The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear
Open accessAbstract
SUMMARY Sensory transduction in auditory and vestibular hair cells requires expression of transmembrane channel-like (Tmc) 1 and 2 genes, but the function of these genes is unknown. To investigate the hypothesis that TMC1 and TMC2 proteins are components of the mechanosensitive ion channels that convert mechanical information into electrical signals, we recorded whole-cell and single-channel currents from mouse hair cells that expressed Tmc1, Tmc2 or mutant Tmc1. Cells that expressed mutant Tmc1 had reduced calcium permeability and reduced single-channel currents, while Tmc2 cells had high calcium permeability and large single-channel currents. Cells that expressed both Tmc1 and Tmc2 had a broad range of single-channel currents, suggesting multiple heteromeric assemblies of TMC subunits. The data demonstrate TMC1 and TMC2 are components of hair cell transduction channels and contribute to permeation properties. Gradients in TMC channel composition may also contribute to variation in sensory transduction along the tonotopic axis of the mammalian cochlea.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kubisch, C., Schroeder, B. C., Friedrich, T., Lütjohann, B., El-Amraoui, A., Marlin, S., Petit, C., & Jentsch, T. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80556-5 · Cited by 867
Greer, P. L., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.002 · Cited by 661
Kinetics of the receptor current in bullfrog saccular hair cells
Corey, D., & Hudspeth, A. (1983) · The Journal of Neuroscience · doi:10.1523/jneurosci.03-05-00962.1983 · Cited by 545
O'Hagan, R., Chalfie, M., & Goodman, M. B. (2005) · Nature Neuroscience · doi:10.1038/nn1362 · Cited by 516
TRP channels in mechanosensation: direct or indirect activation?
Christensen, A. P., & Corey, D. P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2149 · Cited by 513
Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging
Beurg, M., Fettiplace, R., Nam, J.-H., & Ricci, A. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2295 · Cited by 483
Kurima, K., Peters, L. M., Yang, Y., Riazuddin, S., Ahmed, Z. M., Naz, S., Arnaud, D., Drury, S., Mo, J., Makishima, T., et al. (2002) · Nature Genetics · doi:10.1038/ng842 · Cited by 473
Self-citationMechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes
Kawashima, Y., Géléoc, G. S. G., Kurima, K., Labay, V., Lelli, A., Asai, Y., Makishima, T., Wu, D. K., Della Santina, C. C., Holt, J. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci60405 · Cited by 460
Self-citationEukaryotic Mechanosensitive Channels
Árnadóttir, J., & Chalfie, M. (2010) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125836 · Cited by 418
Steel, K. P., & Barkway, C. (1989) · Development · doi:10.1242/dev.107.3.453 · Cited by 412
Cited by
Mechanically Activated Ion Channels
Ranade, S. S., Syeda, R., & Patapoutian, A. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.032 · Cited by 652
Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets
Di, X., Gao, X., Peng, L., Ai, J., Jin, X., Qi, S., Li, H., Wang, K., & Luo, D. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01501-9 · Cited by 622
Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents
Gao, X., Tao, Y., Lamas, V., Huang, M., Yeh, W.-H., Pan, B., Hu, Y.-J., Hu, J. H., Thompson, D. B., Shu, Y., et al. (2018) · Nature · doi:10.1038/nature25164 · Cited by 536
Self-citationTMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells
Pan, B., Akyuz, N., Liu, X.-P., Asai, Y., Nist-Lund, C., Kurima, K., Derfler, B. H., György, B., Limapichat, W., Walujkar, S., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.033 · Cited by 357
Self-citationThe Physiology of Mechanoelectrical Transduction Channels in Hearing
Fettiplace, R., & Kim, K. X. (2014) · Physiological Reviews · doi:10.1152/physrev.00038.2013 · Cited by 313
Metadata
- Authors
- Pan, B., Géléoc, G. S., Asai, Y., Horwitz, G. C., Kurima, K., Ishikawa, K., Kawashima, Y., Griffith, A. J., & Holt, J. R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 79
- Issue
- 3
- Pages
- 504-515
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2023895951
- Cited by
- 447
- References
- 32
- FWCI
- 17.29
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear. https://app.cochat.ai/papers/10.1016/j.neuron.2013.06.019
- The paper
- Pan, B., Géléoc, G. S., Asai, Y., Horwitz, G. C., Kurima, K., Ishikawa, K., Kawashima, Y., Griffith, A. J., & Holt, J. R. (2013). TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear. Neuron. https://doi.org/10.1016/j.neuron.2013.06.019
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
