · Frontiers in Neural Circuits · doi:10.3389/fncir.2025.1596989 · Cited by 2

Convergence and divergence of molecular mechanisms in Hebbian and homeostatic plasticity

Feighan, K. M., Thakare, H. K., Glasgow, S. D., & Kennedy, T. E. (2026) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2026.1761008 · Cited by 2

Inverse Synaptic Tagging by Arc

Okuno, H., Araki, A., & Minatohara, K. (2015) · Springer eBooks · doi:10.1007/978-3-319-24364-1_6 · Cited by 1

Fragile X Syndrome and X-linked Intellectual Disability

Garber, K. B., Warren, S. T., & Visootsak, J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00112-9 · Cited by 1

Strategies for Exploring Local Dendritic Protein Synthesis in Synaptic Plasticity and Memory

Sutton, M. A. (2010) · Cited by 1

Comparison of the role of metabotropic glutamate receptor subtype 1 in developmental refinement of neuronal connectivity between the cerebellum and the sensory thalamus

Narushima, M. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.06.004 · Cited by 1

Regulation of Synaptic Homeostasis by Translational Mechanisms

Mori, M., Penney, J., & Haghighi, A. P. (2019) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190686307.013.14 · Cited by 1

A High-content Assay for Monitoring AMPA Receptor Trafficking

Ghane, M. A., Yakout, D. W., & Mabb, A. M. (2019) · Journal of Visualized Experiments · doi:10.3791/59048-v · Cited by 1

Developmental plasticity of the glutamate synapse: Roles of low frequency stimulation, hebbian induction and the NMDA receptor

Strandberg, J. (2010) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 1

Long-term depression in the rat hippocampus as a memory model : Interrogating the role of protein synthesis in NMDA- and mGluR-dependent synaptic plasticity

Mohammad, S. (2010) · Diva portal (Dalarna University Library) · Cited by 1

Molecular pathways responsible for NMDA receptor-mediated behavioural plasticity

Islam, R. (2016) · doi:10.26226/morressier.5785edc6d462b80296c9940a · Cited by 1

Endoplasmic Reticulum Stress in Disease

Kaufman, R. J., Deng, R., Huang, T. Y., Lebeaupin, C., Yong, J., & Popolo, L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00129-2 · Cited by 1

Role of mGluR5 and FMRP in mouse primary somatosensory cortex

Wijetunge, L. S. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)

Consequences of prenatal ethanol exposure and maternal stress on offspring

Staples, M. C. (2013) · UNM’s Digital Repository (University of New Mexico)

Protein Kinases in Spinal Plasticity: A Role for Metabotropic Glutamate Receptors

Russell, J. A., & Adam, R. (2012) · InTech eBooks · doi:10.5772/37788

THE IDENTIFICATION OF NOVEL SUSCEPTIBILITY GENES INVOLVED IN ANXIETY DISORDERS

McGregor, N. W. (2013) · SUNScholar (Stellenbosch University) · doi:10.13140/2.1.2731.4569

Arc/Arg3.1 mRNA level in hippocampal area CA1 in vivo

Yilmaz, E. (2010)

PostsynapticGABA B ReceptorActivityRegulatesExcitatory NeuronalArchitectureandSpatialMemory

Quadros, I., Deeb, T., & Pangalos, M. (2014)

TheImmediateEarlyGeneArc/Arg3.1:Regulation, Mechanisms,andFunction

Worley, P. F. (2008)

Analysis of the Interaction and Functional Determinants of Arc and Its Regulation of Dynamin

Byers, C. E. (2011)

The Role of LMO4 in the Regulation of Hippocampal and Amygdalar Synaptic Function

Qin, Z. (2013) · uO Research (University of Ottawa) · doi:10.20381/ruor-2709

FMRP and the Pathophysiology of Fragile X Syndrome

Barnes, S. A., Thomson, S. R., Kind, P. C., & Osterweil, E. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00008-x

Activation du gyrus dentelé par le noyau supramammillaire au cours du sommeil paradoxal chez le rongeur : étude neuroanatomique et fonctionnelle

Billwiller, F. (2016) · theses.fr (ABES) · doi:10.70675/005ea76cz4e3dz4be8z87aezb883d3b73c2a

Development of aggression and impulsivity: Modulation by adolescent social stress?

