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GABAA Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses
Open accessAbstract
Proper developmental, neural cell type-specific and activity-dependent regulation of GABAergic transmission is essential for virtually all aspects of CNS function. The number of GABAA receptors in the postsynaptic membrane directly controls the efficacy of GABAergic synaptic transmission. Thus, regulated trafficking of GABAA receptors is essential for understanding of brain function in both health and disease. Here we summarize recent progress in understanding of mechanisms that allow dynamic adaptation of cell surface expression and postsynaptic accumulation and function of GABAA receptors. This includes activity-dependent and cell type-specific changes in subunit gene expression, assembly of subunits into receptors, as well as exocytosis, endocytic recycling, diffusion dynamics and degradation of GABAA receptors. In particular, we focus on the roles of receptor-interacting proteins, scaffold proteins, synaptic adhesion proteins, and enzymes that regulate the trafficking and function of receptors and associated proteins. In addition, we review neuropeptide signaling pathways that affect neural excitability through changes in GABAAR trafficking.
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Metadata
- Authors
- Luscher, B., Fuchs, T., & Kilpatrick, C. L.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 70
- Issue
- 3
- Pages
- 385-409
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2033129564
- Cited by
- 434
- References
- 310
- FWCI
- 16.91
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.