The DOI matches its Crossref record; 86 of the 88 references it cites were found in a registry or an index.
Prospective Identification and Purification of Quiescent Adult Neural Stem Cells from Their In Vivo Niche
Open accessAbstract
Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity has been elusive. Here, we prospectively isolate GFAP(+)CD133(+) (quiescent neural stem cells [qNSCs]) and GFAP(+)CD133(+)EGFR(+) (activated neural stem cells [aNSCs]) from the adult ventricular-subventricular zone. aNSCs are rapidly cycling, highly neurogenic in vivo, and enriched in colony-forming cells in vitro. In contrast, qNSCs are largely dormant in vivo, generate olfactory bulb interneurons with slower kinetics, and only rarely form colonies in vitro. Moreover, qNSCs are Nestin negative, a marker widely used for neural stem cells. Upon activation, qNSCs upregulate Nestin and EGFR and become highly proliferative. Notably, qNSCs and aNSCs can interconvert in vitro. Transcriptome analysis reveals that qNSCs share features with quiescent stem cells from other organs. Finally, small-molecule screening identified the GPCR ligands, S1P and PGD2, as factors that actively maintain the quiescent state of qNSCs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In contrast, G-protein coupled receptor (GPCR) signaling associated with NSC quiescence (Codega et al., 2014) was enriched in the male septal wall (Figure 2C; Table S3).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Codega et al., 2014
In the citing paper
“Although transcriptome analysis in the postnatal V-SVZ has uncovered molecular differences between the dorsal and the lateral walls (Azim et al., 2015), all profiling studies in the adult V-SVZ, including recent low-throughput, single-cell studies, have focused only on the lateral wall and the neuronal lineage (Basak et al., 2018; Codega et al., 2014; Dulken et al., 2017; Llorens-Bobadilla et al.,”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Codega et al., 2014
In the citing paper
“Our findings, in agreement with recent studies, underline the sensitivity and power of single-cell transcriptomics not only to reveal differences in cell identities, but also to reveal changes within individual cell types under different treatments and conditions 23,26,27,70 , including organismal aging 59,60 .”
From Single-cell transcriptomic profiling of the aging mouse brain (2019) · cites this paper as [60]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
CNS stem cells express a new class of intermediate filament protein
Lendahl, U., Zimmerman, L. B., & McKay, R. D. G. (1990) · Cell · doi:10.1016/0092-8674(90)90662-x · Cited by 3,164
A restricted cell population propagates glioblastoma growth after chemotherapy
Chen, J., Li, Y., Yu, T.-S., McKay, R. M., Burns, D. K., Kernie, S. G., & Parada, L. F. (2012) · Nature · doi:10.1038/nature11287 · Cited by 2,354
Doetsch, F. K., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05046.1997 · Cited by 1,909
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908
Direct isolation of human central nervous system stem cells
Uchida, N., Buck, D. W., He, D., Reitsma, M. J., Masek, M., Phan, T. V., Tsukamoto, A. S., Gage, F. H., & Weissman, I. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14720 · Cited by 1,829
A Stem Cell Molecular Signature
Ivanova, N. B., Dimos, J. T., Schaniel, C., Hackney, J. A., Moore, K. A., & Lemischka, I. R. (2002) · Science · doi:10.1126/science.1073823 · Cited by 1,543
Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L., & Fuchs, E. (2004) · Cell · doi:10.1016/j.cell.2004.08.012 · Cited by 1,428
Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
Flagged first, then by citations
2 of the 88 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–300 of 633
Role of Astrocytes in the Neurogenic Niches
Schneider, J., Karpf, J., & Beckervordersandforth, R. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9068-9_2 · Cited by 36
RhoA/ROCK signaling pathway and astrocytes in ischemic stroke
Lu, W., Chen, Z., & Wen, J. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00709-4 · Cited by 35
Kremer, L. P. M., Cerrizuela, S., Dehler, S., Stiehl, T., Weinmann, J., Abendroth, H., Kleber, S., Laure, A., Andari, J. E., Anders, S., et al. (2021) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2021.07.001 · Cited by 34
Sato, Y., Kiyozumi, D., Futaki, S., Nakano, I., Shimono, C., Kaneko, N., Ikawa, M., Okabe, M., Sawamoto, K., & Sekiguchi, K. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-05-0286 · Cited by 35
The vasculature as a neural stem cell niche
Otsuki, L., & Brand, A. H. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.01.010 · Cited by 34
An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins
Li, S., Koe, C. T., Tay, S. T., Tan, A. L. K., Zhang, S., Zhang, Y., Tan, P. B. O., Sung, W.-K. K., & Wang, H. (2017) · Nature Communications · doi:10.1038/s41467-017-00172-9 · Cited by 34
Yeo, R. W., Zhou, O. Y., Zhong, B. L., Sun, E., Negredo, P. N., Nair, S., Sharmin, M., Ruetz, T. J., Wilson, M., Kundaje, A. B., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00449-3 · Cited by 37
Myers, B. L., Brayer, K. J., Paez-Beltran, L. E., Villicana, E., Keith, M. S., Suzuki, H., Newville, J., Anderson, R. H., Lo, Y., Mertz, C. M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54750-9 · Cited by 40
EphA4 Regulates Neuroblast and Astrocyte Organization in a Neurogenic Niche
Todd, K. L., Baker, K. L., Eastman, M. B., Kolling, F. W., Trausch, A. G., Nelson, C. E., & Conover, J. C. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3738-16.2017 · Cited by 34
The instructive role of the vasculature in stem cell niches
Putnam, A. J. (2014) · Biomaterials Science · doi:10.1039/c4bm00200h · Cited by 35
Multifaceted control of adult SVZ neurogenesis by the vascular niche
Ottone, C., & Parrinello, S. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1049785 · Cited by 33
Nath, S., Santamaría, J. C. M., Chu, Y., Choi, J. S., Conforti, P., Lin, J.-D., Sankowski, R., Amann, L., Galanis, C., Wu, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53217-1 · Cited by 34
Neural Stem Cells and Ischemic Brain
Zhang, Z., & Chopp, M. (2016) · Journal of Stroke · doi:10.5853/jos.2016.00206 · Cited by 32
Building a central nervous system: The neural stem cell lineage revealed
Xu, W., Lakshman, N., & Morshead, C. M. (2017) · Neurogenesis · doi:10.1080/23262133.2017.1300037 · Cited by 32
Sun, B., Chang, E., Gerhartl, A., & Szele, F. G. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhx289 · Cited by 30
Liu, J., Li, Z., Liu, Y.-S., Chu, H.-D., Hu, N.-Y., Wu, D., Huang, L., Li, S.-J., Li, X., Yang, J., et al. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00474-x · Cited by 31
Çelikkaya, H., Coşacak, M. İ., Papadimitriou, C., Popova, S. D., Bhattarai, P., Biswas, S. N., Siddiqui, T., Wistorf, S., Nevado-Alcalde, I., Naumann, L., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00023 · Cited by 31
Cochard, L. M., Levros, L.-C., Joppé, S. E., Pratesi, F., Aumont, A., & Fernandes, K. J. L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.621076 · Cited by 31
Sefton, E., Iwasa, S. N., Morrison, T., Naguib, H. E., Popović, M. R., & Morshead, C. M. (2020) · eNeuro · doi:10.1523/eneuro.0273-20.2020 · Cited by 30
