The Role of Caspases in Alzheimer’s Disease: Pathophysiology Implications and Pharmacologic Modulation

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493 · see citing works

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4913 · Cited by 3,676 · see citing works

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276 · see citing works

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898 · see citing works

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738 · see citing works

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

Ji, Y. (1993) · Cell · doi:10.1016/0092-8674(93)90485-9 · Cited by 2,497 · see citing works

PI3K/Akt signalling pathway and cancer

Vara, J. Á. F., Casado, E., de Castro, J., Cejas, P., Belda-Iniesta, C., & González-Barón, M. (2003) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2003.07.007 · Cited by 2,446 · see citing works

MicroRNA

Lu, T. X., & Rothenberg, M. E. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.08.034 · Cited by 2,425 · see citing works

Human ICE/CED-3 Protease Nomenclature

Alnemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G. S., Thornberry, N. A., Wong, W. W., & Yuan, J. (1996) · Cell · doi:10.1016/s0092-8674(00)81334-3 · Cited by 2,371 · see citing works

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

Thornberry, N. A., Rano, T. A., Peterson, E. P., Rasper, D., Timkey, T., Garcia-Calvo, M. M., Houtzager, V. M., Nordstrom, P. A., Roy, S., Vaillancourt, J. P., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.17907 · Cited by 2,072 · see citing works

The role of autophagy in neurodegenerative disease

Nixon, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3232 · Cited by 2,059 · see citing works

Neuroinflammation in Alzheimer's disease: current evidence and future directions

Calsolaro, V., & Edison, P. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.010 · Cited by 1,726 · see citing works

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

Steen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703 · see citing works

Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.113 · Cited by 1,588 · see citing works

NLRP3 inflammasome activation drives tau pathology

Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., et al. (2019) · Nature · doi:10.1038/s41586-019-1769-z · Cited by 1,487 · see citing works

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

de Calignon, A., Polydoro, M., Suárez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.033 · Cited by 1,427 · see citing works

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Cai, Z., Jitkaew, S., Zhao, J., Chiang, H.-C., Choksi, S., Liu, J., Ward, Y., Wu, L.-G., & Liu, Z.-G. (2014) · Nature Cell Biology · doi:10.1038/ncb2883 · Cited by 1,322 · see citing works

Caspases in Cell Death, Inflammation, and Disease

Opdenbosch, N. V., & Lamkanfi, M. (2019) · Immunity · doi:10.1016/j.immuni.2019.05.020 · Cited by 1,230 · see citing works

Clinical Neurology and Epidemiology of the Major Neurodegenerative DiseasesPreprint

Erkkinen, M. G., Kim, M., & Geschwind, M. D. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033118 · Cited by 1,152 · see citing works

A Unified Model for Apical Caspase Activation

Boatright, K. M., Renatus, M., Scott, F. L., Sperandio, S., Shin, H., Pedersen, I. M., Ricci, J., Edris, W. A., Sutherlin, D. P., Green, D. R., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00051-0 · Cited by 963 · see citing works

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

Mebratu, Y. A., & Tesfaigzi, Y. (2009) · Cell Cycle · doi:10.4161/cc.8.8.8147 · Cited by 959 · see citing works

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

Du, H., Guo, L., Fang, F., Chen, D., Sosunov, A. A., McKhann, G. M., Yan, Y., Wang, C., Zhang, H., Molkentin, J. D., et al. (2008) · Nature Medicine · doi:10.1038/nm.1868 · Cited by 935 · see citing works

Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

De Felice, F. G., Velasco, P. T., Lambert, M. P., Viola, K., Fernandez, S. J., Ferreira, S. T., & Klein, W. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607483200 · Cited by 882 · see citing works

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

Caccamo, A., Majumder, S., Richardson, A., Strong, R., & Oddo, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100420 · Cited by 881 · see citing works

Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction

Devi, L., Prabhu, B. M., Galati, D. F., Avadhani, N. G., & Anandatheerthavarada, H. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1469-06.2006 · Cited by 792 · see citing works

The Epidemiology of Alzheimer's Disease Modifiable Risk Factors and Prevention

Zhang, X.-X., Tian, Y., Wang, Z.-T., Ma, Y.-H., Tan, L., & Yu, J.-T. (2021) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2021.15 · Cited by 789 · see citing works

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

Gervais, F. G., Xu, D., Robertson, G. S., Vaillancourt, J. P., Zhu, Y., Huang, J., LeBlanc, A. C., Smith, D., Rigby, M., Shearman, M. S., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80748-5 · Cited by 784 · see citing works

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

Darmon, A. J., Nicholson, D. W., & Bleackley, R. C. (1995) · Nature · doi:10.1038/377446a0 · Cited by 707 · see citing works

The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

Hansson Petersen, C. A., Alikhani, N., Behbahani, H., Wiehager, B., Pavlov, P. F., Alafuzoff, I., Leinonen, V., Ito, A., Winblad, B., Glaser, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806192105 · Cited by 693 · see citing works

ERK1/2 MAP kinases in cell survival and apoptosis

Lu, Z., & Xu, S. (2006) · IUBMB Life · doi:10.1080/15216540600957438 · Cited by 654 · see citing works

Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease

Misrani, A., Tabassum, S., & Yang, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.617588 · Cited by 654 · see citing works

Caspase signalling controls microglia activation and neurotoxicity

Burguillos, M. A., Deierborg, T., Kavanagh, E., Persson, A., Hajji, N., Garcia-Quintanilla, A., Cano, J., Brundin, P., Englund, E., Venero, J. L., et al. (2011) · Nature · doi:10.1038/nature09788 · Cited by 585 · see citing works

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

Walker, N. P. C., Talanian, R. V., Brady, K. D., Dang, L. C., Bump, N. J., Ferenza, C. R., Franklin, S., Ghayur, T., Hackett, M. C., Hammill, L., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90303-4 · Cited by 576 · see citing works

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

D'Amelio, M., Cavallucci, V., Middei, S., Marchetti, C., Pacioni, S., Ferri, A., Diamantini, A., De Zio, D., Carrara, P., Battistini, L., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2709 · Cited by 572 · see citing works

