The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Recruitment of Endophilin to Clathrin-Coated Pit Necks Is Required for Efficient Vesicle Uncoating after Fission
Open accessAbstract
Endophilin is a membrane binding protein with curvature-generating/sensing properties that participates in clathrin-dependent endocytosis of synaptic vesicle membranes. Endophilin also binds the GTPase dynamin and the phosphoinositide phosphatase synaptojanin, and is thought to coordinate constriction of coated pits with membrane fission (via dynamin) and subsequent uncoating (via synaptojanin). We show that although synaptojanin is recruited by endophilin at bud necks before fission, the knockout of all three mouse endophilins results in the accumulation of clathrin-coated vesicles but not of clathrin-coated pits at synapses. The absence of endophilin impairs, but does not abolish synaptic transmission and results in perinatal lethality, while partial endophilin absence causes severe neurological defects, including epilepsy, and neurodegeneration. Our data supports a model in which endophilin recruitment to coated pit necks, due to its curvature-sensing properties, primes vesicle buds for subsequent uncoating after membrane fission, without being critically required for the fission reaction itself.
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Cites
Phosphoinositides in cell regulation and membrane dynamics
Di Paolo, G., & De Camilli, P. (2006) · Nature · doi:10.1038/nature05185 · Cited by 2,790
A Modular Design for the Clathrin- and Actin-Mediated Endocytosis Machinery
Kaksonen, M., Toret, C. P., & Drubin, D. G. (2005) · Cell · doi:10.1016/j.cell.2005.09.024 · Cited by 726 · cited 3×
“Consistent with this scenario, absence of the endophilin homologRvs167 in yeast leads toendocytic invaginations that bounce back and forth and often do not proceed to fission, suggesting a role of Rvs167 in stabilizing a preformed invagination (Kaksonen et al., 2005).”
Molecular Circuitry of Endocytosis at Nerve Terminals
Dittman, J., & Ryan, T. A. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113302 · Cited by 238 · cited 1×
“Clathrin-mediated endocytosis is a major pathway for SV recycling (Dittman and Ryan, 2009; Heuser and Reese, 1973).”
The Mechanochemistry of Endocytosis
Liu, J., Sun, Y., Drubin, D. G., & Oster, G. F. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000204 · Cited by 222
Cited by
Dynamin, a membrane-remodelling GTPase
Ferguson, S. M., & De Camilli, P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3266 · Cited by 992
Self-citationBigay, J., & Antonny, B. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.10.009 · Cited by 567
Endophilin marks and controls a clathrin-independent endocytic pathway
Boucrot, E., Ferreira, A. P. A., Almeida-Souza, L., Debard, S., Vallis, Y., Howard, G., Bertot, L., Sauvonnet, N., & McMahon, H. T. (2015) · Nature · doi:10.1038/nature14067 · Cited by 542
Phosphoinositides as membrane organizers
Posor, Y., Jang, W., & Haucke, V. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00490-x · Cited by 469
Advances in the genetics of Parkinson disease
Trinh, J., & Farrer, M. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.132 · Cited by 466
Metadata
- Authors
- Milosevic, I., Giovedi, S., Lou, X., Raimondi, A., Collesi, C., Shen, H., Paradise, S., O'Toole, E., Ferguson, S., Cremona, O., & De Camilli, P.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 72
- Issue
- 4
- Pages
- 587-601
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2058568944
- Cited by
- 351
- References
- 4
- FWCI
- 10.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Recruitment of Endophilin to Clathrin-Coated Pit Necks Is Required for Efficient Vesicle Uncoating after Fission. https://app.cochat.ai/papers/10.1016/j.neuron.2011.08.029
- The paper
- Milosevic, I., Giovedi, S., Lou, X., Raimondi, A., Collesi, C., Shen, H., Paradise, S., O'Toole, E., Ferguson, S., Cremona, O., & De Camilli, P. (2011). Recruitment of Endophilin to Clathrin-Coated Pit Necks Is Required for Efficient Vesicle Uncoating after Fission. Neuron. https://doi.org/10.1016/j.neuron.2011.08.029
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