The circadian clock in adult neural stem cell maintenance
Draijer, S., Chaves, I., & Hoekman, M. F. M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.05.007 · Cited by 31
Daynac, M., Morizur, L., Kortulewski, T., Gauthier, L., Ruat, M., Mouthon, M., & Boussin, F. D. (2015) · Journal of Visualized Experiments · doi:10.3791/53247 · Cited by 33
Recent advances in tissue stem cells
Fu, X., He, Q., Tao, Y., Wang, M., Wang, W., Wang, Y., Yu, Q. C., Zhang, F., Zhang, X., Chen, Y., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-2007-8 · Cited by 30
García-Garrote, M., Pérez‐Villalba, A., Garrido‐Gil, P., Belenguer, G., Parga, J. A., Pérez‐Sánchez, F., Labandeira-García, J. L., Fariñas, I., & Rodríguez‐Pallares, J. (2019) · Cells · doi:10.3390/cells8121551 · Cited by 28
Endogenous neural precursor cells in health and disease
Bacigaluppi, M., Sferruzza, G., Butti, E., Ottoboni, L., & Martino, G. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146619 · Cited by 29
Goodman, T. H., Nayar, S. G., Clare, S. J., Mikolajczak, M., Rice, R., Mansour, S. L., Bellusci, S., & Hajihosseini, M. K. (2020) · Development · doi:10.1242/dev.180950 · Cited by 31
Schaberg, E., Götz, M., & Faissner, A. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04259-5 · Cited by 32
Dormant state of quiescent neural stem cells links Shank3 mutation to autism development
Kim, H., Cho, B., Park, H., Kim, J., Kim, S., Shin, J., Lengner, C. J., Won, K., & Kim, J. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01563-1 · Cited by 33
Effect of Bmi1 over-expression on gene expression in adult and embryonic murine neural stem cells
Ganapathi, M., Boles, N. C., Charniga, C., Lotz, S., Campbell, M., Temple, S., & Morse, R. H. (2018) · Scientific Reports · doi:10.1038/s41598-018-25921-8 · Cited by 24
Robson, J. P., Wagner, B., Glitzner, E., Heppner, F. L., Steinkellner, T., Khan, D., Petritsch, C. K., Pollak, D. D., Sitte, H. H., & Sibilia, M. C. (2018) · FEBS Journal · doi:10.1111/febs.14603 · Cited by 25
Maybury‐Lewis, S. Y., Brown, A. K., Yeary, M., Sloutskin, A., Dhakal, S., Juven‐Gershon, T., & Webb, A. E. (2021) · Aging Cell · doi:10.1111/acel.13499 · Cited by 27
Neural Stem Cells in the Adult Olfactory Bulb Core Generate Mature Neurons in Vivo
Defteralı, Ç., Moreno‐Estellés, M., Crespo, C., Díaz‐Guerra, E., Díaz‐Moreno, M., Vergaño‐Vera, E., Nieto‐Estévez, V., Hurtado‐Chong, A., Consiglio, A., Mira, H., et al. (2021) · Stem Cells · doi:10.1002/stem.3393 · Cited by 30
Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
Borgenvik, A., Holmberg, K. O., Bolin, S., Zhao, M., Savov, V., Rosén, G., Hutter, S., Garancher, A., Rahmanto, A. S., Bergström, T., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-2108 · Cited by 28
Hunter, M., Demarais, N. J., Faull, R. L. M., Grey, A. C., & Curtis, M. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-20793-4 · Cited by 27
Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective
Coller, H. A. (2019) · Comprehensive physiology · doi:10.1002/cphy.c190014 · Cited by 33
Omega-3 Docosahexaenoic Acid Is a Mediator of Fate-Decision of Adult Neural Stem Cells
Van, A. L., Hachem, M., Lagarde, M., & Bernoud‐Hubac, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174240 · Cited by 25
Weissleder, C., Webster, M. J., Barry, G., & Weickert, C. S. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaa159 · Cited by 28
Luongo, C., Butruille, L., Sébillot, A., Blay, K. L., Schwaninger, M., Heuer, H., DEMENEIX, B. A., & Remaud, S. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.12.009 · Cited by 28
Role of the Retinoblastoma protein, Rb, during adult neurogenesis in the olfactory bulb
