Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

de Calignon, Alix, Polydoro, Manuela, Suárez-Calvet, Marc, William, Christopher, Adamowicz, David H., Kopeikina, Kathy J., Pitstick, Rose, Sahara, Naruhiko +4 more·2012·Neuron

DOI 10.1016/j.neuron.2011.11.033

Cited by (1,003)

Items 101–200 of 1,003

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration
Dominic M. Walsh, Dennis J. Selkoe · 2016 · Nature reviews. Neuroscience
Monoaminergic neuropathology in Alzheimer’s disease
Goran Šimić, Mirjana Babić Leko, Selina Wray, Charles R. Harrington, Ivana Delalle, Nataša Jovanov Milošević, Danira Bažadona, Luc Buée, Rohan de Silva, Giuseppe Di Giovanni et al. · 2016 · Progress in Neurobiology
A walk through tau therapeutic strategies
Santosh Jadhav, Jesús Ávila, Michael Schöll, Gábor Géza Kovács, Enikò Kövari, Rostislav Škrabana, Lewis Evans, Eva Kontseková, Barbara Malawska, Rohan de Silva et al. · 2019 · Acta Neuropathologica Communications
Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species
Xu‐Qiao Chen, William Cary Mobley · 2019 · Frontiers in Neuroscience
Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer’s Disease Brain
DeVos, Sarah L., Corjuc, Bianca T., Oakley, Derek H., Nobuhara, Chloe K., Bannon, Riley N., Chase, Alison, Commins, Caitlin, Gonzalez, Jose A., Dooley, Patrick M., Frosch, Matthew P. et al. · 2018 · Frontiers in Neuroscience
Deciphering the astrocyte reaction in Alzheimer's disease
Perez-Nievas, Beatriz G., Serrano-Pozo, Alberto · 2018 · Frontiers in Aging Neuroscience
Tau-based therapies in neurodegeneration: opportunities and challenges
Li, Chuanzhou, Götz, Jürgen · 2017 · Nature Reviews Drug Discovery
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease
Fu, Hongjun, Rodriguez, Gustavo A., Herman, Mathieu, Emrani, Sheina, Nahmani, Eden, Barrett, Geoffrey, Figueroa, Helen Y., Goldberg, Eliana, Hussaini, S. Abid, Duff, Karen E. · 2017 · Neuron
TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading
Martini-Stoica, Heidi, Cole, Allysa L., Swartzlander, Daniel B., Chen, Fading, Wan, Ying-Wooi, Bajaj, Lakshya, Bader, David A., Lee, Virginia M.Y., Trojanowski, John Q., Liu, Zhandong et al. · 2018 · Journal of Experimental Medicine
Antisense oligonucleotides: translation from mouse models to human neurodegenerative diseases
Schoch, Kathleen M., Miller, Timothy M. · 2017 · Neuron
The parahippocampal gyrus links the default‐mode cortical network with the medial temporal lobe memory system
Andrew M. Ward, Aaron P. Schultz, Willem Huijbers, Koene R. A. Van Dijk, Trey Hedden, Reisa Anne Sperling · 2013 · Human Brain Mapping
Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel
Thor D. Stein, Victor E. Alvarez, Ann Carolyn McKee · 2014 · Alzheimer s Research & Therapy
Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals
Jacobs, Heidi I. L., Hedden, Trey, Schultz, Aaron P., Sepulcre, Jorge, Perea, Rodrigo D., Amariglio, Rebecca E., Papp, Kathryn V., Rentz, Dorene M., Sperling, Reisa A., Johnson, Keith A. · 2018 · Nature Neuroscience
The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease
Hopp, Sarah C., Lin, Yang, Oakley, Derek, Roe, Allyson D., DeVos, Sarah L., Hanlon, David, Hyman, Bradley T. · 2018 · Journal of Neuroinflammation
Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory
Mauro Fà, Daniela Puzzo, Roberto Piacentini, Anna Staniszewski, H. Zhang, Marı́a Antonia Baltrons, Domenica Donatella Li Puma, I. Chatterjee, J. Li, Faisal Saeed et al. · 2016 · Scientific Reports
