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Christianson Syndrome Protein NHE6 Modulates TrkB Endosomal Signaling Required for Neuronal Circuit Development
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NHE6 depletion acidifies early and recycling endosomes.
“NHE6 depletion acidifies early and recycling endosomes (Lucien et al., 2017; Ohgaki et al., 2010; Ouyang et al., 2013; Xinhan et al., 2011).”
From NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load (2021) · cites this paper as Ouyang et al., 2013
Neuronal NHE6 plays a direct role in both synaptic development and plasticity, potentially through BDNF/TrkB and other pathways.
“Neuronal NHE6 plays a direct role in both synaptic development and plasticity, potentially through BDNF/TrkB (Deane et al., 2013; Ouyang et al., 2013) and other pathways.”
From NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load (2021) · cites this paper as Ouyang et al., 2013
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NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load
Pohlkamp, T., Xian, X., Wong, C. H., Durakoglugil, M. S., Werthmann, G. C., Saido, T. C., Evers, B. M., White, C. L., Connor, J., Hammer, R. E., et al. (2021) · eLife · doi:10.7554/elife.72034 · Cited by 46
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NHX-5, an endosomal Na+/H+ exchanger, is associated with metformin action
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Metadata
- Authors
- Ouyang, Q., Lizarraga, S. B., Schmidt, M., Yang, U., Gong, J., Ellisor, D., Kauer, J. A., & Morrow, E. M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 80
- Issue
- 1
- Pages
- 97-112
- ISSN
- 0896-6273
- PMC
- PMC3830955
- Cited by
- 144
- References
- 6
- Language
- en
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