Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior

The functional anatomy of basal ganglia disorders

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Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

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D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons

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NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory

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Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

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REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

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Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

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D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons

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Neural circuits provide insights into reward and aversion

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Concurrent maternal and pup postnatal tobacco smoke exposure in Wistar rats changes food preference and dopaminergic reward system parameters in the adult male offspring

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Development of behavioral preferences for the optimal choice following unexpected reward omission is mediated by a reduction of D 2‐like receptor tone in the nucleus accumbens

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The basal ganglia, the ideal machinery for the cost-benefit analysis of action plans

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The cortico-striatal circuitry in autism-spectrum disorders: a balancing act

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Tonic dopamine and biases in value learning linked through a biologically inspired reinforcement learning model

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Probing striatal microcircuitry to understand the functional role of cholinergic interneurons

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Coding of the long-term value of multiple future rewards in the primate striatum

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BDNF and Huntingtin protein modifications by manganese: implications for striatal medium spiny neuron pathology in manganese neurotoxicity

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Knockdown of Dopamine D2 Receptors in the Nucleus Accumbens Core Suppresses Methamphetamine-Induced Behaviors and Signal Transduction in Mice

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Striatal dopamine D1 receptor suppression impairs reward-associative learning

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Medium spiny neurons of the anterior dorsomedial striatum mediate reversal learning in a cell-type-dependent manner

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NF1-cAMP signaling dissociates cell type–specific contributions of striatal medium spiny neurons to reward valuation and motor control

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Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity

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The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events

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High-Frequency Deep Brain Stimulation of the Substantia Nigra Pars Reticulata Facilitates Extinction and Prevents Reinstatement of Methamphetamine-Induced Conditioned Place Preference

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Dopamine D2L Receptor Is Required for Visual Discrimination and Reversal Learning

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Dopamine Transporter Gene Methylation is Associated with Nucleus Accumbens Activation During Reward Processing in Healthy but not Alcohol‐Dependent Individuals

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Behavioral and Neurochemical Changes in Mesostriatal Dopaminergic Regions of the Rat after Chronic Administration of the Cannabinoid Receptor Agonist WIN55,212-2

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A Review of DNA Risk Alleles to Determine Epigenetic Repair of mRNA Expression to Prove Therapeutic Effectiveness in Reward Deficiency Syndrome (RDS): Embracing “Precision Behavioral Management”

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Role of the Plasticity-Associated Transcription Factor Zif268 in the Early Phase of Instrumental Learning

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Striatal 5-HT6 Receptors Regulate Cocaine Reinforcement in a Pathway-Selective Manner

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Conflict Resolution as Near-Threshold Decision-Making: A Spiking Neural Circuit Model with Two-Stage Competition for Antisaccadic Task

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Dual-task performance is differentially modulated by rewards and punishments

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Chemogenetic Targeting of Dorsomedial Direct-pathway Striatal Projection Neurons Selectively Elicits Rotational Behavior in Mice

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Impaired Learning From Negative Feedback in Stimulant Use Disorder: Dopaminergic Modulation

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Deconstructing 5-HT6 receptor effects on striatal circuit function

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In vivo visualization of single-unit recording sites using MRI-detectable elgiloy deposit marking

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CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron Subtypes Differentially Regulates Behavioral and Physiological Adaptations Over the Course of Cocaine Use

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Adenosine 2 A receptors modulate reward behaviours for methamphetamine

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From valence encoding to motivated behavior: A focus on the nucleus accumbens circuitry

Vieitas‐Gaspar, N., Soares‐Cunha, C., & Rodrigues, A. J. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106125 · Cited by 20

Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice

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The secretogranin II gene is a signal integrator of glutamate and dopamine inputs

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Illuminating Neural Circuits: From Molecules to MRI

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Cholinergic interneurons mediate cocaine extinction in male mice through plasticity across medium spiny neuron subtypes

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Exploring the role of striatal D1 and D2 medium spiny neurons in action selection using a virtual robotic framework

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Exercise-Induced Adaptations to the Mouse Striatal Adenosine System

