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Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice
Open accessAbstract
SUMMARY Itch is the least well understood of all the somatic senses, and the neural circuits that underlie this sensation are poorly defined. Here we show that the atonal-related transcription factor Bhlhb5 is transiently expressed in the dorsal horn of the developing spinal cord and appears to play a role in the formation and regulation of pruritic (itch) circuits. Mice lacking Bhlhb5 develop self-inflicted skin lesions and show significantly enhanced scratching responses to pruritic agents. Through genetic fate-mapping and conditional ablation we provide evidence that the pruritic phenotype in Bhlhb5 mutants may be due to selective loss of a subset of inhibitory interneurons in the dorsal horn. Our findings suggest that Bhlhb5 is required for the survival of a specific population of inhibitory interneurons that regulate pruritis and provide evidence that the loss of inhibitory synaptic input results in abnormal itch.
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Cites
Central sensitization: a generator of pain hypersensitivity by central neural plasticity
Latremoliere, A., & Woolf, C. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.012 · Cited by 3,913
Self-citationThe development of nociceptive circuits
Fitzgerald, M. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1701 · Cited by 778
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Self-citationAstrocytes in chronic pain and itch
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Metadata
- Authors
- Ross, S. E., Mardinly, A. R., McCord, A. E., Zurawski, J., Cohen, S., Jung, C., Hu, L., Mok, S. I., Shah, A., Savner, E. M., Tolias, C., Corfas, R., Chen, S., Inquimbert, P., Xu, Y., McInnes, R. R., Rice, F. L., Corfas, G., Ma, Q., Woolf, C. J., & Greenberg, M. E.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 65
- Issue
- 6
- Pages
- 886-898
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2096194006
- Cited by
- 445
- References
- 2
- FWCI
- 27.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Ross, S. E., Mardinly, A. R., McCord, A. E., Zurawski, J., Cohen, S., Jung, C., Hu, L., Mok, S. I., Shah, A., Savner, E. M., Tolias, C., Corfas, R., Chen, S., Inquimbert, P., Xu, Y., McInnes, R. R., Rice, F. L., Corfas, G., Ma, Q., . . . Greenberg, M. E. (2010). Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice. Neuron. https://doi.org/10.1016/j.neuron.2010.02.025
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
