The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Dendritic Structural Degeneration Is Functionally Linked to Cellular Hyperexcitability in a Mouse Model of Alzheimer’s Disease
Open accessAbstract
Dendritic structure critically determines the electrical properties of neurons and, thereby, defines the fundamental process of input-to-output conversion. The diversity of dendritic architectures enables neurons to fulfill their specialized circuit functions during cognitive processes. It is known that this dendritic integrity is impaired in patients with Alzheimer's disease and in relevant mouse models. It is unknown, however, whether this structural degeneration translates into aberrant neuronal function. Here we use in vivo whole-cell patch-clamp recordings, high-resolution STED imaging, and computational modeling of CA1 pyramidal neurons in a mouse model of Alzheimer's disease to show that structural degeneration and neuronal hyperexcitability are crucially linked. Our results demonstrate that a structure-dependent amplification of synaptic input to action potential output conversion might constitute a novel cellular pathomechanism underlying network dysfunction with potential relevance for other neurodegenerative diseases with abnormal changes of dendritic morphology.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Since AD is also associated with progressive neurite degeneration (51), we examined neurite outgrowth in spheroids.”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [51]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420
The NEURON Simulation Environment
Hines, M. L., & Carnevale, N. T. (1997) · Neural Computation · doi:10.1162/neco.1997.9.6.1179 · Cited by 2,630
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376
Pyramidal neurons: dendritic structure and synaptic integration
Spruston, N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2286 · Cited by 1,688
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653
Verret, L., Mann, E. O., Hang, G. B., Barth, A. M. I., Cobos, I., Ho, K., Devidze, N., Masliah, E., Kreitzer, A. C., Mody, I., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.046 · Cited by 1,216
Jasper's Basic Mechanisms of the Epilepsies
(2012) · Oxford University Press eBooks · doi:10.1093/med/9780199746545.001.0001 · Cited by 1,161
Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease
Busche, M. A., Eichhoff, G., Adelsberger, H., Abramowski, D., Wiederhold, K.-H., Haass, C., Staufenbiel, M., Konnerth, A., & Garaschuk, O. (2008) · Science · doi:10.1126/science.1162844 · Cited by 1,125
Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment
Scheff, S. W., Price, D. A., Schmitt, F. A., & Mufson, E. J. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.012 · Cited by 1,017
Rall, W. (1967) · Journal of Neurophysiology · doi:10.1152/jn.1967.30.5.1138 · Cited by 996
Megı́as, M., Emri, Z., Freund, T. F., & Gulyás, A. I. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00496-6 · Cited by 950
Diversity and Dynamics of Dendritic Signaling
Häusser, M., Spruston, N., & Stuart, G. J. (2000) · Science · doi:10.1126/science.290.5492.739 · Cited by 783
Dendritic integration of excitatory synaptic input
Magee, J. C. (2000) · Nature reviews. Neuroscience · doi:10.1038/35044552 · Cited by 737
Busche, M. A., Chen, X., Henning, H. A., Reichwald, J., Staufenbiel, M., Sakmann, B., & Konnerth, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206171109 · Cited by 715
Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease
Vossel, K. A., Beagle, A. J., Rabinovici, G., Shu, H., Lee, S. E., Naasan, G., Hegde, M., Cornes, S., Henry, M., Nelson, A. B., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.136 · Cited by 709
ELECTROPHYSIOLOGY OF HIPPOCAMPAL NEURONS: II. AFTER-POTENTIALS AND REPETITIVE FIRING
Kandel, E. R., & Spencer, W. A. (1961) · Journal of Neurophysiology · doi:10.1152/jn.1961.24.3.243 · Cited by 687
Roberson, E. D., Halabisky, B., Yoo, J. W., Yao, J., Chin, J., Yan, F., Wu, T., Hamto, P., Devidze, N., Yu, G.-Q., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4152-10.2011 · Cited by 654
Amyloid β-Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy
