GDE2 Regulates Subtype-Specific Motor Neuron Generation through Inhibition of Notch Signaling
Open accessAbstract
The specification of spinal interneuron and motor neuron identities initiates within progenitor cells, while motor neuron subtype diversification is regulated by hierarchical transcriptional programs implemented postmitotically. Here we find that mice lacking GDE2, a six-transmembrane protein that triggers motor neuron generation, exhibit selective losses of distinct motor neuron subtypes, specifically in defined subsets of limb-innervating motor pools that correlate with the loss of force-generating alpha motor neurons. Mechanistically, GDE2 is expressed by postmitotic motor neurons but utilizes extracellular glycerophosphodiester phosphodiesterase activity to induce motor neuron generation by inhibiting Notch signaling in neighboring motor neuron progenitors. Thus, neuronal GDE2 controls motor neuron subtype diversity through a non-cell-autonomous feedback mechanism that directly regulates progenitor cell differentiation, implying that subtype specification initiates within motor neuron progenitor populations prior to their differentiation into postmitotic motor neurons.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GDE2 is one of three known GPI-anchor cleaving enzymes in vertebrates and the only one expressed in neurons.
“GDE2 is one of three known GPI-anchor cleaving enzymes in vertebrates that function at the cell surface, and the only one expressed in neurons (22–26).”
From GDE2-RECK controls ADAM10 α-secretase–mediated cleavage of amyloid precursor protein (2021) · cites this paper as [24]
The Results section (“GDE2 expression in spinal motor neurons”; page unavailable) documents GDE2 expression in motor neurons. The Discussion says GDE2’s direct substrates had not been definitively identified; our copy does not establish that it cleaves GPI anchors, that there are three such vertebrate enzymes, or that GDE2 alone is expressed in neurons. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors
Chenn, A., & Walsh, C. A. (2002) · Science · doi:10.1126/science.1074192 · Cited by 1,431 · see citing works
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
Tsuchida, T., Ensini, M., Brenner‐Morton, S., Baldassare, M., Edlund, H., Jessell, T. M., & Pfaff, S. L. (1994) · Cell · doi:10.1016/0092-8674(94)90027-2 · Cited by 997 · see citing works
Cell-cycle control and cortical development
Dehay, C., & Kennedy, H. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2097 · Cited by 655 · cited 1× · see citing works
“The mechanisms that control neuronal diversity are complex and involve a constant interplay between extrinsic signaling pathways and intrinsic cell-autonomous molecular networks (reviewed in Dasen and Jessell, 2009; Dehay and Kennedy, 2007).”
Requirement for the Homeobox Gene Hb9 in the Consolidation of Motor Neuron Identity
Arber, S., Han, B., Mendelsohn, M. M., Smith, M., Jessell, T. M., & Sockanathan, S. (1999) · Neuron · doi:10.1016/s0896-6273(01)80026-x · Cited by 607 · see citing works
Self-citationdel Corral, R. D., Olivera-Martínez, I., Goriely, A., Gale, E. A., Maden, M., & Storey, K. G. (2003) · Neuron · doi:10.1016/s0896-6273(03)00565-8 · Cited by 605 · see citing works
Anatomy of medial gastrocnemius and soleus motor nuclei in cat spinal cord
Burke, R. E., Strick, P. L., Kanda, K., Kim, C. C., & Walmsley, B. D. (1977) · Journal of Neurophysiology · doi:10.1152/jn.1977.40.3.667 · Cited by 581 · see citing works
Motor Neuron Diversity in Development and Disease
Kanning, K. C., Kaplan, A., & Henderson, C. E. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135722 · Cited by 472 · see citing works
Arber, S., Ladle, D. R., Lin, J. H., Frank, E., & Jessell, T. M. (2000) · Cell · doi:10.1016/s0092-8674(00)80859-4 · Cited by 467 · see citing works
A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity
Dasen, J. S., Tice, B. C., Brenner-Morton, S., & Jessell, T. M. (2005) · Cell · doi:10.1016/j.cell.2005.09.009 · Cited by 461 · see citing works
Motor neuron columnar fate imposed by sequential phases of Hox-c activity
Dasen, J. S., Liu, J.-P., & Jessell, T. M. (2003) · Nature · doi:10.1038/nature02051 · Cited by 381 · see citing works
Measured motion: searching for simplicity in spinal locomotor networks
Grillner, S. E., & Jessell, T. M. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.10.011 · Cited by 380 · see citing works
Dasen, J. S., De Camilli, A., Wang, B., Tucker, P. W., & Jessell, T. M. (2008) · Cell · doi:10.1016/j.cell.2008.06.019 · Cited by 376 · see citing works
Thaler, J. P., Lee, S., Jurata, L. W., Gill, G. N., & Pfaff, S. L. (2002) · Cell · doi:10.1016/s0092-8674(02)00823-1 · Cited by 363 · see citing works
The distribution of motoneurones supplying chick hind limb muscles.