Coppens, C. M. (2013) · University of Groningen research database (University of Groningen / Centre for Information Technology)

Characterisation of low-intensity repetitive transcranial magnetic stimulation induced neuroplasticity in rodent and experimental models

Tang, A. D. (2016) · UWA Profiles and Research Repository (UWA)

Neuronal Dysfunction in Fragile X Spectrum Disorders.

Renoux, A. J. (2015) · Deep Blue (University of Michigan)

O impacto do exercício físico a curto e a longo prazo na evolução da doença de Parkinson em ratos.

Garcia, P. C. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2017.tde-12042017-092731

Interactions between Hebbian and Homeostatic Synaptic Plasticity in Hippocampal Circuits.

Iliff, A. J. (2014) · Deep Blue (University of Michigan)

Molecular pathways responsible for NMDA receptor-mediated behavioural plasticity

Islam, R., Mielnik, C. A., Horsfall, W., Orser, B. A., & Ramsey, A. J. (2016) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(16)31169-5 · Cited by 1

A post-synaptic forgetting mechanism controlled by synaptotagmin 3

Awasthi, A. (2018) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-6858

Local translation of candidate mRNAs for Down's Syndrome

Rodrigues, C. T. D. S. (2011) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Sweet Memories: Hippocampal Regulation of Energy Intake

Hannapel, R. (2022) · Digital Archive @ GSU · doi:10.57709/13428396

An exploration into the link between brain rhythms and synaptic plasticity in health and infectious disease

Hartnell, I. J. (2018) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)

Cellular- and network-level regulation of place cell activity mediated by activity-dependent gene, Arc

Yuan, L. (2019) · doi:10.32657/10220/49828

A Multi-Gene Synaptic Plasticity Array Identifies Candidate Molecular Underpinnings of Cognitive and Mood Deficits in Rats with Heart FailurePreprint

Parent, M. B., Ferreira‐Neto, H. C., Kruemmel, A. R., Althammer, F., Patel, A. A., Keo, S., Whitley, K. E., Cox, D. N., & Stern, J. E. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.03.234831

Differential gene expression in brain and liver tissue of Wistar rats after rapid eye movement sleep deprivationPreprint

Pandey, A., Oliver, R., & Kar, S. K. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/515379

The Nonsense-Mediated mRNA Decay pathway degrades dendritically-targeted mRNAs to regulate long-term potentiation and cognitive functionPreprint

Notaras, M. J., Allen, M., Longo, F., Volk, N. L., Tóth, M., Jeon, N. L., Klann, E., & Colak, D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/389585

Local regulation and function of importin-β1 in hippocampal neurons during transcription-dependent plasticity

Lee, Y. J. (2021) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/151287

Faculty Opinions recommendation of Rapid synthesis of the X-linked mental retardation protein OPHN1 mediates mGluR-dependent LTD through interaction with the endocytic machinery.

Nairn, A. C., & Wiseman, S. L. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.13359966.14730067

Faculty Opinions recommendation of Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5.

Mackie, K., & Lu, H. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.3743957.3593065

Faculty Opinions recommendation of Dendritic spine elimination: molecular mechanisms and implications.

Kano, M., & Watanabe, T. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733168960.793562671

Faculty Opinions recommendation of Mutations causing syndromic autism define an axis of synaptic pathophysiology.

Nairn, A. C., & Wiseman, S. L. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.13385959.14754080

Faculty Opinions recommendation of In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons.

