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Prospective Identification and Purification of Quiescent Adult Neural Stem Cells from Their In Vivo Niche
Open accessAbstract
Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity has been elusive. Here, we prospectively isolate GFAP(+)CD133(+) (quiescent neural stem cells [qNSCs]) and GFAP(+)CD133(+)EGFR(+) (activated neural stem cells [aNSCs]) from the adult ventricular-subventricular zone. aNSCs are rapidly cycling, highly neurogenic in vivo, and enriched in colony-forming cells in vitro. In contrast, qNSCs are largely dormant in vivo, generate olfactory bulb interneurons with slower kinetics, and only rarely form colonies in vitro. Moreover, qNSCs are Nestin negative, a marker widely used for neural stem cells. Upon activation, qNSCs upregulate Nestin and EGFR and become highly proliferative. Notably, qNSCs and aNSCs can interconvert in vitro. Transcriptome analysis reveals that qNSCs share features with quiescent stem cells from other organs. Finally, small-molecule screening identified the GPCR ligands, S1P and PGD2, as factors that actively maintain the quiescent state of qNSCs.
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“In contrast, G-protein coupled receptor (GPCR) signaling associated with NSC quiescence (Codega et al., 2014) was enriched in the male septal wall (Figure 2C; Table S3).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Codega et al., 2014
In the citing paper
“Although transcriptome analysis in the postnatal V-SVZ has uncovered molecular differences between the dorsal and the lateral walls (Azim et al., 2015), all profiling studies in the adult V-SVZ, including recent low-throughput, single-cell studies, have focused only on the lateral wall and the neuronal lineage (Basak et al., 2018; Codega et al., 2014; Dulken et al., 2017; Llorens-Bobadilla et al.,”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Codega et al., 2014
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“Our findings, in agreement with recent studies, underline the sensitivity and power of single-cell transcriptomics not only to reveal differences in cell identities, but also to reveal changes within individual cell types under different treatments and conditions 23,26,27,70 , including organismal aging 59,60 .”
From Single-cell transcriptomic profiling of the aging mouse brain (2019) · cites this paper as [60]
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
CNS stem cells express a new class of intermediate filament protein
Lendahl, U., Zimmerman, L. B., & McKay, R. D. G. (1990) · Cell · doi:10.1016/0092-8674(90)90662-x · Cited by 3,164
A restricted cell population propagates glioblastoma growth after chemotherapy
Chen, J., Li, Y., Yu, T.-S., McKay, R. M., Burns, D. K., Kernie, S. G., & Parada, L. F. (2012) · Nature · doi:10.1038/nature11287 · Cited by 2,354
Doetsch, F. K., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05046.1997 · Cited by 1,909
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908
Direct isolation of human central nervous system stem cells
Uchida, N., Buck, D. W., He, D., Reitsma, M. J., Masek, M., Phan, T. V., Tsukamoto, A. S., Gage, F. H., & Weissman, I. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14720 · Cited by 1,829
A Stem Cell Molecular Signature
Ivanova, N. B., Dimos, J. T., Schaniel, C., Hackney, J. A., Moore, K. A., & Lemischka, I. R. (2002) · Science · doi:10.1126/science.1073823 · Cited by 1,543
Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L., & Fuchs, E. (2004) · Cell · doi:10.1016/j.cell.2004.08.012 · Cited by 1,428
Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
Sanai, N., Tramontin, A. D., Quiñones‐Hinojosa, A., Barbaro, N. M., Gupta, N. M., Kunwar, S., Lawton, M. T., McDermott, M. W., Parsa, A. T., García‐Verdugo, J. M., et al. (2004) · Nature · doi:10.1038/nature02301 · Cited by 1,350
SOX2 Functions to Maintain Neural Progenitor Identity
Graham, V., Khudyakov, J. I., Ellis, P., & Pevny, L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00497-5 · Cited by 1,344
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
Li, L., & Clevers, H. (2010) · Science · doi:10.1126/science.1180794 · Cited by 1,247