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

Rissman, R. A., Poon, W. W., Blurton-Jones, M., Oddo, S., Torp, R., Vitek, M. P., LaFerla, F. M., Rohn, T. T., & Cotman, C. W. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420640 · Cited by 543 · see citing works

Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria

Guo, Y., Srinivasula, S. M., Druilhe, A., Fernandes‐Alnemri, T., & Alnemri, E. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108029200 · Cited by 521 · see citing works

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

Liu, Y. M., Liu, F., Grundke, I., Iqbal, K., & Gong, C. (2011) · The Journal of Pathology · doi:10.1002/path.2912 · Cited by 505 · see citing works

Caspase-9 Can Be Activated without Proteolytic Processing

Stennicke, H. R., Deveraux, Q. L., Humke, E. W., Reed, J. C., Dixit, V. M., & Salvesen, G. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8359 · Cited by 497 · see citing works

A current view on Tau protein phosphorylation in Alzheimer's disease

Wegmann, S., Biernat, J., & Mandelkow�, E. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.03.003 · Cited by 464 · see citing works

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

Ahmed, Z., Cooper, J., Murray, T. K., Garn, K., McNaughton, E., Clarke, H., Parhizkar, S., Ward, M. A., Cavallini, A., Jackson, S., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1254-6 · Cited by 460 · see citing works

Aβ Secretion and Plaque Formation Depend on Autophagy

Nilsson, P., Loganathan, K., Sekiguchi, M., Matsuba, Y., Hui, K., Tsubuki, S., Tanaka, M., Iwata, N., Saito, T., & Saido, T. C. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.042 · Cited by 459 · see citing works

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

Stadelmann, C., Deckwerth, T., Srinivasan, A., Bancher, C., Brück, W., Jellinger, K. A., & Lassmann, H. (1999) · American Journal of Pathology · doi:10.1016/s0002-9440(10)65460-0 · Cited by 449 · see citing works

Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

Calvo-Rodríguez, M., Hou, S. S., Snyder, A. C., Kharitonova, E. K., Russ, A., Das, S., Fan, Z., Muzikansky, A., Garcı́a-Alloza, M., Serrano‐Pozo, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16074-2 · Cited by 432 · see citing works

Targeting the extrinsic apoptosis pathway in cancer

Ashkenazi, A. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.04.001 · Cited by 419 · see citing works

Prevention of Constitutive TNF Receptor 1 Signaling by Silencer of Death Domains

Jiang, Y., Woronicz, J. D., Liu, W., & Goeddel, D. V. (1999) · Science · doi:10.1126/science.283.5401.543 · Cited by 415 · see citing works

Regulation of the Intrinsic Apoptosis Pathway by Reactive Oxygen Species

Wu, C.-C., & Bratton, S. B. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4905 · Cited by 410 · see citing works

Recruitment, activation and retention of caspases‐9 and ‐3 by Apaf‐1 apoptosome and associated XIAP complexes

Bratton, S. B., Walker, G., Srinivasula, S. M., Sun, X., Butterworth, M., Alnemri, E. S., & Cohen, G. M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.5.998 · Cited by 406 · see citing works

Targeting apoptotic caspases in cancer

Boice, A., & Bouchier‐Hayes, L. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118688 · Cited by 402 · see citing works

Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

Gabbouj, S., Ryhänen, S., Marttinen, M., Wittrahm, R., Takalo, M., Kemppainen, S., Martiskainen, H., Tanila, H., Haapasalo, A., Hiltunen, M., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00629 · Cited by 401 · see citing works

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

Young, M. M., Takahashi, Y., Khan, O. A., Park, S., Hori, T., Yun, J. K., Sharma, A. K., Amin, S., Hu, C., Zhang, J., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.309104 · Cited by 372 · see citing works

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

Dickens, L. S., Boyd, R. S., Jukes-Jones, R., Hughes, M. A., Robinson, G. L., Fairall, L., Schwabe, J. W. R., Cain, K., & MacFarlane, M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.004 · Cited by 349 · see citing works

The role of cell signalling in the crosstalk between autophagy and apoptosis

Booth, L. A., Tavallai, S., Hamed, H. A., Cruickshanks, N. A., & Dent, P. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.11.028 · Cited by 340 · see citing works

FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells

Bell, B. D., Leverrier, S., Weist, B. M., Newton, R. H., Arechiga, A. F., Luhrs, K. A., Morrissette, N. S., & Walsh, C. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808597105 · Cited by 290 · see citing works

Insulin signaling pathway and related molecules: Role in neurodegeneration and Alzheimer's disease

Akhtar, A., & Sah, S. P. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104707 · Cited by 290 · see citing works

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

Flores, J., Noël, A., Foveau, B., Lynham, J., Lecrux, C., & LeBlanc, A. C. (2018) · Nature Communications · doi:10.1038/s41467-018-06449-x · Cited by 288 · see citing works

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

Hamano, T., Gendron, T. F., Causevic, E., Yen, S., Lin, W., Isidoro, C., DeTure, M., & Ko, L. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06084.x · Cited by 283 · see citing works

Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy

Piras, A., Collin, L., Grüninger, F., Graff, C., & Rönnbäck, A. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0292-9 · Cited by 271 · see citing works

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis

Betin, V. M. S., & Lane, J. D. (2009) · Journal of Cell Science · doi:10.1242/jcs.046250 · Cited by 261 · see citing works

Activated caspase-3 expression in Alzheimer’s and aged control brain: correlation with Alzheimer pathology

Su, J. H., Zhao, M., Anderson, A. J., Srinivasan, A. N., & Cotman, C. W. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02018-2 · Cited by 260 · see citing works

The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

Nhan, H. S., Chiang, K., & Koo, E. H. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1347-2 · Cited by 256 · see citing works

WD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 Activation

Hu, Y., Ding, L., Spencer, D. M., & Núñez, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33489 · Cited by 256 · see citing works

