The barrier and interface mechanisms of the brain barrier, and brain drug delivery

Structure and function of the blood–brain barrier

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Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., & Deeley, R. G. (1992) · Science · doi:10.1126/science.1360704 · Cited by 3,037 · see citing works

Pericytes regulate the blood–brain barrier

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The blood-brain barrier: Bottleneck in brain drug development

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Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works

A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

Kadry, H., Noorani, B., & Cucullo, L. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00230-3 · Cited by 1,853 · see citing works

Establishment and Dysfunction of the Blood-Brain Barrier

Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell · doi:10.1016/j.cell.2015.10.067 · Cited by 1,670 · see citing works

The glymphatic pathway in neurological disorders.

Rasmussen, M. K., Mestre, H., & Nedergaard, M. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30318-1 · Cited by 1,560 · see citing works

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

Ha, D., Yang, N., & Nadithe, V. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.02.001 · Cited by 1,346 · see citing works

Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands

Saitou, M., Furuse, M., Sasaki, H., Schulzke, J.-D., Fromm, M., Takano, H., Noda, T., & Tsukita, S. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4131 · Cited by 1,195 · see citing works

Lack of Pericytes Leads to Endothelial Hyperplasia and Abnormal Vascular Morphogenesis

Hellström, M., Gerhardt, H., Kalén, M., Li, X., Eriksson, U., Wolburg, H., & Betsholtz, C. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.3.543 · Cited by 1,103 · see citing works

Current Strategies for Brain Drug Delivery

Dong, X. (2018) · Theranostics · doi:10.7150/thno.21254 · Cited by 954 · cited 1× · see citing works

Blood-brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

Lipsman, N., Meng, Y., Bethune, A. J., Huang, Y., Lam, B., Masellis, M., Herrmann, N., Heyn, C., Aubert, I., Boutet, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04529-6 · Cited by 950 · see citing works

Blood–brain barrier structure and function and the challenges for CNS drug delivery

Abbott, N. J. (2013) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-013-9608-0 · Cited by 913 · see citing works

Perivascular spaces in the brain: anatomy, physiology and pathology

Wardlaw, J. M., Benveniste, H., Nedergaard, M., Zlokovic, B. V., Mestre, H., Lee, H., Doubal, F. N., Brown, R., Ramirez, J., MacIntosh, B. J., et al. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0312-z · Cited by 870 · see citing works

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

Jia, G., Han, Y., An, Y., Ding, Y., He, C., Wang, X., & Tang, Q. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.029 · Cited by 753 · see citing works

Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release

Mahmoud, S., Gharagozloo, M., Simard, C., & Gris, D. (2019) · Cells · doi:10.3390/cells8020184 · Cited by 698 · see citing works

CNS Delivery Via Adsorptive Transcytosis

Hervé, F., Ghinea, N., & Scherrmann, J.-M. (2008) · The AAPS Journal · doi:10.1208/s12248-008-9055-2 · Cited by 676 · see citing works

Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies.

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Blood–Brain Barrier Pathophysiology in Traumatic Brain Injury

Chodobski, A., Zink, B. J., & Szmydynger‐Chodobska, J. (2011) · Translational Stroke Research · doi:10.1007/s12975-011-0125-x · Cited by 655 · see citing works

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

Agrawal, M., Saraf, S., Saraf, S., Antimisiaris, S. G., Chougule, M. B., Shoyele, S. A., & Alexander, A. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.05.011 · Cited by 630 · see citing works

The dynamic blood–brain barrier

Keaney, J., & Campbell, M. (2015) · The FEBS Journal · doi:10.1111/febs.13412 · Cited by 616 · see citing works

The Brain’s Glymphatic System: Current Controversies

Mestre, H., Mori, Y., & Nedergaard, M. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.04.003 · Cited by 609 · see citing works

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

Rosenberg, G. A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70016-x · Cited by 594 · see citing works

BindingDB Entry 50042057: Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

BindingDB (2013) · PubMed · doi:10.7270/q2q81fck · Cited by 575 · see citing works

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

Morad, G., Carman, C. V., Hagedorn, E. J., Perlin, J. R., Zon, L. I., Mustafaoğlu, N., Park, T., Ingber, D. E., Daisy, C. C., & Moses, M. A. (2019) · ACS Nano · doi:10.1021/acsnano.9b04397 · Cited by 561 · see citing works

