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Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging
Open accessAbstract
Hair cells detect vibrations of their stereociliary bundle by activation of mechanically sensitive transducer channels. Although evidence suggests the transducer channels are near the stereociliary tops and are opened by force imparted by tip links connecting contiguous stereocilia, the exact channel site remains controversial. We used fast confocal imaging of fluorescence changes reflecting calcium entry during bundle stimulation to localize the channels. Calcium signals were visible in single stereocilia of rat cochlear inner hair cells and were up to tenfold larger and faster in the second and third stereociliary rows than in the tallest first row. The number of functional stereocilia was proportional to transducer current amplitude, indicating that there were about two channels per stereocilium. Comparable results were obtained in outer hair cells. The observations, supported by theoretical simulations, suggest there are no functional mechanically sensitive transducer channels in first row stereocilia and imply the channels are present only at the bottom of the tip links.
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Citations
Cited by
Mechanically Activated Ion Channels
Ranade, S. S., Syeda, R., & Patapoutian, A. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.032 · Cited by 652
Pan, B., Géléoc, G. S., Asai, Y., Horwitz, G. C., Kurima, K., Ishikawa, K., Kawashima, Y., Griffith, A. J., & Holt, J. R. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.019 · Cited by 447
TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells
Pan, B., Akyuz, N., Liu, X.-P., Asai, Y., Nist-Lund, C., Kurima, K., Derfler, B. H., György, B., Limapichat, W., Walujkar, S., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.033 · Cited by 357
The Physiology of Mechanoelectrical Transduction Channels in Hearing
Fettiplace, R., & Kim, K. X. (2014) · Physiological Reviews · doi:10.1152/physrev.00038.2013 · Cited by 313
Self-citationGiese, A. P. J., Weng, W.-H., Kindt, K. S., Chang, H. H. V., Montgomery, J. S., Ratzan, E. M., Beirl, A. J., Rivera, R. A., Lotthammer, J. M., Walujkar, S., et al. (2023) · doi:10.1101/2023.05.26.542533 · Cited by 8
Metadata
- Authors
- Beurg, M., Fettiplace, R., Nam, J.-H., & Ricci, A. J.
- Venue
- Nature Neuroscience
- Published
- 2009-03-29
- Volume
- 12
- Issue
- 5
- Pages
- 553-558
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2163356019
- Cited by
- 483
- References
- 0
- FWCI
- 13.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Beurg, M., Fettiplace, R., Nam, J.-H., & Ricci, A. J. (2009). Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging. Nature Neuroscience. https://doi.org/10.1038/nn.2295
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