Molecular regulation of stem cell quiescence
Cheung, T. H., & Rando, T. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3591 · Cited by 1,148
Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis
Kappos, L., Antel, J. P., Comi, G., Montalbán, X., O'Connor, P. W., Polman, C. H., Haas, T., Korn, A., Karlsson, G., & Radue, E. W. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052643 · Cited by 1,058
EGF Converts Transit-Amplifying Neurogenic Precursors in the Adult Brain into Multipotent Stem Cells
Doetsch, F. K., Petreanu, L., Caillé, I., García‐Verdugo, J. M., & Álvarez-Buylla, A. (2002) · Neuron · doi:10.1016/s0896-6273(02)01133-9 · Cited by 1,048
A specialized vascular niche for adult neural stem cells
Tavazoie, M., Van der Veken, L., Silva-Vargas, V., Louissaint, M., Colonna, L., Zaidi, B., Garcia-Verdugo, J. M., & Doetsch, F. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.025 · Cited by 1,033
Shen, Q., Wang, Y., Kokovay, E., Lin, G., Chuang, S.-M., Goderie, S. K., Roysam, B., & Temple, S. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.026 · Cited by 1,027
Garcia, A. D. R., Doan, N., Imura, T., Bush, T. G., & Sofroniew, M. V. (2004) · Nature Neuroscience · doi:10.1038/nn1340 · Cited by 1,019
Mirzadeh, Z., Merkle, F. T., Soriano-Navarro, M., Garcia-Verdugo, J. M., & Alvarez-Buylla, A. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.004 · Cited by 1,015
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
Holland, E. C., Celestino, J., Dai, C., Schaefer, L., Sawaya, R. A., & Fuller, G. N. (2000) · Nature Genetics · doi:10.1038/75596 · Cited by 906
Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay for Stem Cells
Pastrana, É., Silva-Vargas, V., & Doetsch, F. K. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.04.007 · Cited by 856
Corridors of migrating neurons in the human brain and their decline during infancy
Sanai, N., Nguyen, T., Ihrie, R. A., Mirzadeh, Z., Tsai, H.-H., Wong, M., Gupta, N., Berger, M. S., Huang, E., Garcia-Verdugo, J.-M., et al. (2011) · Nature · doi:10.1038/nature10487 · Cited by 849
Mosaic Organization of Neural Stem Cells in the Adult Brain
Merkle, F. T., Mirzadeh, Z., & Álvarez-Buylla, A. (2007) · Science · doi:10.1126/science.1144914 · Cited by 821
Le Belle, J. E., Orozco, N. M., Paucar, A. A., Saxe, J. P., Mottahedeh, J., Pyle, A. D., Wu, H., & Kornblum, H. I. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2010.11.028 · Cited by 789
Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain
Laywell, E. D., RAKIC, P. T., Kukekov, V. G., Holland, E. C., & Steindler, D. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250471697 · Cited by 722
In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
Ahn, S., & Joyner, A. L. (2005) · Nature · doi:10.1038/nature03994 · Cited by 713
Powell, A. E., Wang, Y., Li, Y., Poulin, E. J., Means, A. L., Washington, M. K., Higginbotham, J. N., Juchheim, A., Prasad, N., Levy, S. E., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.042 · Cited by 694
Regeneration of a germinal layer in the adult mammalian brain
Doetsch, F. K., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11619 · Cited by 662
Zimmerman, L. B., Lendahl, U., Cunningham, M. G., McKay, R. D. G., Parr, B. A., Gavin, B. J., Mann, J. R., Vassileva, G., & McMahon, A. P. (1994) · Neuron · doi:10.1016/0896-6273(94)90148-1 · Cited by 582
Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis
Jensen, K. B., Collins, C. A., Nascimento, E. M., Tan, D. W., Frye, M., Itami, S., & Watt, F. M. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.04.014 · Cited by 523
Maslov, A. Y., Barone, T. A., Plunkett, R. J., & Pruitt, S. C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4608-03.2004 · Cited by 522
Molecular Signature of Quiescent Satellite Cells in Adult Skeletal Muscle
Fukada, S.-I., Uezumi, A., Ikemoto, M., Masuda, S., Segawa, M., Tanimura, N., Yamamoto, H., Miyagoe-Suzuki, Y., & Takeda, S. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0019 · Cited by 506
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis
Knobloch, M., Braun, S., Zurkirchen, L., Schoultz, C., Zamboni, N., Araúzo-Bravo, M., Kovacs, W. J., Karalay, Ö., Suter, U., Machado, R. A. C., et al. (2012) · Nature · doi:10.1038/nature11689 · Cited by 503
