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Cited by 171Barrier Structure and Function StudiesNeurogenesis and neuroplasticity mechanismsAngiogenesis and VEGF in Cancer

Sensory-Related Neural Activity Regulates the Structure of Vascular Networks in the Cerebral Cortex

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Lacoste, Baptiste, Comin, Cesar H., Ben-Zvi, Ayal, Kaeser, Pascal S., Xu, Xiaoyin, Costa, Luciano da F., Gu, Chenghua·2014·Neuron
DOI 10.1016/j.neuron.2014.07.034PMC PMC4166422
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Abstract

Neurovascular interactions are essential for proper brain function. While the effect of neural activity on cerebral blood flow has been extensively studied, whether or not neural activity influences vascular patterning remains elusive. Here, we demonstrate that neural activity promotes the formation of vascular networks in the early postnatal mouse barrel cortex. Using a combination of genetics, imaging, and computational tools to allow simultaneous analysis of neuronal and vascular components, we found that vascular density and branching were decreased in the barrel cortex when sensory input was reduced by either a complete deafferentation, a genetic impairment of neurotransmitter release at thalamocortical synapses, or a selective reduction of sensory-related neural activity by whisker plucking. In contrast, enhancement of neural activity by whisker stimulation led to an increase in vascular density and branching. The finding that neural activity is necessary and sufficient to trigger alterations of vascular networks reveals an important feature of neurovascular interactions.

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  • Deprivation of sensory input in the mouse barrel cortex by either surgical deafferentation or genetic inhibition of neurotransmitter release results in postnatal reduction in vascular density, suggesting that neuronal activity remains an important regulator of vascular plasticity after birth.

    “Deprivation of sensory input in the mouse barrel cortex by either surgical deafferentation or genetic inhibition of neurotransmitter release results in postnatal reduction in vascular density (340), suggesting that neuronal activity remains an important regulator of vascular plasticity after birth.”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [340]

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Authors
Lacoste, B., Comin, C. H., Ben-Zvi, A., Kaeser, P. S., Xu, X., Costa, L. D. F., & Gu, C.
Affiliations
  • Harvard University (US)
  • Universidade de São Paulo (BR)
  • Brigham and Women's Hospital (US)
Corresponding author
Gu, Chenghua
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2014-09
Volume
83
Issue
5
Pages
1117-1130
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2014.07.034
PMC
PMC4166422
OpenAlex
W2014932510
Cited by
171
References
6
Citations by year
2026: 11 · 2025: 17 · 2024: 12 · 2023: 20 · 2022: 23 · 2021: 25 · 2020: 16 · 2019: 8 · 2018: 7 · 2017: 12 · 2016: 10 · 2015: 8 · 2014: 2
FWCI
5.55
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Drug Abuse (K01DA029044)
  • National Institute of Neurological Disorders and Stroke (R01NS064583, P30NS072030)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords
neurovascular interactions, cerebral blood flow, vascular network formation, barrel cortex, sensory input, deafferentation, thalamocortical synapses, neurotransmitter release, whisker stimulation, vessel density, vascular branching, postnatal development, mice
MeSH terms
Afferent Pathways, Age Factors, Animals, Animals, Newborn, Cerebral Cortex, Cerebrovascular Circulation, Luminescent Proteins, Mice, Transgenic, Phosphopyruvate Hydratase, Physical Stimulation, Sensory Receptor Cells, Vibrissae, Gene Expression Regulation, Developmental, GTP-Binding Proteins, rab3 GTP-Binding Proteins, Receptor, TIE-2, Cell Proliferation, Mice, In Vitro Techniques

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