Caspases: A Molecular Switch Node in the Crosstalk between Autophagy and Apoptosis

Wu, H., Che, X., Zheng, Q., Wu, A., Pan, K., Shao, A., Wu, Q., Zhang, J., & Hong, Y. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.9719 · Cited by 255 · see citing works

Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis

Zhu, Y., Zhao, L., Liu, L., Gao, P., Tian, W., Wang, X., Jin, H., Xu, H., & Chen, Q. (2010) · Protein & Cell · doi:10.1007/s13238-010-0048-4 · Cited by 254 · see citing works

Mitochondria and Calcium in Alzheimer’s Disease: From Cell Signaling to Neuronal Cell Death

Calvo-Rodriguez, M., & Bacskai, B. J. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2020.10.004 · Cited by 254 · see citing works

Crystal Structure of a Procaspase-7 Zymogen

Chai, J., Wu, Q. Y., Shiozaki, E. N., Srinivasula, S. M., Alnemri, E. S., & Shi, Y. (2001) · Cell · doi:10.1016/s0092-8674(01)00544-x · Cited by 246 · see citing works

Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain

Rohn, T. T., Rissman, R. A., Davis, M. C., Kim, Y., Cotman, C. W., & Head, E. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0549 · Cited by 242 · see citing works

β-Amyloid-induced Dynamin 1 Degradation Is Mediated by N-Methyl-D-Aspartate Receptors in Hippocampal Neurons

Kelly, B. L., & Ferreira, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605081200 · Cited by 240 · see citing works

Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells

Cho, D., Jo, Y. K., Hwang, J. J., Lee, Y. M., Roh, S. A., & Kim, J. C. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.09.004 · Cited by 230 · see citing works

Structural basis for the activation of human procaspase-7

Riedl, S. J., Fuentes‐Prior, P., Renatus, M., Kairies, N., Krapp, S., Huber, R., Salvesen, G. S., & Bode, W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221580098 · Cited by 220 · see citing works

Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs

Sanz‐Blasco, S., Valero, R. A., Rodríguez‐Crespo, I., Villalobos, C., & Núñez, L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002718 · Cited by 219 · see citing works

The in vitro cleavage of the hAtg proteins by cell death proteases

Norman, J., Cohen, G., & Bampton, E. (2010) · Autophagy · doi:10.4161/auto.6.8.13337 · Cited by 209 · see citing works

Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease

Louneva, N., Cohen, J. W., Han, L., Talbot, K., Wilson, R. S., Bennett, D. A., Trojanowski, J. Q., & Arnold, S. E. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080434 · Cited by 207 · see citing works

Recent developments in Alzheimer's disease therapeutics

Rafii, M., & Aisen, P. (2009) · BMC Medicine · doi:10.1186/1741-7015-7-7 · Cited by 204 · see citing works

Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer’s Disease

Cioffi, F., Adam, R. H. I., & Broersen, K. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190863 · Cited by 204 · see citing works

The biochemical mechanism of caspase-2 activation

Baliga, B. C., Read, S. H., & Kumar, S. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401492 · Cited by 200 · see citing works

Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model

Schleich, K., Warnken, U., Fricker, N., Öztürk, S., Richter, P., Kammerer, K., Schnölzer, M., Krammer, P. H., & Lavrik, I. N. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.006 · Cited by 198 · see citing works

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

Fu, T.-M., Li, Y., Lu, A., Li, Z., Vajjhala, P. R., Cruz, A. C., Srivastava, D. B., DiMaio, F., Penczek, P. A., Siegel, R. M., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.09.009 · Cited by 196 · see citing works

Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia

Liu, Y., Dai, Y., Li, Q., Chen, C., Chen, H., Song, Y., Hua, F., & Zhang, Z. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135279 · Cited by 183 · see citing works

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways

Fatimy, R. E., Li, S., Chen, Z., Mushannen, T., Gongala, S., Wei, Z., Balu, D. T., Rabinovsky, R., Cantlon, A., Elkhal, A., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1880-5 · Cited by 172 · see citing works

Activation of Caspase-8 in the Alzheimer's Disease Brain

Rohn, T. T., Head, E., Nesse, W. H., Cotman, C. W., & Cribbs, D. H. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0449 · Cited by 171 · see citing works

A primer on caspase mechanisms

Ramirez, M. L. G., & Salvesen, G. S. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.01.002 · Cited by 166 · see citing works

Catecholamines Potentiate Amyloid β-Peptide Neurotoxicity: Involvement of Oxidative Stress, Mitochondrial Dysfunction, and Perturbed Calcium Homeostasis

Fu, W., Luo, H., Parthasarathy, S., & Mattson, M. P. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0192 · Cited by 164 · see citing works

The γ-secretase complex: from structure to function

Zhang, X., Li, Y., Xu, H., & Zhang, Y. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00427 · Cited by 164 · see citing works

Correlation between Caspase Activation and Neurofibrillary Tangle Formation in Alzheimer’s Disease

Rohn, T. T., Head, E., Su, J. H., Anderson, A. J., Bahr, B. A., Cotman, C. W., & Cribbs, D. H. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63957-0 · Cited by 164 · see citing works

Neuronal Apoptosis and Autophagy Cross Talk in Aging PS/APP Mice, a Model of Alzheimer's Disease

Yang, D., Kumar, A. R., Stavrides, P. H., Peterson, J. N., Peterhoff, C., Pawlik, M., Levy, E., Cataldo, A. M., & Nixon, R. A. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.071176 · Cited by 164 · see citing works

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

Rohn, T. T., Wirawan, E., Brown, R. J., Harris, J. R., Masliah, E., & Vandenabeele, P. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.11.003 · Cited by 160 · see citing works

Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease

Zheng, F., Qin, C., Chang, Y. S., & Zhang, J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.014 · Cited by 156 · see citing works

Genistein ameliorates β-amyloid peptide (25–35)-induced hippocampal neuronal apoptosis

Zeng, H., Chen, Q., & Zhao, B. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.018 · Cited by 155 · see citing works

Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer’s Disease in APP/PS1 Double-Transgenic Mice