Multidrug Resistance Protein (MRP)-mediated Transport of Leukotriene C4 and Chemotherapeutic Agents in Membrane Vesicles

Loe, D. W., Almquist, K. C., Deeley, R. G., & Cole, S. P. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9675 · Cited by 560 · see citing works

Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions

Saitou, M., Fujimoto, K., Doi, Y., Itoh, M., Fujimoto, T., Furuse, M., Takano, H., Noda, T., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.2.397 · Cited by 548 · see citing works

Development and Cell Biology of the Blood-Brain Barrier

Langen, U. H., Ayloo, S., & Gu, C. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062608 · Cited by 517 · see citing works

CSF, blood-brain barrier, and brain drug delivery

Pardridge, W. M. (2016) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2016.1171315 · Cited by 508 · see citing works

Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles

Saint-Pol, J., Gosselet, F., Duban-Deweer, S., Pottiez, G., & Karamanos, Y. (2020) · Cells · doi:10.3390/cells9040851 · Cited by 503 · see citing works

Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury

Yi, J., & Hazell, A. S. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.001 · Cited by 477 · see citing works

Physiological blood–brain transport is impaired with age by a shift in transcytosis

Yang, A. C., Stevens, M. Y., Chen, M. B., Lee, D. P., Stähli, D., Gate, D., Contrepois, K., Chen, W., Iram, T., Zhang, L., et al. (2020) · Nature · doi:10.1038/s41586-020-2453-z · Cited by 477 · see citing works

First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

Abrahao, A., Meng, Y., Llinas, M., Huang, Y., Hamani, C., Mainprize, T., Aubert, I., Heyn, C., Black, S. E., Hynynen, K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12426-9 · Cited by 476 · see citing works

SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier

Lee, S., Kim, W. J., Choi, Y. K., Song, H. S., Son, M. J., Gelman, I. H., Kim, Y.-J., & Kim, K. (2003) · Nature Medicine · doi:10.1038/nm889 · Cited by 473 · see citing works

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease

Ghersi-Egea, J.-F., Strazielle, N., Catala, M., Silva-Vargas, V., Doetsch, F., & Engelhardt, B. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1807-1 · Cited by 436 · see citing works

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Vieira, D., & Gamarra, L. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s117210 · Cited by 427 · see citing works

Age-associated Physiological and Pathological Changes at the Blood-Brain Barrier: A Review

Erdő, F., Denes, L., & de Lange, E. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16679420 · Cited by 426 · see citing works

Astrocyte Regulation of Blood Flow in the BrainPreprint

MacVicar, B. A., & Newman, E. A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020388 · Cited by 420 · see citing works

Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy

Leggas, M. L., Adachi, M., Scheffer, G. L., Sun, D., Wielinga, P. R., Du, G., Mercer, K. E., Zhuang, Y., Panetta, J. C., Johnston, B., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.17.7612-7621.2004 · Cited by 415 · see citing works

Modulation of cortical excitability induced by repetitive transcranial magnetic stimulation: Influence of timing and geometrical parameters and underlying mechanisms

Pell, G. S., Roth, Y., & Zangen, A. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.10.003 · Cited by 410 · see citing works

Extracellular vesicles: novel promising delivery systems for therapy of brain diseases.

Rufino-Ramos, D., Albuquerque, P. R., Carmona, V., Perfeito, R., Nobre, R. J., & Pereira de Almeida, L. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.07.001 · Cited by 395 · see citing works

Neuroimmune Axes of the Blood–Brain Barriers and Blood–Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions

Erickson, M. A., & Banks, W. A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014647 · Cited by 394 · see citing works

Regulation of blood-brain barrier integrity by microglia in health and disease: A therapeutic opportunity

Ronaldson, P. T., & Davis, T. P. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20951995 · Cited by 392 · see citing works

The blood-brain barrier: structure, function and therapeutic approaches to cross it.

