Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior

The functional anatomy of basal ganglia disorders

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Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

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D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons

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NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory

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Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity.

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Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

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REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

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Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

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D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons

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Cannabinoid type-1 receptor signaling in dopaminergic Engrailed-1 expressing neurons modulates motivation and depressive-like behavior

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Direct and indirect nigrofugal projections to the nucleus reticularis pontis caudalis mediate in the motor execution of the acoustic startle reflex

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Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice.

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Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning

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Differential Roles of Accumbal GSK3β in Cocaine versus Morphine-Induced Place Preference, U50,488H-Induced Place Aversion, and Object Memory

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Nucleus Accumbens Dopamine Receptor 1 Expressing Neurons Are Instrumental in Appetitive Aggression

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Single Exposure to Cocaine Impairs Reinforcement Learning by Potentiating the Activity of Neurons in the Direct Striatal Pathway in Mice

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Hypersexuality in neurological diseases: do we see only the tip of the iceberg?

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Acute binge pattern cocaine administration induces region-specific effects in D1-r- and D2-r-expressing cells in eGFP transgenic mice

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Overexpression of wild type glycine alpha 1 subunit rescues ethanol sensitivity in accumbal receptors and reduces binge drinking in mice

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BDNF/TrkB pathway activation in D1 receptor-expressing striatal projection neurons plays a protective role against L-DOPA-induced dyskinesia

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Identification of neuron-type specific promoters in monkey genome and their functional validation in mice

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Anterior Insular-nucleus Accumbens Pathway Controls Refeeding-induced Analgesia under Chronic Inflammatory Pain Condition

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Dual Roles for Nucleus Accumbens Core Dopamine D1-Expressing Neurons Projecting to the Substantia Nigra Pars Reticulata in Limbic and Motor Control in Male Mice

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Enhanced Cocaine-Associated Contextual Learning in Female H/Rouen Mice Selectively Bred for Depressive-Like Behaviors: Molecular and Neuronal Correlates

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Local field potential power spectra and locomotor activity following treatment with pseudoephedrine in mice

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Signal flow in the NMDA receptor–dependent phosphoproteome regulates postsynaptic plasticity for aversive learning

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Gut microbiome depletion modulates cocaine-induced behavioral and transcriptional responses in female mice

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Neural Circuit Plasticity in Addiction

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Cellular bases for reward-related dopamine actions

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Transcranial Magnetic Stimulation for Methamphetamine Use Disorder: A Scoping Review within the Neurocircuitry Model of Addiction

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Neonatal programming with sex hormones: Effect on expression of dopamine D1 receptor and neurotransmitters release in nucleus accumbens in adult male and female rats

Elgueta-Reyes, M., Martínez-Pinto, J., Renard, G. M., & Sotomayor‐Zárate, R. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174118 · Cited by 7

l-Menthol increases extracellular dopamine and c-Fos-like immunoreactivity in the dorsal striatum, and promotes ambulatory activity in mice

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Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor–Receptor Interaction and Striatal Function

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Modulatory role of intra-accumbal dopamine receptors in the restraint stress-induced antinociceptive responses

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Non-Opioid Anesthetics Addiction: A Review of Current Situation and Mechanism

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The phosphodiesterase 10A selective inhibitor, TAK-063, induces c-Fos expression in both direct and indirect pathway medium spiny neurons and sub-regions of the medial prefrontal cortex in rats

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Dopamine D1 receptor‐expressing neurons activity is essential for locomotor and sensitizing effects of a single injection of cocaine

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Nuclear Calcium Signaling in D1 Receptor–Expressing Neurons of the Nucleus Accumbens Regulates Molecular, Cellular, and Behavioral Adaptations to Cocaine

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Opposing effects of mu opioid receptors on dopamine D1 and D2 receptor expressing neurons in opioid mediated antinociception

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NMDA- and 6-OHDA-induced Lesions in the Nucleus Accumbens Differently Affect Maternal and Infanticidal Behavior in Pup-naïve Female and Male Mice

Alsina‐Llanes, M., & Olazábal, D. E. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2023.12.009 · Cited by 6

Importin α4 deficiency induces psychiatric disorder-related behavioral deficits and neuroinflammation in mice

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Multiple brain regions are involved in reaction to acute restraint stress in CYLD-knockout mice

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A Tet-On System for DRD1-Expressing Cells

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Differential effects of naloxone on rewarding electrical stimulation of the central nucleus of the amygdala and parabrachial complex in a place preference study