Che, H., Li, Q., Zhang, T., Wang, D., Yang, L., Xu, J., Yanagita, T., Xue, C., Chang, Y., & Wang, Y. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b00988 · Cited by 152 · see citing works

Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response

Pagliarini, V., Wirawan, E., Romagnoli, A., Ciccosanti, F., Lisi, G., Lippens, S., Cecconi, F., Fimia, G. M., Vandenabeele, P., Corazzari, M., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.27 · Cited by 149 · see citing works

Enhancement of 45Ca2+ Influx and Voltage-dependent Ca2+ Channel Activity by β-Amyloid-(1–40) in Rat Cortical Synaptosomes and Cultured Cortical Neurons

MacManus, A., Ramsden, M., Murray, M., Henderson, Z., Pearson, H. A., & Campbell, V. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.4713 · Cited by 137 · see citing works

Anti-Inflammatory Action of Donepezil Ameliorates Tau Pathology, Synaptic Loss, and Neurodegeneration in a Tauopathy Mouse Model

Yoshiyama, Y., Kojima, A., Ishikawa, C., & Arai, K. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100681 · Cited by 132 · see citing works

Nicotine attenuates β‐amyloid peptide‐induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures

Liu, Q., & Zhao, B. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705653 · Cited by 130 · see citing works

Mechanisms of Amyloid‐Beta Peptide Uptake by Neurons: The Role of Lipid Rafts and Lipid Raft‐Associated Proteins

Lai, A. Y., & McLaurin, J. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2011/548380 · Cited by 130 · see citing works

Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases

Choi, A. J. S., & Ryter, S. W. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.0104 · Cited by 130 · see citing works

Epigallocatechin‐3‐Gallate Attenuates Microglial Inflammation and Neurotoxicity by Suppressing the Activation of Canonical and Noncanonical Inflammasome via TLR4/NF‐κB Pathway

Zhong, X., Liu, M., Yao, W., Du, K., He, M., Jin, X., Jiao, L., Ma, G., Wei, B., & Wei, M. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801230 · Cited by 129 · see citing works

NLRP3 inflammasome as a novel therapeutic target for Alzheimer’s disease

Zhang, Y., Dong, Z., & Song, W. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0145-7 · Cited by 128 · see citing works

Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease

Noble, W., Garwood, C., Stephenson, J., Kinsey, A. M., Hanger, D., & Anderton, B. (2009) · The FASEB Journal · doi:10.1096/fj.08-113795 · Cited by 123 · see citing works

Tau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular Ca2+ handling

Cieri, D., Vicario, M., Vallese, F., D’Orsi, B., Berto, P., Grinzato, A., Catoni, C., Stefani, D. D., Rizzuto, R., Brini, M., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.07.011 · Cited by 122 · see citing works

The role of acetylcholinesterase inhibitors such as neostigmine and rivastigmine on chronic pain and cognitive function in aging: A review of recent clinical applications

Eldufani, J., & Blaise, G. A. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.03.004 · Cited by 121 · see citing works

Lower cerebral blood flow is associated with faster cognitive decline in Alzheimer’s disease

Benedictus, M. R., Leeuwis, A. E., Binnewijzend, M. A. A., Kuijer, J. P. A., Scheltens, P., Barkhof, F., van der Flier, W. M., & Prins, N. D. (2016) · European Radiology · doi:10.1007/s00330-016-4450-z · Cited by 118 · see citing works

Regulation of Apoptotic Protease Activating Factor-1 Oligomerization and Apoptosis by the WD-40 Repeat Region

Adrain, C., Slee, E. A., Harte, M. T., & Martin, S. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.20855 · Cited by 117 · see citing works

(−)-Epigallocatechin-3-Gallate Ameliorates Learning and Memory Deficits by Adjusting the Balance of TrkA/p75NTR Signaling in APP/PS1 Transgenic Mice

Liu, M., Chen, F., Sha, L., Wang, S., Lin, T., Yao, L., He, M., Yao, Z., Liu, H., Zhu, Z., et al. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8608-2 · Cited by 117 · see citing works

Glycogen Synthase Kinase 3β Induces Caspase-cleaved Tau Aggregation in Situ

Cho, J., & Johnson, G. V. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403364200 · Cited by 116 · see citing works

Simvastatin ameliorate memory deficits and inflammation in clinical and mouse model of Alzheimer’s disease via modulating the expression of miR-106b

Huang, W., Li, Z., Zhao, L., & Zhao, W. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.060 · Cited by 113 · see citing works

Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss

Di, J., Cohen, L. S., Corbo, C. P., Phillips, G. R., Idrissi, A. E., & Alonso, A. D. C. (2016) · Scientific Reports · doi:10.1038/srep20833 · Cited by 112 · see citing works

Caspase cleavage of the amyloid precursor protein modulates amyloid β‐protein toxicity

Lu, D. C.-T., Soriano, S., Bredesen, D. E., & Koo, E. H. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02059.x · Cited by 110 · see citing works

Resveratrol activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced inflammation and oxidative stress

Chiang, M., Nicol, C. J. B., & Cheng, Y. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.10.002 · Cited by 109 · see citing works

Crude caffeine reduces memory impairment and amyloid β1–42 levels in an Alzheimer’s mouse model

Chu, Y.-F., Chang, W.-H., Black, R. M., Liu, J.-R., Sompol, P., Chen, Y., Wei, H., Zhao, Q., & Cheng, I. H. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.04.148 · Cited by 106 · see citing works

Neuroinflammation in Alzheimer’s Disease: from Pathogenesis to a Therapeutic Target

Pimplikar, S. W. (2014) · Journal of Clinical Immunology · doi:10.1007/s10875-014-0032-5 · Cited by 103 · see citing works

Caspase activation in the limbic cortex of subjects with early Alzheimer's disease

Gastard, M. C., Troncoso, J. C., & Koliatsos, V. E. (2003) · Annals of Neurology · doi:10.1002/ana.10680 · Cited by 101 · see citing works