Tajes, M., Ramos-Fernández, E., Weng-Jiang, X., Bosch-Morató, M., Guivernau, B., Eraso-Pichot, A., Salvador, B., Fernàndez-Busquets, X., Roquer, J., & Muñoz, F. J. (2014) · Molecular Membrane Biology · doi:10.3109/09687688.2014.937468 · Cited by 380 · see citing works

Choroid plexus and the blood–cerebrospinal fluid barrier in disease

Solár, P., Zamani, A., Kubíčková, L., Dubový, P., & Joukal, M. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00196-2 · Cited by 365 · see citing works

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

Yao, Y., Chen, Z.-L., Norris, E. H., & Strickland, S. (2014) · Nature Communications · doi:10.1038/ncomms4413 · Cited by 357 · see citing works

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Kariolis, M. S., Wells, R. C., Getz, J. A., Kwan, W., Mahon, C. S., Tong, R. K., Kim, D. J., Srivastava, A., Bédard, C., Henne, K. R., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay1359 · Cited by 356 · see citing works

Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease

Agrawal, M., Ajazuddin, Tripathi, D. K., Saraf, S., Saraf, S., Antimisiaris, S. G., Mourtas, S., Hammarlund-Udenaes, M., & Alexander, A. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.05.019 · Cited by 356 · see citing works

Drug Targeting to the Brain

de Boer, A. G., & Gaillard, P. J. (2006) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105237 · Cited by 355 · see citing works

Transmembrane proteins of the tight junctions at the blood–brain barrier: Structural and functional aspects

Haseloff, R. F., Dithmer, S., Winkler, L., Wolburg, H., & Blasig, I. E. (2015) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.11.004 · Cited by 353 · see citing works

Healthy aging and the blood–brain barrier

Banks, W. A., Reed, M. J., Logsdon, A. F., Rhea, E. M., & Erickson, M. A. (2021) · Nature Aging · doi:10.1038/s43587-021-00043-5 · Cited by 293 · see citing works

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

Blanchard, J. W., Bula, M., Davila-Velderrain, J., Akay, L. A., Zhu, L., Frank, A., Victor, M. B., Bonner, J. M., Mathys, H., Lin, Y.-T., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0886-4 · Cited by 283 · see citing works

Viral Infection of the Central Nervous System and Neuroinflammation Precede Blood-Brain Barrier Disruption during Japanese Encephalitis Virus Infection

Li, F., Wang, Y., Lan, Y., Cao, S., Wang, K., Yuan, J., Wang, C., Wang, K., Cui, M., & Fu, Z. F. (2015) · Journal of Virology · doi:10.1128/jvi.00143-15 · Cited by 277 · see citing works

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

Pizzo, M. E., Wolak, D. J., Kumar, N. N., Brunette, E., Brunnquell, C. L., Hannocks, M., Abbott, N. J., Meyerand, M. E., Sorokin, L., Stanimirovic, D. B., et al. (2018) · The Journal of Physiology · doi:10.1113/jp275105 · Cited by 272 · see citing works

Nanoemulsions for “Nose-to-Brain” Drug Delivery

Bonferoni, M. C., Rossi, S., Sandri, G., Ferrari, F., Gavini, E., Rassu, G., & Giunchedi, P. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11020084 · Cited by 269 · see citing works

The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier

Matsumoto, J., Stewart, T., Banks, W. A., & Zhang, J. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612823666170913164738 · Cited by 267 · see citing works

Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review

Bicker, J., Alves, G., Fortuna, A. C., & Falcão, A. C. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.03.012 · Cited by 264 · see citing works

Blood-brain barrier transport machineries and targeted therapy of brain diseases

Barar, J., Rafi, M. A., Pourseif, M. M., & Omidi, Y. (2016) · Bioimpacts · doi:10.15171/bi.2016.30 · Cited by 259 · see citing works

Tight junction proteins at the blood–brain barrier: far more than claudin-5

Berndt, P., Winkler, L., Cording, J., Breitkreuz-Korff, O., Rex, A., Dithmer, S., Rausch, V., Blasig, R., Richter, M., Sporbert, A., et al. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03030-7 · Cited by 256 · see citing works

Key for crossing the BBB with nanoparticles: the rational design

Lombardo, S. M., Schneider, M., Türeli, A. E., & Günday-Türeli, N. (2020) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.11.72 · Cited by 249 · see citing works

Contributions of the glycocalyx, endothelium, and extravascular compartment to the blood–brain barrier

Kutuzov, N. P., Flyvbjerg, H., & Lauritzen, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802155115 · Cited by 243 · see citing works

Subcellular localization of transporters along the rat blood–brain barrier and blood–cerebral-spinal fluid barrier by in vivo biotinylation

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Development of the choroid plexus and blood-CSF barrier

Liddelow, S. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00032 · Cited by 238 · see citing works

Breast Cancer Resistance Protein Exports Sulfated Estrogens but Not Free Estrogens

