Cited by 383Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatmentsDiabetes Treatment and Management

The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action

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Athauda, Dilan, Foltynie, Thomas·2016·Drug Discovery Today

Abstract

Growing evidence suggests that agonists of the glucagon-like peptide 1 (GLP-1) receptor provide neuroprotection across a range of experimental models of Parkinson's disease (PD) and, recently, a small proof-of-concept, open-label human trial of exenatide in the treatment moderate severity PD appeared to show persistent improvements in motor and cognitive function. The underlying mechanisms of action remain unclear, but as evidence for the potential use of GLP-1 agonists in treating several neurodegenerative disease mounts, and with several clinical trials of GLP-1 analogues in PD and Alzheimer's disease (AD) currently underway, here we review the molecular mechanisms underlying the neuroprotective effects of GLP-1 analogues in the laboratory and their potential therapeutic utility with particular relevance to PD and PD dementia (PDD).

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Authors
Athauda, D., & Foltynie, T.
Affiliations
National Hospital for Neurology and Neurosurgery (GB)
Corresponding author
Athauda, Dilan
Venue
Drug Discovery Today
Publisher
Elsevier BV
Published
2016-05
Volume
21
Issue
5
Pages
802-818
ISSN
1359-6446 (ISSN-L)
OpenAlex
W2270971263
Cited by
383
References
258
Citations by year
2026: 38 · 2025: 51 · 2024: 53 · 2023: 31 · 2022: 46 · 2021: 34 · 2020: 42 · 2019: 32 · 2018: 29 · 2017: 19 · 2016: 8
FWCI
4.07
Type
journal article
Language
en
Open access
Locations
  • Drug Discovery Today (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Michael J. Fox Foundation, Brain Research Trust, Cure Parkinson's Trust, Parkinson's UK
  • European Commission (FP7)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
GLP-1 receptor, GLP-1 receptor agonists, Parkinson's disease, neuroprotection, exenatide, Parkinson's disease dementia, Alzheimer's disease, mechanism of action, therapeutic target
MeSH terms
Glucagon-Like Peptide-1 Receptor, Alzheimer Disease, Animals, Humans, Insulin Resistance, Learning, Mitochondria, Parkinson Disease, Signal Transduction, Proto-Oncogene Proteins c-akt, Glucagon-Like Peptide 1, Neurogenesis

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