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Alternative Functions of Core Cell Cycle Regulators in Neuronal Migration, Neuronal Maturation, and Synaptic Plasticity
Open accessAbstract
Recent studies have demonstrated that boundaries separating a cycling cell from a postmitotic neuron are not as concrete as expected. Novel and unique physiological functions in neurons have been ascribed for proteins fundamentally required for cell cycle progression and control. These "core" cell cycle regulators serve diverse postmitotic functions that span various developmental stages of a neuron, including neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis, and synaptic maturation and plasticity. In this review, we detail the nonproliferative postmitotic roles that these cell cycle proteins have recently been reported to play, the significance of their expression in neurons, mechanistic insight when available, and future prospects.
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“This mechanism of action could be attributed to the ability of DYRK1A to phosphorylate and possibly regulate Cyclin D1 (G1-to-S phase transition and cell proliferation) and p27 (neuronal differentiation and cell cycle exit) (Frank and Tsai, 2009; Hindley and Philpott, 2012; Najas et al., 2015; Tejedor and Hammerle, 2011).”
From Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model (2024) · cites this paper as Frank and Tsai, 2009
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Cites
DNA Replication in Eukaryotic Cells
Bell, S. P., & Dutta, A. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135425 · Cited by 2,065
Genetic Control of the Cell Division Cycle in Yeast
Hartwell, L. H., Culotti, J. G., Pringle, J. R., & Reid, B. J. (1974) · Science · doi:10.1126/science.183.4120.46 · Cited by 1,567
The self-tuning neuron: synaptic scaling of excitatory synapses
Turrigiano, G. G. (2008) · Cell · doi:10.1016/j.cell.2008.10.008 · Cited by 1,533
Fero, M. L., Rivkin, M. J., Tasch, M., Porter, P. L., Carow, C. E., Firpo, E. J., Polyák, K., Tsai, L., Broudy, V. C., Perlmutter, R. M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81239-8 · Cited by 1,459
Self-citationUbiquitin ligases: cell-cycle control and cancer
Nakayama, K. I., & Nakayama, K. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1881 · Cited by 1,450
Chen, M. S., Huber, A. B., van der Haar, M. E., Frank, M., Schnell, L., Spillmann, A. A., Christ, F., & Schwab, M. E. (2000) · Nature · doi:10.1038/35000219 · Cited by 1,445
The anaphase promoting complex/cyclosome: a machine designed to destroy
Peters, J.-M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1988 · Cited by 1,315
Giacinti, C., & Giordano, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209615 · Cited by 1,263
Retinoblastoma protein recruits histone deacetylase to repress transcription
Brehm, A., Miska, E. A., McCance, D. J., Reid, J. L., Bannister, A. J., & Kouzarides, T. (1998) · Nature · doi:10.1038/35404 · Cited by 1,231
Cohesin mediates transcriptional insulation by CCCTC-binding factor
Wendt, K. S., Yoshida, K., Itoh, T., Bando, M., Koch, B., Schirghuber, E., Tsutsumi, S., Nagae, G., Ishihara, K., Mishiro, T., et al. (2008) · Nature · doi:10.1038/nature06634 · Cited by 1,193
CDK inhibitors: Cell cycle regulators and beyond
Besson, A., Dowdy, S. F., & Roberts, J. M. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.013 · Cited by 1,152
Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein
GrandPré, T., Nakamura, F., Vartanian, T. K., & Strittmatter, S. M. (2000) · Nature · doi:10.1038/35000226 · Cited by 1,139
Polo-like kinases and the orchestration of cell division
Barr, F. A., Silljé, H. H. W., & Nigg, E. A. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1401 · Cited by 1,092
Dhavan, R., & Tsai, L. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096019 · Cited by 1,052
Self-citationGeminin, an inhibitor of DNA replication, is degraded during mitosis.
