Molecular Circuitry of Endocytosis at Nerve Terminals
Abstract
Presynaptic terminals are specialized compartments of neurons responsible for converting electrical signals into secreted chemicals. This self-renewing process of chemical synaptic transmission is accomplished by the calcium-triggered fusion of neurotransmitter-containing vesicles with the plasma membrane and subsequent retrieval and recycling of vesicle components. Whereas the release of neurotransmitters has been studied for over 50 years, the process of synaptic vesicle endocytosis has remained much more elusive. The advent of imaging techniques suited to monitor membrane retrieval at presynaptic terminals and the discovery of the molecules that orchestrate endocytosis have revolutionized our understanding of this critical trafficking event.
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Endocytosis after exocytosis maintains a sufficient number of synaptic vesicles at presynapses.
“After exocytosis, vesicle membrane must be retrieved from the plasma membrane through endocytosis to keep the area of the plasma membrane constant and maintain a sufficient number of synaptic vesicles at presynapses1–4.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [3]
After exocytosis, vesicle membrane must be retrieved from the plasma membrane through endocytosis to keep the area of the plasma membrane constant.
“After exocytosis, vesicle membrane must be retrieved from the plasma membrane through endocytosis to keep the area of the plasma membrane constant and maintain a sufficient number of synaptic vesicles at presynapses1–4.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [3]
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Kinetic efficiency of endocytosis at mammalian CNS synapses requires synaptotagmin I
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Dual interaction of synaptotagmin with μ2‐ and α‐adaptin facilitates clathrin‐coated pit nucleation
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Activity-Dependent Acceleration of Endocytosis at a Central Synapse
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Clathrin Dependence of Synaptic-Vesicle Formation at the Drosophila Neuromuscular Junction
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Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development
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Clathrin-Dependent and Clathrin-Independent Retrieval of Synaptic Vesicles in Retinal Bipolar Cells
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Synaptic Vesicle Recycling at CNS Synapses without AP-2
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Self-citationInactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake
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A Genome-Wide Search for Synaptic Vesicle Cycle Proteins in Drosophila
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Quantum dots provide an optical signal specific to full collapse fusion of synaptic vesicles
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Self-citationContribution of Active Zone Subpopulation of Vesicles to Evoked and Spontaneous Release
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Sorting Nexin 9 Interacts with Dynamin 1 and N-WASP and Coordinates Synaptic Vesicle Endocytosis
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The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling
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The Products of the Drosophila stoned Locus Interact with Synaptic Vesicles via Synaptotagmin
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Caenorhabditis elegansIntersectin: A Synaptic Protein Regulating Neurotransmission
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Dynamin, a membrane-remodelling GTPase
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- Authors
- Dittman, J., & Ryan, T. A.
- Affiliations
- Weill Cornell Medicine (US)
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2009-11-01
- Volume
- 25
- Issue
- 1
- Pages
- 133-160
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2167118899
- Cited by
- 238
- References
- 157
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 20 · 2019: 9 · 2018: 6 · 2017: 9 · 2016: 8 · 2015: 22 · 2014: 27 · 2013: 28 · 2012: 28
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS036942)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- synaptic vesicle endocytosis, presynaptic terminals, neurotransmitter release, membrane retrieval, vesicle recycling, calcium-triggered exocytosis, synaptic vesicle trafficking, endocytic machinery
- MeSH terms
- Animals, Cell Membrane, Endocytosis, Synapses, Synaptic Vesicles, Presynaptic Terminals
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