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Serotonin neurobiology in cocaine use disorder

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On and Off switches in the brain

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A decision-space model explains context-specific decision-making

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Aging in nucleus accumbens and its impact on alcohol use disorders

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Glutamate receptor-interacting protein 1 in D1- and D2-dopamine receptor-expressing medium spiny neurons differentially regulates cocaine acquisition, reinstatement, and associated spine plasticity

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A novel small molecule, AS1, reverses the negative hedonic valence of noxious stimuli

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A Kpna1-deficient psychotropic drug-induced schizophrenia model mouse for studying gene–environment interactions

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Enhancing reinforcement learning models by including direct and indirect pathways improves performance on striatal dependent tasks

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Genetic tools to study complexity of striatal function

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Effects of intrastriatal injection of the dopamine receptor agonist SKF38393 and quinpirole on locomotor behavior in hemiparkinsonism rats

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Neural basis of aggressive behavior toward newborns in Mice: Advances and future Challenges

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The neurophysiology of aggressiveness: From adaptive behavior to pathology and deep brain stimulation

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The Rostromedial Tegmental Nucleus: Connections With the Basal Ganglia

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Translational approach to apathy‐like behavior in mice: From the practical point of view

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Double dissociation between actions of dopamine D1 and D2 receptors of the ventral and dorsolateral striatum to produce reinstatement of cocaine seeking behavior

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Identification of novel target molecules of l-menthol

Umezu, T. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07329 · Cited by 4

Striatopallidal cannabinoid type-1 receptors mediate amphetamine-induced sensitization

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Whole brain Probabilistic Generative Model toward Realizing Cognitive Architecture for Developmental RobotsPreprint

Taniguchi, T., Yamakawa, H., Nagai, T., Doya, K., Sakagami, M., Suzuki, M., Nakamura, T., & Taniguchi, A. (2021) · arXiv (Cornell University) · Cited by 4

Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin volesPreprint

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A Drd1-cre mouse line with nucleus accumbens gene dysregulation exhibits blunted fentanyl seeking

Montemarano, A., Fox, L. D., Alkhaleel, F. A., Ostman, A. E., Sohail, H., Pandey, S., Murdaugh, L. B., & Fox, M. E. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02116-0 · Cited by 3

Transposable Elements Are Dynamically Regulated in Medium Spiny Neurons and May Contribute to the Molecular and Behavioral Adaptations to Cocaine

Silva, G. M., Picone, J. A., Kaplan, A. L., Park, C. R., Lira, D. P., Kim, R. K., Truby, N. L., Neve, R. L., Cui, X., & Hamilton, P. J. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.07.014 · Cited by 4

A midbrain-to-ventral-striatum dopaminergic pathway orchestrates odor-guided insect predation in mice

Wang, W., Zhong, Y., Tan, R., Wang, M., Liu, J., Wang, D., Wang, H., Li, Y., Li, G., Yang, J., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2514847122 · Cited by 3

Dysregulation of dopamine neurotransmission in the nucleus accumbens in immobilization-induced hypersensitivity

Kishikawa, Y., Kawahara, Y., Ohnishi, Y. N., Sotogaku, N., Koeda, T., Kawahara, H., & Nishi, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.988178 · Cited by 3

Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles

Zhang, L., Qu, Y., Young, L. J., Hou, W., Liu, L., Liu, J., Wang, Y., Li, L., Guo, X., Yin, L., et al. (2025) · eLife · doi:10.1101/2024.07.24.604911 · Cited by 3

Inhibition of GAPDH aggregation as a potential treatment for acute ischemic stroke

Itakura, M., Kubo, T., Kaneshige, A., Nakatsuji, M., Harada, N., Yamaji, R., Hikida, T., Inui, T., & Nakajima, H. (2025) · iScience · doi:10.1016/j.isci.2025.112564 · Cited by 3

Mechanistic and translational insights from preclinical cocaine choice procedures on the economic substitutability of cocaine and nondrug reinforcers

Marcus, M. M., & Banks, M. L. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106217 · Cited by 3

Reevaluation of anti-obesity action of mazindol and elucidation of its effect on the reward system

Aotani, D., Son, C., Shimizu, Y., Nomura, H., Hikida, T., Kusakabe, T., Tanaka, T., Miyazawa, T., Hosoda, K., & Nakao, K. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.09.014 · Cited by 3

Adenosine Control of Striatal Function—Implications for the Treatment of Apathy in Basal Ganglia Disorders