Naser, R., Vandenbosch, R., Omais, S., Hayek, D., Jaafar, C., Lafi, S. M. A., Saliba, A., Baghdadi, M., Skaf, L., & Ghanem, N. (2016) · Scientific Reports · doi:10.1038/srep20230 · Cited by 25
Liang, J., She, X., Chen, J., Zhai, Y., Liu, Y., Zheng, K., Gong, Y., Zhu, H., Luo, X., & Sun, X. (2018) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-018-04206-w · Cited by 26
To Become or Not to Become Tumorigenic: Subventricular Zone Versus Hippocampal Neural Stem Cells
Fontán‐Lozano, Á., Morcuende, S., de Carrizosa, M. A. D., Benítez‐Temiño, B., Mejı́as, R., & Matarredona, E. R. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.602217 · Cited by 28
A novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis
Baur, K., Abdullah, Y., Mandl, C., Hölzl‐Wenig, G., Shi, Y., Schmidt-Edelkraut, U., Khatri, P. R., Hagenston, A. M., Irmler, M., Beckers, J., et al. (2022) · EMBO Reports · doi:10.15252/embr.202154078 · Cited by 22
Genet, N., Genet, G., Chavkin, N. W., Paila, U., Fang, J. S., Vasavada, H. H., Goldberg, J. S., Acharya, B. R., Bhatt, N. S., Baker, K. L., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112371 · Cited by 25
Marcy, G., Foucault, L., Babina, E., Capeliez, T., Texeraud, E., Zweifel, S., Heinrich, C., Hernández‐Vargas, H., Parras, C. M., Jabaudon, D., et al. (2023) · Science Advances · doi:10.1126/sciadv.abq7553 · Cited by 25
TOX3 regulates neural progenitor identity
Sahu, S. K., Fritz, A., Tiwari, N., Kovács, Z., Pouya, A., Wüllner, V., Bora, P., Schacht, T., Baumgart, J., Péron, S., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.04.005 · Cited by 25
Nakafuku, M., & del Águila, Á. (2019) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.369 · Cited by 25
Zhou, B., Osinski, J. M., Mateo, J. L., Martynoga, B., Sim, F. J., Campbell, C. E., Guillemot, F., Piper, M., & Gronostajski, R. M. (2015) · Stem Cells and Development · doi:10.1089/scd.2015.0136 · Cited by 24
Live Imaging of Adult Neural Stem Cells in Rodents
Ortega, F., & Costa, M. R. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00078 · Cited by 23
Adult neurogenesis and reproductive functions in mammals
Migaud, M., Butruille, L., Duittoz, A. H., Pillon, D., & Batailler, M. (2016) · Theriogenology · doi:10.1016/j.theriogenology.2016.04.044 · Cited by 24
Luberto, C., Haley, J. D., & Poeta, M. D. (2019) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2019.01.001 · Cited by 24
Paß, T., Aßfalg, M., Tolve, M., Blaess, S., Rothermel, M., Wiesner, R. J., & Ricke, K. M. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01947-w · Cited by 24
Quaresima, S., Istiaq, A., Jono, H., Cacci, E., Ohta, K., & Lupo, G. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.845567 · Cited by 26
Seasonal reorganization of hypothalamic neurogenic niche in adult sheep
Butruille, L., Batailler, M., Mazur, D., Prévot, V., & Migaud, M. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1478-z · Cited by 24
Reeve, R. L., Yammine, S. Z., Morshead, C. M., & van der Kooy, D. (2017) · Stem Cells · doi:10.1002/stem.2662 · Cited by 26
Dual role for DOCK7 in tangential migration of interneuron precursors in the postnatal forebrain
Nakamuta, S., Yang, Y.-T., Wang, C.-L., Gallo, N. B., Yu, J.-R., Tai, Y., & Van Aelst, L. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201704157 · Cited by 24
The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells
Gonzalez, L., Domingo-Muelas, A., Duart-Abadía, P., Nuñez, M., Mikolčević, P., Llonch, E., Cubillos‐Rojas, M., Cánovas, B., Forrow, S., Morante‐Redolat, J. M., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106202 · Cited by 23
The Future of Neuroepigenetics in the Human Brain
