The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction
Open accessAbstract
SUMMARY The ten-eleven translocation (Tet) family of methylcytosine dioxygenases catalyze oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylacytosine (5hmC) and promote DNA demethylation. Despite the abundance of 5hmC and Tet proteins in the brain, little is known about the functions of the neuronal Tet enzymes. Here, we analyzed Tet1 knockout mice (Tet1KO) and found downregulation of multiple neuronal activity-regulated genes, including Npas4, c-Fos, and Arc. Furthermore, Tet1KO animals exhibited abnormal hippocampal long-term depression and impaired memory extinction. Analysis of the key regulatory gene, Npas4, indicated that its promoter region, containing multiple CpG dinucleotides, is hypermethylated in both naive Tet1KO mice and following extinction training. Such hypermethylation may account for the diminished expression of Npas4 itself and its downstream targets, impairing transcriptional programs underlying cognitive processes. In summary, we show that neuronal Tet1 regulates normal DNA methylation levels, expression of activity-regulated genes, synaptic plasticity, and memory extinction.
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Cites
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Self-citationConversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836
Morris water maze: procedures for assessing spatial and related forms of learning and memory
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“These brain regions were chosen as both cingulate cortex and hippocampus have been implicated in contextual memory extinction and cognitive flexibility (Myers and Davis, 2007; Floresco and Jentsch, 2011; Etkin et al., 2011).”
MethodTet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
He, Y.-F., Li, B.-Z., Li, Z., Liu, P., Wang, Y., Tang, Q., Ding, J., Jia, Y., Chen, Z., Li, L., et al. (2011) · Science · doi:10.1126/science.1210944 · Cited by 2,770
The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
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Driving fast-spiking cells induces gamma rhythm and controls sensory responses
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Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain
Guo, J. U., Su, Y., Zhong, C., Ming, G.-L., & Song, H. (2011) · Cell · doi:10.1016/j.cell.2011.03.022 · Cited by 1,360
Cited by
TET-mediated active DNA demethylation: mechanism, function and beyond
Wu, X., & Zhang, Y. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.33 · Cited by 1,661
Role of TET enzymes in DNA methylation, development, and cancer
Rasmussen, K. D., & Helin, K. (2016) · Genes & Development · doi:10.1101/gad.276568.115 · Cited by 1,040
Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions
Wu, H., & Zhang, Y. (2014) · Cell · doi:10.1016/j.cell.2013.12.019 · Cited by 1,065
“Another study of adult Tet1 / mice revealed that multiple neuronal activity-regulated genes, including Npas4, c-Fos, and Arc, are transcriptionally downregulated, and promoter of Npas4 becomes hypermethylated in absence of TET1 (Rudenko et al., 2013).”
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis
Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637
Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390
“Furthermore, gene knockdown of Tet1 impairs extinction (Rudenko et al., 2013).”
Background
Metadata
- Authors
- Rudenko, A., Dawlaty, M. M., Seo, J., Cheng, A. W., Meng, J., Le, T., Faull, K. F., Jaenisch, R., & Tsai, L.-H.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 79
- Issue
- 6
- Pages
- 1109-1122
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2073902410
- Cited by
- 441
- References
- 74
- FWCI
- 27.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rudenko, A., Dawlaty, M. M., Seo, J., Cheng, A. W., Meng, J., Le, T., Faull, K. F., Jaenisch, R., & Tsai, L.-H. (2013). Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction. Neuron. https://doi.org/10.1016/j.neuron.2013.08.003
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