Landmesser, L. T. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012545 · Cited by 356 · see citing works
Thaler, J., Harrison, K., Sharma, K., Lettieri, K., Kehrl, J., & Pfaff, S. L. (1999) · Neuron · doi:10.1016/s0896-6273(01)80027-1 · Cited by 354 · see citing works
Novitch, B. G., Wichterle, H., Jessell, T. M., & Sockanathan, S. (2003) · Neuron · doi:10.1016/j.neuron.2003.08.006 · Cited by 350 · see citing works
Self-citationCommitted Neuronal Precursors Confer Astrocytic Potential on Residual Neural Precursor Cells
Namihira, M., Kohyama, J., Semi, K., Sanosaka, T., Deneen, B., Taga, T., & Nakashima, K. (2009) · Developmental Cell · doi:10.1016/j.devcel.2008.12.014 · Cited by 345 · see citing works
Lin, J. H., Saito, T., Anderson, D. J., Lance-Jones, C. C., Jessell, T. M., & Arber, S. (1998) · Cell · doi:10.1016/s0092-8674(00)81770-5 · Cited by 334 · see citing works
Chapter Six Hox Networks and the Origins of Motor Neuron Diversity
Dasen, J. S., & Jessell, T. M. (2009) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(09)88006-x · Cited by 309 · see citing works
Lee, S., & Pfaff, S. L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00296-4 · Cited by 288 · see citing works
Badea, T. C., Wang, Y., & Nathans, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02314.2003 · Cited by 256 · see citing works
Rousso, D. L., Gaber, Z. B., Wellik, D. M., Morrisey, E. E., & Novitch, B. G. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.025 · Cited by 254 · see citing works
VanderHorst, V., & Holstege, G. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970526)382:1 · Cited by 239 · see citing works
Gamma and alpha motor neurons distinguished by expression of transcription factor Err3
Friese, A., Kaltschmidt, J. A., Ladle, D. R., Sigrist, M., Jessell, T. M., & Arber, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906809106 · Cited by 235 · see citing works
Distinct Roles for Secreted Semaphorin Signaling in Spinal Motor Axon Guidance
Huber, A. B., Kania, A., Tran, T. S., Gu, C., García, N. D. M., Lieberam, I., Johnson, D., Jessell, T. M., Ginty, D. D., & Kolodkin, A. L. (2005) · Neuron · doi:10.1016/j.neuron.2005.12.003 · Cited by 233 · see citing works
Seuntjens, E., Nityanandam, A., Miquelajáuregui, A., Debruyn, J., Stryjewska, A., Goebbels, S., Nave, K., Huylebroeck, D., & Tarabykin, V. S. (2009) · Nature Neuroscience · doi:10.1038/nn.2409 · Cited by 217 · see citing works
Haase, G., Dessaud, É., Garcès, A., de Bovis, B., Birling, M., Filippi, P., Schmalbruch, H., Arber, S., & deLapeyrière, O. (2002) · Neuron · doi:10.1016/s0896-6273(02)00864-4 · Cited by 193 · see citing works
Neurogenesis in spinal cord of mouse: an autoradiographic analysis
Nornes, H. O., & Carry, M. (1978) · Brain Research · doi:10.1016/0006-8993(78)90105-1 · Cited by 191 · see citing works
Pecho‐Vrieseling, E., & Arber, S. (2006) · Cell · doi:10.1016/j.cell.2006.10.042 · Cited by 187 · see citing works
Notch and MAML Signaling Drives Scl-Dependent Interneuron Diversity in the Spinal Cord
Peng, C., Yajima, H., Burns, C. E., Zon, L. I., Sisodia, S. S., Pfaff, S. L., & Sharma, K. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.019 · Cited by 178 · see citing works
Organization of motor pools in the chick lumbar lateral motor column
Hollyday, M. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901940108 · Cited by 169 · see citing works
Global Control of Motor Neuron Topography Mediated by the Repressive Actions of a Single Hox Gene
Jung, H., Lacombe, J., Mazzoni, E. O., Liem, K. F., Grinstein, J. D., Mahony, S., Mukhopadhyay, D., Gifford, D. K., Young, R. A., Anderson, K. V., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.008 · Cited by 153 · see citing works
Regulation of neural progenitor cell development in the nervous system
Corbin, J. G., Gaiano, N., Juliano, S. L., Poluch, S., Stancik, E. K., & Haydar, T. F. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05522.x · Cited by 145 · see citing works
