The neural circuitry of restricted repetitive behavior: Magnetic resonance imaging in neurodevelopmental disorders and animal models

Wilkes, B.J.; Lewis, M.H.

doi:10.1016/j.neubiorev.2018.05.022

Cited by 64Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersObsessive-Compulsive Spectrum Disorders

The neural circuitry of restricted repetitive behavior: Magnetic resonance imaging in neurodevelopmental disorders and animal models

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Wilkes, B.J., Lewis, M.H.·2018·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2018.05.022PMC PMC6169529

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Abstract

Restricted, repetitive behaviors (RRBs) are patterns of behavior that exhibit little variation in form and have no obvious function. RRBs although transdiagonstic are a particularly prominent feature of certain neurodevelopmental disorders, yet relatively little is known about the neural circuitry of RRBs. Past work in this area has focused on isolated brain regions and neurotransmitter systems, but implementing a neural circuit approach has the potential to greatly improve understanding of RRBs. Magnetic resonance imaging (MRI) is well-suited to studying the structural and functional connectivity of the nervous system, and is a highly translational research tool. In this review, we synthesize MRI research from both neurodevelopmental disorders and relevant animal models that informs the neural circuitry of RRB. Together, these studies implicate distributed neural circuits between the cortex, basal ganglia, and cerebellum. Despite progress in neuroimaging of RRB, there are many opportunities for conceptual and methodological improvement. We conclude by suggesting future directions for MRI research in RRB, and how such studies can benefit from complementary approaches in neuroscience.

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Frontostriatal systems play a critical role in mediating restricted and repetitive behaviours transdiagnostically.
“Studies of the neural circuitry underlying RRBs transdiagostically point to a critical role for frontostriatal systems in mediating these behaviours71.”
From Cognitive and behavioural flexibility: Neural mechanisms and clinical considerations (2021) · cites this paper as [71]

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Authors: Wilkes, B. J., & Lewis, M. H.
Affiliations: University of Florida (US)
Corresponding author: Wilkes, B.J.
ORCID: Wilkes, B.J.
Lewis, M.H.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2018-09
Volume: 92
Pages: 152-171
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2018.05.022
PMC: PMC6169529
OpenAlex: W2803633340
Cited by: 64
References: 178
Citations by year: 2026: 3 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 10 · 2021: 18 · 2020: 6 · 2019: 6 · 2018: 2
FWCI: 1.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (R21MH110911, R01MH080055)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Keywords: restricted and repetitive behaviors, neural circuits, neurodevelopmental disorders, autism spectrum disorder, functional connectivity, structural connectivity, basal ganglia, cerebellum, cortex, animal models, neuroimaging
MeSH terms: Animals, Brain, Disease Models, Animal, Humans, Neural Pathways, Cumulative Trauma Disorders, Neurodevelopmental Disorders

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The neural circuitry of restricted repetitive behavior: Magnetic resonance imaging in neurodevelopmental disorders and animal models

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