Lost after translation: missorting of Tau protein and consequences for Alzheimer disease
Hans Zempel, Eckhard Mandelkow� · 2014 · Trends in Neurosciences
Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation
Jose Francisco Abisambra, Umesh K. Jinwal, Laura J. Blair, John C. O’Leary, Qingyou Li, Sarah Brady, Li Wang, Chantal Guidi, Bo Zhang, Bryce A. Nordhues et al. · 2013 · Journal of Neuroscience
Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody
Luo, Wenjie, Liu, Wencheng, Hu, Xiaoyan, Hanna, Mary, Caravaca, April, Paul, Steven M. · 2015 · Scientific Reports
Molecular nexopathies: a new paradigm of neurodegenerative disease
Jason D. Warren, Jonathan Daniel Rohrer, Jonathan M. Schott, Nick C. Fox, John Hardy, Martin N. Rossor · 2013 · Trends in Neurosciences
The Emerging Link between O-GlcNAc and Alzheimer Disease
Zhu, Yanping, Shan, Xiaoyang, Yuzwa, Scott A., Vocadlo, David J. · 2014 · Journal of Biological Chemistry
A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer’s disease dementia
Pontecorvo, Michael J, Devous, Michael D, Kennedy, Ian, Navitsky, Michael, Lu, Ming, Galante, Nicholas, Salloway, Stephen, Doraiswamy, P Murali, Southekal, Sudeepti, Arora, Anupa K et al. · 2019 · Brain
Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells
Usenovic, Marija, Niroomand, Shahriar, Drolet, Robert E., Yao, Lihang, Gaspar, Renee C., Hatcher, Nathan G., Schachter, Joel, Renger, John J., Parmentier-Batteur, Sophie · 2015 · The Journal of Neuroscience
Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains
Susana Boluda, Michiyo Iba, Bin Zhang, Kevin M. Raible, Virginia M.‐Y. Lee, John Q. Trojanowski · 2014 · Acta Neuropathologica
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology
Hongjun Fu, Andrea Possenti, Rosie Freer, Yoshikazu Nakano, Nancy C. Hernandez Villegas, Maoping Tang, Paula Maglio Cauhy, Benjamin Lassus, Shuo Chen, Stephanie L. Fowler et al. · 2018 · Nature Neuroscience
Unconventional Secretion Mediates the Trans-cellular Spreading of Tau
Taxiarchis Katsinelos, Marcel Zeitler, Eleni Dimou, Andromachi Karakatsani, Hans‐Michael Müller, Eliana Nachman, Julia P. Steringer, Carmen Ruiz de Almodóvar, Walter Nickel, Thomas Robert Jahn · 2018 · Cell Reports
Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies
Chen, Yu, Fu, Amy K.Y., Ip, Nancy Y. · 2019 · Pharmacology & Therapeutics
Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation
Sara Calafate, Arjan Buist, Katarzyna Miśkiewicz, V. A. Vijayan, Guy Daneels, Bart De Strooper, Joris de Wit, Patrik Verstreken, Diederik Moechars · 2015 · Cell Reports
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies
Simon Dujardin, Katia Lécolle, Raphaëlle Caillierez, Séverine Bégard, Nadège Zommer, Cédrick Lachaud, Sébastien Carrier, Noëlle Dufour, Gwennaëlle Aurégan, Joris Winderickx et al. · 2014 · Acta Neuropathologica Communications
Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review
Gibbons, Garrett S., Lee, Virginia M. Y., Trojanowski, John Q. · 2019 · JAMA Neurology
Entorhinal cortex dysfunction in Alzheimer's disease
Kei M. Igarashi · 2022 · Trends in Neurosciences
Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates
Benjamin Falcon, Annalisa Cavallini, Rachel C. Angers, Sarah J. Glover, Tracey K. Murray, Luanda Barnham, Samuel Jackson, Michael J. O'Neill, Adrian M. Isaacs, Michael L. Hutton et al. · 2014 · Journal of Biological Chemistry
Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo
Bolós, Marta, Llorens-Martín, María, Jurado-Arjona, Jerónimo, Hernández, Félix, Rábano, Alberto, Avila, Jesús · 2016 · Journal of Alzheimer's Disease