Minkeviciene, R., Rheims, S., Dobszay, M. B., Zilberter, M. Y., Hartikainen, J., Fülöp, L., Penke, B., Zilberter, Y., Harkany, T., Pitkänen, A., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5215-08.2009 · Cited by 648
Sanchez, P. E., Zhu, L., Verret, L., Vossel, K. A., Orr, A. G., Cirrito, J. R., Devidze, N., Ho, K., Yu, G.-Q., Palop, J. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121081109 · Cited by 638
Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons
Magee, J. C., & Cook, E. P. (2000) · Nature Neuroscience · doi:10.1038/78800 · Cited by 637
Active Properties of Neuronal Dendrites
Johnston, D., Magee, J. C., Colbert, C. M., & Christie, B. R. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001121 · Cited by 608
Impact of Active Dendrites and Structural Plasticity on the Memory Capacity of Neural Tissue
Poirazi, P., & Mel, B. W. (2001) · Neuron · doi:10.1016/s0896-6273(01)00252-5 · Cited by 601
Propagation of action potentials in dendrites depends on dendritic morphology
Vetter, P., Roth, A., & Häusser, M. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.2.926 · Cited by 598
Incidence and Predictors of Seizures in Patients with Alzheimer's Disease
Amatniek, J. C., Hauser, W. A., del Castillo–Castañeda, C., Jacobs, D. M., Marder, K. S., Bell, K. L., Albert, M., Brandt, J., & Stern, Y. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00554.x · Cited by 592
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
Tsai, J., Grutzendler, J., Duff, K., & Gan, W.-B. (2004) · Nature Neuroscience · doi:10.1038/nn1335 · Cited by 561
Electrophysiology of a Dendritic Neuron Model
Rall, W. (1962) · Biophysical Journal · doi:10.1016/s0006-3495(62)86953-7 · Cited by 495
Routing of spike series by dynamic circuits in the hippocampus
Pouille, F., & Scanziani, M. (2004) · Nature · doi:10.1038/nature02615 · Cited by 434
Branch Input Resistance and Steady Attenuation for Input to One Branch of a Dendritic Neuron Model
Rall, W., & Rinzel, J. (1973) · Biophysical Journal · doi:10.1016/s0006-3495(73)86014-x · Cited by 352
Jarsky, T., Roxin, A., Kath, W. L., & Spruston, N. (2005) · Nature Neuroscience · doi:10.1038/nn1599 · Cited by 311
Input normalization by global feedforward inhibition expands cortical dynamic range
Pouille, F., Marin-Burgin, A., Adesnik, H., Atallah, B. V., & Scanziani, M. (2009) · Nature Neuroscience · doi:10.1038/nn.2441 · Cited by 306
Mechanisms and consequences of action potential burst firing in rat neocortical pyramidal neurons
Williams, S. R., & Stuart, G. J. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00467.x · Cited by 300
Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease
Zaja-Milatovic, S., Milatovic, D., Schantz, A. M., Zhang, J., Montine, K. S., Samii, A., Deutch, A. Y., & Montine, T. J. (2005) · Neurology · doi:10.1212/01.wnl.0000150591.33787.a4 · Cited by 300
Noebels, J. L. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2010.02909.x · Cited by 261
Plasticity of intrinsic neuronal properties in CNS disorders
Beck, H., & Yaari, Y. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2371 · Cited by 250
Dendrite and dendritic spine alterations in alzheimer models
Moolman, D. L., Vitolo, O. V., Vonsattel, J.-P. G., & Shelanski, M. L. (2004) · Journal of Neurocytology · doi:10.1023/b:neur.0000044197.83514.64 · Cited by 245
Geula, C. (1998) · Neurology · doi:10.1212/wnl.51.1_suppl_1.s18 · Cited by 184
Ittner, L. M., Ke, Y. D., & Götz, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.014472 · Cited by 156
Passive Normalization of Synaptic Integration Influenced by Dendritic Architecture
Jaffe, D. B., & Carnevale, N. T. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.6.3268 · Cited by 151
Grutzendler, J., Helmin, K. A., Tsai, J., & Gan, W. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.003 · Cited by 143
Brown, J. T., Chin, J., Leiser, S. C., Pangalos, M. N., & Randall, A. D. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.05.025 · Cited by 128
Neuronal Structure is Altered by Amyloid Plaques
Spires‐Jones, T. L., & Hyman, B. T. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.4.267 · Cited by 108
Neurons and Their Dendrites in Frontotemporal Dementia
Ferrer, I. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051214 · Cited by 105
Le, R., Cruz, L., Urbanc, B., Knowles, R. B., Ashe, K. H., Duff, K., Irizarry, M. C., Stanley, E., & Hyman, B. T. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.753 · Cited by 90