Mcgarry, T., & Kirschner, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81209-x · Cited by 988
Rb Interacts with Histone Deacetylase to Repress Transcription
Luo, R. X., Postigo, A. A., & Dean, D. C. (1998) · Cell · doi:10.1016/s0092-8674(00)80940-x · Cited by 957
Nevins, J. R. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.7.699 · Cited by 939
Sudakin, V., Chan, G. K. T., & Yen, T. J. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200102093 · Cited by 927
Retinoblastoma protein represses transcription by recruiting a histone deacetylase
Magnaghi-Jaulin, L., Groisman, R., Naguibneva, I., Robin, P., Lorain, S., Levillain, J. P., Troalen, F., Trouche, D., & Harel‐Bellan, A. (1998) · Nature · doi:10.1038/35410 · Cited by 906
Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms
Parelho, V., Hadjur, S., Spivakov, M., Leleu, M., Sauer, S., Gregson, H. C., Jarmuz, A., Canzonetta, C., Webster, Z., Nesterova, T., et al. (2008) · Cell · doi:10.1016/j.cell.2008.01.011 · Cited by 900
Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex
Russo, A. A., Jeffrey, P. D., Patten, A. K., Massagué, J., & Pavletich, N. P. (1996) · Nature · doi:10.1038/382325a0 · Cited by 899
Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
Glover, D. M., Leibowitz, M. H., McLean, D., & Parry, H. D. (1995) · Cell · doi:10.1016/0092-8674(95)90374-7 · Cited by 838
The murine gene p27Kip1 is haplo-insufficient for tumour suppression
Fero, M. L., Randel, E., Gurley, K. E., Roberts, J. M., & Kemp, C. J. (1998) · Nature · doi:10.1038/24179 · Cited by 778
Coordination of Growth and Cell Division in the Drosophila Wing
Neufeld, T. P., de la Cruz, A. F. A., Johnston, L. A., & Edgar, B. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81462-2 · Cited by 769
GENETIC CONTROL OF THE CELL DIVISION CYCLE IN YEAST: V. GENETIC ANALYSIS OF cdc MUTANTS
Hartwell, L. H., Mortimer, R., Culotti, J. G., & Culotti, M. (1973) · Genetics · doi:10.1093/genetics/74.2.267 · Cited by 740
The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1Preprint
Pfleger, C. M., & Kirschner, M. W. (2000) · Genes & Development · doi:10.1101/gad.14.6.655 · Cited by 733
The Phosphatase Cdc14 Triggers Mitotic Exit by Reversal of Cdk-Dependent Phosphorylation
Visintin, R., Craig, K. L., Hwang, E. S., Prinz, S., Tyers, M., & Amon, A. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80286-5 · Cited by 725
The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall
Takahashi, T., Nowakowski, R. S., & Caviness, V. S. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06046.1995 · Cited by 673
THE STRUCTURE AND FUNCTION OF SMC AND KLEISIN COMPLEXES
Nasmyth, K., & Haering, C. H. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133219 · Cited by 629
Trekking across the Brain: The Journey of Neuronal Migration
Ayala, R., Shu, T., & Tsai, L.-H. (2007) · Cell · doi:10.1016/j.cell.2006.12.021 · Cited by 620
Self-citationThe E2F1–3 transcription factors are essential for cellular proliferation
Wu, L., Timmers, C. D., Maiti, B., Saavedra, H. I., Sang, L., Chong, G. T., Nuckolls, F., Giangrande, P. H., Wright, F. A., Field, S. J., et al. (2001) · Nature · doi:10.1038/35106593 · Cited by 620
Chromosomal Cohesin Forms a Ring
Gruber, S., Haering, C. H., & Nasmyth, K. (2003) · Cell · doi:10.1016/s0092-8674(03)00162-4 · Cited by 603
Fang, G., Yu, H., & Kirschner, M. W. (1998) · Genes & Development · doi:10.1101/gad.12.12.1871 · Cited by 594
A Self-Enabling TGFβ Response Coupled to Stress Signaling
Kang, Y., Chen, C.-R., & Massagué, J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00109-6 · Cited by 563
CTCF physically links cohesin to chromatin
Rubio, E. D., Reiss, D. J., Welcsh, P. L., Disteche, C. M., Filippova, G. N., Baliga, N. S., Aebersold, R., Ranish, J. A., & Krumm, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801273105 · Cited by 511
Control of Cyclin Ubiquitination by CDK-Regulated Binding of Hct1 to the Anaphase Promoting Complex
Zachariae, W., Schwab, M., Nasmyth, K., & Seufert, W. (1998) · Science · doi:10.1126/science.282.5394.1721 · Cited by 511
Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?
