Cited by 100Parkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatmentsNeurotransmitter Receptor Influence on Behavior

Dopaminergic modulation of striatal function and Parkinson’s disease

Open access
Zhai, Shenyu, Shen, Weixing, Graves, Steven M., Surmeier, D. James·2019·Journal of Neural Transmission

Abstract

The striatum is richly innervated by mesencephalic dopaminergic neurons that modulate a diverse array of cellular and synaptic functions that control goal-directed actions and habits. The loss of this innervation has long been thought to be the principal cause of the cardinal motor symptoms of Parkinson's disease (PD). Moreover, chronic, pharmacological overstimulation of striatal dopamine (DA) receptors is generally viewed as the trigger for levodopa-induced dyskinesia (LID) in late-stage PD patients. Here, we discuss recent advances in our understanding of the relationship between the striatum and DA, particularly as it relates to PD and LID. First, it has become clear that chronic perturbations of DA levels in PD and LID bring about cell type-specific, homeostatic changes in spiny projection neurons (SPNs) that tend to normalize striatal activity. Second, perturbations in DA signaling also bring about non-homeostatic aberrations in synaptic plasticity that contribute to disease symptoms. Third, it has become evident that striatal interneurons are major determinants of network activity and behavior in PD and LID. Finally, recent work examining the activity of SPNs in freely moving animals has revealed that the pathophysiology induced by altered DA signaling is not limited to imbalance in the average spiking in direct and indirect pathways, but involves more nuanced disruptions of neuronal ensemble activity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s00702-019-01997-y

Cites

130 of 130 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Various conditions including Parkinson's disease and psychiatric disorders are accompanied by striatal dysfunction.

    “APOE4 non-carriers demonstrated a distinct pattern of reduced striatal intracellular integrity (caudate RI) with cognitive impairment, which may point to AD-independent striatal contributions to clinical symptoms, as various conditions including Parkinson’s disease and psychiatric disorders are accompanied by striatal dysfunction [52, 53].”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Zhai, S., Shen, W., Graves, S. M., & Surmeier, D. J.
Affiliations
  • Northwestern University (US)
  • University of Minnesota (US)
Corresponding author
Surmeier, D. James
Venue
Journal of Neural Transmission
Published
2019-04
Volume
126
Issue
4
Pages
411-422
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
OpenAlex
W2934839137
Cited by
100
References
130
Citations by year
2026: 8 · 2025: 10 · 2024: 14 · 2023: 16 · 2022: 20 · 2021: 18 · 2020: 10 · 2019: 3 · 2012: 1
FWCI
1.70
Type
journal article
Language
en
Open access
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • JPB Foundation
  • IDP Foundation
  • USPHS
  • Bumpus Foundation
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
Parkinson's disease, striatum, dopaminergic modulation, levodopa-induced dyskinesia, medium spiny neurons, striatal interneurons, synaptic plasticity, direct and indirect pathways, neuronal ensembles, dopamine receptors, goal-directed behavior, homeostatic adaptation
MeSH terms
Animals, Corpus Striatum, Dopamine, Dyskinesia, Drug-Induced, Humans, Levodopa, Parkinson Disease, Dopaminergic Neurons

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review