Inhibitory Control of Linear and Supralinear Dendritic Excitation in CA1 Pyramidal Neurons
Müller, C., Beck, H., Coulter, D. A., & Remy, S. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.025 · Cited by 89
Self-citationFalke, E., Nissanov, J., Mitchell, T. W., Bennett, D. A., Trojanowski, J. Q., & Arnold, S. E. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63518-3 · Cited by 82
Hall, G. F., Chu, B., Lee, G. S., & Yao, J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.8.1373 · Cited by 78
Chen, C. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.169 · Cited by 74
Cognitive and Behavioral Comorbidities of Epilepsy
Kleen, J. K., Scott, R. C., Lenck‐Santini, P., & Holmes, G. L. (2012) · Oxford University Press eBooks · doi:10.1093/med/9780199746545.003.0072 · Cited by 73
Early-Onset and Robust Amyloid Pathology in a New Homozygous Mouse Model of Alzheimer's Disease
Willuweit, A., Velden, J., Godemann, R., Manook, A., Jetzek, F., Tintrup, H., Kauselmann, G., Zevnik, B., Henriksen, G., Drzezga, A. E., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007931 · Cited by 60
Adlard, P. A., & Vickers, J. C. (2002) · Acta Neuropathologica · doi:10.1007/s00401-001-0476-6 · Cited by 47
Abnormal excitability of oblique dendrites implicated in early Alzheimer's: a computational study
Morse, T. M. (2010) · Frontiers in Neural Circuits · doi:10.3389/fncir.2010.00016 · Cited by 43
Šišková, Z., Reynolds, R. A., O'Connor, V. M., & Perry, V. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055004 · Cited by 35
Self-citationKim, W., Im, M. J., Park, C. H., Lee, C. J., Choi, S., & Yoon, B.-J. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.10.049 · Cited by 22
Purkinje cells in degenerative diseases of the cerebellum and its connections: a Golgi study.
Ferrer, I., Kulisevsky, J., Vazquez, J., Gónzalez González, G., & Pineda, M. (1988) · PubMed · Cited by 22
Cited by
Sorted by citations
Network abnormalities and interneuron dysfunction in Alzheimer disease
Palop, J. J., & Mucke, L. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.141 · Cited by 1,022
Neuronal activity enhances tau propagation and tau pathology in vivo
Wu, J. W., Hussaini, S. A., Bastille, I. M., Rodriguez, G. A., Mrejeru, A., Rilett, K., Sanders, D. W., Cook, C., Fu, H., Boonen, R. A. C. M., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4328 · Cited by 820
Epileptic activity in Alzheimer’s disease: Causes and clinical relevance
Vossel, K. A., Tartaglia, M. C., Nygaard, H. B., Zeman, A. Z., & Miller, B. L. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30044-3 · Cited by 590
The road to restoring neural circuits for the treatment of Alzheimer's disease
Canter, R. G., Penney, J., & Tsai, L.-H. (2016) · Nature · doi:10.1038/nature20412 · Cited by 565
Targa Dias Anastacio, H., Matosin, N., & Ooi, L. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02024-7 · Cited by 401
Metadata
- Authors
- Šišková, Z., Justus, D., Kaneko, H., Friedrichs, D., Henneberg, N., Beutel, T., Pitsch, J., Schoch, S., Becker, A., von der Kammer, H., & Remy, S.
- Affiliations
- German Center for Neurodegenerative Diseases (DE)
- University of Bonn (DE)
- Corresponding author
- Remy, Stefan
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 84
- Issue
- 5
- Pages
- 1023-1033
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2062605351
- Cited by
- 320
- References
- 54
- Citations by year
- 2026: 21 · 2025: 31 · 2024: 39 · 2023: 23 · 2022: 34 · 2021: 44 · 2020: 32 · 2019: 21 · 2018: 18 · 2017: 19 · 2016: 23 · 2015: 13 · 2014: 2
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- DZNE Pub (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- neuronal hyperexcitability, Alzheimer's disease, CA1 pyramidal neurons, dendritic morphology, network dysfunction, mouse models of Alzheimer's disease, computational modeling
- MeSH terms
- Action Potentials, Alzheimer Disease, Animals, Computer Simulation, Dendrites, Disease Models, Animal, Electric Stimulation, Female, Hippocampus, Humans, Lysine, Male, Mice, Transgenic, Models, Neurological, Mutation, Nerve Degeneration, Neurons, Amyloid beta-Protein Precursor, Mice, Presenilin-1, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
