Identification of Spinal Circuits Transmitting and Gating Mechanical Pain
Open accessAbstract
Pain information processing in the spinal cord has been postulated to rely on nociceptive transmission (T) neurons receiving inputs from nociceptors and Aβ mechanoreceptors, with Aβ inputs gated through feed-forward activation of spinal inhibitory neurons (INs). Here, we used intersectional genetic manipulations to identify these critical components of pain transduction. Marking and ablating six populations of spinal excitatory and inhibitory neurons, coupled with behavioral and electrophysiological analysis, showed that excitatory neurons expressing somatostatin (SOM) include T-type cells, whose ablation causes loss of mechanical pain. Inhibitory neurons marked by the expression of dynorphin (Dyn) represent INs, which are necessary to gate Aβ fibers from activating SOM(+) neurons to evoke pain. Therefore, peripheral mechanical nociceptors and Aβ mechanoreceptors, together with spinal SOM(+) excitatory and Dyn(+) inhibitory neurons, form a microcircuit that transmits and gates mechanical pain. PAPERCLIP:
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The Prkcg dorsal excitatory family comprised Excit-3 and Excit-4 and likely corresponded to neurons involved in light static touch and allodynic pain in pathological situations.
“The Prkcg dorsal, excitatory family was comprised of Excit-3 and Excit-4 and likely corresponded to neurons involved in light static touch and allodynic pain in pathological situations46,48–56.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [52]
The Pdyn dorsal inhibitory family comprised Inhib-9, Inhib-10, and Inhib-11 and expressed markers suggestive of a role in chemical itch.
“The Pdyn dorsal, inhibitory family was comprised of Inhib-9, Inhib-10, and Inhib-11 and expressed markers suggestive of a role in chemical itch52,61,73–77.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [52]
The Sox5 dorsal excitatory family comprised Excit-14, Excit-15, Excit-16, Excit-17, Excit-18, and Excit-19 and expressed markers suggestive of a role in coping pain and mechanical nociception.
“The Sox5 dorsal, the excitatory family was comprised of Excit-14, Excit-15, Excit-16, Excit-17, Excit-18, and Excit-19, and expressed markers suggestive of a role in coping pain and mechanical nociception46,52,56,63–67.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [52]
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- Authors
- Duan, B., Cheng, L., Bourane, S., Britz, O., Padilla, C., Garcia-Campmany, L., Krashes, M., Knowlton, W., Velasquez, T., Ren, X., Ross, S. E., Lowell, B. B., Wang, Y., Goulding, M., & Ma, Q.
- Affiliations
- Harvard University (US)
- Salk Institute for Biological Studies (US)
- National Institutes of Health (US)
- University of Pittsburgh (US)
- Beth Israel Deaconess Medical Center (US)
- Fudan University (CN)
- Corresponding author
- Goulding, Martyn
- Ma, Qiufu
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 159
- Issue
- 6
- Pages
- 1417-1432
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4258511
- OpenAlex
- W1969751124
- Cited by
- 582
- References
- 78
- Citations by year
- 2026: 38 · 2025: 40 · 2024: 49 · 2023: 58 · 2022: 58 · 2021: 57 · 2020: 59 · 2019: 68 · 2018: 58 · 2017: 33 · 2016: 34 · 2015: 29 · 2013: 1
- FWCI
- 21.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK057521, R01DK075632, R01DK089044, R01DK071051, P30DK046200, F32DK089710, R01DK096010, R37DK053477)
- National Institute of Neurological Disorders and Stroke (P01NS072040, R01NS086372, R01NS047710, P01 NS072031, P01NS047572, NS047710, R01NS080586)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21AR064445, R01AR063772)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- mechanical pain, spinal nociception, somatostatin neurons, pain transmission, excitatory neurons, neuronal ablation
- MeSH terms
- Animals, Dynorphins, Mechanoreceptors, Neurons, Pain, Somatostatin, Spinal Cord, Mice, Pain Perception
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