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Rapid Translation of Arc/Arg3.1 Selectively Mediates mGluR-Dependent LTD through Persistent Increases in AMPAR Endocytosis Rate
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Salient stimuli that modify behavior induce transcription of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) and transport Arc mRNA into dendrites, suggesting that local Arc translation mediates synaptic plasticity that encodes such stimuli. Here, we demonstrate that long-term synaptic depression (LTD) in hippocampal neurons induced by group 1 metabotropic glutamate receptors (mGluRs) relies on rapid translation of Arc. mGluR-LTD induction causes long-term increases in AMPA receptor endocytosis rate and dendritic synthesis of Arc, a component of the AMPAR endocytosis machinery. Knockdown of Arc prevents mGluRs from triggering AMPAR endocytosis or LTD, and acute blockade of new Arc synthesis with antisense oligonucleotides blocks mGluR-LTD and AMPAR trafficking. In contrast, LTD induced by NMDA receptors does not persistently alter AMPAR endocytosis rate, induce Arc synthesis, or require Arc protein. These data demonstrate a role for local Arc synthesis specifically in mGluR-LTD and suggest that mGluR-LTD may be one consequence of Arc mRNA induction during experience.
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“ARC is required for mGluR-LTD and AMPAR internalization (Waung et al., 2008)”
From CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation (2013) · cites this paper as Waung et al., 2008
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“Translation of Arc mRNA is enhanced during, and crucial for, mGluR-dependent LTD59,60.”
From Activity-dependent neuronal signalling and autism spectrum disorder (2013) · cites this paper as [60]
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Cites
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D. (2002) · Science · doi:10.1126/science.1067081 · Cited by 1,992
Protein synthesis and memory: A review.
Davis, H. P., & Squire, L. R. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.96.3.518 · Cited by 1,505
Altered synaptic plasticity in a mouse model of fragile X mental retardation
Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349
Self-citationLyford, G. L., Yamagata, K., Kaufmann, W. E., Barnes, C. A., Sanders, L. K., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Lanahan, A. A., & Worley, P. F. (1995) · Neuron · doi:10.1016/0896-6273(95)90299-6 · Cited by 1,212
Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting
Ehlers, M. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00129-x · Cited by 1,096
Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles
Guzowski, J. F., McNaughton, B. L., Barnes, C. A., & Worley, P. F. (1999) · Nature Neuroscience · doi:10.1038/16046 · Cited by 1,032
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
Huber, K., Kayser, M., & Bear, M. (2000) · Science · doi:10.1126/science.288.5469.1254 · Cited by 1,015
Self-citationGuzowski, J. F., Lyford, G. L., Stevenson, G. D., Houston, F. P., McGaugh, J. L., Worley, P. F., & Barnes, C. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-03993.2000 · Cited by 992
Steward, O., Wallace, C. S., Lyford, G., & Worley, P. (1998) · Neuron · doi:10.1016/s0896-6273(00)80591-7 · Cited by 845
Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories
Plath, N., Ohana, O., Dammermann, B., Errington, M. L., Schmitz, D., Gross, C., Mao, X., Engelsberg, A., Mahlke, C., Welzl, H., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.024 · Cited by 827
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Costa-Mattioli, M., Sossin, W. S., Klann, E., & Sonenberg, N. (2009) · Neuron · doi:10.1016/j.neuron.2008.10.055 · Cited by 944
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Ebert, D. H., & Greenberg, M. E. (2013) · Nature · doi:10.1038/nature11860 · Cited by 666
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Self-citationMutations causing syndromic autism define an axis of synaptic pathophysiology
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Pastuzyn, E. D., Day, C. E., Kearns, R. B., Kyrke-Smith, M., Taibi, A. V., McCormick, J., Yoder, N., Belnap, D. M., Erlendsson, S., Morado, D. R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.024 · Cited by 213
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Dever, T. E., & Green, R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a013706 · Cited by 561
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Bramham, C. R., Worley, P. F., Moore, M. J., & Guzowski, J. F. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3864-08.2008 · Cited by 495
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Shepherd, J. D., & Bear, M. F. (2011) · Nature Neuroscience · doi:10.1038/nn.2708 · Cited by 481
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Dieterich, D. C., Hodas, J. J. L., Gouzer, G., Shadrin, I. Y., Ngo, J. T., Triller, A., Tirrell, D. A., & Schuman, E. M. (2010) · Nature Neuroscience · doi:10.1038/nn.2580 · Cited by 470
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Renner, M., Lacor, P. N., Velasco, P. T., Xu, J., Contractor, A., Klein, W. L., & Triller, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.029 · Cited by 468
Bramham, C. R., Alme, M. N., Bittins, M., Kuipers, S. D., Nair, R. R., Pai, B., Panja, D., Schubert, M., Soule, J., Tiron, A., et al. (2010) · Experimental Brain Research · doi:10.1007/s00221-009-1959-2 · Cited by 452
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Tsai, N.-P., Wilkerson, J. R., Guo, W., Maksimova, M. A., DeMartino, G. N., Cowan, C. W., & Huber, K. M. (2012) · Cell · doi:10.1016/j.cell.2012.11.040 · Cited by 316