Mitchell, A., Roussos, P., Peter, C. J., Tsankova, N. M., & Akbarian, S. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800977-2.00008-5 · Cited by 24
Fong, B. C., Chakroun, I., Iqbal, M. A., Paul, S., Bastasic, J., O’Neil, D., Yakubovich, E., Bejjani, A. T., Ahmadi, N., Carter, A., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111578 · Cited by 24
Verma, R., Chen, X., Xin, D. E., Luo, Z., Ogurek, S., Xin, M., Rao, R., Berry, K., & Lu, Q. R. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-1577 · Cited by 23
Navarro‐Guerrero, E., Platero-Luengo, A., Linares‐Clemente, P., Cases, I., López‐Barneo, J., & Pardal, R. (2016) · Stem Cells · doi:10.1002/stem.2331 · Cited by 23
Neural stem cell heterogeneity in the mammalian forebrain
Adams, K. V., & Morshead, C. M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.06.005 · Cited by 26
High density is a property of slow-cycling and treatment-resistant human glioblastoma cells
Sabelström, H., Quigley, D. A., Fenster, T., Foster, D. J., Fuchshuber, C. A. M., Saxena, S., Yuan, E., Li, N., Paterno, F., Phillips, J. J., et al. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.03.003 · Cited by 23
Functions of subventricular zone neural precursor cells in stroke recovery
Williamson, M. R., Jones, T. A., & Drew, M. R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112209 · Cited by 24
Ledur, P. F., Liu, C., He, H., Harris, A. R., Minussi, D. C., Zhou, H., Shaffrey, M. E., Asthagiri, A. R., Lopes, M. B. S., Schiff, D., et al. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now062 · Cited by 23
Jeong, D., Casasbuenas, D. L., Gengatharan, A., Edwards, K. M., Saghatelyan, A., Kaplan, D. R., Miller, F. D., & Yuzwa, S. A. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108257 · Cited by 23
Zhang, J., Uchiyama, J., Imami, K., Ishihama, Y., Kageyama, R., & Kobayashi, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.762293 · Cited by 22
The vasculature of neurogenic niches: Properties and function
Karakatsani, A., Álvarez-Vergara, M. I., & de Almodóvar, C. R. (2023) · Cells and Development · doi:10.1016/j.cdev.2023.203841 · Cited by 25
Tanner, G., Barrow, R., Ajaib, S., Jabri, M. A., Ahmed, N., Pollock, S., Finetti, M. A., Rippaus, N., Bruns, A. F., Syed, K. W., et al. (2024) · Genome biology · doi:10.1186/s13059-024-03172-3 · Cited by 22
Joppé, S. E., Hamilton, L. K., Cochard, L. M., Levros, L.-C., Aumont, A., Barnabé‐Heider, F., & Fernandes, K. J. L. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00407 · Cited by 22
Soluble APP functions as a vascular niche signal that controls adult neural stem cell number
Sato, Y., Uchida, Y., Hu, J., Young‐Pearse, T. L., Niikura, T., & Mukouyama, Y. (2017) · Development · doi:10.1242/dev.143370 · Cited by 22
Ferreira, A. C., Sousa, N., Bessa, J. M., Sousa, J. C., & Marques, F. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.014 · Cited by 24
Differentiation Induction as a Response to Irradiation in Neural Stem Cells In Vitro
Konířová, J., Cupal, L., Jarošová, Š., Michaelidesova, A. J., Vachelová, J., Davídková, M., Bartůněk, P., & Zı́ková, M. (2019) · Cancers · doi:10.3390/cancers11070913 · Cited by 22
Song, B., Xiong, G., Luo, H., Zuo, Z., Zhou, Z., & Chang, X. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111936 · Cited by 23
Erfani, P., Tomé-García, J., Canoll, P., Doetsch, F. K., & Tsankova, N. M. (2015) · Epigenetics · doi:10.1080/15592294.2015.1042645 · Cited by 21
Physiological Interactions between Microglia and Neural Stem Cells in the Adult Subependymal Niche