Herrup, K., & Yang, Y. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2124 · Cited by 507
Control of the SCFSkp2–Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase
Bashir, T., Dorrello, N. V., Amador, V., Guardavaccaro, D., & Pagano, M. (2004) · Nature · doi:10.1038/nature02330 · Cited by 504
Polo on the Rise—from Mitotic Entry to Cytokinesis with Plk1
Petronczki, M. P., Lénárt, P., & Peters, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.04.014 · Cited by 503
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
Wei, W., Ayad, N. G., Wan, Y., Zhang, G.-J., Kirschner, M. W., & Kaelin, W. G. (2004) · Nature · doi:10.1038/nature02381 · Cited by 495
Wu, L., Wells, D., Tay, J., Mendis, D., Abbott, M.-A., Barnitt, A., Quinlan, E., Heynen, A., Fallon, J. R., & Richter, J. D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80630-3 · Cited by 488 · cited 2×
“Building on work that originally implicated CPEB-1 in synaptic activity-induced polyadenylation and translation of CaMKII mRNA (Wu et al., 1998), Huang et al.”
p27 Kip1 modulates cell migration through the regulation of RhoA activationPreprint
Besson, A., Gurian-West, M., Schmidt, A., Hall, A., & Roberts, J. M. (2004) · Genes & Development · doi:10.1101/gad.1185504 · Cited by 487
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF β-TrCP
Watanabe, N., Arai, H., Nishihara, Y., Taniguchi, M., Watanabe, N., Hunter, T., & Osada, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307700101 · Cited by 472
X-linked Cornelia de Lange syndrome owing to SMC1L1 mutations
Musio, A., Selicorni, A., Focarelli, M. L., Gervasini, C., Milani, D., Russo, S., Vezzoni, P., & Larizza, L. (2006) · Nature Genetics · doi:10.1038/ng1779 · Cited by 468
Geley, S., Kramer, E., Gieffers, C., Gannon, J., Peters, J., & Hunt, T. (2001) · Journal of Cell Biology · doi:10.1083/jcb.153.1.137 · Cited by 462
Mitotic Regulation of the APC Activator Proteins CDC20 and CDH1
Kramer, E. R., Scheuringer, N., Podtelejnikov, A. V., Mann, M., & Peters, J. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.5.1555 · Cited by 455
Si, K., Giustetto, M., Etkin, A., Hsu, R., Janisiewicz, A. M., Miniaci, M. C., Kim, J., Zhu, H., & Kandel, E. R. (2003) · Cell · doi:10.1016/s0092-8674(03)01021-3 · Cited by 442
Hauf, S., Roitinger, E., Koch, B., Dittrich, C. M., Mechtler, K., & Peters, J. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030069 · Cited by 438
The Aurora kinase family in cell division and cancer
Vader, G., & Lens, S. M. A. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.07.003 · Cited by 436
Mitotic regulation of the human anaphase‐promoting complex by phosphorylation
Kraft, C., Herzog, F., Gieffers, C., Mechtler, K., Hagting, A., Pines, J., & Peters, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg627 · Cited by 421
Association of the Origin Recognition Complex with Heterochromatin and HP1 in Higher Eukaryotes
Pak, D. T. S., Pflumm, M. F., Chesnokov, I. N., Huang, D. W., Kellum, R., Marr, J., Romanowski, P., & Botchan, M. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80415-8 · Cited by 408
Axon Pruning during Drosophila Metamorphosis
Watts, R. J., Hoopfer, E. D., & Luo, L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00295-2 · Cited by 376
p27 kip1 independently promotes neuronal differentiation and migration in the cerebral cortexPreprint
Nguyen, L., Besson, A., Heng, J. I., Schuurmans, C., Teboul, L., Parras, C. M., Philpott, A., Roberts, J. M., & Guillemot, F. (2006) · Genes & Development · doi:10.1101/gad.377106 · Cited by 373
Calegari, F., & Huttner, W. Β. (2003) · Journal of Cell Science · doi:10.1242/jcs.00825 · Cited by 367
Stedman, W., Kang, H., Lin, S., Kissil, J. L., Bartolomei, M. S., & Lieberman, P. M. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.1 · Cited by 366
Cdh1-APC Controls Axonal Growth and Patterning in the Mammalian Brain