A Complex between Atg7 and Caspase-9

Han, J., Hou, W., Goldstein, L. A., Stolz, D. B., Watkins, S. C., & Rabinowich, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.536854 · Cited by 101 · see citing works

Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death

Britti, E., Ros, J., Esteras, N., & Abramov, A. Y. (2019) · Cell Calcium · doi:10.1016/j.ceca.2019.102150 · Cited by 101 · see citing works

Montelukast targeting the cysteinyl leukotriene receptor 1 ameliorates Aβ1-42-induced memory impairment and neuroinflammatory and apoptotic responses in mice

Lai, J., Hu, M., Wang, H., Hu, M. Y., Long, Y., Miao, M., Li, J.-C., Wang, X., Kong, L., & Hong, H. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.011 · Cited by 98 · see citing works

Mechanism of amyloidogenesis: nucleation-dependent fibrillation versus double-concerted fibrillation

Bhak, G., Choe, Y., & Paik, S.-R. (2009) · BMB Reports · doi:10.5483/bmbrep.2009.42.9.541 · Cited by 95 · see citing works

TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism

Zheng, H., Cheng, B., Li, Y., Li, X., Chen, X., & Zhang, Y.-W. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00395 · Cited by 94 · see citing works

Melatonin attenuates amyloid beta25–35-induced apoptosis in mouse microglial BV2 cells

Jang, M.-H., Jung, S.-B., Lee, M., Kim, C., Oh, Y.-T., Kang, I., Kim, J., & Kim, E. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.01.003 · Cited by 93 · see citing works

Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer’s Disease

Park, G., Nhan, H. S., Tyan, S.-H., Kawakatsu, Y., Zhang, C., Navarro, M., & Koo, E. H. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107839 · Cited by 92 · see citing works

The Role of ERK1/2 Pathway in the Pathophysiology of Alzheimer’s Disease: An Overview and Update on New Developments

Khezri, M. R., Yousefi, K., Esmaeili, A., & Ghasemnejad‐Berenji, M. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01191-x · Cited by 92 · see citing works

Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice

Puzzo, D., Loreto, C., Giunta, S., Musumeci, G., Frasca, G., Podda, M. V., Arancio, O., & Palmeri, A. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.002 · Cited by 88 · see citing works

Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice

Wang, J., Sun, B.-L., Xiang, Y., Tian, D.-Y., Zhu, C., Li, W.-W., Liu, Y.-H., Bu, X.-L., Shen, L.-L., Jin, W.-S., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00918-y · Cited by 87 · see citing works

Early Stages of Pathogenesis in Memory Impairment during Normal Senescence and Alzheimer's Disease

Daulatzai, M. A. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1374 · Cited by 82 · see citing works

Emricasan (IDN‐6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension

García–Tsao, G., Fuchs, M. A., Shiffman, M. L., Borg, B. B., Pyrsopoulos, N., Shetty, K., Gallegos-Orozco, J. F., Reddy, K. R., Feyssa, E. L., Chan, J. L., et al. (2018) · Hepatology · doi:10.1002/hep.30199 · Cited by 82 · see citing works

Protective effect of paeoniflorin on inflammation and apoptosis in the cerebral cortex of a transgenic mouse model of Alzheimer's disease

Gu, X., CAI, Z., Cai, M., Liu, K., Liu, D., ZHANG, Q., Tan, J. H., & Ma, Q. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4805 · Cited by 81 · see citing works

Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues

Seaman, J. E., Julien, O., Lee, P. S., Rettenmaier, T. J., Thomsen, N. D., & Wells, J. A. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.62 · Cited by 81 · see citing works

Caspase 1 Activation Is Protective against Hepatocyte Cell Death by Up-regulating Beclin 1 Protein and Mitochondrial Autophagy in the Setting of Redox Stress

Sun, Q., Gao, W., Loughran, P., Shapiro, R., Fan, J., Billiar, T. R., & Scott, M. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.426791 · Cited by 80 · see citing works

Mechanisms of action of amyloid-beta and its precursor protein in neuronal cell death

Leong, Y. Q., Ng, K. Y., Chye, S. M., Ling, A. P. K., & Koh, R. Y. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00516-y · Cited by 78 · see citing works

The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease

Small, D. H., Gasperini, R., Vincent, A. J., Hung, A. C., & Foa, L. C. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0951 · Cited by 75 · see citing works

A nonapoptotic role for CASP2/caspase 2

Tiwari, M., Sharma, L. K., Vanegas, D., Callaway, D. A., Bai, Y., Lechleiter, J. D., & Herman, B. A. (2014) · Autophagy · doi:10.4161/auto.28528 · Cited by 75 · see citing works

Challenges in Neuronal Apoptosis

Jellinger, K. A. (2006) · Current Alzheimer Research · doi:10.2174/156720506778249434 · Cited by 74 · see citing works

TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation

You, M., Savaraj, N., Kuo, M. T., Wangpaichitr, M., Varona-Santos, J., Wu, C., Nguyen, D. M., & Feun, L. G. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1518-1 · Cited by 72 · see citing works

Loss of Caspase-2-dependent Apoptosis Induces Autophagy after Mitochondrial Oxidative Stress in Primary Cultures of Young Adult Cortical Neurons

Tiwari, M., Lopez‐Cruzan, M., MORGAN, W. W., & Herman, B. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.163824 · Cited by 71 · see citing works

Protective effects of galantamine against Aβ-induced PC12 cell apoptosis by preventing mitochondrial dysfunction and endoplasmic reticulum stress

Liu, X., Xu, K., Yan, M., Wang, Y., & Zheng, X. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.07.007 · Cited by 71 · see citing works

Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model

Kim, Y., Choi, H., Lee, W., Park, H., Kam, T.-I., Hong, S.-H., Nah, J., Jung, S., Shin, B., Lee, H., et al. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.12.006 · Cited by 71 · see citing works

Trigonelline protects hippocampus against intracerebral Aβ(1–40) as a model of Alzheimer’s disease in the rat: insights into underlying mechanisms

