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Cited by 272

The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.

Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice

Open access
Sun, Suya, Zhang, Hua, Liu, Jie, Popugaeva, Elena, Xu, Nan-Jie, Feske, Stefan, White, Charles L., Bezprozvanny, Ilya·2014·Neuron
DOI 10.1016/j.neuron.2014.02.019
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Abstract

SUMMARY Mushroom dendritic spine structures are essential for memory storage and the loss of mushroom spines may explain memory defects in Alzheimer's disease (AD). Here we show a significant reduction in the fraction of mushroom spines in hippocampal neurons from the presenilin-1 M146V knockin (KI) mouse model of familial AD (FAD). The stabilization of mushroom spines depends on STIM2-mediated neuronal store operated calcium influx (nSOC) and continuous activity of Ca2+-calmodulin-dependent protein kinase II (CaMKII). We demonstrate that STIM2-nSOC-CaMKII pathway is compromised in KI neurons, in aging neurons and in sporadic AD brains due to downregulation of STIM2 protein. We further establish that overexpression of STIM2 rescues synaptic nSOC, CaMKII activity and mushroom spine loss in KI neurons. Our results identify STIM2-nSOC-CaMKII synaptic pathway as a novel potential therapeutic target for treatment of AD and age-related memory decline.

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Metadata

Authors
Sun, S., Zhang, H., Liu, J., Popugaeva, E., Xu, N.-J., Feske, S., White, C. L., & Bezprozvanny, I.
Venue
Neuron
Publisher
Elsevier BV
Published
2014-04
Volume
82
Issue
1
Pages
79-93
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2014.02.019
OpenAlex
W2007706380
Cited by
272
References
64
FWCI
11.41
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice. https://app.cochat.ai/papers/10.1016/j.neuron.2014.02.019
The paper
Sun, S., Zhang, H., Liu, J., Popugaeva, E., Xu, N.-J., Feske, S., White, C. L., & Bezprozvanny, I. (2014). Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice. Neuron. https://doi.org/10.1016/j.neuron.2014.02.019

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.