Imai, Y., Asada, S., Tsukahara, S., Ishikawa, E., Tsuruo, T., & Sugimoto, Y. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.3.610 · Cited by 235 · see citing works

Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS

Illés, P., Rubini, P., Ulrich, H., Zhao, Y., & Tang, Y. (2020) · Cells · doi:10.3390/cells9051108 · Cited by 235 · see citing works

Structural Features of Tight-Junction Proteins

Heinemann, U., & Schuetz, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236020 · Cited by 234 · see citing works

Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease

Goyal, D., Shuaib, S., Mann, S., & Goyal, B. (2017) · ACS Combinatorial Science · doi:10.1021/acscombsci.6b00116 · Cited by 229 · see citing works

Current concepts of blood-brain barrier development

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The Extracellular Matrix Protein Laminin α2 Regulates the Maturation and Function of the Blood–Brain Barrier

Menezes, M. J., McClenahan, F. K., Leiton, C. V., Aranmolate, A., Shan, X., & Colognato, H. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3678-13.2014 · Cited by 226 · see citing works

Neurotherapeutic applications of nanoparticles in Alzheimer’s disease

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The cerebrospinal fluid and barriers – anatomic and physiologic considerations

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Increase in blood–brain barrier leakage in healthy, older adults

Verheggen, I. C. M., de Jong, J. J. A., van Boxtel, M. P. J., Gronenschild, E. H. B. M., Palm, W. M., Postma, A. A., Jansen, J. F. A., Verhey, F. R. J., & Backes, W. H. (2020) · GeroScience · doi:10.1007/s11357-020-00211-2 · Cited by 205 · see citing works

Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery

Vazana, U., Veksler, R., Pell, G. S., Prager, O., Fassler, M., Chassidim, Y., Roth, Y., Shahar, H., Zangen, A., Raccah, R., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0587-16.2016 · Cited by 205 · see citing works

Brain delivery and activity of a lysosomal enzyme using a blood–brain barrier transport vehicle in mice

Ullman, J. C., Arguello, A., Getz, J. A., Bhalla, A., Mahon, C. S., Wang, J., Giese, T., Bedard, C., Kim, D. J., Blumenfeld, J. R., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay1163 · Cited by 205 · see citing works

APOE4 derived from astrocytes leads to blood–brain barrier impairment

Jackson, R. J., Meltzer, J. C., Nguyen, H., Commins, C., Bennett, R. E., Hudry, E., & Hyman, B. T. (2022) · Brain · doi:10.1093/brain/awab478 · Cited by 205 · see citing works

Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

Mäe, M. A., He, L., Nordling, S., Vázquez-Liébanas, E., Nahar, K., Jung, B., Li, X., Tan, B. C., Foo, J. C., Cazenave‐Gassiot, A., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.317473 · Cited by 203 · see citing works

Epithelial junctions and Rho family GTPases: the zonular signalosome

Citi, S., Guerrera, D., Spadaro, D., & Shah, J. (2014) · Small GTPases · doi:10.4161/21541248.2014.973760 · Cited by 199 · see citing works

Transcytosis of Macromolecules at the Blood–Brain Barrier

Preston, J. E., Abbott, N. J., & Begley, D. J. (2014) · Advances in pharmacology · doi:10.1016/bs.apha.2014.06.001 · Cited by 182 · see citing works

Borneol, a novel agent that improves central nervous system drug delivery by enhancing blood–brain barrier permeability

Zhang, Q., Fu, B. M., & Zhang, Z. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1346002 · Cited by 181 · see citing works

Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor

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Cellular Export of Drugs and Signaling Molecules by the ATP-binding Cassette Transporters MRP4 (ABCC4) and MRP5 (ABCC5)

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The mechanobiology of tight junctions

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Sensory-Related Neural Activity Regulates the Structure of Vascular Networks in the Cerebral Cortex

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Drug Delivery Across the Blood-Brain Barrier

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Nanoparticle formulations in the diagnosis and therapy of Alzheimer's disease

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Microglial activation and blood–brain barrier permeability in cerebral small vessel disease

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Blood–brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery

Pardridge, W. M. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1042364 · Cited by 159 · see citing works

Formulations for Intranasal Delivery of Pharmacological Agents to Combat Brain Disease: A New Opportunity to Tackle GBM?

