Cited by 238Cellular transport and secretionNeuroscience and Neuropharmacology ResearchExtracellular vesicles in disease

Molecular Circuitry of Endocytosis at Nerve Terminals

Dittman, Jeremy, Ryan, Timothy A.·2009·Annual Review of Cell and Developmental Biology

Abstract

Presynaptic terminals are specialized compartments of neurons responsible for converting electrical signals into secreted chemicals. This self-renewing process of chemical synaptic transmission is accomplished by the calcium-triggered fusion of neurotransmitter-containing vesicles with the plasma membrane and subsequent retrieval and recycling of vesicle components. Whereas the release of neurotransmitters has been studied for over 50 years, the process of synaptic vesicle endocytosis has remained much more elusive. The advent of imaging techniques suited to monitor membrane retrieval at presynaptic terminals and the discovery of the molecules that orchestrate endocytosis have revolutionized our understanding of this critical trafficking event.

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Crossref · 10.1146/annurev.cellbio.042308.113302

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157 of 157 references verified0 citation errors · 0 not checkable

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  • Endocytosis after exocytosis maintains a sufficient number of synaptic vesicles at presynapses.

    “After exocytosis, vesicle membrane must be retrieved from the plasma membrane through endocytosis to keep the area of the plasma membrane constant and maintain a sufficient number of synaptic vesicles at presynapses1–4.”
  • After exocytosis, vesicle membrane must be retrieved from the plasma membrane through endocytosis to keep the area of the plasma membrane constant.

    “After exocytosis, vesicle membrane must be retrieved from the plasma membrane through endocytosis to keep the area of the plasma membrane constant and maintain a sufficient number of synaptic vesicles at presynapses1–4.”

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Authors
Dittman, J., & Ryan, T. A.
Affiliations
Weill Cornell Medicine (US)
Venue
Annual Review of Cell and Developmental Biology
Published
2009-11-01
Volume
25
Issue
1
Pages
133-160
ISSN
  • 1081-0706 (ISSN-L)
  • 1530-8995
OpenAlex
W2167118899
Cited by
238
References
157
Citations by year
2026: 4 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 20 · 2019: 9 · 2018: 6 · 2017: 9 · 2016: 8 · 2015: 22 · 2014: 27 · 2013: 28 · 2012: 28
FWCI
1.85
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS036942)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
synaptic vesicle endocytosis, presynaptic terminals, neurotransmitter release, membrane retrieval, vesicle recycling, calcium-triggered exocytosis, synaptic vesicle trafficking, endocytic machinery
MeSH terms
Animals, Cell Membrane, Endocytosis, Synapses, Synaptic Vesicles, Presynaptic Terminals

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