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The Aversion Function of the Limbic Dopaminergic Neurons and Their Roles in Functional Neurological Disorders

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Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia

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cAMP-Fyn signaling in the dorsomedial striatum direct pathway drives excessive alcohol use

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D1- and D2-like receptors differentially mediate the effects of dopaminergic transmission on cost–benefit evaluation and motivation in monkeys

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Chronic inflammatory pain decreases the glutamate vesicles in presynaptic terminals of the nucleus accumbens

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Adaptive Cost-Benefit Control Fueled by Striatal Dopamine

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Specific behavioral and cellular adaptations induced by chronic morphine are reduced by dietary omega-3 polyunsaturated fatty acids

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Identification of dual inhibitor of phosphodiesterase 1B/10A using structure-based drug design approach

Al-Nema, M. Y., Gaurav, A., Lee, V. S., Gunasekaran, B., Lee, M. T., & Okechukwu, P. N. (2021) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2021.117485 · Cited by 15

Evidence that GIRK Channels Mediate the DREADD-hM4Di Receptor Activation-Induced Reduction in Membrane Excitability of Striatal Medium Spiny Neurons

Shan, Q., Fang, Q., & Tian, Y. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00304 · Cited by 15

Synaptic and cellular endocannabinoid signaling mechanisms regulate stress-induced plasticity of nucleus accumbens somatostatin neurons

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Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor

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Exploring the Intricacies of Neurogenic Niches: Unraveling the Anatomy and Neural Microenvironments

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A Functional 3′UTR Polymorphism (rs2235749) of Prodynorphin Alters microRNA-365 Binding in Ventral Striatonigral Neurons to Influence Novelty Seeking and Positive Reward Traits

Egervári, G., Jutras‐Aswad, D., Landry, J. A., Miller, M. L., Anderson, S. A., Michaelides, M., Jacobs, M. M., Peter, C. J., Yiannoulos, G., Liu, X., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.53 · Cited by 15

Early life stress influences basal ganglia dopamine receptors and novel object recognition of adolescent and adult rats

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Distinct Functions of the Primate Putamen Direct and Indirect Pathways in Adaptive Outcome-Based Action Selection

Ueda, Y., Yamanaka, K., Noritake, A., Enomoto, K., Matsumoto, N., Yamada, H., Samejima, K., Inokawa, H., Hori, Y., Nakamura, K., et al. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00066 · Cited by 15

High ethanol sensitive glycine receptors regulate firing in D1 medium spiny neurons in the nucleus accumbens

Gallegos, S., Muñoz, B., Araya, A., & Aguayo, L. G. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107773 · Cited by 15

Cell-type specific asynchronous modulation of PKA by dopamine during reward based learningPreprint

Lee, S. J., Lodder, B., Chen, Y., Patriarchi, T., Tian, L., & Sabatini, B. L. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/839035 · Cited by 15

Nucleus accumbens core single cell ensembles bidirectionally respond to experienced versus observed aversive events

Dinçkol, Ö., Wenger, N. H., Zachry, J. E., & Kutlu, M. G. (2023) · Scientific Reports · doi:10.1038/s41598-023-49686-x · Cited by 13

Nucleus accumbens neurons dynamically respond to appetitive and aversive associative learning

Deseyve, C., Domingues, A. V., Carvalho, T. T. A., Armada, G., Correia, R. G., Vieitas‐Gaspar, N., Wezik, M., Pinto, L., Sousa, N., Coimbra, B., et al. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16063 · Cited by 14

Longitudinal magnetic resonance imaging reveals striatal hypertrophy in a rat model of long-term stimulant treatment

Biezonski, D. K., Shah, R., Krivko, A., Cha, J., Guilfoyle, D. N., Hrabě, J., Gerum, S. V., Xie, S., Duan, Y., Bansal, R., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.158 · Cited by 14

Discovery of natural product inhibitors of phosphodiesterase 10A as novel therapeutic drug for schizophrenia using a multistep virtual screening

Al-Nema, M. Y., Gaurav, A., & Akowuah, G. A. (2018) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2018.09.001 · Cited by 12