Babaei, J. F., Baluchnejadmojarad, T., Nikbakht, F., & Roghani, M. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0338-8 · Cited by 71 · see citing works

Cilostazol Suppresses Aβ-induced Neurotoxicity in SH-SY5Y Cells through Inhibition of Oxidative Stress and MAPK Signaling Pathway

Oguchi, T., Ono, R., Tsuji, M., Shozawa, H., Somei, M., Inagaki, M., Mori, Y., Yasumoto, T., Ono, K., & Kiuchi, Y. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00337 · Cited by 66 · see citing works

The Synaptic Autophagy Cycle

Lieberman, O. J., & Sulzer, D. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.028 · Cited by 65 · see citing works

Apoptosis: A Potential Therapeutic Target for Retinal Degenerations

Doonan, F., & Cotter, T. G. (2004) · Current Neurovascular Research · doi:10.2174/1567202043480215 · Cited by 64 · see citing works

Potential protection of curcumin against intracellular amyloid β-induced toxicity in cultured rat prefrontal cortical neurons

Qin, X., Cheng, Y., & Yu, L. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.05.062 · Cited by 62 · see citing works

miR-137 attenuates Aβ-induced neurotoxicity through inactivation of NF-κB pathway by targeting TNFAIP1 in Neuro2a cells

He, D., Tan, J., & Zhang, J. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.144 · Cited by 61 · see citing works

An Uncleavable Procaspase-3 Mutant Has a Lower Catalytic Efficiency but an Active Site Similar to That of Mature Caspase-3

Bose, K., Pop, C., Feeney, B., & Clark, A. C. (2003) · Biochemistry · doi:10.1021/bi034998x · Cited by 60 · see citing works

Effect of Resveratrol on Reactive Oxygen Species-Induced Cognitive Impairment in Rats with Angiotensin II-Induced Early Alzheimer’s Disease †

Lin, Y., Wu, Y., Sun, G., Ho, C., Wong, T., Lin, C., Chen, H., Yeh, T., Li, C., Tseng, C., et al. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7100329 · Cited by 60 · see citing works

Comparative Effects of Alpha- and Gamma-Tocopherol on Mitochondrial Functions in Alzheimer’s Disease In Vitro Model

Arrozi, A. P., Shukri, S. N. S., Ngah, W. Z. W., Yusof, Y. A. M., Damanhuri, H. A., Jaafar, F., & Makpol, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-65570-4 · Cited by 59 · see citing works

Targeting Aggrephagy for the Treatment of Alzheimer’s Disease

Malampati, S., Song, J., Tong, B. C., Nalluri, A., Yang, C., Wang, Z., Sreenivasmurthy, S. G., Zhu, Z., Liu, J., Su, C.-F., et al. (2020) · Cells · doi:10.3390/cells9020311 · Cited by 58 · see citing works

Galantamine inhibits β‐amyloid‐induced cytostatic autophagy in PC 12 cells through decreasing ROS production

Jiang, S., Zhao, Y., Zhang, T., Lan, J., Yang, J., Yuan, L., Zhang, Q., Pan, K., & Zhang, K. (2018) · Cell Proliferation · doi:10.1111/cpr.12427 · Cited by 54 · see citing works

Effects of resveratrol on learning and memory in rats with vascular dementia

Zhang, Y., Li, Y., Wang, Y., Wang, G., Mao, L., Zhang, D., & Wang, J. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10723 · Cited by 54 · see citing works

Aluminum-Induced Synaptic Plasticity Impairment via PI3K-Akt-mTOR Signaling Pathway

Li, H., Xue, X., Li, L., Li, Y., Wang, Y., Huang, T., Wang, Y., Meng, H., Pan, B., & Niu, Q. L. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00165-5 · Cited by 53 · see citing works

Effects of Nicorandil in Neuroprotective Activation of PI3K/AKT Pathways in a Cellular Model of Alzheimer's Disease

Kong, J., Ren, G., Jia, N., Wang, Y., Zhang, H., Zhang, W., Chen, B., & Cao, Y. (2013) · European Neurology · doi:10.1159/000351247 · Cited by 49 · see citing works

Molecular Mechanism of Vitamin K2 Protection against Amyloid-β-Induced Cytotoxicity

Huang, S.-H., Fang, S.-T., & Chen, Y.-C. (2021) · Biomolecules · doi:10.3390/biom11030423 · Cited by 49 · see citing works

Icariin Prevents Amyloid Beta-Induced Apoptosis via the PI3K/Akt Pathway in PC-12 Cells

Zhang, D., Wang, Z., Sheng, C., Peng, W., Hui, S., Gong, W., & Chen, S. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/235265 · Cited by 48 · see citing works

Increased caspase activation in peripheral blood mononuclear cells of patients with Alzheimer's disease

Tacconi, S., Perri, R., Balestrieri, E., Grelli, S., Bernardini, S., Annichiarico, R., Mastino, A., Caltagirone, C., & Macchi, B. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.07.009 · Cited by 44 · see citing works

Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy

Cavieres, V. A., González, A., Muñoz, V. C., Yefi, C. P., Bustamante, H. A., Barraza, R. R., Tapia-Rojas, C., Otth, C., Barrera, M. J., González, C., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0136313 · Cited by 43 · see citing works

Truncated tau at D421 is associated with neurodegeneration and tangle formation in the brain of Alzheimer transgenic models

Zhang, Q., Zhang, X., & Sun, A. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0491-6 · Cited by 43 · see citing works

The neuroprotective effects of Berberine against amyloid β-protein-induced apoptosis in primary cultured hippocampal neurons via mitochondria-related caspase pathway

Liang, Y., Huang, M., Jiang, X., Liu, Q., Chang, X., & Guo, Y. C. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.06.048 · Cited by 43 · see citing works

Emodin protected against synaptic impairment and oxidative stress induced by fluoride in SH‐SY5Y cells by modulating ERK1 /2/Nrf2/ HO ‐1 pathway

Lai, C., Chen, Q., Ding, Y., Liu, H., & Tang, Z. (2020) · Environmental Toxicology · doi:10.1002/tox.22928 · Cited by 43 · see citing works

