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Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain
Open accessAbstract
We used affinity-purification mass spectrometry to identify 747 candidate proteins that are complexed with Huntingtin (Htt) in distinct brain regions and ages in Huntington's disease (HD) and wild-type mouse brains. To gain a systems-level view of the Htt interactome, we applied Weighted Correlation Network Analysis to the entire proteomic data set to unveil a verifiable rank of Htt-correlated proteins and a network of Htt-interacting protein modules, with each module highlighting distinct aspects of Htt biology. Importantly, the Htt-containing module is highly enriched with proteins involved in 14-3-3 signaling, microtubule-based transport, and proteostasis. Top-ranked proteins in this module were validated as Htt interactors and genetic modifiers in an HD Drosophila model. Our study provides a compendium of spatiotemporal Htt-interacting proteins in the mammalian brain and presents an approach for analyzing proteomic interactome data sets to build in vivo protein networks in complex tissues, such as the brain.
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“Interestingly, in vivo PPI screening by large-scale co-immunoprecipitation and mass spectrometry provided tissue- and time-specific information that was not found by Y2H studies167.”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [167]
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“WGCNA identified spatially and temporally specific modules associated with mutant Htt (which encodes huntingtin); and proteins with high intra-modular connectivity (hub proteins) modulated neurodegeneration in flies.”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [167]
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Metadata
- Authors
- Shirasaki, D. I., Greiner, E. R., Al-Ramahi, I., Gray, M., Boontheung, P., Geschwind, D. H., Botas, J., Coppola, G., Horvath, S., Loo, J. A., & Yang, X. W.
- Affiliations
- University of California, Los Angeles (US)
- Baylor College of Medicine (US)
- Corresponding author
- Loo, Joseph A.
- Yang, X. William
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 75
- Issue
- 1
- Pages
- 41-57
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3432264
- OpenAlex
- W2028159081
- Cited by
- 297
- References
- 77
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 17 · 2023: 13 · 2022: 28 · 2021: 31 · 2020: 26 · 2019: 18 · 2018: 27 · 2017: 28 · 2016: 22 · 2015: 19 · 2014: 22 · 2013: 19 · 2012: 1
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R37MH060233)
- National Institute on Drug Abuse (R01DA030913)
- National Institute of General Medical Sciences (T32GM008496, R01GM103479)
- National Institute of Neurological Disorders and Stroke (T32NS043124, R01NS049501, R01NS074312, P30NS062691)
- National Center for Research Resources (R01RR020004, R01RR20004)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- huntingtin, protein-protein interaction network, Huntington's disease, brain regions, age-related changes, microtubule transport, proteostasis, genetic modifiers, Drosophila model, weighted gene co-expression network analysis
- MeSH terms
- Huntingtin Protein, Animals, Brain, Disease Models, Animal, Drosophila, Female, Humans, Mice, Transgenic, Nerve Tissue Proteins, Proteomics, Mice, Gene Regulatory Networks
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