Konishi, Y., Stegmüller, J., Matsuda, T., Bonni, S., & Bonni, A. (2004) · Science · doi:10.1126/science.1093712 · Cited by 363
Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells
Lindon, C., & Pines, J. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200309035 · Cited by 358
Margottin-Goguet, F., Hsu, J. Y., Loktev, A. V., Hsieh, H.-M., Reimann, J. D. R., & Jackson, P. K. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00153-9 · Cited by 337
Losada, A., Hirano, M., & Hirano, T. (2002) · Genes & Development · doi:10.1101/gad.249202 · Cited by 335
INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions
Cánepa, E. T., Scassa, M. É., Ceruti, J. M., Marazita, M. C., Carcagno, A. L., Sirkin, P. F., & Ogara, M. F. (2007) · IUBMB Life · doi:10.1080/15216540701488358 · Cited by 325
APC/C and SCF: Controlling Each Other and the Cell Cycle
Vodermaier, H. C. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.020 · Cited by 323
Méndez, J., Zou-Yang, X. H., Kim, S. Y., Hidaka, M., Tansey, W. P., & Stillman, B. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00467-7 · Cited by 320
Bagri, A., Cheng, H.-J., Yaron, A., Pleasure, S. J., & Tessier‐Lavigne, M. (2003) · Cell · doi:10.1016/s0092-8674(03)00267-8 · Cited by 319
Identification and Characterization of Sa/Scc3p Subunits in the Xenopus and Human Cohesin Complexes
Losada, A., Yokochi, T., Kobayashi, R., & Hirano, T. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.3.405 · Cited by 315
Littlepage, L. E., & RUDERMAN, J. V. (2002) · Genes & Development · doi:10.1101/gad.1007302 · Cited by 308
Targeted Protein Degradation and Synapse Remodeling by an Inducible Protein Kinase
Pak, D. T. S., & Sheng, M. (2003) · Science · doi:10.1126/science.1082475 · Cited by 305
Polo-Like Kinases: A Team in Control of the Division
van de Weerdt, B. C. M., & Medema, R. H. (2006) · Cell Cycle · doi:10.4161/cc.5.8.2692 · Cited by 301
Kotani, S., Tugendreich, S., Fujii, M., Jorgensen, P.-M., Watanabe, N., Höög, C., Hieter, P., & Todokoro, K. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80037-4 · Cited by 301
Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth
Lasorella, A., Stegmüller, J., Guardavaccaro, D., Liu, G., Carro, M. S., Rothschild, G., de la Torre-Ubieta, L., Pagano, M., Bonni, A., & Iavarone, A. (2006) · Nature · doi:10.1038/nature04895 · Cited by 298
Peschiaroli, A., Dorrello, N. V., Guardavaccaro, D., Venere, M., Halazonetis, T., Sherman, N. E., & Pagano, M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.013 · Cited by 289
Evidence that Loading of Cohesin Onto Chromosomes Involves Opening of Its SMC Hinge
Gruber, S., Arumugam, P., Katou, Y., Kuglitsch, D., Helmhart, W., Shirahige, K., & Nasmyth, K. (2006) · Cell · doi:10.1016/j.cell.2006.08.048 · Cited by 286
Kawauchi, T., Chihama, K., Nabeshima, Y., & Hoshino, M. (2005) · Nature Cell Biology · doi:10.1038/ncb1338 · Cited by 284
Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2–M transition
Dutertre, S., Cazalès, M., Quaranta, M., Froment, C., Trabut, V., Dozier, C., Mirey, G., Bouché, J., Theis‐Febvre, N., Schmitt, E., et al. (2004) · Journal of Cell Science · doi:10.1242/jcs.01108 · Cited by 284
Cell-Type-Specific TEV Protease Cleavage Reveals Cohesin Functions in Drosophila Neurons
Pauli, A., Althoff, F., Oliveira, R. A., Heidmann, S. K., Schuldiner, O., Lehner, C. F., Dickson, B. J., & Nasmyth, K. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.009 · Cited by 276
Huang, Y., Jung, M., Sarkissian, M., & Richter, J. D. (2002) · The EMBO Journal · doi:10.1093/emboj/21.9.2139 · Cited by 270
Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance
Prasanth, S. G., Prasanth, K. V., Siddiqui, K., Spector, D. L., & Stillman, B. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600255 · Cited by 264
Aurora kinases, aneuploidy and cancer, a coincidence or a real link?
