Cited by 900Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsMicrotubule and mitosis dynamics

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The Many Faces of Tau

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Morris, Meaghan, Maeda, Sumihiro, Vossel, Keith, Mucke, Lennart·2011·Neuron

DOI 10.1016/j.neuron.2011.04.009PMC PMC3319390

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Abstract

While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.

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Authors: Morris, M., Maeda, S., Vossel, K., & Mucke, L.
Affiliations: Gladstone Institutes (US)
Corresponding author: Mucke, Lennart
ORCID: Morris, Meaghan
Maeda, Sumihiro
Vossel, Keith
Mucke, Lennart
Venue: Neuron
Publisher: Elsevier BV
Published: 2011-05
Volume: 70
Issue: 3
Pages: 410-426
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2011.04.009
PMC: PMC3319390
OpenAlex: W2125985978
Cited by: 899
References: 196
Citations by year: 2026: 29 · 2025: 33 · 2024: 36 · 2023: 52 · 2022: 59 · 2021: 65 · 2020: 59 · 2019: 59 · 2018: 72 · 2017: 65 · 2016: 67 · 2015: 70 · 2014: 67 · 2013: 80 · 2012: 59
FWCI: 7.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 808 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (AG011385, NS041787)
Tau Consortium
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: tau protein, microtubule binding, cytoskeletal organization, signaling, neurodegenerative diseases, tauopathy
MeSH terms: Animals, Humans, Microtubules, Models, Biological, Signal Transduction, tau Proteins, Neurodegenerative Diseases

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