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Advanced Drug Delivery Technologies for Enhancing Bioavailability and Efficacy of Risperidone

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Dobutamine-induced alterations in internal carotid artery blood flow and cerebral blood flow in healthy adults

Yu, F., Liu, D., Ma, X., Liu, Y., Cai, L., Zhao, E., Huang, Z., Zhang, Z., Zhang, T., Qiao, P., et al. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111204 · Cited by 4 · see citing works

ADMET properties, antioxidant activity and determination of Artocarpin level in hydroalcohol extract of Artocarpus lakoocha Buch. Ham leaves

Satria, D., Nazliniwaty, N., Hanafiah, O. A., Pertiwi, D., Waruwu, S. B., & Kaban, V. E. (2025) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2025.00440 · Cited by 4 · see citing works

Synaptic aging and neurodegeneration: the role of synaptic vesicle dynamics and neurotransmitter imbalance

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Acute brain injury and nanomedicine: sex as a biological variable

Simmons, A., Mihalek, O., Nelson, H. A. B., Sirianni, R. W., & Stabenfeldt, S. E. (2024) · Frontiers in Biomaterials Science · doi:10.3389/fbiom.2024.1348165 · Cited by 4 · see citing works

Discovery of Novel Cholinesterase Inhibitors Easily Crossing the Blood‐Brain Barrier via Structure‐Property Relationship Investigation: Methylenedioxy‐Cinnamicamide Containing Tertiary Amine Side Chain

Shi, Q. X., Yang, Z., Wang, Y., Yi, B., Gao, X., Ding, Y. J., Peng, D., Chen, Y., & Liu, H. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202400557 · Cited by 4 · see citing works

Carboxylic Acid- and Amine-Modified Pluronic F127-Based Thermoresponsive Nanogels as Smart Carriers for Brain Drug Delivery

Andrgie, A. T., Liao, C.-H., Wu, T.-Y., Yang, H., Harn, H., Lin, S., Chen, Y.-S., & Tsai, H. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s507362 · Cited by 4 · see citing works

“Proteinjury”: a universal pathological mechanism mediated by cerebrospinal fluid in neurodegeneration and trauma

Lazarev, V. F., Alhasan, B. A., Guzhova, I. V., & Margulis, B. A. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1593122 · Cited by 4 · see citing works

Investigation of the Binding Interaction of Mfsd2a with NEDD4-2 via Molecular Dynamics Simulations

Yuan, W., Qiu, Z., Li, H., Huang, M., Yuan, J., Niu, S.-L., Chen, Q., Yang, Q., & Ouyang, Q. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00791 · Cited by 4 · see citing works

Innovative nanoparticle-based therapeutic strategies against glioblastoma multiform: a focus on enhanced delivery systems and efficacy

Wang, K. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1601673 · Cited by 3 · see citing works

Modulating Cerebrospinal Fluid Composition in Neurodegenerative Processes: Modern Drug Delivery and Clearance Strategies

Dutysheva, E. A., Викторовна, З. А., Valko, M. A., Antipina, E. O., Zimatkin, S. M., Margulis, B. A., Guzhova, I. V., & Lazarev, V. F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311541 · Cited by 3 · see citing works

Neuroprotective Effects of the Combination of Green Tea, Saffron, Docosahexaenoic Acid, and α-Lipoic Acid in an In Vitro Model of Parkinson's Disease

Galla, R., Mulè, S., Battaglia, S., Curti, V., Ranieri, F. R., Parini, F., & Uberti, F. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05800-4 · Cited by 3 · see citing works

The interventional effect of acupuncture on overall cognitive function in Alzheimer's disease spectrum disorders: A meta-analysis

Chen, Y., Zhao, S., Yang, F., Wang, Y., Han, Z., Han, F., Wang, Z., Chen, Z., Sun, K., Liang, P., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261438495 · Cited by 3 · see citing works

Blood-brain barrier permeability revisited: Predicting intrinsic passive BBB permeability using the Solubility-diffusion model

Ebert, A., & Goss, K. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107354 · Cited by 3 · see citing works

In-situ Gels for Brain Delivery: Breaching the Barriers

Fatima, G. N., Maurya, P., Nishtha, & Saraf, S. K. (2023) · Current Pharmaceutical Design · doi:10.2174/1381612829666230803114513 · Cited by 4 · see citing works

