The DOI matches its Crossref record; 162 of the 162 references it cites were found in a registry or an index.
SIRT1 in Neurodevelopment and Brain Senescence
Open accessAbstract
Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have traditionally been linked with calorie restriction and aging in mammals. These proteins also play an important role in maintaining neuronal health during aging. During neuronal development, the SIR2 ortholog SIRT1 is structurally important, promoting axonal elongation, neurite outgrowth and dendritic branching. This sirtuin also plays a role in memory formation by modulating synaptic plasticity. Hypothalamic functions that affect feeding behavior, endocrine function and circadian rhythmicity are all regulated by SIRT1. Finally, SIRT1 plays protective roles in several neurodegenerative diseases including Alzheimer’s, Parkinson’s and motor neuron diseases, which may relate to its functions in metabolism, stress resistance and genomic stability. Drugs that activate SIRT1 may offer a promising approach to treat these disorders.
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2 retracted
RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
Donmez, G., Wang, D., Cohen, D. E., & Guarente, L. (2010) · Cell · doi:10.1016/j.cell.2010.06.020 · Cited by 432
Self-citationRetractedSIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones
Donmez, G., Arun, A., Chung, C.-Y., McLean, P. J., Lindquist, S., & Guarente, L. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3442-11.2012 · Cited by 208
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Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
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“…a functionally diverse set of genes have been identified including SOD1 (Rosen et al., 1993), TDP43 (Arai et al., 2006; Neumann et al., 2006), FUS (Kwiatkowski et al., 2009), VCP (Johnson et al., 2010), UBQLN2 (Deng et al., 2011), and C9ORF72 (DeJesus-Hernandez et al., 2011; Renton et al., 2011).”
A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
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Self-citationStress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
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Cited by
Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress
Rodgers, A. B., Morgan, C. P., Leu, N. A., & Bale, T. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508347112 · Cited by 751
Healthy Effects of Plant Polyphenols: Molecular Mechanisms
Leri, M., Scuto, M., Ontario, M. L., Calabrese, V., Calabrese, E. J., Bucciantini, M., & Stefani, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041250 · Cited by 435
Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1
Gomes, B. A. Q., Silva, J. P. B., Romeiro, C. F. R., dos Santos, S. M., Rodrigues, C. A., Gonçalves, P. R., Sakai, J. T., Mendes, P. F. S., Varela, E. L. P., & Monteiro, M. C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8152373 · Cited by 403
Athauda, D., & Foltynie, T. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.01.013 · Cited by 383
Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies
Chew, H., Solomon, V. A., & Fonteh, A. N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00598 · Cited by 353
Metadata
- Authors
- Herskovits, A. Z., & Guarente, L.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 81
- Issue
- 3
- Pages
- 471-483
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1544057566
- Cited by
- 488
- References
- 162
- FWCI
- 17.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