Cocaine-Induced Behavioral Sensitization in Mice: Effects of Microinjection of Dopamine D2 Receptor Antagonist into the Nucleus Accumbens

Jung, E.-S., Lee, H. J., Sim, H.-R., & Baik, J. (2013) · Experimental Neurobiology · doi:10.5607/en.2013.22.3.224 · Cited by 14

Suppression of inhibitory G protein signaling in forebrain pyramidal neurons triggers plasticity of glutamatergic neurotransmission in the nucleus accumbens core

de Velasco, E. M. F., Carlblom, N., Xia, Z., & Wickman, K. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.021 · Cited by 15

Unilateral Optogenetic Inhibition and Excitation of Basal Ganglia Output Affect Directional Lick Choices and Movement Initiation in Mice

Morrissette, A. E., Chen, P., Bhamani, C., Borden, P. Y., Waiblinger, C., Stanley, G. B., & Jaeger, D. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.10.031 · Cited by 14

Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors: Association with Preference and Avoidance

Zhang, X., Tsuboi, D., Funahashi, Y., Yamahashi, Y., Kaibuchi, K., & Nagai, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911643 · Cited by 15

Opponent learning with different representations in the cortico-basal ganglia pathways can develop obsession-compulsion cycle

Sato, R., Shimomura, K., & Morita, K. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011206 · Cited by 13

Bisphenol A Does Not Affect Memory Performance in Adult Male Rats

Kuwahara, R., Kawaguchi, S., Kohara, Y., Jojima, T., & Yamashita, K. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-0017-6 · Cited by 13

Tyrosine hydroxylase in the ventral tegmental area of rams with high or low libido—A role for dopamine

Kramer, A. C., Mirto, A. J., Austin, K. J., Roselli, C. E., & Alexander, B. M. (2017) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2017.10.019 · Cited by 13

Effect of optogenetic manipulation of accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine‐induced behavioral sensitization

Kang, B. J., Song, S. S., Wen, L., Hong, K., Augustine, G. J., & Baik, J. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13648 · Cited by 12

Striatopallidal Pathway Distinctly Modulates Goal-Directed Valuation and Acquisition of Instrumental Behavior via Striatopallidal Output Projections

He, Y., Li, Y., Pu, Z., Chen, M., Gao, Y., Chen, L., Ruan, Y., Pan, X., Zhou, Y., Ge, Y., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz172 · Cited by 13

Global research status and trends of compulsive sexual behavior disorder: A comprehensive bibliometric analysis

Zhang, W., Wang, P., Gao, B., & Wang, Z. (2025) · Journal of Behavioral Addictions · doi:10.1556/2006.2025.00059 · Cited by 12

How genetically engineered systems are helping to define, and in some cases redefine, the neurobiological basis of sleep and wake

Fuller, P. M., Yamanaka, A., & Lazarus, M. (2015) · Temperature · doi:10.1080/23328940.2015.1075095 · Cited by 12

Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry

Schülke, J.-P., & Brandon, N. J. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-58811-7_2 · Cited by 11

Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function

Richter, A., de Boer, L., Guitart‐Masip, M., Behnisch, G., Seidenbecher, C. I., & Schott, B. H. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-021-02382-4 · Cited by 11

Cell-type- and region-specific modulation of cocaine seeking by micro-RNA-1 in striatal projection neurons

Forget, B., Martín‐García, E., Godino, A., Rodriguez, L. D., Kappès, V., Poirier, P., Andrianarivelo, A., Senabre, E., Allichon, M., Marias, M., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01328-2 · Cited by 14

Muscarinic signaling regulates voltage‐gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning

Faruk, M. O., Tsuboi, D., Yamahashi, Y., Funahashi, Y., Lin, Y., Ahammad, R. U., Hossen, E., Amano, M., Nishioka, T., Tzingounis, A. V., et al. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15555 · Cited by 12

RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease

Montañez‐Miranda, C., Bramlett, S. N., & Hepler, J. R. (2022) · Hippocampus · doi:10.1002/hipo.23492 · Cited by 12

