The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Hippocampal Replay of Extended Experience
Open accessAbstract
During pauses in exploration, ensembles of place cells in the rat hippocampus re-express firing sequences corresponding to recent spatial experience. Such "replay" co-occurs with ripple events: short-lasting (approximately 50-120 ms), high-frequency (approximately 200 Hz) oscillations that are associated with increased hippocampal-cortical communication. In previous studies, rats exploring small environments showed replay anchored to the rat's current location and compressed in time into a single ripple event. Here, we show, using a neural decoding approach, that firing sequences corresponding to long runs through a large environment are replayed with high fidelity and that such replay can begin at remote locations on the track. Extended replay proceeds at a characteristic virtual speed of approximately 8 m/s and remains coherent across trains of ripple events. These results suggest that extended replay is composed of chains of shorter subsequences, which may reflect a strategy for the storage and flexible expression of memories of prolonged experience.
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“The reactivation of task-relevant regions was found to be particular prominent during sleep oscillatory events linked to memory consolidation, such as spindles and SOs.”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [108]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“both sleep and wake replay can represent knowledge about an environment and also share anticipatory features, such that they can e.g., include offline ''pre-activations'' of trajectories entailing visible but yet unexplored paths and locations.”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [148]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Spindle activity is increased over cortical regions involved in prior learning and, moreover, positively correlates with post sleep retrieval performance 180,181 and appears to accompany memory reactivations during sleep.108,114”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [108]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Reactivations of hippocampal cell firing patterns occur also during waking when the animal rests after task performance or during brief pauses of active behavior like explo-ration or running in a maze (191, 268, 556, 673, 870; see Ref. 175 for a review).”
From About Sleep's Role in Memory (2013) · cites this paper as [268]
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“In larger experimental environments, both forward and reverse replay can occur over multiple SW-R events thereby covering longer distances (268).”
From About Sleep's Role in Memory (2013) · cites this paper as [268]
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Citations
Cites
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010
Mental Rotation of Three-Dimensional Objects
Shepard, R. N., & Metzler, J. (1971) · Science · doi:10.1126/science.171.3972.701 · Cited by 6,246
The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
O'Keefe, J., & Dostrovsky, J. (1971) · Brain Research · doi:10.1016/0006-8993(71)90358-1 · Cited by 6,151 · cited 1×
“Place cells in the hippocampal formation fire selectively when an animal moves through particular locations (‘‘place fields’’) in the environment (O’Keefe and Dostrovsky, 1971; Wilson and McNaughton, 1993).”
Bootstrap Methods and Their Application
Loughin, T. M., Davison, A. C., & HINKLEY, D. V. (1999) · Journal of the American Statistical Association · doi:10.2307/2669707 · Cited by 5,478
The hippocampus as a cognitive map
Passingham, R. E. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90015-0 · Cited by 5,128
Reactivation of hippocampal ensemble memories during sleep
Wilson, M. A., & McNaughton, B. L. (1994) · Science · doi:10.1126/science.8036517 · Cited by 3,118 · cited 3×
“…replay detection in the decoded spatial domain affords advantages over methods that examine firing order across individual units, such as pair-wise correlation (Wilson and McNaughton, 1994) and spike-sequence detection (Diba and Buzsáki, 2007; Foster and Wilson, 2006; Lee and Wilson, 2004).”
Self-citationBuckner, R. L., & Carroll, D. C. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.11.004 · Cited by 2,691
Remembering the past to imagine the future: the prospective brain
Schacter, D. L., Addis, D. R., & Buckner, R. L. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2213 · Cited by 2,394 · cited 2×
“This interpretation of the functional role of awake replay is also consistent with work suggesting a high degree of overlap in the cognitive processes supporting both episodic recall and the evaluation of future events in humans (Buckner and Carroll, 2007; Schacter et al., 2007).”
InfluentialDynamics of the Hippocampal Ensemble Code for Space
Wilson, M. A., & McNaughton, B. L. (1993) · Science · doi:10.1126/science.8351520 · Cited by 2,350 · cited 3×
“Place cells in the hippocampal formation fire selectively when an animal moves through particular locations (‘‘place fields’’) in the environment (O’Keefe and Dostrovsky, 1971; Wilson and McNaughton, 1993).”
Self-citationSleep-dependent memory consolidation
Stickgold, R. (2005) · Nature · doi:10.1038/nature04286 · Cited by 1,857 · cited 2×
“For example, the reverse replay event in Figure 4D proceeds in the B/A direction (from 7.5 to 2.5 m on the track) but uses the hippocampal ensemble code associated with running in the opposite A/B direction, as indicated by the blue color.”
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Items 801–806 of 806
Disruption of theta-timescale spiking impairs learning but spares hippocampal replayPreprint
Joshi, A., Comrie, A. E., Bray, S. R., Mankili, A., Guidera, J. A., Nevers, R., Sun, X., Monroe, E., Kharazia, V., Ly, R., et al. (2026) · eLife · doi:10.7554/elife.109375.2
Simultaneous awake replay of multiple spatial representations
Mou, X., & Ji, D. (2026) · Neuron · doi:10.1016/j.neuron.2026.09.014
Dual-mode dynamics in hippocampal populations enable rapid and precise spatial coding
Ren, M., Feng, S., Chen, Q., Lin, L., & Xu, J. (2026) · Current Biology · doi:10.1016/j.cub.2026.09.052
Post-Learning Reactivation of Memories for Naturalistic Continuous ExperiencesPreprint
Wolf, N., Antony, J. W., Delarazan, A. I., Reagh, Z. M., Michelmann, S., Ranganath, C., & Liu, X. L. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.20.760554
“Evidence suggests that place cell sequence replays consist of fragmented, short segments of spatial trajectories (Davidson et al., 2009; Berners-Lee et al., 2022; Eliav et al., 2025), and studies of post-learning reactivation in humans generally focus on memory for arbitrary, unstructured…”
EFFECTS OF RESTING STATE ON PERCEPTUAL LEARNING
Eagleman, S. L. (2014) · Digital Commons-TMC (Texas Medical Center)
Ólafsdóttir, H. F. (2014) · UCL Discovery (University College London)
Metadata
- Authors
- Davidson, T. J., Kloosterman, F., & Wilson, M. A.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Kloosterman, Fabian
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 63
- Issue
- 4
- Pages
- 497-507
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4364032
- OpenAlex
- W2079161053
- Cited by
- 806
- References
- 53
- Citations by year
- 2026: 41 · 2025: 54 · 2024: 68 · 2023: 57 · 2022: 56 · 2021: 65 · 2020: 49 · 2019: 72 · 2018: 42 · 2017: 41 · 2016: 49 · 2015: 42 · 2014: 57 · 2013: 40 · 2012: 26
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1477 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Lirias (KU Leuven) (submittedVersion)
- Funders
- National Institutes of Health (MH061976)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- hippocampal replay, place cells, spatial memory, neural decoding, memory storage
- MeSH terms
- Animals, Exploratory Behavior, Hippocampus, Learning, Male, Spatial Behavior, Time Factors, Rats, Long-Evans, Rats
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