A Role for Correlated Spontaneous Activity in the Assembly of Neural Circuits
Open accessAbstract
Before the onset of sensory transduction, developing neural circuits spontaneously generate correlated activity in distinct spatial and temporal patterns. During this period of patterned activity, sensory maps develop and initial coarse connections are refined, which are critical steps in the establishment of adult neural circuits. Over the last decade, there has been substantial evidence that altering the pattern of spontaneous activity disrupts refinement, but the mechanistic understanding of this process remains incomplete. In this review, we discuss recent experimental and theoretical progress toward the process of activity-dependent refinement, focusing on circuits in the visual, auditory, and motor systems. Although many outstanding questions remain, the combination of several novel approaches has brought us closer to a comprehensive understanding of how complex neural circuits are established by patterned spontaneous activity during development.
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Early synchronous events are thought to play a fundamental role in the maturation of neuronal circuits.
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- Authors
- Kirkby, L. A., Sack, G. S., Firl, A., & Feller, M. B.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Feller, Marla B.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 80
- Issue
- 5
- Pages
- 1129-1144
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4560201
- OpenAlex
- W2145935221
- Cited by
- 338
- References
- 16
- Citations by year
- 2026: 20 · 2025: 25 · 2024: 28 · 2023: 20 · 2022: 28 · 2021: 36 · 2020: 32 · 2019: 24 · 2018: 25 · 2017: 19 · 2016: 37 · 2015: 25 · 2014: 19
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Update notices
- erratum (2014-01-08)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Eye Institute (R01EY013528)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- neural circuit assembly, visual system development, auditory development, motor system development
- MeSH terms
- Animals, Brain, Brain Mapping, Humans, Models, Neurological, Nerve Net, Neural Pathways, Neurons
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