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Okuno, H., Akashi, K., Ishii, Y., Yagishita-Kyo, N., Suzuki, K., Nonaka, M., Kawashima, T., Fujii, H., Takemoto-Kimura, S., Abe, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.062 · Cited by 310
Genetic Risk for Schizophrenia: Convergence on Synaptic Pathways Involved in Plasticity
Hall, J., Trent, S., Thomas, K. L., O’Donovan, M. C., & Owen, M. J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.011 · Cited by 290
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Bramham, C. R. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.09.013 · Cited by 301
De Rubeis, S., Pasciuto, E., Li, K. W., Fernández, E., Di Marino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.039 · Cited by 296
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Okuno, H. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.12.007 · Cited by 294
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Hu, J.-H., Park, J. M., Park, S. J., Xiao, B., Dehoff, M. H., Kim, S., Hayashi, T., Schwarz, M. K., Huganir, R. L., Seeburg, P. H., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.008 · Cited by 263
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Lüscher, C. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-013920 · Cited by 270
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Self-citationFragile X mental retardation protein and synaptic plasticity
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Lee, C., Hsu, L., Wu, I.-L., Wang, Y., Chen, W.-C., Liu, Y., Yang, L.-T., Tan, C.-L., Luo, Y.-H., Wang, C.-C., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128431 · Cited by 237
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Zhang, W., Wu, J., Ward, M. D., Yang, S., Chuang, Y.-A., Xiao, M.-F., Li, R., Leahy, D. J., & Worley, P. F. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.030 · Cited by 160
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Kumaresan, V., Yuan, M., Yee, J., Famous, K. R., Anderson, S. M., Schmidt, H. D., & Pierce, R. C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.039 · Cited by 158
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Pfeiffer, B. E., Zang, T., Wilkerson, J. R., Taniguchi, M., Maksimova, M. A., Smith, L. N., Cowan, C. W., & Huber, K. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.017 · Cited by 153
Self-citationChen, Y., Zhang, X., Wang, C., Li, G.-W., Gu, Y., & Huang, L.-Y. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801793105 · Cited by 154
Niere, F., Wilkerson, J. R., & Huber, K. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4650-11.2012 · Cited by 153
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Cooke, S. F., & Bear, M. F. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0284 · Cited by 119
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Czöndör, K., Mondin, M., Garcia, M., Heine, M., Frischknecht, R., Choquet, D., Sibarita, J., & Thoumine, O. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109818109 · Cited by 114
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Kallergi, E., Daskalaki, A.-D., Kolaxi, A., Camus, C., Ioannou, E., Mercaldo, V., Haberkant, P., Stein, F., Sidiropoulou, K., Dalezios, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28301-z · Cited by 113
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Troca-Marín, J. A., Alves-Sampaio, A., & Montesinos, M. L. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.01.005 · Cited by 109
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Wintzer, M. E., Boehringer, R., Polygalov, D., & McHugh, T. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2563-13.2014 · Cited by 98
Jakkamsetti, V., Tsai, N., Groß, C., Molinaro, G., Collins, K. A., Nicoletti, F., Wang, K. H., Osten, P., Bassell, G. J., Gibson, J. R., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.020 · Cited by 96
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D’Antoni, S., Spatuzza, M., Bonaccorso, C. M., Musumeci, S. A., Ciranna, L., Nicoletti, F., Huber, K. M., & Catania, M. V. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.003 · Cited by 97
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Metadata
- Authors
- Waung, M. W., Pfeiffer, B. E., Nosyreva, E. D., Ronesi, J. A., & Huber, K. M.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Huber, Kimberly M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 59
- Issue
- 1
- Pages
- 84-97
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2580055
- OpenAlex
- W2030040408
- Cited by
- 474
- References
- 56
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 18 · 2023: 14 · 2022: 23 · 2021: 27 · 2020: 28 · 2019: 26 · 2018: 27 · 2017: 45 · 2016: 33 · 2015: 27 · 2014: 23 · 2013: 32 · 2012: 33
- FWCI
- 14.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1878 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- FRAXA Research Foundation
- National Institutes of Health (1F31NS050992, HD052731, NS045711, T32 GM08014)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Arc/Arg3.1, local protein synthesis, metabotropic glutamate receptors, long-term depression, AMPA receptor endocytosis, dendritic translation, synaptic plasticity, hippocampal neurons, AMPA receptor trafficking, activity-regulated cytoskeleton-associated protein
- MeSH terms
- Analysis of Variance, Animals, Animals, Newborn, Cells, Cultured, Cytoskeletal Proteins, Electric Stimulation, Endocytosis, Gene Expression Regulation, Hippocampus, Methoxyhydroxyphenylglycol, Mice, Inbred C57BL, Nerve Tissue Proteins, Neurons, Synaptosomes, Transfection, Protein Biosynthesis, Long-Term Potentiation, Receptors, AMPA, Patch-Clamp Techniques, Biotinylation, Oligodeoxyribonucleotides, Antisense, Green Fluorescent Proteins, Mice, Rats, In Vitro Techniques
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