Sirerol-Piquer, M. S., Belenguer, G., Morante‐Redolat, J. M., Duart-Abadía, P., Pérez‐Villalba, A., & Fariñas, I. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.01.009 · Cited by 23
Tamoxifen promotes differentiation of oligodendrocyte progenitors in vitro
Barratt, H. E., Budnick, H. C., Parra, R., Lolley, R. J., Perry, C. N., & Nesic, O. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.026 · Cited by 22
Quiescent Adult Neural Stem Cells: Developmental Origin and Regulatory Mechanisms
Meng, H., Yu, H., Zhang, K., Yi, X., Meng, X., Kang, E., Wu, S., Deng, W., & Wang, Y. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01206-1 · Cited by 23
Cyclosporin A enhances neurogenesis in the dentate gyrus of the hippocampus
Chow, A., & Morshead, C. M. (2015) · Stem Cell Research · doi:10.1016/j.scr.2015.12.007 · Cited by 20
Zhang, Z., Wei, D., Li, Z., Guo, H., Wu, Y., & Feng, J. (2022) · Computational Intelligence and Neuroscience · doi:10.1155/2022/9325302 · Cited by 21
Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian Brain
Radecki, D. Z., & Samanta, J. (2022) · Cells · doi:10.3390/cells11132101 · Cited by 21
Injury primes mutation-bearing astrocytes for dedifferentiation in later life
Ragdale, H. S., Clements, M., Tang, W., Deltcheva, E. M., Andreassi, C., Lai, A. G., Chang, W. H., Pandrea, M., Andrew, I., Gamé, L., et al. (2023) · Current Biology · doi:10.1016/j.cub.2023.02.013 · Cited by 20
Pérez‐Villalba, A., Sirerol-Piquer, M. S., Belenguer, G., Soriano‐Cantón, R., Muñoz‐Manchado, A. B., Villadiego, J., Alarcón-Arís, D., Soria, F. N., Dehay, B., Bézard, E., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2276-17.2017 · Cited by 21
Acute Implantation of Aligned Hydrogel Tubes Supports Delayed Spinal Progenitor Implantation
Ciciriello, A. J., Smith, D. R., Munsell, M. K., Boyd, S. J., Shea, L. D., & Dumont, C. M. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00844 · Cited by 21
Radecki, D. Z., Messling, H. M., Haggerty-Skeans, J. R., Bhamidipati, S. K., Clawson, E. D., Overman, C. A., Thatcher, M. M., Salzer, J. L., & Samanta, J. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.10.003 · Cited by 21
Deciphering neural heterogeneity through cell lineage tracing
Figueres‐Oñate, M., Sánchez‐González, R., & López‐Mascaraque, L. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03689-3 · Cited by 20
Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone
Cebrián‐Silla, A., Nascimento, M. A., Mancia, W., González-Granero, S., Romero-Rodriguez, R., Obernier, K., Steffen, D. M., Lim, D. A., García‐Verdugo, J. M., & Álvarez-Buylla, A. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115264 · Cited by 22
Wu, J., Tian, W., Liu, Y., Wang, H. J., Zheng, J., Wang, X., Pan, H., Li, J., Luo, J., Yang, X., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019101679 · Cited by 20
Choroid plexus APP regulates adult brain proliferation and animal behavior
Arnaud, K., Moreira, V. O., Vincent, J., Dallérac, G., Dubreuil, C., Dupont, E., Richter, M., Müller, U. C., Rondi-Reig, L., Prochiantz, A., et al. (2021) · Life Science Alliance · doi:10.26508/lsa.202000703 · Cited by 17
Ganglioside GD3 regulates neural stem cell quiescence and controls postnatal neurogenesis
Fuchigami, T., Itokazu, Y., & Yu, R. K. (2023) · Glia · doi:10.1002/glia.24468 · Cited by 4
Autofluorescence is a biomarker of neural stem cell activation state
Morrow, C. S., Tweed, K. E., Farhadova, S., Walsh, A. J., Lear, B. P., Roopra, A., Risgaard, R. D., Klosa, P. C., Arndt, Z. P., Peterson, E. R., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.02.011 · Cited by 23
Postembryonic Fish Brain Proliferation Zones Exhibit Neuroepithelial-Type Gene Expression Profile
