Cited by 63Axon Guidance and Neuronal SignalingNerve injury and regenerationNeurogenesis and neuroplasticity mechanisms

SAD Kinases Sculpt Axonal Arbors of Sensory Neurons through Long- and Short-Term Responses to Neurotrophin Signals

Open access
Lilley, Brendan N., Pan, Y. Albert, Sanes, Joshua R.·2013·Neuron

Abstract

Extrinsic cues activate intrinsic signaling mechanisms to pattern neuronal shape and connectivity. We showed previously that three cytoplasmic Ser/Thr kinases, LKB1, SAD-A, and SAD-B, control early axon-dendrite polarization in forebrain neurons. Here, we assess their role in other neuronal types. We found that all three kinases are dispensable for axon formation outside of the cortex but that SAD kinases are required for formation of central axonal arbors by subsets of sensory neurons. The requirement for SAD kinases is most prominent in NT-3 dependent neurons. SAD kinases transduce NT-3 signals in two ways through distinct pathways. First, sustained NT-3/TrkC signaling increases SAD protein levels. Second, short-duration NT-3/TrkC signals transiently activate SADs by inducing dephosphorylation of C-terminal domains, thereby allowing activating phosphorylation of the kinase domain. We propose that SAD kinases integrate long- and short-duration signals from extrinsic cues to sculpt axon arbors within the CNS.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2013.05.017

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Several genes were assigned to clusters enriched for gene sets consistent with their known functions, including KDM1B, BRSK2, and ITSN1, consistent with published functional evidence.

    “Several genes were assigned to clusters that showed enrichment for gene sets consistent with their known functions, including KDM1B,41 BRSK2,42 and ITSN143 consistent with published functional evidence”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Lilley, B. N., Pan, Y. A., & Sanes, J. R.
Affiliations
Harvard University (US)
Corresponding author
Sanes, Joshua R.
Venue
Neuron
Publisher
Elsevier BV
Published
2013-07
Volume
79
Issue
1
Pages
39-53
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2071055050
Cited by
63
References
69
Citations by year
2026: 3 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 8 · 2019: 3 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 5
FWCI
3.93
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Damon Runyon Cancer Research Foundation
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (R21NS076880, R37NS019195, R01NS029169)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
LKB1, sensory neurons, neurotrophin signaling, neurotrophin-3, TrkC, kinase dephosphorylation, kinase activation, central nervous system neurons
MeSH terms
Animals, Axons, Cerebral Cortex, HeLa Cells, Humans, Sensory Receptor Cells, Signal Transduction, Cell Polarity, Protein Serine-Threonine Kinases, Receptor, trkC, Neurotrophin 3, Mice, AMP-Activated Protein Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review