Cited by 227Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchDeep Brain Stimulation and Movement Disorders

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Dopamine D2 Receptors Regulate the Anatomical and Functional Balance of Basal Ganglia Circuitry

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Cazorla, Maxime, de Carvalho, Fernanda Delmondes, Chohan, Muhammad O., Shegda, Mariya, Chuhma, Nao, Rayport, Stephen, Ahmari, Susanne E., Moore, Holly, Kellendonk, Christoph·2014·Neuron

DOI 10.1016/j.neuron.2013.10.041PMC PMC3899717

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Abstract

Structural plasticity in the adult brain is essential for adaptive behavior. We have found a remarkable anatomical plasticity in the basal ganglia of adult mice that is regulated by dopamine D2 receptors (D2Rs). By modulating neuronal excitability, striatal D2Rs bidirectionally control the density of direct pathway collaterals in the globus pallidus that bridge the direct pathway with the functionally opposing indirect pathway. An increase in bridging collaterals is associated with enhanced inhibition of pallidal neurons in vivo and disrupted locomotor activation after optogenetic stimulation of the direct pathway. Chronic blockade with haloperidol, an antipsychotic medication used to treat schizophrenia, decreases the extent of bridging collaterals and rescues the locomotor imbalance. These findings identify a role for bridging collaterals in regulating the concerted balance of striatal output and may have important implications for understanding schizophrenia, a disease involving excessive activation of striatal D2Rs that is treated with D2R blockers.

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Authors: Cazorla, M., de Carvalho, F. D., Chohan, M. O., Shegda, M., Chuhma, N., Rayport, S., Ahmari, S. E., Moore, H., & Kellendonk, C.
Affiliations: New York State Psychiatric Institute (US)
University of Pittsburgh (US)
Columbia University Irving Medical Center (US)
Corresponding author: Kellendonk, Christoph
ORCID: Cazorla, Maxime
Chohan, Muhammad O.
Chuhma, Nao
Rayport, Stephen
Ahmari, Susanne E.
Moore, Holly
Kellendonk, Christoph
Venue: Neuron
Publisher: Elsevier BV
Published: 2014-01
Volume: 81
Issue: 1
Pages: 153-164
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2013.10.041
PMC: PMC3899717
OpenAlex: W1993833941
Cited by: 226
References: 43
Citations by year: 2026: 5 · 2025: 10 · 2024: 8 · 2023: 24 · 2022: 9 · 2021: 22 · 2020: 22 · 2019: 28 · 2018: 22 · 2017: 18 · 2016: 35 · 2015: 15 · 2014: 8
FWCI: 11.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 372 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
Funders: National Institute of Mental Health (P50MH086404, R01MH093672, K08MH087718)
National Institute on Drug Abuse (R01DA038966)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords: dopamine D2 receptor, basal ganglia, anatomical plasticity, direct pathway, indirect pathway, globus pallidus, striatal output, neuronal excitability, locomotor behavior, haloperidol, schizophrenia, antipsychotic drugs, dopamine D2 receptor antagonists
MeSH terms: Action Potentials, Animals, Basal Ganglia, Corpus Striatum, Doxycycline, Gene Expression Regulation, Globus Pallidus, Haloperidol, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Nerve Net, Neural Pathways, Neurons, Time Factors, Receptors, Dopamine D1, Receptors, Dopamine D2, Dopamine Antagonists, Potassium Channels, Inwardly Rectifying, Green Fluorescent Proteins, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2

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Dopamine D2 Receptors Regulate the Anatomical and Functional Balance of Basal Ganglia Circuitry

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