Studies on the Neuroprotection of Osthole on Glutamate-Induced Apoptotic Cells and an Alzheimer’s Disease Mouse Model via Modulation Oxidative Stress

Chu, Q., Zhu, Y., Cao, T., Zhang, Y., Chang, Z., Lü, J., Lu, J., & Zhang, Y. (2019) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-019-03101-2 · Cited by 42 · see citing works

β-Secretase1 biological markers for Alzheimer’s disease: state-of-art of validation and qualification

Hampel, H. J., Lista, S., Vanmechelen, E., Zetterberg, H., Giorgi, F. S., Galgani, A., Blennow, K., Caraci, F., Das, B., Yan, R., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00686-3 · Cited by 42 · see citing works

Metformin in Alzheimer’s disease: An overview of potential mechanisms, preclinical and clinical findings

Khezri, M. R., Yousefi, K., Mahboubi, N., Hodaei, D., & Ghasemnejad‐Berenji, M. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114945 · Cited by 41 · see citing works

Melatonin ameliorates Aβ1-42-induced Alzheimer's cognitive deficits in mouse model

Gong, Y., Hua, N., Zang, X., Huang, T., & He, L. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12830 · Cited by 39 · see citing works

Activation of the Nrf2 Pathway Prevents Mitochondrial Dysfunction Induced by Caspase-3 Cleaved Tau: Implications for Alzheimer’s Disease

Villavicencio-Tejo, F., Olesen, M. A., Aránguiz, A., & Quintanilla, R. A. (2022) · Antioxidants · doi:10.3390/antiox11030515 · Cited by 39 · see citing works

Potential protection of curcumin against amyloid β-induced toxicity on cultured rat prefrontal cortical neurons

Qin, X., Cheng, Y., Cui, J., Zhang, Y., & Yu, L. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.07.047 · Cited by 38 · see citing works

Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling

Gupta, P., Tiwari, S., Singh, A., Pal, A., Mishra, A., & Singh, S. (2021) · Biochemical Journal · doi:10.1042/bcj20200754 · Cited by 38 · see citing works

Galantamine attenuates amyloid-β deposition and astrocyte activation in APP/PS1 transgenic mice

Wu, Z., Zhao, L., Chen, X., Cheng, X., & Zhang, Y. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.10.015 · Cited by 36 · see citing works

Genistein Inhibits Aβ25–35 –Induced Neurotoxicity in PC12 Cells via PKC Signaling Pathway

Luo, S., Lan, T., Liao, W., Zhao, M., & Yang, H. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0872-4 · Cited by 36 · see citing works

Blockade of 5-HT3 receptor with MDL72222 and Y25130 reduces β-amyloid protein (25–35)-induced neurotoxicity in cultured rat cortical neurons

Ban, J. Y., & Seong, Y. H. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.07.021 · Cited by 36 · see citing works

Critical Molecular and Cellular Contributors to Tau Pathology

Song, L., Wells, E. A., & Robinson, A. S. (2021) · Biomedicines · doi:10.3390/biomedicines9020190 · Cited by 36 · see citing works

Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans

Hengartner, M. O. (1997) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00167-2 · Cited by 31 · see citing works

Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid β1–40

Miguel-Hidalgo, J. J., Paul, I. A., Wanzo, V., & Banerjee, P. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.07.032 · Cited by 31 · see citing works

A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease

Smith, B. R., Nelson, K. M., Kemper, L. J., Leinonen-Wright, K., Petersen, A. J., Keene, C. D., & Ashe, K. H. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0765-8 · Cited by 30 · see citing works

Sildenafil protects neuronal cells from mitochondrial toxicity induced by β-amyloid peptide via ATP-sensitive K+ channels

Son, Y., Kim, K., & Cho, H.-R. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.04.128 · Cited by 29 · see citing works

Inhibitory Effects of Isobavachalcone on Tau Protein Aggregation, Tau Phosphorylation, and Oligomeric Tau-Induced Apoptosis

Xiao, S., Wu, Q., Yao, X., Zhang, J., Zhong, W., Zhao, J., Liu, Q., & Zhang, M. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00617 · Cited by 27 · see citing works

Caspase-Mediated Truncation of Tau Potentiates Aggregation

Lee, S., & Shea, T. B. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/731063 · Cited by 25 · see citing works

MicroRNA-20b-5p aggravates neuronal apoptosis induced by β-Amyloid via down-regulation of Ras homolog family member C in Alzheimer’s disease

Tian, Z., Dong, Q., Wu, T., & Guo, J. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135542 · Cited by 25 · see citing works

Neuroprotective Effects of Statins in an In Vitro Model of Alzheimer's Disease

Fonseca, A. C. R. G., Proença, T., Resende, R., Oliveira, C. R., & Pereira, C. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1067 · Cited by 24 · see citing works

Effects of homocysteine and memantine on oxidative stress related TRP cation channels inin-vitromodel of Alzheimer’s disease

Övey, İ. S., & Nazıroğlu, M. (2020) · Journal of Receptors and Signal Transduction · doi:10.1080/10799893.2020.1806321 · Cited by 23 · see citing works

Berberine enhances gemcitabine‑induced cytotoxicity in bladder cancer by downregulating Rad51 expression through inactivating the PI3K/Akt pathway

Gao, X., Liu, J., Fan, D., Li, X., Fang, Z., Yan, K., & Fan, Y. (2021) · Oncology Reports · doi:10.3892/or.2021.8244 · Cited by 22 · see citing works

MicroRNAs in the pathophysiology of Alzheimer’s disease and Parkinson's disease: an overview

Khezri, M. R., Yousefi, K., Zolbanin, N. M., & Ghasemnejad‐Berenji, M. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02727-4 · Cited by 22 · see citing works

Upregulation of miR-34a by Inhibition of IRE1 α Has Protective Effect against A β -Induced Injury in SH-SY5Y Cells by Targeting Caspase-2