Marzesco, A., Janich, P., Wilsch‐Bräuninger, M., Dubreuil, V., Langenfeld, K., Corbeil, D., & Huttner, W. Β. (2005) · Journal of Cell Science · doi:10.1242/jcs.02439 · Cited by 455
Pastrana, É., Cheng, L.-C., & Doetsch, F. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810407106 · Cited by 399
Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells
Bowman, T. V., Merchant, A. A., Ramos, C. A., Whitehouse, N. L., Young, A., Shaw, C. A., & Goodell, M. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020301 · Cited by 378
Imura, T., Kornblum, H. I., & Sofroniew, M. V. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02824.2003 · Cited by 369
Live Astrocytes Visualized by Green Fluorescent Protein in Transgenic Mice
Zhuo, L., Sun, B., Zhang, C.-L., Fine, A., Chiu, S. Y., & Messing, A. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8601 · Cited by 364
Kokovay, E., Goderie, S. K., Wang, Y., Lotz, S., Lin, G., Sun, Y., Roysam, B., Shen, Q., & Temple, S. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.05.019 · Cited by 358
Young, K., Fogarty, M., Kessaris, N., & Richardson, W. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0476-07.2007 · Cited by 353
Beckervordersandforth, R., Tripathi, P., Ninkovic, J., Bayam, E., Lepier, A., Stempfhuber, B., Kirchhoff, F., Hirrlinger, J., Haslinger, A., Lie, D. C., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.11.017 · Cited by 335
CD133 + neural stem cells in the ependyma of mammalian postnatal forebrain
Coskun, V., Wu, H., Blanchi, B., Tsao, S. W., Kim, K., Zhao, J., Biancotti, J. C., Hutnick, L. K., Krueger, R. C., Fan, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710000105 · Cited by 331
Jensen, K. B., & Watt, F. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601886103 · Cited by 321
Groves, A., Kihara, Y., & Chun, J. J. M. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.02.011 · Cited by 318
Garza, L. A., Liu, Y., Yang, Z., Alagesan, B., Lawson, J. A., Norberg, S. M., Loy, D. E., Zhao, T., Blatt, H. B., Stanton, D. C., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003122 · Cited by 308
Pallafacchina, G., François, S., Regnault, B., Czarny, B., Dive, V., Cumano, A., Montarras, D., & BUCKINGHAM, M. E. (2009) · Stem Cell Research · doi:10.1016/j.scr.2009.10.003 · Cited by 295
High Levels of Id1 Expression Define B1 Type Adult Neural Stem Cells
Nam, H.-S., & Benezra, R. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.08.017 · Cited by 272
Ponti, G., Obernier, K., Guinto, C. D., Jose, L., Bonfanti, L., & Álvarez-Buylla, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219563110 · Cited by 258
Ortega, F., Gascón, S., Masserdotti, G., Deshpande, A., Simon, C., Fischer, J., Dimou, L., Chichung Lie, D., Schroeder, T., & Berninger, B. (2013) · Nature Cell Biology · doi:10.1038/ncb2736 · Cited by 247
Morshead, C. M., Garcia, A. D., Sofroniew, M. V., & van der Kooy, D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02727.x · Cited by 223
Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescencePreprint
Martynoga, B., Mateo, J. L., Zhou, B., Andersen, J., Achimastou, A., Urbán, N., van den Berg, D. L. C., Georgopoulou, D., Hadjur, S., Wittbrodt, J., et al. (2013) · Genes & Development · doi:10.1101/gad.216804.113 · Cited by 214
Kokovay, E., Wang, Y., Kusek, G., Wurster, R., Lederman, P. L., Lowry, N. A., Shen, Q., & Temple, S. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.06.016 · Cited by 213
Marqués‐Torrejón, M. Á., Porlan, E., Banito, A., Gómez-Ibarlucea, E., Lopez-Contreras, A. J., Fernández-Capetillo, Ó., Vidal, A., Gil, J., Torres, J., & Fariñas, I. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.12.001 · Cited by 203
The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
Mirzadeh, Z., Doetsch, F. K., Sawamoto, K., Wichterle, H., & Álvarez-Buylla, A. (2010) · Journal of Visualized Experiments · doi:10.3791/1938 · Cited by 199
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex
Ishizuka, K., Kamiya, A., Oh, E. C. T., Kanki, H., Seshadri, S., Robinson, J. F., Murdoch, H., Dunlop, A. J., Kubo, K., Furukori, K., et al. (2011) · Nature · doi:10.1038/nature09859 · Cited by 195