Ferré, S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803724-9.00012-0 · Cited by 3

Direct-Pathway Spiny Projection Neuron Inhibition Evokes Transient Circuit Imbalance Manifested as Rotational Behavior

Christensen, M. E., Nørr, S. E., Gether, U., & Rickhag, M. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.035 · Cited by 3

Region-specific involvement of ventral striatal dopamine D2 receptor-expressing medium spiny neurons in nociception

Natsubori, A., Miyazawa, M., Kojima, T., & Honda, M. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.12.008 · Cited by 3

DREADD to the Core. Commentary on Purohit et al. (2018): Pharmacogenetic Manipulation of the Nucleus Accumbens Alters Binge‐Like Alcohol Drinking in Mice

Pomrenze, M. B., & Giovanetti, S. M. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13822 · Cited by 3

Neurogenetics and Nutrigenomics of Reward Deficiency Syndrome (RDS): Stratification of Addiction Risk and Mesolimbic Nutrigenomic Manipulation of Hypodopaminergic Function

Blum, K., Han, D. C., Giordano, J., Lohmann, R., Braverman, E. R., Madigan, M. A., Barh, D., Femino, J., Hauser, M., Downs, B. W., et al. (2013) · Springer eBooks · doi:10.1007/978-81-322-1184-6_18 · Cited by 3

Cocaine and Striatal Projection Neuron Subtype Mechanisms

Engeln, M., & Lobo, M. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803750-8.00030-0 · Cited by 3

The reward integrator

LeGates, T. A. (2020) · Science · doi:10.1126/science.abe1481 · Cited by 3

A novel giant non-cholinergic striatal interneuron restricted to the ventrolateral striatum coexpresses Kv3.3 potassium channel, parvalbumin, and the vesicular GABA transporter

Lebenheim, L., Booker, S. A., Derst, C., Weiß, T., Wagner, F., Gruber, C., Vida, I., Zahm, D. S., & Veh, R. W. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00948-4 · Cited by 3

Dorsal and ventral striatal neuronal subpopulations differentially disrupt male mouse copulatory behavior

Detraux, B., Vilella, A., Groote, A. D., Schiffmann, S. N., Zoli, M., & d’Exaerde, A. D. K. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.03.007 · Cited by 2

Contributions of Dorsal/Ventral Hippocampus and Dorsolateral/Dorsomedial Striatum to Interval Timing

Yin, B. (2016) · DukeSpace (Duke University) · Cited by 3

Distinct Roles of Dopamine D1 and D2 Receptor-expressing Neurons in the Nucleus Accumbens for a Strategy Dependent Decision MakingPreprint

Nishioka, T., Macpherson, T., Hamaguchi, K., & Hikida, T. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.05.455353 · Cited by 3

Dual roles for nucleus accumbens core dopamine D1-expressing neurons projecting to the substantia nigra pars reticulata in limbic and motor controlPreprint

Attachaipanich, S., Ozawa, T., Macpherson, T., & Hikida, T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.25.534237 · Cited by 3

A chromosome region linked to neurodevelopmental disorders acts in distinct neuronal circuits in males and females to control locomotor behaviorPreprint

Kim, J., Vanrobaeys, Y. S., Davatolhagh, M. F., Kelvington, B. A., Chatterjee, S., Ferri, S. L., Angelakos, C. C., Mills, A. A., Fuccillo, M. V., Nickl‐Jockschat, T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.17.594746 · Cited by 3

Cortico‐Striatal‐Midbrain Circuit Dysregulation Underlying MK‐801 Induced Impulsivity and the Ameliorative Effects of SEP

Wang, X., Li, Q., Li, Z., Wang, X., Yuan, H., Yang, P., & Qin, L. (2025) · Advanced Science · doi:10.1002/advs.202502079 · Cited by 3

Motivation meets sleep: tuning arousal via nucleus accumbens and Basal Ganglia circuits

Sayegh, F. J. P., & Bonnavion, P. (2025) · npj Biological Timing and Sleep · doi:10.1038/s44323-025-00059-9 · Cited by 2

Dopamine Bidirectionally Biases Incentive and Aversive Salience in Humans

Herrero, E. M., Ferreri, L., Ripollés, P., Valle, M., Riba, J., & Rodríguez‐Fornells, A. (2026) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2026.03.020 · Cited by 2

Optogenetic Regulation of Dopamine Receptor-Expressing Neurons

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