The acquisition of motoneuron subtype identity and motor circuit formation
Landmesser, L. T. (2001) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00090-3 · Cited by 136 · see citing works
Shneider, N. A., Brown, M. N., Smith, C., Pickel, J. M., & Álvarez, F. J. (2009) · Neural Development · doi:10.1186/1749-8104-4-42 · Cited by 133 · see citing works
The Spinal Motor System in Early Vertebrates and Some of Its Evolutionary Changes
Fetcho, J. R. (2008) · Brain Behavior and Evolution · doi:10.1159/000113905 · Cited by 126 · see citing works
Motor Neurons with Axial Muscle Projections Specified by Wnt4/5 Signaling
Agalliu, D., Takada, S., Agalliu, I., McMahon, A. P., & Jessell, T. M. (2009) · Neuron · doi:10.1016/j.neuron.2008.12.026 · Cited by 110 · see citing works
Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons
Wu, Y., Wang, G., Scott, S. A., & Capecchi, M. R. (2007) · Development · doi:10.1242/dev.009225 · Cited by 108 · see citing works
García, N. V. D. M., & Jessell, T. M. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.033 · Cited by 103 · see citing works
Yan, Y., Sabharwal, P., Rao, M., & Sockanathan, S. (2009) · Cell · doi:10.1016/j.cell.2009.06.042 · Cited by 103 · see citing works
Self-citationGallazzini, M., Ferraris, J. D., & Burg, M. B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805496105 · Cited by 95 · see citing works
Zhuang, B., Su, Y. S., & Sockanathan, S. (2009) · Neuron · doi:10.1016/j.neuron.2008.12.022 · Cited by 94 · see citing works
Self-citationTransmembrane Protein GDE2 Induces Motor Neuron Differentiation in Vivo
Rao, M., & Sockanathan, S. (2005) · Science · doi:10.1126/science.1117156 · Cited by 83 · see citing works
Self-citationA critical period for the specification of motor pools in the chick lumbosacral spinal cord
Matise, M. P., & Lance-Jones, C. C. (1996) · Development · doi:10.1242/dev.122.2.659 · Cited by 73 · see citing works
Development and migration of avian sympathetic preganglionic neurons
Prasad, A., & Hollyday, M. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903070207 · Cited by 72 · see citing works
Shah, V. S., Drill, E., & Lance-Jones, C. C. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20103 · Cited by 66 · see citing works
Marklund, U., Hansson, E. M., Sundström, E., de Angelis, M. H., Przemeck, G. K. H., Lendahl, U., Muhr, J., & Ericson, J. (2010) · Development · doi:10.1242/dev.036806 · Cited by 63 · see citing works
Location of motor pools innervating chick wing
Hollyday, M., & Jacobson, R. D. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903020313 · Cited by 61 · see citing works
Whitelaw, V., & Hollyday, M. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-06-01199.1983 · Cited by 58 · see citing works
Organization of motor pools supplying axial muscles in the chicken
Gutman, C. R., Ajmera, M. K., & Hollyday, M. (1993) · Brain Research · doi:10.1016/0006-8993(93)90865-k · Cited by 57 · see citing works
Buss, R. R., Gould, T. W., Ma, J., Vinsant, S. L., Prevette, D. M., Winseck, A. K., Toops, K. A., Hammarback, J. A., Smith, T. L., & Oppenheim, R. W. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3528-06.2006 · Cited by 49 · see citing works
Yanaka, N., Imai, Y., Kawai, E., Akatsuka, H., Wakimoto, K., Nogusa, Y., Katô, N., Chiba, H., Kotani, E., Omori, K., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302867200 · Cited by 49 · see citing works
Nogusa, Y., Fujioka, Y., Komatsu, R., Katô, N., & Yanaka, N. (2004) · Gene · doi:10.1016/j.gene.2004.04.026 · Cited by 35 · see citing works
Ji, S., Periz, G., & Sockanathan, S. (2008) · Development · doi:10.1242/dev.028043 · Cited by 34 · see citing works
Self-citationHui, K. K., Kučera, J., & Henderson, J. T. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402294 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hox Genes: Choreographers in Neural Development, Architects of Circuit Organization
Philippidou, P., & Dasen, J. S. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.020 · Cited by 423 · see citing works