Computing reward‐prediction error: an integrated account of cortical timing and basal‐ganglia pathways for appetitive and aversive learning

Morita, K., & Kawaguchi, Y. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12994 · Cited by 12

Pathway-specific engagement of ephrinA5-EphA4/EphA5 system of the substantia nigra pars reticulata in cocaine-induced responses

Kimura, K., Hikida, T., Yawata, S., Yamaguchi, T., & Nakanishi, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107592108 · Cited by 12

Reduction of Cocaine-Induced Locomotor Effects by Enriched Environment Is Associated with Cell-Specific Accumulation of ΔFosB in Striatal and Cortical Subregions

Lafragette, A., Bardo, M. T., Lardeux, V., Solinas, M., & Thiriet, N. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw097 · Cited by 13

The medial septum enhances reversal learning via opposing actions on ventral tegmental area and substantia nigra dopamine neurons

Bortz, D. M., Gazo, K. L., & Grace, A. A. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0453-1 · Cited by 14

Depression in the Direct Pathway of the Dorsomedial Striatum Permits the Formation of Habitual Action

Yu, X., Chen, S., & Shan, Q. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab031 · Cited by 12

Dopaminergic Neurons in Parkinson’s Disease

Prediger, R. D., Bortolanza, M., Issy, A. C., dos Santos, B. L., Bel, E. A. D., & Raisman‐Vozari, R. (2014) · Springer eBooks · doi:10.1007/978-1-4614-5836-4_7 · Cited by 12

Hyperactive behavioral phenotypes and an altered brain monoaminergic state in male offspring mice with perinatal hypothyroidism

Umezu, T., Kita, T., & Morita, M. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.10.005 · Cited by 13

Distinct nucleus accumbens neural pathways underlie separate behavioral features of chronic pain and comorbid depression

Liu, D., Xu, F.-X., Yu, Z., Huang, X., Zhu, Y.-B., Wang, L.-J., Wu, C., Zhang, X., Cao, J., & Li, J. (2025) · Journal of Clinical Investigation · doi:10.1172/jci191270 · Cited by 14

Movement errors during skilled motor performance engage distinct prediction error mechanisms

Gabitov, E., Lungu, O., Albouy, G., & Doyon, J. (2020) · Communications Biology · doi:10.1038/s42003-020-01465-4 · Cited by 17

A plastic corticostriatal circuit model of adaptation in perceptual decision making

Hsiao, P.-Y. (2013) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2013.00178 · Cited by 10

Differential mitochondrial morphology in ventral striatal projection neuron subtypes

Chandra, R., Calarco, C. A., & Lobo, M. K. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24511 · Cited by 14

Topographic distinction in long-term value signals between presumed dopamine neurons and presumed striatal projection neurons in behaving monkeys

Enomoto, K., Matsumoto, N., Inokawa, H., Kimura, M., & Yamada, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-65914-0 · Cited by 9

Altered brain intrinsic functional hubs and connectivity associated with relapse risk in heroin dependents undergoing methadone maintenance treatment: A resting-state fMRI study

Wang, L., Hu, F., Wang, W., Li, Q., Li, Y., Zhu, J., Qin, Y., Shi, H., Li, W., & Wang, Y. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108503 · Cited by 11

Nucleus Accumbens Core Dopamine D2 Receptor-Expressing Neurons Control Reversal Learning but Not Set-Shifting in Behavioral Flexibility in Male Mice

Macpherson, T., Kim, J. Y., & Hikida, T. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.885380 · Cited by 10

Modulation of neuronal excitability by binge alcohol drinking

Giménez‐Gómez, P., Le, T., & Martin, G. E. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1098211 · Cited by 12

From avoidance to new action: the multifaceted role of the striatal indirect pathway

Lee, J., & Sabatini, B. L. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00925-2 · Cited by 10

Rewiring of Prelimbic Inputs to the Nucleus Accumbens Core Underlies Cocaine-Induced Behavioral Sensitization

Kwon, J., Kim, H. J., Lee, H., Ho, W., Kim, J., & Lee, S. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.12.024 · Cited by 10