O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond
Scott A. Yuzwa, David J. Vocadlo · 2014 · Chemical Society Reviews
The synapse in traumatic brain injury
Aimun A. B. Jamjoom, Jonathan K. J. Rhodes, Peter Andrews, Seth G. N. Grant · 2020 · Brain
Functional connectivity associated with tau levels in ageing, Alzheimer’s, and small vessel disease
Nicolai Franzmeier, Anna Rubinski, Julia Neitzel, Yeshin Kim, Alexander Damm, Duk Lyul Na, Hee Jin Kim, Chul Hyoung Lyoo, Hanna Cho, Sofia Finsterwalder et al. · 2019 · Brain
Tau in neurodegenerative disease
Gao, Yong-Lei, Wang, Nan, Sun, Fu-Rong, Cao, Xi-Peng, Zhang, Wei, Yu, Jin-Tai · 2018 · Annals of Translational Medicine
Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation
Mirbaha, Hilda, Holmes, Brandon B., Sanders, David W., Bieschke, Jan, Diamond, Marc I. · 2015 · Journal of Biological Chemistry
Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau
McInnes, Joseph, Wierda, Keimpe, Snellinx, An, Bounti, Laura, Wang, Yu-Chun, Stancu, Ilie-Cosmin, Apóstolo, Nuno, Gevaert, Kris, Dewachter, Ilse, Spires-Jones, Tara L. et al. · 2018 · Neuron
Connectomics: A new paradigm for understanding brain disease
Alex Fornito, Edward Thomas Bullmore · 2014 · European Neuropsychopharmacology
Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation
David Howett, Andrea Castegnaro, Katarzyna Krzywicka, Johanna Hagman, Deepti Marchment, Richard N. Henson, Miguel Rio, John A. King, Neil Burgess, Dennis Chan · 2019 · Brain
Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse
Samuel G. A. Frère, Inna Slutsky · 2018 · Neuron
Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease
Pooler, Amy M, Polydoro, Manuela, Maury, Eduardo A, Nicholls, Samantha B, Reddy, Snigdha M, Wegmann, Susanne, William, Christopher, Saqran, Lubna, Cagsal-Getkin, Ozge, Pitstick, Rose et al. · 2015 · Acta Neuropathologica Communications
A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies
Miranda E. Orr, Anna Campbell Sullivan, Bess E Frost · 2017 · Trends in Pharmacological Sciences
Analyzing dendritic spine pathology in Alzheimer’s disease: Problems and opportunities
Dorostkar, Mario M., Zou, Chengyu, Blazquez-Llorca, Lidia, Herms, Jochen · 2015 · Acta Neuropathologica
miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo
Pascal Y. Smith, Julia Hernandez-Rapp, Francis Jolivette, Cynthia Lecours, Kanchan Bisht, Claudia Goupil, Veronique Dorval, Sepideh Parsi, Françoise Morin, Emmanuel Planel et al. · 2015 · Human Molecular Genetics
Soluble forms of tau are toxic in Alzheimer's disease
Kopeikina, Katherine, Hyman, Bradley, Spires-Jones, Tara · 2012 · Translational Neuroscience
Human secreted tau increases amyloid-beta production
Bright, Jessica, Hussain, Sami, Dang, Vu, Wright, Sarah, Cooper, Bonnie, Byun, Tony, Ramos, Carla, Singh, Andrew, Parry, Graham, Stagliano, Nancy et al. · 2015 · Neurobiology of Aging
Protein amyloids develop an intrinsic fluorescence signature during aggregation
Fiona T.S. Chan, Gabriele S. Kaminski Schierle, Janet R. Kumita, Carlos W. Bertoncini, Christopher Martin Dobson, Clemens F. Kaminski · 2013 · The Analyst
Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials
Markus Mandler, Elvira Valera, Edward M. Rockenstein, Harald Weninger, Christina Patrick, Anthony Adame, Radmila Santic, Stefanie Meindl, Benjamin Vigl, Oskar W. Smrzka et al. · 2014 · Acta Neuropathologica
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline
Heidi I.L. Jacobs, John Alex Becker, Kenneth K. Kwong, Nina Engels, Prokopis C. Prokopiou, Kathryn V. Papp, Michael J Properzi, Olivia L. Hampton, Federico d’Oleire Uquillas, Justin S. Sanchez et al. · 2021 · Science Translational Medicine
Mechanisms of Protein Seeding in Neurodegenerative Diseases
Walker, Lary C., Diamond, Marc I., Duff, Karen E., Hyman, Bradley T. · 2013 · JAMA Neurology
Developing Therapeutic Antibodies for Neurodegenerative Disease
Y. Joy Yu, Ryan J. Watts · 2013 · Neurotherapeutics
Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy
Chen‐Chen Tan, Jin‐Tai Yu, Meng‐Shan Tan, Teng Jiang, Xi‐Chen Zhu, Lan Tan · 2013 · Neurobiology of Aging
Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connections
Iba, Michiyo, McBride, Jennifer D., Guo, Jing L., Zhang, Bin, Trojanowski, John Q., Lee, Virginia M.-Y. · 2015 · Acta Neuropathologica
Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
Jada M. Lewis, Dennis W. Dickson · 2015 · Acta Neuropathologica
Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein
Simon Dujardin, Séverine Bégard, Raphaëlle Caillierez, Cédrick Lachaud, Lucie Delattre, Sébastien Carrier, Anne Loyens, Marie‐Christine Galas, Luc Bousset, Ronald Melki et al. · 2014 · PLoS ONE
Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease
Colgan, N., Siow, B., O'Callaghan, J.M., Harrison, I.F., Wells, J.A., Holmes, H.E., Ismail, O., Richardson, S., Alexander, D.C., Collins, E.C. et al. · 2016 · NeuroImage
Dendritic Spine Pathology in Neurodegenerative Diseases
Herms, Jochen, Dorostkar, Mario M. · 2016 · Annual Review of Pathology: Mechanisms of Disease
Dural lymphatics regulate clearance of extracellular tau from the CNS
Tirth K. Patel, LeMoyne Habimana-Griffin, Xuefeng Gao, Baogang J. Xu, Samuel Achilefu, Kari K. Alitalo, Celia A. McKee, Patrick W. Sheehan, Erik S. Musiek, Chengjie Xiong et al. · 2019 · Molecular Neurodegeneration
Intersection of pathological tau and microglia at the synapse
Vogels, Thomas, Murgoci, Adriana-Natalia, Hromádka, Tomáš · 2019 · Acta Neuropathologica Communications
Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice
Peeraer, Eve, Bottelbergs, Astrid, Van Kolen, Kristof, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Mahieu, Michel, Duytschaever, Hilde, Ver Donck, Luc, Torremans, An, Sluydts, Ellen et al. · 2015 · Neurobiology of Disease
Transmissible Proteins: Expanding the Prion Heresy
Claudio A. Soto · 2012 · Cell
Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes
Scheiblich, Hannah, Eikens, Frederik, Wischhof, Lena, Opitz, Sabine, Jüngling, Kay, Cserép, Csaba, Schmidt, Susanne V., Lambertz, Jessica, Bellande, Tracy, Pósfai, Balázs et al. · 2024 · Neuron
18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy
Luca Passamonti, Patricia Vázquez Rodríguez, Young T. Hong, Kieren S. J. Allinson, David Williamson, Robin Jacob Borchert, Saber A. K. Sami, Thomas Cope, William Richard Bevan-Jones, Peter Simon Jones et al. · 2016 · Brain
Modifiable Risk Factors for Alzheimer’s Disease
Edwards III, George A., Gamez, Nazaret, Escobedo Jr., Gabriel, Calderon, Olivia, Moreno-Gonzalez, Ines · 2019 · Frontiers in Aging Neuroscience
Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer‘s disease
Ludovic Collin, Bernd Bohrmann, Ulrich Göpfert, Krisztina Oroszlan‐Szovik, Laurence Ozmen, Fiona Grüninger · 2014 · Brain
DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins
Sarah N. Fontaine, Dali Zheng, Jonathan J. Sabbagh, Mackenzie D. Martin, Dale Chaput, April L. Darling, Justin H. Trotter, Andrew R. Stothert, Bryce A. Nordhues, April L. Lussier et al. · 2016 · The EMBO Journal