Motor neurons and the generation of spinal motor neuron diversity
Stifani, N. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00293 · Cited by 306 · see citing works
Biosynthesis and biology of mammalian GPI-anchored proteins
Kinoshita, T. (2020) · Open Biology · doi:10.1098/rsob.190290 · Cited by 344 · see citing works
BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets
Tiberi, L., van den Ameele, J., Dimidschstein, J., Piccirilli, J., Gall, D., Herpoel, A., Bilheu, A., Bonnefont, J., Iacovino, M., Kyba, M., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3264 · Cited by 132 · see citing works
GDE2 Promotes Neurogenesis by Glycosylphosphatidylinositol-Anchor Cleavage of RECK
Park, S., Lee, C., Sabharwal, P., Zhang, M., Meyers, C. L. F., & Sockanathan, S. (2013) · Science · doi:10.1126/science.1231921 · Cited by 118 · see citing works
Self-citationThe emerging physiological roles of the glycerophosphodiesterase family
Corda, D., Mosca, M. G., Ohshima, N., Grauso, L., Yanaka, N., & Mariggiò, S. (2013) · FEBS Journal · doi:10.1111/febs.12699 · Cited by 117 · see citing works
Fujihara, Y., Noda, T., Kobayashi, K., Oji, A., Kobayashi, S., Matsumura, T., Larasati, T., Oura, S., Kojima‐Kita, K., Yu, Z., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908736116 · Cited by 85 · see citing works
GPI-AP release in cellular, developmental, and reproductive biology
Fujihara, Y., & Ikawa, M. (2015) · Journal of Lipid Research · doi:10.1194/jlr.r063032 · Cited by 74 · see citing works
GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation
Choi, B., Cave, C., Na, C. H., & Sockanathan, S. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107540 · Cited by 72 · see citing works
Self-citationYan, Y., Wladyka, C., Fujii, J., & Sockanathan, S. (2015) · Nature Communications · doi:10.1038/ncomms8006 · Cited by 62 · see citing works
Self-citationMatas-Rico, E., van Veen, M., Leyton-Puig, D., van den Berg, J., Köster, J., Kedziora, K. M., Molenaar, B., Weerts, M. J. A., de Rink, I., Medema, R. H., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.08.016 · Cited by 60 · see citing works
Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons
Machado, C. B., Kanning, K. C., Kreis, P., Stevenson, D. C., Crossley, M., Nowak, M., Iacovino, M., Kyba, M., Chambers, D. J., Blanc, E., et al. (2014) · Development · doi:10.1242/dev.097188 · Cited by 53 · see citing works
Reduce, reuse, recycle – Developmental signals in spinal cord regeneration
Cardozo, M. J., Mysiak, K. S., Becker, T., & Becker, C. G. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.05.011 · Cited by 49 · see citing works
The Glycosylphosphatidylinositol Anchor: A Linchpin for Cell Surface Versatility of Trypanosomatids
Borges, A. R., Link, F., Engstler, M., & Jones, N. G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.720536 · Cited by 45 · see citing works
Generating spinal motor neuron diversity: a long quest for neuronal identity
Francius, C., & Clotman, F. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1398-x · Cited by 35 · see citing works
Ashrafi, S., Lalancette–Hébert, M., Friese, A., Sigrist, M., Arber, S., Shneider, N. A., & Kaltschmidt, J. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1160-12.2012 · Cited by 39 · see citing works
GDE2-RECK controls ADAM10 α-secretase–mediated cleavage of amyloid precursor protein
Nakamura, M., Li, Y., Choi, B.-R., Matas-Rico, E., Troncoso, J., Takahashi, C., & Sockanathan, S. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe6178 · Cited by 38 · see citing works
Self-citationDifferences in lumbar motor neuron pruning in an animal model of early onset spasticity
Brandenburg, J. E., Gransee, H. M., Fogarty, M. J., & Sieck, G. C. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00186.2018 · Cited by 38 · see citing works
Prss55 but not Prss51 is required for male fertility in mice†
Kobayashi, K., Endo, T., Matsumura, T., Lu, Y., Yu, Z., Matzuk, M. M., & Ikawa, M. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioaa041 · Cited by 37 · see citing works