Dambroise, E., Simion, M., Bourquard, T., Bouffard, S., Rizzi, B., Jaszczyszyn, Y., Bourge, M., Affaticati, P., Heuzé, A., Jouralet, J., et al. (2017) · Stem Cells · doi:10.1002/stem.2588 · Cited by 20
Tomé-García, J., Tejero, R., Nudelman, G., Yong, R. L. M., Sebra, R., Wang, H., Fowkes, M. E., Magid, M. S., Walsh, M. J., Silva-Vargas, V., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.03.019 · Cited by 20
Wu, H., Cao, X., Fang, Z., Zhang, Y.-F., Han, W., Yue, K., Cao, Y., Zheng, M., Wang, L.-L., & Han, H. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.04.181 · Cited by 20
Shah, K. K., King, G. D., & Jiang, H. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz036 · Cited by 21
Bakhshinyan, D., Savage, N. J., Salim, S. K., Venugopal, C., & Singh, S. K. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.603738 · Cited by 21
Origin, molecular specification, and stemness of astrocytes
Zheng, K., Huang, H., Yang, J., & Qiu, M. S. (2022) · Developmental Neurobiology · doi:10.1002/dneu.22863 · Cited by 19
Chaker, Z., Makarouni, E., & Doetsch, F. K. (2024) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120320-040213 · Cited by 21
Targeted activation of primitive neural stem cells in the mouse brain
Reeve, R. L., Yammine, S. Z., DeVeale, B., & van der Kooy, D. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13228 · Cited by 19
Regulation of Adult Neurogenesis by the Fragile X Family of RNA Binding Proteins
Patzlaff, N. E., Shen, M., & Zhao, X. (2017) · Brain Plasticity · doi:10.3233/bpl-170061 · Cited by 18
A New Twist for Neurotrophins: Endothelial-Derived NT-3 Mediates Adult Neural Stem Cell Quiescence
Silva-Vargas, V., & Doetsch, F. K. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.029 · Cited by 19
Revisit the Candidacy of Brain Cell Types as the Cell(s) of Origin for Human High-Grade Glioma
Shao, F., & Liu, C. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00048 · Cited by 17
Metadata
- Authors
- Codega, P., Silva-Vargas, V., Paul, A., Maldonado-Soto, A. R., DeLeo, A. M., Pastrana, E., & Doetsch, F.
- Affiliations
- Columbia University (US)
- Herbert Irving Comprehensive Cancer Center (US)
- Corresponding author
- Doetsch, Fiona
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 82
- Issue
- 3
- Pages
- 545-559
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4360885
- OpenAlex
- W2065970275
- Cited by
- 634
- References
- 88
- Citations by year
- 2026: 17 · 2025: 35 · 2024: 36 · 2023: 63 · 2022: 61 · 2021: 61 · 2020: 63 · 2019: 75 · 2018: 47 · 2017: 63 · 2016: 49 · 2015: 49 · 2014: 14
- FWCI
- 20.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- David and Lucile Packard Foundation
- Foundation for the National Institutes of Health
- Leona M. and Harry B. Helmsley Charitable Trust
- National Institutes of Health (TL1TR000082)
- National Institute of Mental Health (T32 MH 15174-29, T32MH015174)
- National Institute of General Medical Sciences (T32GM008224, T32GM007088)
- National Institute of Neurological Disorders and Stroke (F31NS081990, R01NS053884, NS074039, R01NS074039, NS053884, NS053884-03S109, F31NS079057)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Keywords
- quiescent neural stem cells, ventricular-subventricular zone, stem cell activation, EGFR, nestin, olfactory bulb interneurons, stem cell quiescence, GPCR ligands, sphingosine-1-phosphate, prostaglandin D2, small molecule screening, colony-forming cells
- MeSH terms
- Animals, Astrocytes, Cell Separation, Cells, Cultured, Humans, Mice, Transgenic, Prospective Studies, Biomarkers, Lateral Ventricles, Mice, Adult Stem Cells, Neural Stem Cells, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