Kazanis, I., Lathia, J. D., Vadakkan, T. J., Raborn, E., Wan, R., Mughal, M. R., Eckley, D. M., Sasaki, T., Patton, B. L., Mattson, M. P., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0700-10.2010 · Cited by 178
Başak, O., Giachino, C., Fiorini, E., MacDonald, H. R., & Taylor, V. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0455-12.2012 · Cited by 175
Dorsal Radial Glia Generate Olfactory Bulb Interneurons in the Postnatal Murine Brain
Ventura, R. E., & Goldman, J. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0399-07.2007 · Cited by 161
Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging
Silva-Vargas, V., Crouch, E. E., & Doetsch, F. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.09.004 · Cited by 157
Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis
Kawaguchi, D., Furutachi, S., Kawai, H., Hozumi, K., & Gotoh, Y. (2013) · Nature Communications · doi:10.1038/ncomms2895 · Cited by 154
van den Berge, S. A., Middeldorp, J., Zhang, C. E., Curtis, M., Leonard, B. W., Mastroeni, D., Voorn, P., van de Berg, W. V. D., Huitinga, I., & Hol, E. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00556.x · Cited by 152
CD133 (Prominin) Negative Human Neural Stem Cells Are Clonogenic and Tripotent
Sun, Y., Kong, W., Falk, A., Jin, H., Zhou, L., Pollard, S. M., & Smith, A. G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005498 · Cited by 134
Molecular Diversity Subdivides the Adult Forebrain Neural Stem Cell Population
Giachino, C., Başak, O., Lugert, S., Knuckles, P., Obernier, K., Fiorelli, R., Frank, S., Raineteau, O., Álvarez-Buylla, A., & Taylor, V. (2013) · Stem Cells · doi:10.1002/stem.1520 · Cited by 130
Alfonso, J., Magueresse, C. L., Zuccotti, A., Khodosevich, K., & Monyer, H. (2012) · Cell stem cell · doi:10.1016/j.stem.2011.11.011 · Cited by 127
Molecular Signatures of Quiescent, Mobilized and Leukemia-Initiating Hematopoietic Stem Cells
Forsberg, E. C., Passegué, E., Prohaska, S. S., Wagers, A. J., Koeva, M., Stuart, J. M., & Weissman, I. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008785 · Cited by 127
Neurotransmitters couple brain activity to subventricular zone neurogenesis
Young, S. Z., Taylor, M. M., & Bordey, A. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07611.x · Cited by 120
In vivo contribution of nestin‐ and GLAST‐lineage cells to adult hippocampal neurogenesis
DeCarolis, N. A., Mechanic, M., Petřík, D., Carlton, A., Ables, J. L., Malhotra, S., Bachoo, R. M., Götz, M., Lagace, D. C., & Eisch, A. J. (2013) · Hippocampus · doi:10.1002/hipo.22130 · Cited by 116
Platel, J., Gordon, V., Heintz, T. G., & Bordey, A. (2008) · Glia · doi:10.1002/glia.20735 · Cited by 110
Pinto, L., Mader, M. T., Irmler, M., Gentilini, M., Santoni, F. A., Drechsel, D., Blum, R., Stahl, R., Bulfone, A., Malatesta, P., et al. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.01.012 · Cited by 103
López‐Juárez, A., Howard, J., Ullom, K., Howard, L., Grande, A. W., Pardo, A. C., Waclaw, R. R., Sun, Y., Yang, D., Kuan, C.-Y., et al. (2013) · Genes & Development · doi:10.1101/gad.217539.113 · Cited by 95
Lacar, B., Young, S. Z., Platel, J., & Bordey, A. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07901.x · Cited by 86
Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone
Lacar, B., Hermán, P., Platel, J., Kubera, C., Hyder, F., & Bordey, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1457-12.2012 · Cited by 84
Transcriptional repression of Bmp2 by p21Waf1/Cip1 links quiescence to neural stem cell maintenance
Porlan, E., Morante‐Redolat, J. M., Marqués‐Torrejón, M. Á., Andreu-Agulló, C., Carneiro, C., Gómez-Ibarlucea, E., Soto, A., Vidal, A., Ferrón, S. R., & Fariñas, I. (2013) · Nature Neuroscience · doi:10.1038/nn.3545 · Cited by 78
G-Protein-Coupled Receptors in Adult Neurogenesis
Doze, V. A., & Perez, D. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.004762 · Cited by 75
Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation
Barnabé‐Heider, F., Meletis, K., Eriksson, M., Bergmann, O., Sabelström, H., Harvey, M., Mikkers, H. M. M., & Frisén, J. (2008) · Nature Methods · doi:10.1038/nmeth.1174 · Cited by 74