Nano-Biomaterial-Assisted Targeted Therapy of Central Nervous System Disorders

Phatale, V., Kolipaka, T., Khairnar, P., Pandey, G., Negi, M., Saraf, S., & Srivastava, S. (2024) · Springer eBooks · doi:10.1007/978-981-97-3925-7_11 · Cited by 3 · see citing works

Dysregulation of Multiple Solute Carrier genes and Metabolic Deficits in SLC1A4 -Mutant Human iPSC-Derived Hippocampal NeuronsPreprint

Nayak, R., Sharma, O., Mizrahi, L., Shemen, A., Tripathi, U., Hussein, Y., Rike, W. A., Rosh, I., Radzishevsky, I. S., Mandel, H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.25.650669 · Cited by 3 · see citing works

Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease

Silva, R., Monteiro, J., Ramalho, M. J., Andrade, S., Loureiro, J. A., & Pereira, M. C. (2026) · Pharmaceuticals · doi:10.3390/ph19050685 · Cited by 2 · see citing works

Cutting-edge Approach of Carbon Nanostructures: Targeted Drug Delivery to Central Nervous System

Sethumadhavan, V., Guleria, M., Kumar, P., Bhowmick, M., Bhowmick, P., Ashique, S., Husain, I., & Pal, R. (2024) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/0118715249305383240705045921 · Cited by 2 · see citing works

Octa-Arginine-Conjugated Liposomal Nimodipine Incorporated in a Temperature-Responsive Gel for Nasoencephalic Delivery

Hong, S., Lin, C., Hu, J., Piao, J., & Piao, M. G. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.4c00634 · Cited by 2 · see citing works

Structure–Tissue Exposure/Selectivity Relationship (STR) on Carbamates of Cannabidiol

Wang, S., Yang, J.-G., Rong, K., Li, H., Wu, C., & Tang, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252211888 · Cited by 2 · see citing works

Material considerations for delivering therapeutics across the blood–brain barrier

Zoba, A. N., & Tringides, C. M. (2025) · APL Materials · doi:10.1063/5.0284305 · Cited by 2 · see citing works

Cutting-edge strategies for delivering drugs to the brain based on nanocarriers

Shaw, T. K., Shuvo, S. M., Paul, P., Jana, A., & Ali, K. A. (2025) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2025.2555858 · Cited by 2 · see citing works

Rethinking on bile acid-brain axis: decoding neurotoxic and neuroprotective landscape in aging and Alzheimer’s disease

Singh, G., & Aran, K. R. (2026) · Biogerontology · doi:10.1007/s10522-025-10384-y · Cited by 2 · see citing works

Reimagining Brain Drug Delivery: Mechanistic and Translational Advances in Carbon Nanotube Nanomedicine

Gupta, R. V., Kumar, R., Kumar, N., & Singh, P. (2026) · Journal of Applied Toxicology · doi:10.1002/jat.70154 · Cited by 2 · see citing works

Recent innovative approaches for drug delivery systems targeting cancer and CNS disorders

Anand, M. K., Premalatha, E., Moorthy, H., & Govindaraju, T. (2026) · Journal of Materials Chemistry B · doi:10.1039/d6tb00411c · Cited by 3 · see citing works

Therapeutic monoclonal antibodies in the central nervous system: Pharmacokinetics, bioanalysis and clinical implications

Onyango, I. G., Woolf, N., Green, J., Stinchcomb, M., & Matveyeva, M. (2026) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2026.104350 · Cited by 2 · see citing works

Colored microplastics: A review on environmental and health risks from dyed textiles

Ahmed, N., Jahan, N., Smriti, S. A., Karim, R., Himu, H. A., Naebe, M., & Haque, A. N. M. A. (2026) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2026.123423 · Cited by 2 · see citing works

Recent Advances on Extracellular Vesicles: A Natural Nanomaterial for Biomedical Application

Li, F., Liu, S. L., Xu, S., Duan, H., Wang, Y., & Li, J. (2026) · Biomimetics · doi:10.3390/biomimetics11060416 · Cited by 2 · see citing works

Breaking through the blood-brain barrier for different kinds of drugs: challenges, solutions, and perspectives

She, P., Ao, X., Zhan, X., Zhou, W., Cheng, Y., Yang, H. J., Wu, S., Zhang, X., Peng, W., & Wang, J. (2024) · BME Horizon · doi:10.70401/bmeh.2024.124 · Cited by 1 · see citing works

