Cited by 154Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationIon Channels and Receptors

The cellular and molecular basis of somatosensory neuron development

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Meltzer, Shan, Santiago, Celine, Sharma, Nikhil, Ginty, David D.·2021·Neuron

Abstract

Primary somatosensory neurons convey salient information about our external environment and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of innocuous and noxious stimuli. Pseudo-unipolar in shape, and among the largest (longest) cells of most mammals, dorsal root ganglia (DRG) somatosensory neurons have peripheral axons that extend into skin, muscle, viscera, or bone and central axons that innervate the spinal cord and brainstem, where they synaptically engage the central somatosensory circuitry. Here, we review the diversity of mammalian DRG neuron subtypes and the intrinsic and extrinsic mechanisms that control their development. We describe classical and contemporary advances that frame our understanding of DRG neurogenesis, transcriptional specification of DRG neurons, and the establishment of morphological, physiological, and synaptic diversification across somatosensory neuron subtypes.

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Crossref · 10.1016/j.neuron.2021.09.004

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  • Sensory neurons in skin organoids form ganglia and fasciculated axons mimicking the architecture of a dorsal root or trigeminal ganglion/nerve in the body.

    “We have identified that sensory neurons in skin organoids form ganglia and fasciculated axons mimicking the architecture of a dorsal root or trigeminal ganglion/nerve in the body”

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2 of the 199 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Grueber WB, and Sagasti A (2010b). Self-avoidance and tiling: Mechanisms of dendrite and axon spacing. Cold Spring Harbor Perspectives in Biology 2, a001750– a001750. 20573716 PMC2926746
  2. Ozaki S, and Snider WD (1997). Initial trajectories of sensory axons toward laminar targets in the developing mouse spinal cord. J. Comp. Neurol. 380, 215– 229. 9100133
  3. Segal RA (2003). Selectivity in neurotrophin signaling: theme and variations. Annu. Rev. Neurosci. 26, 299– 330. 12598680

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Authors
Meltzer, S., Santiago, C., Sharma, N., & Ginty, D. D.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Ginty, David D.
Venue
Neuron
Publisher
Elsevier BV
Published
2021-12
Volume
109
Issue
23
Pages
3736-3757
ISSN
0896-6273 (ISSN-L)
OpenAlex
W3202416243
Cited by
149
References
199
Citations by year
2026: 38 · 2025: 33 · 2024: 39 · 2023: 23 · 2022: 15 · 2021: 1
FWCI
3.12
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • Israel National Road Safety Authority (5F32NS106807-03)
  • National Institutes of Health (1R01 AT011447-01, R35 5R35NS097344-05)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
somatosensory neurons, dorsal root ganglia, neuronal development, peripheral nervous system development, nociception
MeSH terms
Animals, Axons, Ganglia, Spinal, Mammals, Neurons, Spinal Cord, Neurogenesis

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