The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
In Vivo Cocaine Experience Generates Silent Synapses
Open accessAbstract
Summary Studies over the past decade have enunciated silent synapses as prominent cellular substrates for synaptic plasticity in the developing brain. However, little is known about whether silent synapses can be generated post-developmentally. Here, we demonstrate that highly salient in vivo experience, such as exposure to cocaine, generates silent synapses in the nucleus accumbens (NAc) shell, a key brain region mediating addiction-related learning and memory. Furthermore, this cocaine-induced generation of silent synapses is mediated by membrane insertions of new, NR2B–containing N-methyl-D-aspartic acid receptors (NMDARs). These results provide evidence that silent synapses can be generated de novo by in vivo experience and thus may act as highly efficient neural substrates for the subsequent experience-dependent synaptic plasticity underlying extremely long-lasting memory.
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The Neuroscience of Drug Reward and Addiction
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Metadata
- Authors
- Huang, Y. H., Lin, Y., Mu, P., Lee, B. R., Brown, T. E., Wayman, G., Marie, H., Liu, W., Yan, Z., Sorg, B. A., Schlüter, O. M., Zukin, R. S., & Dong, Y.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 63
- Issue
- 1
- Pages
- 40-47
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1978597334
- Cited by
- 289
- References
- 38
- FWCI
- 7.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Huang, Y. H., Lin, Y., Mu, P., Lee, B. R., Brown, T. E., Wayman, G., Marie, H., Liu, W., Yan, Z., Sorg, B. A., Schlüter, O. M., Zukin, R. S., & Dong, Y. (2009). In Vivo Cocaine Experience Generates Silent Synapses. Neuron. https://doi.org/10.1016/j.neuron.2009.06.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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