Iterative role of Notch signaling in spinal motor neuron diversification
Tan, C., Mazzoni, E. O., & Wichterle, H. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.067 · Cited by 31 · see citing works
Rodriguez, M., Choi, J., Park, S., & Sockanathan, S. (2012) · Development · doi:10.1242/dev.081083 · Cited by 34 · see citing works
Self-citationTranscription factor mechanisms guiding motor neuron differentiation and diversification
Cave, C., & Sockanathan, S. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.04.012 · Cited by 29 · see citing works
Self-citationProstaglandin E2 facilitates neurite outgrowth in a motor neuron-like cell line, NSC-34
Nango, H., Kosuge, Y., Miyagishi, H., Sugawa, K., Ito, Y., & Ishige, K. (2017) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2017.09.001 · Cited by 26 · see citing works
GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord
Cave, C., Park, S., Rodriguez, M., Nakamura, M., Höke, A., Pletnikov, M. V., & Sockanathan, S. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0148-1 · Cited by 24 · see citing works
Self-citationGDE3 regulates oligodendrocyte precursor proliferation via release of soluble CNTFRα
Dobrowolski, M., Cave, C., Levy-Myers, R., Lee, C., Park, S., Choi, B., Xiao, B., Yang, W., & Sockanathan, S. (2020) · Development · doi:10.1242/dev.180695 · Cited by 23 · see citing works
Self-citationRetinoic Acid Signaling during Early Spinal Cord Development
del Corral, R. D., & Morales, A. V. (2014) · Journal of Developmental Biology · doi:10.3390/jdb2030174 · Cited by 17 · see citing works
Proteases at work: cues for understanding neural development and degeneration
Säftig, P. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00013 · Cited by 17 · see citing works
Hanley, P. J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1327769 · Cited by 15 · see citing works
Neuronal differentiation through GPI-anchor cleavage
Matas-Rico, E., van Veen, M., & Moolenaar, W. H. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1259894 · Cited by 15 · see citing works
Westerhaus, A., Joseph, T., Meyers, A. J., Jang, Y., Na, C. H., Cave, C., & Sockanathan, S. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01376-x · Cited by 14 · see citing works
Self-citationSalgado-Polo, F., van Veen, M., van den Broek, B., Jalink, K., Leyton-Puig, D., Perrakis, A., Moolenaar, W. H., & Matas-Rico, E. (2020) · Journal of Cell Science · doi:10.1242/jcs.235044 · Cited by 13 · see citing works
GDPD5 Related to Lipid Metabolism Is a Potential Prognostic Biomarker in Neuroblastoma
Luo, T., Peng, J., Li, Q., Zhang, Y., Huang, Y., Xu, L., Yang, G., Tan, D., Zhang, Q., & Tan, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213740 · Cited by 12 · see citing works
Regenerative replacement of neural cells for treatment of spinal cord injury
McIntyre, W. B., Pieczonka, K., Khazaei, M., & Fehlings, M. G. (2021) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2021.1914582 · Cited by 12 · see citing works
GDE2 expression in oligodendroglia regulates the pace of oligodendrocyte maturation
Choi, B., Dobrowolski, M., & Sockanathan, S. (2020) · Developmental Dynamics · doi:10.1002/dvdy.265 · Cited by 10 · see citing works
Self-citationPhysiological regulation of neuronal Wnt activity is essential for TDP-43 localization and function
Zhang, N., Westerhaus, A., Wilson, M. M., Wang, E., Goff, L. A., & Sockanathan, S. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00156-8 · Cited by 9 · see citing works
Self-citationGlycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish
van Veen, M., Mans, L. A., Matas-Rico, E., van Pelt, J., Anastassis Perrakis, A., Moolenaar, W. H., & Haramis, A.-P. G. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.11.015 · Cited by 9 · see citing works
Pirson, M., Debrulle, S., Clippe, A., Clotman, F., & Knoops, B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142280 · Cited by 4 · see citing works