Giet, R., Petretti, C., & Prigent, C. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.03.004 · Cited by 263
Mitosis: a matter of getting rid of the right protein at the right time
Pines, J. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.11.006 · Cited by 262
Ferreira, R., Magnaghi-Jaulin, L., Robin, P., Harel‐Bellan, A., & Trouche, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10493 · Cited by 251
Schuldiner, O., Berdnik, D., Levy, J. M., Wu, J., Luginbuhl, D. J., Gontang, A. C., & Luo, L. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.11.001 · Cited by 246
Revisiting the Role of the Mother Centriole in Centriole Biogenesis
Rodrigues-Martins, A., Riparbelli, M. G., Callaini, G., Glover, D. M., & Bettencourt‐Dias, M. (2007) · Science · doi:10.1126/science.1142950 · Cited by 245
Seeburg, D. P., Feliú-Mójer, M. I., Gaiottino, J., Pak, D. T. S., & Sheng, M. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.021 · Cited by 239
Orc6 Involved in DNA Replication, Chromosome Segregation, and Cytokinesis
Prasanth, S. G., Prasanth, K. V., & Stillman, B. (2002) · Science · doi:10.1126/science.1072802 · Cited by 236
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complexPreprint
Pfleger, C. M., Lee, E. N., & Kirschner, M. W. (2001) · Genes & Development · doi:10.1101/gad.918201 · Cited by 236
Cyclin-Dependent Kinases and S Phase Control in Mammalian Cells
Woo, R. A., & Poon, R. Y. C. (2003) · Cell Cycle · doi:10.4161/cc.2.4.468 · Cited by 234
Zheng, X., Wang, J., Haerry, T. E., Wu, A. Y.-H., Martin, J. L., O’Connor, M. B., Lee, C.-H. J., & Lee, T. (2003) · Cell · doi:10.1016/s0092-8674(03)00072-2 · Cited by 233
Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways
Watanabe, N., Arai, H., Iwasaki, J.-I., Shiina, M., Ogata, K., Hunter, T. R., & Osada, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500410102 · Cited by 229
Polo-like Kinase-1 Controls Proteasome-Dependent Degradation of Claspin during Checkpoint Recovery
Mamely, I., van Vugt, M. A., Smits, V. A., Semple, J. I., Lemmens, B., Perrakis, A., Medema, R. H., & Freire, R. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.026 · Cited by 227
Independent Regulation of Synaptic Size and Activity by the Anaphase-Promoting Complex
van Roessel, P., Elliott, D. A., Robinson, I. M., Prokop, A., & Brand, A. H. (2004) · Cell · doi:10.1016/j.cell.2004.11.028 · Cited by 220
Cohesin Complex Promotes Transcriptional Termination between Convergent Genes in S. pombe
Gullerová, M., & Proudfoot, N. J. (2008) · Cell · doi:10.1016/j.cell.2008.02.040 · Cited by 216
Misulovin, Z., Schwartz, Y. B., Li, X., Kahn, T. G., Gause, M., MacArthur, S., Fay, J. C., Eisen, M. B., Pirrotta, V., Biggin, M. D., et al. (2007) · Chromosoma · doi:10.1007/s00412-007-0129-1 · Cited by 214
Moshe, Y., Boulaire, J., Pagano, M., & Hershko, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402442101 · Cited by 213
McAllister, S. S., Becker‐Hapak, M., Pintucci, G., Pagano, M., & Dowdy, S. F. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.216-228.2003 · Cited by 212
Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis
Ko, M. A., Rosario, C. O., Hudson, J. W., Kulkarni, S., Pollett, A. F., Dennis, J. W., & Swallow, C. J. (2005) · Nature Genetics · doi:10.1038/ng1605 · Cited by 206
Kauselmann, G., Weiler, M., Wulff, P., Jessberger, S., Konietzko, U., Scafidi, J., Staubli, U., Bereiter‐Hahn, J., Strebhardt, K., & Kuhl, D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.20.5528 · Cited by 205
Cip/Kip proteins: more than just CDKs inhibitors: Figure 1.Preprint
Denicourt, C., & Dowdy, S. F. (2004) · Genes & Development · doi:10.1101/gad.1205304 · Cited by 203
Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts
Losada, A., Yokochi, T., & Hirano, T. (2005) · Journal of Cell Science · doi:10.1242/jcs.02355 · Cited by 199
Identification of an Early-Growth-Response Gene Encoding a Novel Putative Protein Kinase
Simmons, D. L., Neel, B. G., Stevens, R. E., Evett, G. E., & Erikson, R. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.9.4164-4169.1992 · Cited by 195
Theis, M., Si, K., & Kandel, E. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133424100 · Cited by 193
Donohue, P. J., Alberts, G. F., Guo, Y. H., & Winkles, J. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.10351 · Cited by 192
A Centrosomal Cdc20-APC Pathway Controls Dendrite Morphogenesis in Postmitotic Neurons
Kim, A. H., Puram, S. V., Bilimoria, P. M., Ikeuchi, Y., Keough, S., Wong, M., Rowitch, D. H., & Bonni, A. (2009) · Cell · doi:10.1016/j.cell.2008.11.050 · Cited by 190
