Structure-stability-function relationships of dendritic spines
Abstract
Dendritic spines, which receive most of the excitatory synaptic input in the cerebral cortex, are heterogeneous with regard to their structure, stability and function. Spines with large heads are stable, express large numbers of AMPA-type glutamate receptors, and contribute to strong synaptic connections. By contrast, spines with small heads are motile and unstable and contribute to weak or silent synaptic connections. Their structure-stability-function relationships suggest that large and small spines are "memory spines" and "learning spines", respectively. Given that turnover of glutamate receptors is rapid, spine structure and the underlying organization of the actin cytoskeleton are likely to be major determinants of fast synaptic transmission and, therefore, are likely to provide a physical basis for memory in cortical neuronal networks. Characterization of supramolecular complexes responsible for synaptic memory and learning is key to the understanding of brain function and disease.
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Spine morphogenesis and remodeling provide a physical basis for memory in neural networks.
“Thus, spine morphogenesis and remodeling provide a physical basis for memory in neural networks (Kasai et al., 2003).”
From The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning (2017) · cites this paper as Kasai et al., 2003
Spine number and structural plasticity are tightly correlated with synaptic function in the mammalian brain.
“Spine number and structural plasticity are tightly correlated with synaptic function in the mammalian brain [23], [51].”
From Arf4 Determines Dentate Gyrus-Mediated Pattern Separation by Regulating Dendritic Spine Development (2012) · cites this paper as [51]
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- Authors
- Kasai, H., Matsuzaki, M., Noguchi, J., Yasumatsu, N., & Nakahara, H.
- Affiliations
- The Graduate University for Advanced Studies, SOKENDAI (JP)
- RIKEN Center for Brain Science (JP)
- Corresponding author
- Kasai, Haruo
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 26
- Issue
- 7
- Pages
- 360-368
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W1980574091
- Cited by
- 847
- References
- 16
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 21 · 2023: 39 · 2022: 42 · 2021: 39 · 2020: 33 · 2019: 40 · 2018: 42 · 2017: 41 · 2016: 49 · 2015: 40 · 2014: 46 · 2013: 47 · 2012: 56
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- dendritic spines, synaptic stability, AMPA receptors, synaptic plasticity, actin cytoskeleton, fast synaptic transmission, supramolecular complexes, cerebral cortex
- MeSH terms
- Animals, Cerebral Cortex, Cytoskeleton, Dendrites, Learning, Memory, Synaptic Transmission, Neurons, Structure-Activity Relationship, Receptors, Glutamate
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