GDE6 promotes progenitor identity in the vertebrate neural tube
McKean, M., Napoli, F. R., Hasan, T., Joseph, T., Wheeler, A., Beebe, K., Soriano-Cruz, S., Kawano, M., & Cave, C. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1047767 · Cited by 7 · see citing works
Loss of GDE2 leads to complex behavioral changes including memory impairment
Daudelin, D., Westerhaus, A., Zhang, N., Leyder, E. C., Savonenko, A. V., & Sockanathan, S. (2024) · Behavioral and Brain Functions · doi:10.1186/s12993-024-00234-1 · Cited by 8 · see citing works
Self-citationRegulation of glypican 6-mediated Wnt activation maintains TDP-43 nuclear localization in neurons
Zhang, N., & Sockanathan, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-32069-9 · Cited by 4 · see citing works
Self-citationFranks, N. E., & Allen, B. L. (2024) · Development · doi:10.1242/dev.203012 · Cited by 2 · see citing works
Patterning and generation of neural diversity in the spinal cord
Catela, C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00007-2 · Cited by 2 · see citing works
Bushati, N., & Briscoe, J. (2012) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0000795.pub2 · Cited by 2 · see citing works
Diseases Associated With GPI Anchors
Murakami, Y. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819475-1.00025-0
Novel Roles of the GPI-Anchor Cleaving Enzyme, GDE2, in Hippocampal Synaptic Morphology and Function
Daudelin, D., Sama-Borbon, D., Zhang, N., & Sockanathan, S. (2025) · eNeuro · doi:10.1523/eneuro.0102-25.2025
Self-citationAngla-Navarro, A., Bajo, A. D., Toch, M., Francius, C., Hidalgo‐Figueroa, M., Zhang, J., Finet, M., Schakman, O., Martin, M., Mu, X., et al. (2025) · eLife · doi:10.1101/2025.07.27.665825
Additional file 1 of Loss of GDE2 leads to complex behavioral changes including memory impairment
Daudelin, D., Westerhaus, A., Zhang, N., Leyder, E. C., Savonenko, A. V., & Sockanathan, S. (2024) · Figshare · doi:10.6084/m9.figshare.26702176
Self-citationAdditional file 2 of Loss of GDE2 leads to complex behavioral changes including memory impairment
Daudelin, D., Westerhaus, A., Zhang, N., Leyder, E., Savonenko, A. V., & Sockanathan, S. (2024) · Figshare · doi:10.6084/m9.figshare.26702179
Self-citationPeroxiredoxin-Mediated Redox Regulation in Neurons: From Neurite Development to Degeneration
Kim, G., 이재연, Kwon, S., Yeom, E., & Lee, D. (2026) · Antioxidants · doi:10.3390/antiox15050604
Blauth, O., Sławińska, U., & Zawadzka, M. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1819322
Angla-Navarro, A., Bajo, A. D., Toch, M., Francius, C., Hidalgo‐Figueroa, M., Zhang, J., Finet, M., Schakman, O., Martin, M., Mu, X., et al. (2026) · eLife · doi:10.7554/elife.110788.2
The Roles of RECK, a Membrane-Anchored Regulator of Pericellular Proteolysis, in Neural Development
Noda, M. (2013) · Springer eBooks · doi:10.1007/978-4-431-54496-8_10
- Authors
- Sabharwal, P., Lee, C., Park, S., Rao, M., & Sockanathan, S.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Sockanathan, Shanthini
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 71
- Issue
- 6
- Pages
- 1058-1070
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3183458
- OpenAlex
- W2120120735
- Cited by
- 54
- References
- 52
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 8 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 4
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Muscular Dystrophy Association
- Johns Hopkins University
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS046336)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- Notch signaling inhibition, motor neuron progenitors, glycerophosphodiester phosphodiesterase, alpha motoneurons, non-cell-autonomous signaling, spinal cord development
- MeSH terms
- Animals, Cell Differentiation, Embryo, Mammalian, Female, Isoenzymes, Mice, Inbred C57BL, Motor Neurons, Phosphoric Diester Hydrolases, Signal Transduction, Mice, Receptors, Notch, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