Li, Q., Liu, T., Yang, S., & Zhang, Z. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2140427 · Cited by 20 · see citing works

Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits

Noël, A., Foveau, B., & LeBlanc, A. C. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03506-0 · Cited by 16 · see citing works

The effect of vitamin B12 on synaptic plasticity of hippocampus in Alzheimer’s disease model rats

Jahanshahi, M., Elyasi, L., & Nikmahzar, E. (2021) · International Journal of Neuroscience · doi:10.1080/00207454.2021.1962863 · Cited by 16 · see citing works

Naproxen as a potential candidate for promoting rivastigmine anti-Alzheimer activity against aluminum chloride-prompted Alzheimer's-like disease in rats; neurogenesis and apoptosis modulation as a possible underlying mechanism

Abdel‐Aal, R. A., Hussein, O. A., Elsaady, R. G., & Abdelzaher, L. A. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174695 · Cited by 16 · see citing works

Celecoxib effect on rivastigmine anti-Alzheimer activity against aluminum chloride-induced neurobehavioral deficits as a rat model of Alzheimer's disease; novel perspectives for an old drug

Abdel-Aal, R., Hussein, O. A., Elsaady, R. G., & Abdelzaher, L. A. (2021) · Journal of medical and life sciences · doi:10.21608/jmals.2021.210630 · Cited by 16 · see citing works

Limited activation of the intrinsic apoptotic pathway plays a main role in amyloid-β-induced apoptosis without eliciting the activation of the extrinsic apoptotic pathway

Islam, M. R., Sharoar, M. G., Ryu, E.-K., & Park, I. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3193 · Cited by 16 · see citing works

Anticancer potential of metformin: focusing on gastrointestinal cancers

Khezri, M. R., Malekinejad, H., Zolbanin, N. M., & Ghasemnejad‐Berenji, M. (2021) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-021-04256-8 · Cited by 12 · see citing works

Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights

Nagori, K., Nakhate, K. T., Yadav, K., Ajazuddin, & Pradhan, M. (2023) · Future Pharmacology · doi:10.3390/futurepharmacol3040053 · Cited by 61 · see citing works

Therapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidence

Khezri, M. R., Mohebalizadeh, M., & Ghasemnejad‐Berenji, M. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01072-w · Cited by 41 · see citing works

Interplay between PI3k/AKT signaling and caspase pathway in Alzheimer disease: mechanism and therapeutic implications

Bhatia, V., Sharma, V. V., Chandel, A., & Rattan, A. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01715-z · Cited by 21 · see citing works

The PI3K/AKT Signaling Pathway and Caspase-3 in Alzheimer’s Disease: Which One Is the Beginner?

Khezri, M. R., Ghasemnejad‐Berenji, M., & Moloodsouri, D. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221157 · Cited by 13 · see citing works

Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice

Chen, H., Guo, F., Zhao, Y., Liu, W., Chen, B., Wang, C., Huang, L., Jiang, S., Ma, X., Ren, H., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1572976 · Cited by 8 · see citing works

Alleviation of Neurological Disorders by Targeting Neurodegenerative-Associated Enzymes: Natural and Synthetic Molecules

Singh, A. A., Khan, F., & Song, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104707 · Cited by 8 · see citing works

In Vitro Assessment of Cholinesterase Inhibition and Neuroprotective Effects of Elaeocarpus angustifolius Blume Against Amyloid-Beta Peptide-Induced Toxicity in SH-SY5Y and BV-2 Cells

Banu, Z., & Das, N. R. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04478-9 · Cited by 4 · see citing works

Decoding the secretase puzzle in amyloid-β generation: A state-of-the-art overview of the protease-mediated APP processing cascade in Alzheimer’s disease

Senkowska, Z., & Węglarz‐Tomczak, E. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103116 · Cited by 2 · see citing works

Exploring the Potential of Herbal Compounds as Autophagy Modulators in Alzheimer's Disease: A Comprehensive Review

Yadav, E., Mandal, A. K., Sah, A. K., Poudel, S., Pathak, P., Khalilullah, H., Jaremko, M., Emwas, A.-H. M., Yadav, P. S., & Verma, A. (2024) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273298025240905130205 · Cited by 1 · see citing works

Advances in Developing Small Molecule Drugs for Alzheimer's Disease

Zhang, W., Zhang, L., Lv, M., Fu, Y., Meng, X., Wang, M., & Wang, H. (2024) · Current Alzheimer Research · doi:10.2174/0115672050329828240805074938

Five Key Criteria for Identifying Optimal Therapeutic Targets in Protein‐Mediated Diseases

Al‐Shuhaib, M. B. S., & Al‐Shuhaib, J. M. B. (2025) · ChemistrySelect · doi:10.1002/slct.202403409

AI Accelerated Chemical Screening Integrates ChemBERTa to Identify Repositionable CASP4 Inhibitors via MD Simulations and MM/PBSA Analysis

Hassan, M., Bhatti, S. G., Yasir, M., Chun, W., & Kloczkowski, A. (2026) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.6c02284

Caspases in Alzheimer’s Disease: Mechanism of Activation, Role, and Potential Treatment

Wójcik, P., Jastrzębski, M. K., Zięba, A., Matosiuk, D., & Kaczor, A. A. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03847-1 · Cited by 71 · see citing works

Role of Caspases in Alzheimer's Disease

Kabra, U. D., & Pathak, C. (2026) · Apple Academic Press eBooks · doi:10.1201/9781779642684-10

Caspases as therapeutic targets in Alzheimer's disease: is it time to "cut" to the chase?

Rohn, T. T., & Head, E. (2009) · PubMed Central · Cited by 63 · see citing works

Review Article Caspases as Therapeutic Targets in Alzheimer’s Disease: Is It Time to “Cut ” to the Chase?

Rohn, T. T., & Head, E. (2008)

Caspase Activation in Alzheimer's Disease: Early to Rise and Late to Bed

Rohn, T. T., & Head, E. (2008) · Reviews in the Neurosciences · doi:10.1515/revneuro.2008.19.6.383 · Cited by 46 · see citing works