Cited by 489Deep Brain Stimulation and Movement DisordersNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

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Differential Innervation of Direct- and Indirect-Pathway Striatal Projection Neurons

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Wall, Nicholas R., De La Parra, Mauricio, Callaway, Edward M., Kreitzer, Anatol C.·2013·Neuron

DOI 10.1016/j.neuron.2013.05.014PMC PMC3729794

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Abstract

The striatum integrates information from multiple brain regions to shape motor learning. The two major projection cell types in striatum target different downstream basal ganglia targets and have opposing effects on motivated behavior, yet differential innervation of these neuronal subtypes is not well understood. To examine whether input specificity provides a substrate for information segregation in these circuits, we used a monosynaptic rabies virus system to generate brain-wide maps of neurons that form synapses with direct- or indirect-pathway striatal projection neurons. We discovered that sensory cortical and limbic structures preferentially innervated the direct pathway, whereas motor cortex preferentially targeted the indirect pathway. Thalamostriatal input, dopaminergic input, as well as input from specific cortical layers, was similar onto both pathways. We also confirm synaptic innervation of striatal projection neurons by the raphe and pedunculopontine nuclei. Together, these findings provide a framework for guiding future studies of basal ganglia circuit function.

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Self-citation

Authors: Wall, N. R., De La Parra, M., Callaway, E. M., & Kreitzer, A. C.
Affiliations: Salk Institute for Biological Studies (US)
Gladstone Institutes (US)
Corresponding author: Callaway, Edward M.
Kreitzer, Anatol C.
ORCID: Wall, Nicholas R.
Callaway, Edward M.
Kreitzer, Anatol C.
Venue: Neuron
Publisher: Elsevier BV
Published: 2013-07
Volume: 79
Issue: 2
Pages: 347-360
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2013.05.014
PMC: PMC3729794
OpenAlex: W2074651284
Cited by: 489
References: 69
Citations by year: 2026: 19 · 2025: 33 · 2024: 39 · 2023: 40 · 2022: 28 · 2021: 44 · 2020: 38 · 2019: 36 · 2018: 42 · 2017: 48 · 2016: 53 · 2015: 34 · 2014: 32 · 2013: 3
FWCI: 25.83
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 388 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Gatsby Charitable Foundation
National Institutes of Health
National Institute of Mental Health (MH063912, R01MH063912)
National Institute on Drug Abuse (P01DA010154, DA-010154)
National Institute of Neurological Disorders and Stroke (NS064984, R01NS078435, R01NS064984)
Topics: Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: striatum, direct pathway, indirect pathway, striatal projection neurons, synaptic innervation, basal ganglia, dopaminergic input, motor cortex, sensory cortex, limbic structures, raphe nuclei, information segregation, motor learning
MeSH terms: Animals, Cerebral Cortex, Corpus Striatum, Female, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neural Pathways, Neurons, Mice, HEK293 Cells

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Differential Innervation of Direct- and Indirect-Pathway Striatal Projection Neurons

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