Leone, G. W., Nuckolls, F., Ishida, S., Adams, M., Sears, R. C., Jakoi, L., Miron, A., & Nevins, J. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3626-3632.2000 · Cited by 187
Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons
Gieffers, C., Peters, B. H., Kramer, E. R., Dotti, C. G., & Peters, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11317 · Cited by 185
Golan, A., Yudkovsky, Y., & Hershko, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111476200 · Cited by 173
Differential Functions of the Aurora-B and Aurora-C Kinases in Mammalian Spermatogenesis
Kimmins, S., Crosio, C., Kotaja, N., Hirayama, J., Monaco, L., Höög, C., van Duin, M., Gossen, J. A., & Sassone‐Corsi, P. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0332 · Cited by 168
Cytoplasmic p21Cip1 Is Involved in Ras-induced Inhibition of the ROCK/LIMK/Cofilin Pathway
Lee, S., & Helfman, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306968200 · Cited by 166
Juo, P., & Kaplan, J. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.010 · Cited by 164
Gallo, G. (2006) · Journal of Cell Science · doi:10.1242/jcs.03084 · Cited by 163
Cell-Intrinsic Regulation of Axonal Morphogenesis by the Cdh1-APC Target SnoN
Stegmüller, J., Konishi, Y., Huynh, M. A., Yuan, Z., DiBacco, S., & Bonni, A. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.034 · Cited by 163
Alarcón, J. M., Hodgman, R., Theis, M., Huang, Y.-S., Kandel, E. R., & Richter, J. D. (2004) · Learning & Memory · doi:10.1101/lm.72704 · Cited by 161
Cytoplasmic p21Cip1/WAF1 regulates neurite remodeling by inhibiting Rho-kinase activity
Tanaka, H., Yamashita, T., Asada, M., Mizutani, S., Yoshikawa, H., & Tohyama, M. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202071 · Cited by 157
Li, M., Shin, Y.-H., Hou, L., Huang, X., Wei, Z., Klann, E., & Zhang, P. (2008) · Nature Cell Biology · doi:10.1038/ncb1768 · Cited by 156
Ferguson, K. L., Vanderluit, J. L., Hébert, J. M., McIntosh, W. C., Tibbo, E., MacLaurin, J. G., Park, D. S., Wallace, V. A., Vooijs, M., McConnell, S. K., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf338 · Cited by 156
Sun, A., Bagella, L., Tutton, S., Romano, G., & Giordano, A. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21609 · Cited by 155
Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis
Tang, C.-J. C., Lin, C., & Tang, T. K. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2005.11.036 · Cited by 152
Late mitotic failure in mice lacking Sak, a polo-like kinase
Hudson, J. W., Kozarova, A., Cheung, P., Macmillan, J. C., Swallow, C. J., Cross, J. C., & Dennis, J. W. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00117-8 · Cited by 152
Polo-like Kinase-2 Is Required for Centriole Duplication in Mammalian Cells
Warnke, S., Kemmler, S., Hames, R. S., Tsai, H.-L., Hoffmann‐Rohrer, U., Fry, A. M., & Hoffmann, I. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.059 · Cited by 150
Winkles, J. A., & Alberts, G. F. (2005) · Oncogene · doi:10.1038/sj.onc.1208219 · Cited by 148
Dorsett, D. (2006) · Chromosoma · doi:10.1007/s00412-006-0072-6 · Cited by 147
Complex Transcriptional Regulatory Mechanisms Control Expression of the E2F3 Locus
Adams, M. R., Sears, R. C., Nuckolls, F., Leone, G. W., & Nevins, J. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3633-3639.2000 · Cited by 146
Essential role of Id2 in negative regulation of IgE class switching
Sugai, M., Gonda, H., Kusunoki, T., Katakai, T., Yokota, Y., & Shimizu, A. (2002) · Nature Immunology · doi:10.1038/ni874 · Cited by 139
Plk1- and β-TrCP–dependent degradation of Bora controls mitotic progression
Seki, A., Coppinger, J. A., Du, H., Jang, C., Yates, J. R., & Fang, G. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712027 · Cited by 134
Sarkissian, M., Méndez, R., & Richter, J. D. (2004) · Genes & Development · doi:10.1101/gad.1136004 · Cited by 134
Boynton, S., & Tully, T. (1992) · Genetics · doi:10.1093/genetics/131.3.655 · Cited by 133
Liu, J., & Krantz, I. D. (2008) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164211 · Cited by 131
Reduction of Cytosolic p27Kip1 Inhibits Cancer Cell Motility, Survival, and Tumorigenicity
Wu, F. Y., Wang, S. E., Sanders, M. E., Shin, I., Rojo, F., Baselga, J. M., & Arteaga, C. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3304 · Cited by 130
Sørensen, C. S., Lukas, C., Kramer, E. R., Peters, J., Bártek, J., & Lukas, J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3692-3703.2001 · Cited by 126
The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons.
