Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

de Calignon, Alix, Polydoro, Manuela, Suárez-Calvet, Marc, William, Christopher, Adamowicz, David H., Kopeikina, Kathy J., Pitstick, Rose, Sahara, Naruhiko, Ashe, Karen H., Carlson, George A., Spires-Jones, Tara L., Hyman, Bradley T.·2012·Neuron

DOI 10.1016/j.neuron.2011.11.033

Cited by (1,003)

Items 901–1,000 of 1,003

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Natalia Fernández‐Borges, Hasier Eraña, Vanesa Venegas, Saioa R. Elezgarai, Chafik Harrathi, Joaquı́n Castilla · 2015 · Virus Research
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Qinyue Zhao, Youqi Tao, Yuxuan Yao, Kaien Liu, Shiran Lv, Bingyao Cui, Weidi Xiao, Tianyi Cao, Weidong Li, Feng Gao et al. · 2025 · Nature Chemical Biology
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Luning Wang, Yanjun Guo, Mingwei Zhu, Honghong Zhang, Yazhuo Hu, Zhitao Han, Jia Liu, Weiqin Zhao, Dexin Wang · 2016 · Neuropsychiatric Disease and Treatment
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Himal Kanti Ganguly, Michael B. Elbaum, Neal Joseph Zondlo · 2025 · Biochemistry
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Nan Zheng, Qiong Zhou, Zihao Chen, Lihua Xie, Xinyu Yang, Ziwen Chen, Fuwei Wang, Qiang Sun, Jikun Du, Jiantao Lin et al. · 2025 · Journal of Neurophysiology
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Jorge Sepulcre, Joseph C. Masdeu · 2015 · Methods in molecular biology
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