The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain
Open accessAbstract
SUMMARY Cytosine methylation is the major covalent modification of mammalian genomic DNA and plays important roles in transcriptional regulation. The molecular mechanism underlying the enzymatic removal of this epigenetic mark, however, remains elusive. Here we show that 5-methylcytosine (5mC) hydroxylase TET1, by converting 5mCs to 5-hydroxymethylcytosines (5hmCs), promotes DNA demethylation in mammalian cells through a process that requires the base-excision repair pathway. While expression of the 12 known human DNA glycosylases individually did not enhance removal of 5hmCs in mammal cells, demethylation of both exogenously introduced and endogenous 5hmCs is promoted by the AID (activation-induced deaminase)/APOBEC (apolipoprotein B mRNA-editing enzyme complex) family of cytidine deaminases. Furthermore, Tet1 and Apobec1 are involved in neuronal activity-induced, region-specific, active DNA demethylation and subsequent gene expression in the dentate gyrus of the adult mouse brain in vivo. Our study suggests a TET1-induced oxidation-deamination mechanism for active DNA demethylation in mammals.
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Cites
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Human DNA methylomes at base resolution show widespread epigenomic differences
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The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
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Stability and flexibility of epigenetic gene regulation in mammalian development
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“Cytosine methylation is catalyzed by a family of DNA methyltransferases (DNMTs), and deficiencies in these enzymes result in profound developmental defects (Goll and Bestor, 2005; Reik, 2007).”
Molecular Signals of Epigenetic States
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Cited by
DNA methylation and its basic function
Moore, L. D., Le, T., & Fan, G. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.112 · Cited by 4,906
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
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Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
Self-citationIDH mutation impairs histone demethylation and results in a block to cell differentiation
Lu, C., Ward, P. S., Kapoor, G. S., Rohle, D., Turcan, S., Abdel-Wahab, O., Edwards, C. R., Khanin, R., Figueroa, M. E., Melnick, A., et al. (2012) · Nature · doi:10.1038/nature10860 · Cited by 1,985
Global epigenomic reconfiguration during mammalian brain development
Lister, R., Mukamel, E. A., Nery, J. R., Urich, M., Puddifoot, C. A., Johnson, N. D., Lucero, J., Huang, Y., Dwork, A. J., Schultz, M. D., et al. (2013) · Science · doi:10.1126/science.1237905 · Cited by 1,830
Metadata
- Authors
- Guo, J. U., Su, Y., Zhong, C., Ming, G.-L., & Song, H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 145
- Issue
- 3
- Pages
- 423-434
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2032882684
- Cited by
- 1,360
- References
- 10
- FWCI
- 66.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Guo, J. U., Su, Y., Zhong, C., Ming, G.-L., & Song, H. (2011). Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain. Cell. https://doi.org/10.1016/j.cell.2011.03.022
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