Sunabori, T., Tokunaga, A., Nagai, T., Sawamoto, K., Okabe, M., Miyawaki, A., Matsuzaki, Y., Miyata, T., & Okano, H. (2008) · Journal of Cell Science · doi:10.1242/jcs.025064 · Cited by 73
Genetic Methods to Identify and Manipulate Newly Born Neurons in the Adult Brain
Imayoshi, I., Sakamoto, M., & Kageyama, R. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00064 · Cited by 72
The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
Mirzadeh, Z., Doetsch, F. K., Sawamoto, K., Wichterle, H., & Álvarez-Buylla, A. (2010) · Journal of Visualized Experiments · doi:10.3791/1938-v · Cited by 71
The Molecular Profiles of Neural Stem Cell Niche in the Adult Subventricular Zone
Lee, C., Hu, J., Ralls, S., Kitamura, T., Loh, Y. P., Yang, Y., Mukouyama, Y., & Ahn, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050501 · Cited by 63
Human placental alkaline phosphatase as a histochemical marker of gene expression in transgenic mice
DePrimo, S. E., Stambrook, P. J., & Stringer, J. R. (1996) · Transgenic Research · doi:10.1007/bf01980211 · Cited by 59
Giachino, C., & Taylor, V. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06798.x · Cited by 55
Sato, K., Malchinkhuu, E., Horiuchi, Y., Mogi, C., Tomura, H., Tosaka, M., Yoshimoto, Y., Kuwabara, A., & Okajima, F. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.131 · Cited by 34
Cesetti, T., Fila, T., Obernier, K., Bengtson, C. P., Li, Y., Mandl, C., Hölzl‐Wenig, G., & Ciccolini, F. (2010) · Stem Cells · doi:10.1002/stem.573 · Cited by 30
"Color Timer" mice: visualization of neuronal differentiation with fluorescent proteins
Kanki, H., Shimabukuro, M. K., Miyawaki, A., & Okano, H. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-5 · Cited by 14
Evaluation of prostaglandin D2 as a CSF leak marker: implications in safe epidural anesthesia
Pentyala, Kondabolu, S., Adsumelli, R. S. N., Schabel, J., & Glass, P. S. A. (2011) · Local and Regional Anesthesia · doi:10.2147/lra.s18053 · Cited by 6
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Shin, J., Berg, D. A., Zhu, Y., Shin, J. Y., Song, J., Bonaguidi, M. A., Enikolopov, G., Nauen, D. W., Christian, K. M., Ming, G.-L., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.07.013 · Cited by 784
Llorens-Bobadilla, E., Zhao, S., Baser, A., Saiz-Castro, G., Zwadlo, K., & Martin-Villalba, A. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.07.002 · Cited by 778
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Metadata
- Authors
- Codega, P., Silva-Vargas, V., Paul, A., Maldonado-Soto, A. R., DeLeo, A. M., Pastrana, E., & Doetsch, F.
- Affiliations
- Columbia University (US)
- Herbert Irving Comprehensive Cancer Center (US)
- Corresponding author
- Doetsch, Fiona
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 82
- Issue
- 3
- Pages
- 545-559
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4360885
- OpenAlex
- W2065970275
- Cited by
- 634
- References
- 88
- Citations by year
- 2026: 17 · 2025: 35 · 2024: 36 · 2023: 63 · 2022: 61 · 2021: 61 · 2020: 63 · 2019: 75 · 2018: 47 · 2017: 63 · 2016: 49 · 2015: 49 · 2014: 14
- FWCI
- 20.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- David and Lucile Packard Foundation
- Foundation for the National Institutes of Health
- Leona M. and Harry B. Helmsley Charitable Trust
- National Institutes of Health (TL1TR000082)
- National Institute of Mental Health (T32 MH 15174-29, T32MH015174)
- National Institute of General Medical Sciences (T32GM008224, T32GM007088)
- National Institute of Neurological Disorders and Stroke (F31NS081990, R01NS053884, NS074039, R01NS074039, NS053884, NS053884-03S109, F31NS079057)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Keywords
- quiescent neural stem cells, ventricular-subventricular zone, stem cell activation, EGFR, nestin, olfactory bulb interneurons, stem cell quiescence, GPCR ligands, sphingosine-1-phosphate, prostaglandin D2, small molecule screening, colony-forming cells
- MeSH terms
- Animals, Astrocytes, Cell Separation, Cells, Cultured, Humans, Mice, Transgenic, Prospective Studies, Biomarkers, Lateral Ventricles, Mice, Adult Stem Cells, Neural Stem Cells, Transcriptome
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