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Cited by 24Neurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal SignalingDevelopmental Biology and Gene Regulation

Dual role for DOCK7 in tangential migration of interneuron precursors in the postnatal forebrain

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Nakamuta, Shinichi, Yang, Yu-Ting, Wang, Chia-Lin, Gallo, Nicholas B., Yu, Jia-Ray, Tai, Yilin, Van Aelst, Linda·2017·Journal of Cell Biology
DOI 10.1083/jcb.201704157PMC PMC5716287
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Abstract

Throughout life, stem cells in the ventricular-subventricular zone generate neuroblasts that migrate via the rostral migratory stream (RMS) to the olfactory bulb, where they differentiate into local interneurons. Although progress has been made toward identifying extracellular factors that guide the migration of these cells, little is known about the intracellular mechanisms that govern the dynamic reshaping of the neuroblasts' morphology required for their migration along the RMS. In this study, we identify DOCK7, a member of the DOCK180-family, as a molecule essential for tangential neuroblast migration in the postnatal mouse forebrain. DOCK7 regulates the migration of these cells by controlling both leading process (LP) extension and somal translocation via distinct pathways. It controls LP stability/growth via a Rac-dependent pathway, likely by modulating microtubule networks while also regulating F-actin remodeling at the cell rear to promote somal translocation via a previously unrecognized myosin phosphatase-RhoA-interacting protein-dependent pathway. The coordinated action of both pathways is required to ensure efficient neuroblast migration along the RMS.

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Cited by

Sorted by citations

Authors
Nakamuta, S., Yang, Y.-T., Wang, C.-L., Gallo, N. B., Yu, J.-R., Tai, Y., & Van Aelst, L.
Affiliations
  • Cold Spring Harbor Laboratory (US)
  • Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 1
ORCID
Venue
Journal of Cell Biology
Publisher
Rockefeller University Press
Published
2017-10-31
Volume
216
Issue
12
Pages
4313-4330
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.201704157
PMC
PMC5716287
OpenAlex
W2766102202
Cited by
24
References
1
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 1
FWCI
0.93
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Cell Biology (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Funders
  • National Institutes of Health (R01MH082808, R01NS082266, T32 CA 148056-1)
  • Uehara Memorial Foundation
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
DOCK7, rostral migratory stream, tangential migration, neuroblast migration, olfactory bulb, Rac signaling, microtubule cytoskeleton, F-actin reorganization, myosin phosphatase, ventricular-subventricular zone
MeSH terms
Actins, Animals, Animals, Newborn, Cell Differentiation, Cell Movement, Embryo, Mammalian, HeLa Cells, Humans, Microtubules, Neurons, Signal Transduction, Prosencephalon, Gene Expression Regulation, Developmental, Guanine Nucleotide Exchange Factors, GTPase-Activating Proteins, rho GTP-Binding Proteins, rhoA GTP-Binding Protein, Myosin-Light-Chain Phosphatase, Cell Line, Tumor, Proto-Oncogene Proteins c-akt, Mice, HEK293 Cells, Primary Cell Culture

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