Lee, M., Nikolić, M., Baptista, C. A., Lai, E., Tsai, L., & Massagué, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3259 · Cited by 124
Self-citationCell Cycle Dependent Regulation of the Origin Recognition Complex
Depamphilis, M. (2004) · Cell Cycle · doi:10.4161/cc.4.1.1333 · Cited by 123
RB, the conductor that orchestrates life, death and differentiation
Khidr, L., & Chen, P.-L. (2006) · Oncogene · doi:10.1038/sj.onc.1209612 · Cited by 123
Aurora A, mitotic entry, and spindle bipolarity
Liu, Q., & RUDERMAN, J. V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601425103 · Cited by 120
Bi-directional signaling by Semaphorin 1a during central synapse formation in Drosophila
Godenschwege, T. A., Hu, H., Shan-Crofts, X., Goodman, C. S., & Murphey, R. K. (2002) · Nature Neuroscience · doi:10.1038/nn976 · Cited by 118
p57Kip2 Regulates Actin Dynamics by Binding and Translocating LIM-kinase 1 to the Nucleus
Yokoo, T., Toyoshima, H., Miura, M., Wang, Y., Iida, K., Suzuki, H., Sone, H., Shimano, H., Gotoda, T., Nishimori, S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309334200 · Cited by 115
Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development.
Zindy, F., Soares, H. D., Herzog, K., Morgan, J., Sherr, C. J., & Roussel, M. F. (1997) · PubMed · Cited by 114
Degradation of human Aurora‐A protein kinase is mediated by hCdh1
Taguchi, S.-I., Honda, K., Sugiura, K., Yamaguchi, A., Furukawa, K., & Urano, T. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02711-4 · Cited by 113
Spatial Regulation of an E3 Ubiquitin Ligase Directs Selective Synapse Elimination
Ding, M., Chao, D. L., Wang, G., & Shen, K. (2007) · Science · doi:10.1126/science.1145727 · Cited by 111
Chesnokov, I. N., Chesnokova, O. N., & Botchan, M. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1633580100 · Cited by 108
Cell cycle molecules and vertebrate neuron death: E2F at the hub
Greene, L. A., Biswas, S. C., & Liu, D. X. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401341 · Cited by 108
Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb.
Saavedra, H. I., Wu, L., de Bruin, A., Timmers, C. D., Rosol, T. J., Weinstein, M. B., Robinson, M. L., & Leone, G. W. (2002) · PubMed · Cited by 108
The Origin Recognition Complex Functions in Sister-Chromatid Cohesion in Saccharomyces cerevisiae
Shimada, K., & Gasser, S. M. (2007) · Cell · doi:10.1016/j.cell.2006.11.045 · Cited by 107
Pinto, S., Quintana, D. G., Smith, P., Mihalek, R., Hou, Z.-H., Boynton, S., Jones, C. J., Hendricks, M., Velinzon, K., Wohlschlegel, J. A., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)80752-7 · Cited by 105
Zhang, B., Jain, S. R., Song, H., Fu, M., Heuckeroth, R. O., Erlich, J. M., Jay, P. Y., & Milbrandt, J. (2007) · Development · doi:10.1242/dev.005884 · Cited by 104
The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression
Turnell, A. S., Stewart, G. S., Grand, R. J. A., Rookes, S. M., Martin, A., Yamano, H., Elledge, S. J., & Gallimore, P. H. (2005) · Nature · doi:10.1038/nature04151 · Cited by 100
Why do Neurons Enter the Cell Cycle?
