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Cited by 469Cellular transport and secretionLipid metabolism and biosynthesisProtein Kinase Regulation and GTPase Signaling

Phosphoinositides as membrane organizers

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Posor, York, Jang, Wonyul, Haucke, Volker·2022·Nature Reviews Molecular Cell Biology
DOI 10.1038/s41580-022-00490-xPMC PMC9117997
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Abstract

Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their roles in cell signalling, phosphoinositides are now widely recognized as key integrators of membrane dynamics that broadly impact on all aspects of cell physiology and on disease. The past decade has witnessed a vast expansion of our knowledge of phosphoinositide biology. On the endocytic and exocytic routes, phosphoinositides direct the inward and outward flow of membrane as vesicular traffic is coupled to the conversion of phosphoinositides. Moreover, recent findings on the roles of phosphoinositides in autophagy and the endolysosomal system challenge our view of lysosome biology. The non-vesicular exchange of lipids, ions and metabolites at membrane contact sites in between organelles has also been found to depend on phosphoinositides. Here we review our current understanding of how phosphoinositides shape and direct membrane dynamics to impact on cell physiology, and provide an overview of emerging concepts in phosphoinositide regulation.

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  • Extending the novel SHIP1 functions identified in this study to SHIP2 has broad implications, given SHIP2's established roles in various cancers, metabolic diseases such as diabetes and diseases of the vasculature such as arteriosclerosis.

    “Extending the novel SHIP1 functions identified in this study to SHIP2 has broad implications, given SHIP2’s established roles in various cancers, metabolic diseases such as diabetes and diseases of the vasculature such as arteriosclerosis68.”

    From INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia (2025) · cites this paper as [68]

    Table 2 (Introduction; page unavailable) identifies SHIP2 as a phosphatase associated with opsismodysplasia and reports elevated insulin sensitivity in a mouse model. This supports a disease association and a link to insulin regulation, but our copy does not establish the claimed SHIP2 roles in cancers, diabetes or arteriosclerosis. The proposed extension of this study’s SHIP1 findings is the citing authors’ own framing. (LLM, conf=0.83)

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200 of 216 shown

Cited by

Sorted by citations

Authors
Posor, Y., Jang, W., & Haucke, V.
Affiliations
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (DE)
Corresponding author
Haucke, Volker
ORCID
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2022-05-19
Volume
23
Issue
12
Pages
797-816
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
DOI
10.1038/s41580-022-00490-x
PMC
PMC9117997
OpenAlex
W4280609606
Cited by
469
References
8
Citations by year
2026: 126 · 2025: 139 · 2024: 112 · 2023: 73 · 2022: 19
FWCI
12.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • European Commission (H2020-MSCA-ITN, H2020-MSCA ITN-2015, H2020, 675392, H2020-MSCA)
  • National Research Foundation
  • Deutscher Akademischer Austauschdienst (57423756)
  • Deutsche Forschungsgemeinschaft (TRR186/A08, TRR186, HA2686/22-1, HA2686)
  • National Research Foundation of Korea
  • Horizon 2020 Framework Programme (H2020‐MSCA‐ITN‐2015, H2020-MSCA, H2020-MSCA-ITN)
  • Leibniz-Gemeinschaft
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
phosphoinositides, phosphatidylinositol, membrane dynamics, vesicle trafficking, endocytosis, exocytosis, autophagy, endolysosomal system, membrane contact sites, phosphoinositide kinases, phosphoinositide phosphatase, lipid signaling
MeSH terms
Cell Membrane, Lysosomes, Phosphatidylinositols, Endosomes, Signal Transduction

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