A role for tau at the synapse in Alzheimer’s disease pathogenesis
Pooler, Amy M., Noble, Wendy, Hanger, Diane P. · 2014 · Neuropharmacology
The paradox of syndromic diversity in Alzheimer disease
Jason D. Warren, Phillip D. Fletcher, Hannah L. Golden · 2012 · Nature Reviews Neurology
Synaptic oligomeric tau in Alzheimer’s disease — A potential culprit in the spread of tau pathology through the brain
Martí Colom‐Cadena, Caitlin Davies, Sònia Sirisi, Jieun Lee, Elizabeth M. Simzer, Makis Tzioras, Marta Querol‐Vilaseca, Érika Sánchez‐Aced, Ya Yin Chang, Kristján Holt et al. · 2023 · Neuron
Prion-like Properties of Tau Protein: The Importance of Extracellular Tau as a Therapeutic Target
Holmes, Brandon B., Diamond, Marc I. · 2014 · Journal of Biological Chemistry
Traumatic Brain Injury Induces Tau Aggregation and Spreading
Edwards, George, Zhao, Jing, Dash, Pramod K., Soto, Claudio, Moreno-Gonzalez, Ines · 2020 · Journal of Neurotrauma
Network Dysfunction in Alzheimer's Disease: Refining the Disconnection Hypothesis
Matthew R. Brier, Jewell Thomas, Beau M. Ances · 2014 · Brain Connectivity
Antibody Uptake into Neurons Occurs Primarily via Clathrin-dependent Fcγ Receptor Endocytosis and Is a Prerequisite for Acute Tau Protein Clearance
Congdon, Erin E., Gu, Jiaping, Sait, Hameetha B.R., Sigurdsson, Einar M. · 2013 · Journal of Biological Chemistry
It’s all about tau
Cheril Tapia‐Rojas, Fabian Cabezas-Opazo, Carol A. Deaton, Erick H. Vergara, Gail V.W. Johnson, Rodrigo A. Quintanilla · 2018 · Progress in Neurobiology
The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush
Susanne Wegmann, Izhar D. Medalsy, Eckhard Mandelkow�, Daniel J. Müller · 2012 · Proceedings of the National Academy of Sciences
Human-to-mouse prion-like propagation of mutant huntingtin protein
Iksoo Jeon, Francesca Cicchetti, Giulia Cisbani, Suji Lee, Endan Li, Jiwoo Bae, Nayeon Lee, Ling Li, Wooseok Im, Manho Kim et al. · 2016 · Acta Neuropathologica
Mutant huntingtin is present in neuronal grafts in huntington disease patients
Cicchetti, Francesca, Lacroix, Steve, Cisbani, Giulia, Vallières, Nicolas, Saint‐Pierre, Martine, St‐Amour, Isabelle, Tolouei, Ranna, Skepper, Jeremy N., Hauser, Robert A., Mantovani, Diego et al. · 2014 · Annals of Neurology
From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy
Colin, Morvane, Dujardin, Simon, Schraen-Maschke, Susanna, Meno-Tetang, Guy, Duyckaerts, Charles, Courade, Jean-Philippe, Buée, Luc · 2020 · Acta Neuropathologica
Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies
Mathieu Bourdenx, Nikolaos Stavros Koulakiotis, Despina Sanoudou, Erwan Bézard, Benjamin Dehay, Anthony Tsarbopoulos · 2015 · Progress in Neurobiology
Epigenetic Pathways in Human Disease: The Impact of DNA Methylation on Stress-Related Pathogenesis and Current Challenges in Biomarker Development
M. Austin Argentieri, Sairaman Nagarajan, Bobak Seddighzadeh, Andrea Baccarelli, Alexandra E. Shields · 2017 · EBioMedicine
Anti‐tau antibody reduces insoluble tau and decreases brain atrophy
Yanamandra, Kiran, Jiang, Hong, Mahan, Thomas E., Maloney, Susan E., Wozniak, David F., Diamond, Marc I., Holtzman, David M. · 2015 · Annals of Clinical and Translational Neurology
Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo
Vasconcelos, Bruno, Stancu, Ilie-Cosmin, Buist, Arjan, Bird, Matthew, Wang, Peng, Vanoosthuyse, Alexandre, Van Kolen, Kristof, Verheyen, An, Kienlen-Campard, Pascal, Octave, Jean-Noël et al. · 2016 · Acta Neuropathologica
Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons
Eline Pecho‐Vrieseling, Claus Rieker, Sascha Fuchs, Dorothée Bleckmann, Maria Soledad Esposito, Paolo Botta, Chris Goldstein, Mario Bernhard, Ivan Galimberti, Mathias M. Müller et al. · 2014 · Nature Neuroscience
Prion-like spread of protein aggregates in neurodegeneration
Polymenidou, Magdalini, Cleveland, Don W. · 2012 · Journal of Experimental Medicine
Amyloid assembly and disassembly
Edward Chuang, Acacia M Hori, Christina D. Hesketh, James Shorter · 2018 · Journal of Cell Science
Frontotemporal lobar degeneration
Grossman, Murray, Seeley, William W., Boxer, Adam L., Hillis, Argye E., Knopman, David S., Ljubenov, Peter A., Miller, Bruce, Piguet, Olivier, Rademakers, Rosa, Whitwell, Jennifer L. et al. · 2023 · Nature Reviews Disease Primers
Fluid Biomarkers for Synaptic Dysfunction and Loss
Camporesi, Elena, Nilsson, Johanna, Brinkmalm, Ann, Becker, Bruno, Ashton, Nicholas J, Blennow, Kaj, Zetterberg, Henrik · 2020 · Biomarker Insights
Tau Oligomers Impair Artificial Membrane Integrity and Cellular Viability
Flach, Katharina, Hilbrich, Isabel, Schiffmann, Andrea, Gärtner, Ulrich, Krüger, Martin, Leonhardt, Marion, Waschipky, Hanka, Wick, Lukas, Arendt, Thomas, Holzer, Max · 2012 · Journal of Biological Chemistry
Networks of tau distribution in Alzheimer’s disease
Merle C. Hoenig, Gérard N. Bischof, Joseph Seemiller, Jochen Hammes, Juraj Kukolja, Oezguer A. Onur, Frank Jessen, Klaus Fließbach, Bernd Neumaier, Gereon R. Fink et al. · 2017 · Brain
Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody
Marie Albert, Georges Mairet‐Coello, Clément Danis, Sarah Lieger, Raphaëlle Caillierez, Sébastien Carrier, Emilie Skrobala, Isabelle Landrieu, Anne Michel, Mathieu Schmitt et al. · 2019 · Brain
Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology
Michel, Claire H., Kumar, Satish, Pinotsi, Dorothea, Tunnacliffe, Alan, St. George-Hyslop, Peter, Mandelkow, Eckhard, Mandelkow, Eva-Maria, Kaminski, Clemens F., Kaminski Schierle, Gabriele S. · 2014 · Journal of Biological Chemistry
The concept of alpha-synuclein as a prion-like protein: ten years after
Steiner, Jennifer A., Quansah, Emmanuel, Brundin, Patrik · 2018 · Cell and Tissue Research
Synaptic pathology: A shared mechanism in neurological disease
Christopher M. Henstridge, Eleanor K. Pickett, Tara L. Spires‐Jones · 2016 · Ageing Research Reviews
In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain
Jorge Sepulcre, Aaron P. Schultz, Mert Rory Sabuncu, Teresa Gómez‐Isla, Jasmeer P. Chhatwal, Alex Becker, Reisa Anne Sperling, Keith A. Johnson · 2016 · Journal of Neuroscience
Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer’s disease
Nicolai Franzmeier, Anna Dewenter, Lukas K. Frontzkowski, Martin Dichgans, Anna Rubinski, Julia Neitzel, Ruben A Smith, Olof T. Strandberg, Rik Ossenkoppele, Katharina Büerger et al. · 2020 · Science Advances
Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses
2024 · aging and disease
Intercellular (Mis)communication in Neurodegenerative Disease
Gwenn A. Garden, Albert R. La Spada · 2012 · Neuron
Two Novel Tau Antibodies Targeting the 396/404 Region Are Primarily Taken Up by Neurons and Reduce Tau Protein Pathology
Jiaping Gu, Erin E. Congdon, Einar M. Sigurdsson · 2013 · Journal of Biological Chemistry
Tau Oligomers: The Toxic Player at Synapses in Alzheimer’s Disease
Guerrero-Muñoz, Marcos J., Gerson, Julia, Castillo-Carranza, Diana L. · 2015 · Frontiers in Cellular Neuroscience