Kruman, I. I. (2004) · Cell Cycle · doi:10.4161/cc.3.6.901 · Cited by 99
The mechanism of sister chromatid cohesion
Uhlmann, F. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.03.005 · Cited by 98
The many faces of the origin recognition complex
Sasaki, T., & Gilbert, D. M. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.04.007 · Cited by 98
Siegel, P. M., Shu, W., & Massagué, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301413200 · Cited by 98
Zearfoss, N. R., Alarcón, J. M., Trifilieff, P., Kandel, E. R., & Richter, J. D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1756-08.2008 · Cited by 95
Toyoda, Y., & Yanagida, M. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-11-1089 · Cited by 95
Li, C., Vassilev, A. P., & Depamphilis, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5875-5886.2004 · Cited by 93
The cell cycle as a therapeutic target for Alzheimer's disease
Neve, R. L., & McPhie, D. L. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.09.005 · Cited by 92
Liu, X.-B., Low, L. K., Jones, E. G., & Cheng, H.-J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2648-05.2005 · Cited by 91
Rb-Mediated Neuronal Differentiation through Cell-Cycle–Independent Regulation of E2f3a
Chen, D., Opavsky, R., Pacal, M., Tanimoto, N., Wenzel, P., Seeliger, M. W., Leone, G., & Bremner, R. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050179 · Cited by 91
Unique Requirement for Rb/E2F3 in Neuronal Migration: Evidence for Cell Cycle-Independent Functions
McClellan, K. A., Ruzhynsky, V. A., Douda, D. N., Vanderluit, J. L., Ferguson, K. L., Chen, D., Bremner, R., Park, D. S., Leone, G., & Slack, R. S. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02100-06 · Cited by 88
Goukassian, D. A., Díez‐Juan, A., Asahara, T., Schratzberger, P., Silver, M., Murayama, T., Isner, J. M., & Andrés, V. (2001) · The FASEB Journal · doi:10.1096/fj.01-0065com · Cited by 88
Itoh, Y., Masuyama, N., Nakayama, K., Nakayama, K., & Gotoh, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609944200 · Cited by 87
TGFβ-Smad2 Signaling Regulates the Cdh1-APC/SnoN Pathway of Axonal Morphogenesis
Stegmüller, J., Huynh, M. A., Yuan, Z., Konishi, Y., & Bonni, A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3061-07.2008 · Cited by 86
latheo, a Drosophila Gene Involved in Learning, Regulates Functional Synaptic Plasticity
Rohrbough, J. C., Pinto, S., Mihalek, R., Tully, T., & Broadie, K. S. (1999) · Neuron · doi:10.1016/s0896-6273(00)80753-9 · Cited by 84
Conn, C. W., Hennigan, R. F., Dai, W. H., Sánchez, Y., & Stambrook, P. J. (2000) · PubMed · Cited by 81
Strachan, T. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.04.005 · Cited by 74
Why do neurons enter the cell cycle?
Kruman (2004) · PubMed · Cited by 67
The origin recognition core complex regulates dendrite and spine development in postmitotic neurons
Huang, Z. D., Zang, K., & Reichardt, L. F. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505075 · Cited by 65
A cell‐autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration
Ferguson, K. L., McClellan, K. A., Vanderluit, J. L., McIntosh, W. C., Schuurmans, C., Polleux, F., & Slack, R. S. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600887 · Cited by 65
Requirements for dE2F function in proliferating cells and in post‐mitotic differentiating cells.
Brook, A., Xie, J. E., Du, W., & Dyson, N. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00737.x · Cited by 65
Cambronne, X. A., Seeburg, D. P., Sheng, M., & Harper, J. W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802475200 · Cited by 61
Alzheimer's disease and the cell cycle
Raina, A. K., Zhu, X., & Smith, M. A. (2004) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2004-1496 · Cited by 43
Cuvier, O., Lutzmann, M., & Méchali, M. (2006) · Current Biology · doi:10.1016/j.cub.2006.01.059 · Cited by 24
The chromosome glue gets a little stickier
McNairn, A. J., & Gerton, J. L. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.06.002 · Cited by 20
p27Kip1 Promotes Migration of Metastatic Hepatocellular Carcinoma Cells
Wang, X. Q., Lui, E. L. H., Cai, Q., Ching, W. Y. P., Liu, K. S. Y., Poon, R. T. P., & Fan, S. T. (2008) · Tumor Biology · doi:10.1159/000152939 · Cited by 14
Conway, A.-M., James, A. B., Zang, J., & MORRIS, B. J. (2007) · Synapse · doi:10.1002/syn.20387 · Cited by 9
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Metadata
- Authors
- Frank, C. L., & Tsai, L.-H.
- Affiliations
- Howard Hughes Medical Institute (US)
- Broad Institute (US)
- Corresponding author
- Tsai, Li-Huei
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 62
- Issue
- 3
- Pages
- 312-326
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2757047
- OpenAlex
- W2009951375
- Cited by
- 118
- References
- 173
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 7 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 10 · 2012: 7
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Funders
- Howard Hughes Medical Institute
- National Institute on Aging (P01AG27916, P01AG027916)
- National Institute of Neurological Disorders and Stroke (R01 NS51876, R01NS051874)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- postmitotic neurons, neuronal migration, neuronal maturation, synaptic plasticity, axon elongation, axon pruning, dendrite morphogenesis, synapse maturation, cell cycle proteins
- MeSH terms
- Animals, Cell Movement, Gene Expression Regulation, Humans, Synaptic Transmission, Neuronal Plasticity, Neurons, Cell Cycle Proteins, Cell Proliferation, Neurogenesis
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