Zhang, X. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.4938957.793544890

The individual vulnerability to develop compulsive adjunctive behavior is associated with the recruitment of activity-regulated cytoskeleton-associated protein (Arc) within the Locus CoeruleusPreprint

Velázquez-Sánchez, C., Mureşan, L., & Belin, D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.13.507749

Living on the edge

Scheefhals, N. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/1224

Roles for the MEF2 Transcription Factors in Synapse and Circuit Development and Plasticity

Zhang, Z., & Huber, K. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-68550-7_11

Retrodictive Evidence for the Structure of Memory EngramPreprint

Vadakkan, K. I. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5072253

mRNA trafficking to synapses and memory formation

Steward, O., & Farris, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00092-4

Changes in synaptic proteins in hippocampal area CA1 of a rat learned helpless model of depression

Bieler, M. (2013) · BIBSYS Brage (BIBSYS (Norway))

Additional file 1 of Ribosome profiling in mouse hippocampus: plasticity-induced regulation and bidirectional control by TSC2 and FMRP

Hien, A., Molinaro, G., Liu, B., Huber, K. M., & Richter, J. D. (2020) · Figshare · doi:10.6084/m9.figshare.13093721

Involvement of mGluR5/Homer crosstalk disruption in the pathophysiology of Fragile X Syndrome

Aloisi, E. (2015) · theses.fr (ABES) · doi:10.70675/e628d840zb6adz4e63z9d1fz71559b23fe24

Mécanismes responsables de l'activation corticale pendant le sommeil paradoxal

Renouard, L. (2011) · theses.fr (ABES) · doi:10.70675/fb03b5cez134bz4527zb76cz110ad804221c

Rôle de la neuroinflammation dans les atteintes de la plasticité synaptique glutamatergique induites par le binge drinking dans l'hippocampe de rat

Bertrand, C. (2021) · theses.fr (ABES) · doi:10.70675/05df8357z6906z4971za054z1b8e0b0127ee

Pathophysiological consequences of a Fragile X missense mutation

Garcia, M. P. (2020) · theses.fr (ABES) · doi:10.70675/b8e86263z5926z4a83zbaf6z0f61bf2d15f9

Cellular memory: Learning without building

Kukushkin, N. V. (2026) · Current Biology · doi:10.1016/j.cub.2026.03.038

Defective Hippocampus-Dependent Spatial Memory in Mouse Model of Polyendocrine metabolic ovarian syndrome (PMOS, formerly PCOS)Preprint

Rao, S., Johnson, B. S., & Laloraya, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.30.721991

Ribosome profiling to study translation in cortical synaptoneurosomes on group 1 mGluR activationPreprint

Kute, P. M., Labun, K., Tjeldnes, H., Valen, E., & Muddashetty, R. S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.10.723250 · Cited by 1

Manganese-Enhanced Magnetic Resonance Imaging: From Translational Research to First-in-Human Trials in Oncology

Remiszewski, P., Drabik, M. A., Filipowicz, P., Wełniak-Kamińska, M., Piwowarek, K. J., Wieteska, M., Fiedorowicz, M., & Czarnecka, A. M. (2026) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-026-00874-1

Toll-like receptor signaling modulates AMPA receptor trafficking in homeostatic synaptic downscaling

Koga, A., 周平, 貴., & Matsuda, S. (2026) · The Journal of Physiological Sciences · doi:10.1016/j.jphyss.2026.100112

Inhibitory neurotransmission in the Fmr1 knockout mouse model of Fragile X Syndrome : region- and circuit-specific deficits

Paluszkiewicz, S. M. (2011) · DigitalGeorgetown (Georgetown University Library)

ARC de LTD

Wiedemann, C. G. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2482 · Cited by 3

The Ups and Downs of Translation-Dependent Plasticity

Castillo, P. E., Francesconi, A., & Carroll, R. C. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.016 · Cited by 12

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Wilkerson, J. R., Albanesi, J. P., & Huber, K. M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.09.035 · Cited by 60

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Jakkamsetti, V., Tsai, N., Groß, C., Molinaro, G., Collins, K. A., Nicoletti, F., Wang, K. H., Osten, P., Bassell, G. J., Gibson, J. R., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.020 · Cited by 96

Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD

Park, S., Park, J. M., Kim, S., Kim, J.-A., Shepherd, J. D., Smith-Hicks, C. L., Chowdhury, S., Kaufmann, W., Kuhl, D., Ryazanov, A. G., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.023 · Cited by 516