Bitter Taste Receptors as Gatekeepers of Brain Barriers

Duarte, A. C., Costa, A. R., Gonçalves, I., Quintela, T., & Santos, C. R. A. (2025) · Current human cell research and applications · doi:10.1007/978-981-97-9495-9_4 · Cited by 1 · see citing works

Computational exploration of aphrodisiac potential: identifying inhibitors from Tribulus terrestris L., and Securidaca longepedunculata targeting human phosphodiesterase 5

Ahmed, S. A., Aremu, A. A., Shafiq, M., & Ul‐Haq, Z. (2025) · In Silico Pharmacology · doi:10.1007/s40203-025-00402-9 · Cited by 1 · see citing works

From glia limitans to glial scars: in vitro co-culture studies of the astrocyte and meningeal interaction

Reardon, E. C., Greaney, A. J., & Mulvihill, J. J. (2025) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00715-z · Cited by 1 · see citing works

Research Progress on Nasal Delivery of siRNA Nanocarrier Systems for the Treatment of Neurodegenerative Diseases

Huang, Q., Wu, W., Liu, Y., Li, W., Chen, X., Yu, S., Gong, G., & Shu, H. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17111407 · Cited by 1 · see citing works

Brain delivery of lipid nanoparticles with shuttle peptides

Martínez-Martínez, N., CARRERA-RODRÍGUEZ, L., Vargas, R., Hernández-Munaín, C., Suñé-Pou, M., & Suñé, C. M. I. (2026) · Advances in pharmacology · doi:10.1016/bs.apha.2026.02.005 · Cited by 1 · see citing works

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

Connor, K. L., Souza, N. I. S., dos Anjos, B. G., Matthews, S. G., & Bloise, E. (2026) · The Journal of Physiology · doi:10.1113/jp289627 · Cited by 1 · see citing works

Blood-brain barrier modulation for targeted central nervous system drug delivery in neurodegenerative and demyelinating disorders

Uti, D. E., Alum, E. U., Okpe, J. M., Egbung, J. E., & Mbah, J. O. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103524 · Cited by 1 · see citing works

Intranasal nanoemulsion for targeted medication delivery to the brain: a novel approach to treat psychotic disorder

Das, S., Sarkar, M., Bagchi, A., & Bahadur, S. (2026) · Drug Delivery and Translational Research · doi:10.1007/s13346-026-02054-4 · Cited by 1 · see citing works

Physical activity and the brain barriers: Mechanisms of neuroprotection and disease resilience

Morys, J., Solarz, A., Mi, J., Gilicinska, M., Kostka, M., Burek, M., Małecki, A., Toborek, M. J., & Nowacka-Chmielewska, M. M. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119554 · Cited by 1 · see citing works

Ion-Triggered In Situ Gel Combined with Melatonin Liposomes: Breaking Through the Dual Barriers of Nasal and Brain Delivery to Treat Insomnia

Dong, Z., Dong, X., Wang, H., Pan, Y., Yang, M., Zhao, S., Deng, W., Han, M., Ye, T., & Wang, S. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18060656 · Cited by 1 · see citing works

Carbohydrate-Functionalized Liposomal Nanocarriers: Design Strategies for Receptor-Mediated Organ Targeting and Advanced Theranostic Applications

Beliraya, J., Seenivasan, R., Halagali, P., Rathnanand, M., & Tippavajhala, V. K. (2026) · AAPS PharmSciTech · doi:10.1208/s12249-026-03453-z · Cited by 1 · see citing works

Synergistic drug homing for glioblastoma: Integrating biomimetic nanocarriers with MR-guided focused ultrasound across the blood-brain barrier

Sami, I. S., & Ahamed, J. U. (2026) · Materials Today Advances · doi:10.1016/j.mtadv.2026.100859 · Cited by 1 · see citing works

The Guardian of the Brain: Understanding the Blood–Brain Barrier and its Role in CNS Drug Discovery

Rohfleisch, L., & Mishuris, B. (2024) · Springer eBooks · doi:10.1007/978-3-031-61992-2_5 · Cited by 1 · see citing works

Blood–Brain Barrier and CNS Drug Penetration: Mechanisms, Challenges, and Strategies for Enhanced Therapeutic Delivery

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Blood-Brain Barrier Modulation In CNS Drug Development: Current Strategies And Clinical Perspectives

A.1*, U. F. G. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.22110915

Physiology of the blood–brain barrier and its consequences for drug transport to the brain

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Drug targeting to the brain

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