Cited by 136Axon Guidance and Neuronal SignalingDevelopmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

The acquisition of motoneuron subtype identity and motor circuit formation

Landmesser, Lynn T.·2001·International Journal of Developmental Neuroscience

Abstract

Experiments in chick embryos using classical transplantation techniques introduced by Viktor Hamburger are reviewed; these demonstrated that chick-limb innervating motoneurons become specified by extrinsic signals prior to axon outgrowth and that they selectively grow to appropriate muscles by actively responding to guidance cues within the limb. More recent experiments reveal that fast/slow and flexor/extensor subclasses of motoneurons are distinct by E4-5 and that they exhibit patterned spontaneous activity while still growing to their targets. These observations are then related to the combinatorial code of LIM transcription factor expression, which has been hypothesized to specify motoneuron subtypes.

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Crossref · 10.1016/s0736-5748(00)00090-3

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Authors
Landmesser, L. T.
Affiliations
Case Western Reserve University (US)
Corresponding author
Landmesser, Lynn T.
Venue
International Journal of Developmental Neuroscience
Publisher
Wiley
Published
2001-03-12
Volume
19
Issue
2
Pages
175-182
ISSN
  • 0736-5748 (ISSN-L)
  • 1873-474X
OpenAlex
W1978370395
Cited by
136
References
51
Citations by year
2026: 4 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 11
FWCI
0.60
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Developmental Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
NIH (NS 19640, NS 23678)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
chick embryo, limb innervation, extrinsic signals, axon guidance, spontaneous activity
MeSH terms
Animals, Axons, Chick Embryo, Extremities, Gestational Age, Morphogenesis, Motor Neurons, Species Specificity, Transcription Factors, Transplantation, Heterologous, Homeodomain Proteins, Gene Expression Regulation, Developmental, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Cell Lineage, Mice

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