Inducible CRISPR Epigenome Systems Mimic Cocaine Induced Bidirectional Regulation of Nab2 and Egr3

Choi, E. Y., Franco, D., Stapf, C. A., Gordin, M., Chow, A., Cover, K. K., Chandra, R., & Lobo, M. K. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1802-22.2022 · Cited by 11

Dopamine modulates striatal response to reward and punishment in patients with Parkinson’s disease

Árgyelán, M., Herzallah, M. M., Sako, W., DeLucia, I., Sarpal, D. K., Vo, A., Fitzpatrick, T., Moustafa, A. A., Eidelberg, D., & Gluck, M. A. (2018) · Neuroreport · doi:10.1097/wnr.0000000000000970 · Cited by 12

Nicotine improves probabilistic reward learning in wildtype but not alpha7 nAChR null mutants, yet alpha7 nAChR agonists do not improve probabilistic learning

Milienne-Petiot, M., Higa, K. K., Grim, A., Deben, D. S., Groenink, L., Twamley, E. W., Geyer, M. A., & Young, J. W. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.08.005 · Cited by 9

Nucleus accumbens pathways control cell-specific gene expression in the medial prefrontal cortex

Hikida, T., Yao, S., Macpherson, T., Fukakusa, A., Morita, M., Kimura, H., Hirai, K., Ando, T., Toyoshiba, H., & Sawa, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-58711-2 · Cited by 10

Selective Manipulation of G-Protein γ7Subunit in Mice Provides New Insights into Striatal Control of Motor Behavior

Brunori, G., Pelletier, O. B., Stauffer, A. M., & Robishaw, J. D. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1211-21.2021 · Cited by 11

Comorbidité entre la dépression et l’addiction

Arango-Lievano, M., & Kaplitt, M. G. (2015) · médecine/sciences · doi:10.1051/medsci/20153105017 · Cited by 10

Cocaine administration increases angiotensin I-converting enzyme (ACE) expression and activity in the rat striatum and frontal cortex

Visniauskas, B., Perry, J. C., Oliveira, V., Dalio, F. M., Andersen, M. L., Tufik, S., & Chagas, J. R. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.10.054 · Cited by 10

Brain regions and monoaminergic neurotransmitters that are involved in mouse ambulatory activity promoted by bupropion

Umezu, T., & Shibata, Y. (2016) · Toxicology Reports · doi:10.1016/j.toxrep.2016.06.005 · Cited by 11

Fronto-striatal projections regulate approach-avoidance conflictPreprint

Loewke, A. C., Minerva, A. R., Nelson, A. B., Kreitzer, A., & Gunaydin, L. A. (2020) · bioRxiv · doi:10.1101/2020.03.05.979708 · Cited by 7

Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors

Hikida, T., Yawata, S., Yamaguchi, T., Danjo, T., Sasaoka, T., Wang, Y., & Nakanishi, S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220358110 · Cited by 128

Distinct dopaminergic control of the direct and indirect pathways in reward-based and avoidance learning behaviors

Nakanishi, S., Hikida, T., & Yawata, S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.026 · Cited by 103

Pathway-specific control of reward learning and its flexibility via selective dopamine receptors in the nucleus accumbens

Yawata, S., Yamaguchi, T., Danjo, T., Hikida, T., & Nakanishi, S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210797109 · Cited by 112

Bidirectional plasticity in striatonigral synapses: A switch to balance direct and indirect basal ganglia pathwaysPreprint

Buendia, J. D. J. A., Rueda‐Orozco, P. E., Hernandez-Martinez, R., Galarraga, E., & Bargas, J. (2011) · Learning & Memory · doi:10.1101/lm.023432.111 · Cited by 21

Synaptic Connections Between Spiny Neurons of the Direct and Indirect Pathways in the Neostriatum of the Rat: Evidence from Dopamine Receptor and Neuropeptide Immunostaining

Yung, K. K. L., Smith, A. D., Levey, A. I., & Bolam, J. P. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01573.x · Cited by 128